Dietary Sucralose Exacerbates Ovalbumin-Induced Food Allergy via Dendritic Cells Modulation: In Vitro and In Vivo Studies.

Sucralose, a common zero-calorie sweetener, may increase food allergy (FAs) risk via immune modulation, although its mechanisms remain poorly understood. This study investigates how sucralose exacerbates allergic responses in mice that are OVA-sensitized through specific immunologic mechanisms. Sucralose exposure markedly aggravated allergic symptoms, including diarrhea, elevated serum IgE, MCP-1, and mast cell mediators, and preferentially enhanced Th2 responses without affecting Th1 or Treg cytokine pathways.

Regulatory Effects of Alkali-Extracted Polysaccharide Induced Intestinal Enrichment on Peripheral Blood Proteomics in Tumor-Bearing Mice.

polysaccharides have demonstrated multiple biological activities including immune regulation, antitumor, and antioxidant properties. The rapid development and integrated application of multi-omics can facilitate the unraveling of the complex network of immune system regulation. In this study, alkali-extracted polysaccharide (CPAP) were prepared, and their effects on gut microbiota compositions, metabolic pathways, and protein expressions in peripheral blood and solid tumors in mice were further evaluated.

Optimization strategies for ultrasound zoning of cervical lymph nodes in esophageal cancer: a precision medicine approach.

Esophageal cancer is a common malignancy with high incidence and mortality rates. Its pathological types vary by region, with squamous cell carcinoma predominant in Asia and adenocarcinoma in Western countries. Accurate staging before treatment is crucial for selecting appropriate therapeutic strategies.

Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review.

Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small cell lung cancer (NSCLC) that is closely associated with Epstein-Barr virus (EBV) infection. While radiotherapy after induction chemotherapy have shown marked efficacy in nasopharyngeal carcinoma (NPC), its effectiveness in pLELC remains uncertain. A female with stage IIIB pLELC was treated with 4 cycles of gemcitabine plus cisplatin, achieving partial response(PR), followed by radical radiotherapy.

Research progress of nano-based drug delivery systems based on stimuli-responsive materials for the treatment of lung diseases.

Since the lungs are directly connected to the external environment and have a rich blood supply, they are susceptible to damage and tumor growth. However, the pharmacokinetics of traditional drugs in the lungs are limited when administered orally or intravenously, posing challenges for clinical treatment. Compared to traditional drug delivery methods, nano-based drug delivery systems (NDDSs) have the advantages of high drug loading capacity, strong targeting, low cellular toxicity, and extended circulation time in the blood.

Acesulfame Potassium Alleviates Food Allergy via Mast Cell Stabilization and MAPK-Mediated Immune Regulation.

Acesulfame potassium (AK), a widely used synthetic non-nutritive sweetener in low-calorie food and beverage products, has not been comprehensively investigated for its potential modulatory effects on food allergies. This study systematically investigated the therapeutic potential of AK using both an ovalbumin (OVA)-induced murine food allergy model and IgE/BSA-activated RBL-2H3 mast cells. experiments demonstrated that AK administration during OVA sensitization significantly alleviated allergic manifestations, showing a 78% reduction in diarrhea incidence and systemic anaphylactic scores compared with those of the OVA-sensitized controls.

Latent profiles of job embeddedness and their predictors among specialist nurses in China.

Objective: The aim of this study is to identify potential categories of job embeddedness among specialist nurses using latent profile analysis, explore the demographic characteristics of each subgroup, and examine the relationship between these profiles and their sense of professional mission.

Methods: From March to April 2024, 492 specialist nurses from six general hospitals in Sichuan Province, China, were selected in this study using convenience sampling. A socio-demographic characteristic questionnaire, job embeddedness scale, and professional mission scale were used.

Composites of Pea Protein Nanofibril and Epigallocatechin Gallate: Formation Mechanism, Structural Characterization, and Antioxidant Activity.

The EGCG/PPN composite, prepared by combining pea protein nanofibrils (PPNs) with epigallocatechin gallate (EGCG), could be used as a multifunctional nanocarrier. Compared to pea protein isolate (PPI), EGCG/PPN composites exhibited remarkably higher turbidity and zeta potential, along with similar UV spectra. Intrinsic fluorescence spectroscopy, ThT fluorescence spectroscopy, and surface hydrophobicity analysis suggested that the interactions between EGCG and PPN were primarily driven by hydrophobic forces.

Controlled low central venous pressure in laparoscopic left hemihepatectomy for left hepatolithiasis with prior upper abdominal surgery: A retrospective cohort study.

This study aimed to evaluate the safety and effectiveness of controlled low central venous pressure (CLCVP) during middle hepatic vein (MHV)-guided laparoscopic anatomical left hemihepatectomy for patients with intrahepatic bile duct stones and a prior history of upper abdominal surgery. A retrospective analysis was conducted on the clinical data of patients who had undergone MHV-guided laparoscopic anatomical left hemihepatectomy for hepatolithiasis with a prior history of upper abdominal surgery. The patients were treated at the Second Affiliated Hospital of Nanchang University and the Second Hospital of Longyan between January 2018 and January 2024.

Human Milk Oligosaccharide Composition at 6 Weeks Is Associated with Temperament and Eating Behaviors of Children in the STRONG Kids 2 Cohort Through 4 Years of Age.

Early childhood is a critical window of development, which is influenced by early life exposures including breastfeeding. Observational and preclinical studies have linked human milk oligosaccharides (HMOs) with neurocognitive development. However, less attention has focused on behavioral outcomes including temperament and eating behaviors.

Life's Crucial 9 Score as a Novel Role for Chronic Obstructive Pulmonary Disease Screening.

Purpose: This study aims to investigate the association between the Life's Crucial 9 (LC9) score and chronic obstructive pulmonary disease (COPD) in middle-aged and older adults.

Patients And Methods: We screened the NHANES database for data from 2007-2018. Logistic regression analysis and subgroup analysis were used to explore the association between LC9 score and COPD in middle-aged and older adults.

Subversion of phosphorylated SR proteins by enterovirus A71 in IRES-dependent translation revealed by RNA-interactome analysis.

During infection by positive-sense single-stranded RNA viruses, understanding the mechanisms governing the fate of viral RNA, whether directed towards translation, replication, or virion assembly, remains a significant challenge. In this study, we conducted RNA-interactome analysis using metabolic labeling coupled with quantitative proteomics to investigate the protein composition of temporal ribonucleoprotein complexes (RNPs) during enterovirus A71 (EV-A71) infection. Comparative analysis of RNPs during the early and late infection stages, representing the eclipse and maturation phases, revealed dynamic RNP remodeling over time.

Association between different modes of physical activity and sleep disorders in young and middle-aged adults: a population-based study.

Objectives: This study aims to investigate the correlation between different modes of physical activity (PA) and sleep health.

Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) database from 2007 to 2014. Logistic regression was used to explore the association between leisure-time PA (LTPA), work-time PA (WTPA), and transportation-time PA (TTPA) and sleep disorders.

-Mediated Regulation of the Microbial-Immune Axis: A Review of Key Mechanisms, Influencing Factors, and Application Prospects.

, as the main member of food microorganisms, is an important component of the intestinal microbial community and plays crucial roles in regulating the immune capacity of the body. This review provides a comprehensive exploration of the key components of -mediated immune regulation effects, including the immunogenic components (peptidoglycan and lipoteichoic acid) and metabolites (short-chain fatty acids, bacteriocins, and exopolysaccharides), which can interact with host immune cell receptors to initiate complex immune signaling pathways. In addition, the immunomodulatory activity can be influenced by multiple factors including species differences, host-related factors (age, physiological conditions, and gut microbiota), and environmental factors (nutrient substrates, temperatures, etc.

The impact of innovative city policies on land use efficiency.

Under the background of realizing the strategy of advanced country and superior development, the innovative cities pilot, as an important institutional exploration path, can effectively stimulate the innovation vitality of cities, enhance the industrial framework, improve the urban environment, and significantly affect the urban land elements. This research integrates the notion of high-quality development into urban land components, creates an index system for evaluation using the input-output model, and uses the Super-SBM model to evaluate the land-use efficiency of 279 cities nationwide. This paper using a multi-period DID model discusses the impact of innovative city pilot policies on land use efficiency.

Di(2-ethylhexyl) Phthalate (DEHP) Exacerbates Food Allergy via Intestinal Barrier Dysfunction and Enhancing Allergic Sensitization.

Di(2-ethylhexyl) phthalate (DEHP), a ubiquitous plasticizer, has raised concerns due to its potential role in exacerbating food allergy through chronic human exposure. The study aimed to investigate the potential effects of DEHP on ovalbumin (OVA)-induced food allergy and elucidate the underlying mechanisms related to intestinal barrier homeostasis. In OVA-sensitized BALB/c mice, DEHP exposure significantly exacerbated allergic responses by functioning as an immunoadjuvant, as evidenced by heightened anaphylactic symptoms, elevated serum levels of inflammatory mediators (IgE, IgG, IgG1, IgG2), and increased concentrations of histamine and monocyte chemoattractant protein-1 (MCP-1).

Anti-Hyperuricemic and Nephroprotective Effects of Hydrolysate Derived from Silkworm Pupae (): In Vitro and In Vivo Study.

Background: Hyperuricemia is a prevalent metabolic disorder characterized by elevated serum uric acid (UA) levels.

Methods: In this study, hydrolysate (SPP) derived from silkworm pupae protein was isolated and identified, demonstrating anti-hyperuricemic activity. The research aimed to investigate its anti-hyperuricemic and nephroprotective effects, along with potential mechanisms, through in vitro assays and in vivo experiments using potassium oxonate/hypoxanthine-induced hyperuricemic mice.

Relationships between transformational leadership, perceived social support, occupational coping self-efficacy and presenteeism among Chinese ICU nurses: a cross-sectional study.

Objective: This study aimed to investigate the relationship between transformational leadership and presenteeism among intensive care unit (ICU) nurses in tertiary hospitals and further investigate the chain-mediated role of perceived social support and occupational coping self-efficacy.

Design: This is a cross-sectional survey study.

Setting: Six tertiary hospitals in Sichuan Province, China.

Association between compound dietary antioxidant index and all-cause and cancer mortality in patients with chronic obstructive pulmonary disease: results from NHANES 1999-2018.

Objective: Chronic obstructive pulmonary disease (COPD) is one of the most important causes of death in the world, and its core is chronic inflammation. Antioxidants play a positive role in the onset and prognosis of chronic respiratory diseases. In maintaining human health, the composite dietary antioxidant index (CDAI) plays an important function.

Clinicopathological Characteristics and Outcomes of Lupus Nephritis Patients With Thrombocytopenia: A Single-Center Retrospective Study.

Objectives: The objective of this study is to analyze and summarize the clinical characteristics and prognosis of lupus nephritis (LN) patients with thrombocytopenia and to improve the cognition of the disease.

Methods: 896 LN patients were enrolled in this study and their clinical and pathological data were collected and analyzed. The primary end point was mortality.

Construction and validation of a presenteeism prediction model for ICU nurses in China.

Background: Presenteeism, also known as impaired health productivity, refers to the condition of impaired productivity of an individual due to physiological or mental health problems. ICU, as a place of intensive care for patients with acute and critical illnesses, nurses have long faced the nature of work with high loads, high pressures, and high intensities, which makes them a high prevalence group of presenteeism. Presenteeism not only affects the physical and mental health and work wellbeing of nurses but also reduces the quality of nursing services and affects the life safety of patients, such as increasing the risk of falls during hospitalization, increasing the risk of medication errors, and prolonging the hospitalization time of patients.

Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics.

Systemic lupus erythematosus (SLE) is a chronic inflammatory illness with heterogeneous clinical manifestations covering multiple organs. Diversified types of medications have been shown effective for alleviating SLE syndromes, ranging from cytokines, antibodies, hormones, molecular inhibitors or antagonists, to cell transfusion. Drugs developed for treating other diseases may benefit SLE patients, and agents established as SLE therapeutics may be SLE-inductive.

Research on the Dynamic Apparent Permeability of Shale: Coupling Anisotropic Deformation Characteristics and Multiple Transport Mechanisms.

As shale gas is an unconventional energy source, it is believed to be essential for achieving green resource development and improving the energy supply-demand balance. However, owing to shale's substantial anisotropic properties and various microstructures, its gas flow characteristics and transport mechanisms are exceedingly complex. Therefore, accurately predicting gas permeability evolution in shale pores was considered to be important for energy development.

Effects of chemical modifications on allergenicity and functional properties of silkworm pupae proteins.

Silkworm pupae proteins (SPP) have been exploited as a new functional protein, but there are still some people who are allergic to it. This study investigated the effects of different chemical modifications (phosphorylation, succinylation, deamidation, glycosylation) on SPP's allergenicity and its structural and functional impact. Spectroscopic analysis showed that all three modifications except glycosylation loosened the three-dimensional structure of SPP.

BuZhong YiQi Formula Alleviates Postprandial Hyperglycemia in T2DM Rats by Inhibiting α-Amylase and α-Glucosidase In Vitro and In Vivo.

BuZhong YiQi Formula (BZYQF) can alleviate type 2 diabetes mellitus (T2DM). However, its efficacy in managing postprandial hyperglycemia in T2DM needs to be further confirmed, and its underlying mechanism and pharmacodynamic material basis have not been sufficiently investigated. A T2DM rat model was induced to measure postprandial glycemic responses following glucose and starch ingestion.