Serum sortilin as a potential diagnostic and therapeutic target for cardiovascular calcification in uremic patients: A single-center prospective and observational study.

Background: Cardiovascular disease (CVD) is the principal cause of mortality in chronic kidney disease (CKD) patients. Vascular calcification (VC) and cardiac valve calcification (CVC) significantly contribute to the increased CVD incidence in uremic patients. This study sought to determine the relationship between serum sortilin protein and both VC and CVC in uremic patients.

A bibliometric analysis of synaptic plasticity and epilepsy from 2003 to 2023.

Background And Purpose: Epilepsy is a prevalent and chronic neurological disorder. Recent studies suggest that synaptic plasticity could be a promising therapeutic target for epilepsy. This research employed bibliometric techniques to assess the study trends of synaptic plasticity in epilepsy over the last 20 years, highlighting major areas of focus and new topics.

Association of Human Leukocyte Antigen Polymorphisms With Moderate-to-Severe Dry Eye With and Without Sjögren's Syndrome.

Purpose: Sjögren's syndrome dry eye (SSDE) has been described in relation to human leukocyte antigen (HLA) polymorphisms. It is unknown whether non-Sjögren's syndrome dry eye (NSDE) is related to HLA. This study aimed to evaluate the genetic association of HLA polymorphism with dry eye disease (DED).

Comparison of the efficacy of PFNA and InterTAN intramedullary nail in the treatment of unstable intertrochanteric femoral fractures in the elderly.

Purpose: To compare clinical outcomes between Proximal Femoral Nail Anti-rotation (PFNA) and intramedullary nail system in treating unstable intertrochanteric femoral fractures (IFF) in elderly patients.

Methods: A retrospective study of 381 patients with IFF at Tianjin Third Central Hospital compared PFNA ( = 189) and InterTAN ( = 192) surgical treatments. Patient demographics, surgical parameters, postoperative outcomes, Visual Analog Scale (VAS) pain scores, and Harris hip scores were analyzed.

Projecting future disease and economic burdens of heatwave-related preterm birth in China under different climate scenarios.

Background: The increasing frequency of heatwaves poses significant risks for preterm birth (PTB). However, the extent of the disease and economic burdens attributable to heatwave-related PTB in China remains uncertain.

Methods: We defined a heatwave event as two or more consecutive days in which the daily maximum temperature exceeded the 90th percentile during 1995-2014, and estimated the burdens of heatwave-related PTB under different Shared Socioeconomic Pathway (SSP) scenarios, including cases, deaths, disability-adjusted life years (DALY), and the value of a statistical life (VSL) from 2015 to 2100, at the city level in China.

Bright-light treatment ameliorates motor and non-motor deficits through distinct visual circuits in a mouse model of Parkinson's disease.

Light has a profound impact on non-visual functions, and clinical evidence suggests bright-light therapy's effectiveness in alleviating motor and non-motor symptoms of Parkinson's disease (PD). However, the neural mechanisms underlying these effects remain unclear. Here, we demonstrate that bright-light treatment alleviates PD symptoms in mice via distinct visual circuits.

Unraveling the deterioration mechanism of tender coconut water: A comprehensive study integrating aquaphotomics, metabolomics, and 16S rDNA analysis.

Coconut water is a nutritious beverage that is susceptible to deterioration. This study aimed to elucidate the deterioration mechanism of coconut water by integrating aquaphotomics, metabolomics, and 16S rDNA analysis. Aquaphotomics revealed primary association of quality deterioration with hydrogen bond vibrations and O-H vibrations at room temperature and cold storage, respectively.

The relationship between N-terminal pro-brain natriuretic and coronary artery lesions in Kawasaki disease: A meta-analysis.

Background: Regarding the value of N-terminal brain natriuretic peptide precursors in evaluating coronary artery lesions (CAL) in Kawasaki disease.

Objective: To conduct a meta-analysis of relevant literature and explore the value of N-terminal brain natriuretic peptide NT ProBNP in evaluating coronary artery lesions (CAL) in Kawasaki disease.

Method: Retrieve publicly published literature on the relationship between serum NT ProBNP concentration and coronary artery disease in Kawasaki disease from CNKI, Wanfang, VIP, China Biomedical Database, Pubmed, Embase, Cochrane Library, Web of Science, and OVID databases, as well as manually search for other resource literature.

Proactive vs. passive algorithmic ethics practices in healthcare: the moderating role of healthcare engagement type in patients' responses.

Background: Artificial intelligence (AI) is transforming healthcare, but concerns about algorithmic biases and ethical challenges hinder patient acceptance. This study examined the effects of proactive versus passive algorithmic ethics practices on patient responses across different healthcare engagement types (privacy-focused vs. utility-focused).

Roles of plasma proteins in mediating the causal effect of the lipid species on gastric cancer: Insights from proteomic and two-step Mendelian randomization.

The change of plasma lipid species has close contacts with gastric cancer (GC). However, the specific mechanism still needs to be explored further. We aim to utilize plasma proteins to decipher the association between lipid species and GC, and seek possible drug targets for GC.

The overexpression of miR-146a in hippocampal microglia via IRAK1/TRAF6/NF-κB pathway improves cognitive function in diabetic mice.

Background And Objective: Diabetic encephalopathy (DEP), a central nervous system complication of diabetes, is primarily characterized by cognitive dysfunction. Despite its high prevalence and significant risks, the pathogenesis remains poorly understood. This study investigates the effects and mechanisms of miR-146a on cognitive function in DEP mice.

Circulating Inflammatory Proteins and Age-related Macular Degeneration: New Insights from Mendelian Randomization.

Background: Inflammation is a key mechanism underlying age-related macular degeneration (AMD); however, the specific circulating inflammatory proteins involved remain unclear. This study investigated the causal relationship between 91 circulating inflammatory proteins and AMD using a two-sample Mendelian randomization (MR) approach.

Methods: We conducted a two-sample magnetic resonance imaging MR analysis using genomewide association study (GWAS) data.

Network pharmacology of the regulation of Th17/Treg cell immune balance in the pathogenesis of arthritis by the combination of Chuanxiong Rhizoma, Radix Angelicae Biseratae and Achyranthis Bidentatae Radix.

This study explores the network pharmacological mechanism of the regulatory effect of Chuanxiong Rhizoma, Radix Angelicae Biseratae and Achyranthis Bidentatae Radix combination on Th17/Treg cell immune balance in the pathogenesis of arthritis. Databases such as the Chinese Pharmacopoeia, TCMSP, and BATMAN-TCM were used to obtain the active ingredients of Chuanxiong Rhizoma, Radix Angelicae Biseratae and Achyranthis Bidentatae Radix. After screening and weight removal, the target of action was determined using the TCMSP database.

Associations of long-term exposure to PM and its constituents with children renal function: a national retrospective study in China.

Introduction: Ambient fine particulate matter with aerodynamic diameter ≤2.5 μm (PM) harms adult's renal health. However, research on the associations of PM and its chemical constituents (black carbon (BC), ammonium ( [Formula: see text] ), nitrate (NO), organic matter (OM), and sulfate (SO)) with children' kidney health is lacking.

Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis.

This study aimed to evaluate the causal effect of sodium-glucose cotransporter protein 2 (SGLT2) inhibition on primary open-angle glaucoma (POAG) and explore potential mechanisms. A drug-targeted Mendelian randomization (MR) study was conducted using genetic variation related to SGLT2 inhibition, based on SGLT2 gene expression and glycated hemoglobin levels. Genetic summary statistics for POAG were obtained from the FinnGen consortium and a multi-ancestry genome-wide association study.

Intermittent fasting applied in combination with astaxanthin alleviates D-galactose-induced aging in rats: Comparison in oxidative stress, immune response, and metabolomics.

Effective anti-aging strategies involving dietary restriction and antioxidant supplementation are gaining increasing research attention, while the health effects of their combined intervention are rarely reported. In this study, for the first time, we investigated the anti-aging effects and underlying mechanisms of intermittent fasting (IF), astaxanthin (AX), and their combination in D-galactose-induced aging rats. Our results demonstrated that these three treatments effectively inhibited malondialdehyde levels and improved the activity of endogenous antioxidant enzymes in the brain, liver, and serum of aging rats.

A comprehensive evaluation of stability and safety for HEK293F-derived extracellular vesicles as promising drug delivery vehicles.

HEK293F-derived extracellular vesicles (HEK293F-EVs) have great potential as next-generation drug delivery vehicles. A comprehensive understanding of their batch stability and in vivo safety is prerequisite for clinical translation. HEK293F-EVs were purified using ultracentrifugation combined with size exclusion chromatography, and their physicochemical properties, such as morphology, size distribution, and biomarkers, were thoroughly characterized.

Clinicopathological Characteristics and Outcomes of Lupus Nephritis Patients With Thrombocytopenia: A Single-Center Retrospective Study.

Objectives: The objective of this study is to analyze and summarize the clinical characteristics and prognosis of lupus nephritis (LN) patients with thrombocytopenia and to improve the cognition of the disease.

Methods: 896 LN patients were enrolled in this study and their clinical and pathological data were collected and analyzed. The primary end point was mortality.

Upper limit of ice content at the lunar south pole as revealed by the Earth-based SYISR-FAST bistatic radar system.

An increasing amount of evidence indicates that lunar water ice exists in permanently shadowed regions at the poles and will soon become an important resource for lunar exploration. However, the water ice content and distribution are still uncertain. We report a new 70-cm-wavelength radar image of the lunar south pole obtained by an Earth-based bistatic radar system consisting of the Sanya incoherent scatter radar (SYISR) and the five-hundred-meter aperture spherical radio telescope (FAST).

Associations of prenatal exposure to fine particulate matter and its constituents with small for gestational age risk: A twin study in China.

This study aimed to examine the impact of PM and its constituents on small for gestational age (SGA). We collected records of 8082 twin pairs and their mothers from 21 hospitals across China. Concentrations of PM and its constituents were from the Tracking Air Pollution dataset.

Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS.

Background: Osteosarcoma (OS) exhibits significant epigenetic heterogeneity, yet its systematic characterization and clinical implications remain largely unexplored.

Methods: We analyzed single-cell transcriptomes of five primary OS samples, identifying cell type-specific epigenetic features and their evolutionary trajectories. An epigenetics-based Random Survival Forest (RSF) model was constructed using 801 curated epigenetic factors and validated in multiple independent cohorts.

Targeted lipidomics analysis of possible molecular mechanisms of lipid changes in temporal lobe epilepsy models.

Background: Lipids are vital biomolecules involved in the formation of various biofilms. Seizures can cause changes in lipid metabolism in the brain. In-depth studies at multiple levels are urgently needed to elucidate lipid composition, distribution, and metabolic pathways in the brain after seizure.

Clinicopathological characteristics and prognosis of lupus nephritis patients with positive anti-ribonucleoprotein antibodies.

Background: Positive anti-ribonucleoprotein antibodies may characterize a subgroup of patients affected by lupus nephritis with mild kidney damage, but little is known about their clinical features and long-term prognosis.

Methods: Patients were retrospectively selected from the lupus nephritis database ( http://ln.medidata.