COG6 is an essential host factor for influenza A virus infection.

Influenza A virus (IAV) relies on the host cellular machinery to support its replication. Understanding these host dependencies can inform the development of novel antiviral strategies. In this study, we identified conserved oligomeric Golgi complex subunit 6 (COG6) as a novel host factor critical for IAV replication through a genome-wide clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) knockout screen.

A Decade of Research on C9orf72 in Frontotemporal Dementia (2014-2024): A Bibliometric Analysis of Global Trends and Hotspots.

Introduction: Frontotemporal dementia (FTD) is the third most frequent dementia and the leading dementia subtype in individuals under 65. The discovery of C9orf72 (chromosome 9 open reading frame 72) GGGGCC abnormal expansion is a major genetic cause of both FTD and amyotrophic lateral sclerosis (ALS), linking these diseases along a clinicopathological spectrum. This study aimed to depict the research landscape of C9orf72 in FTD over the past decade, track emerging research hotspots, and provide insights into under-researched areas.

Gastrodin ameliorates ulcerative colitis via modulating gut microbial tryptophan metabolism and AhR/NLRP3 pathway.

Background: Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disorder, presents persistent therapeutic challenges in clinical management. Gastrodin (GAS) is an active compound isolated from traditional Chinese medicine Gastrodia elata (Tianma), exhibits robust anti-inflammatory bioactivity. However, the role of GAS in UC has not been thoroughly studied.

Initial Insights into the NET-Associated ceRNA Network in Pulpitis: Transcriptomic and Functional Exploration.

Background: Pulpitis is an oral disease primarily triggered by microbial infections. Current therapeutic strategies lack specific agents targeting the underlying pathogenic mechanisms. Non-coding RNAs (ncRNAs) and their competitive endogenous RNA (ceRNA) networks have emerged as critical regulators of diverse biological processes, offering novel insights into the pathogenesis of pulpitis and the identification of potential therapeutic targets.

Language Development in Preschool Children Living with Chronic Health Conditions: A Cohort Study.

Objective: To investigate whether the presence of childhood chronic conditions affect the early stages of language development.

Study Design: The study is based on data of three-year-old (n = 8821) and five-year-old (n = 8564) children from the Growing Up in Ireland longitudinal cohort study. A series of multilinear regression models were used to analyze the contribution of child health on caregiver perception of language development and children's vocabulary development.

Added prognostic value of histogram features from preoperative multi-modal diffusion MRI in predicting Ki-67 proliferation for adult-type diffuse gliomas.

Background: Ki-67 labelling index (LI), a critical marker of tumor proliferation, is vital for grading adult-type diffuse gliomas and predicting patient survival. However, its accurate assessment currently relies on invasive biopsy or surgical resection. This makes it challenging to non-invasively predict Ki-67 LI and subsequent prognosis.

Epidermal Growth Factor Receptor Activation Stimulates SOX9 Expression in Injured Renal Proximal Tubule Epithelial Cells.

Background: In surviving renal proximal tubule cells (RPTCs) following acute kidney injury (AKI), the induction of SOX9 expression plays a crucial role in promoting kidney repair. However, persistent upregulation of SOX9 in RPTCs contributes to the development of chronic kidney disease (CKD). The molecular mechanisms underlying SOX9 induction in response to kidney injury are not completely understood.

Restrictive strabismus caused by infantile myositis masquerading as Duane retraction syndrome.

We report a rare case of restrictive strabismus in a pediatric patient who was initially misdiagnosed with Duane retraction syndrome (DRS) because she had large-angle exotropia, restricted adduction, globe retraction, narrowing of the palpebral fissure, and downshoot on attempted adduction. Notably, the parents first observed strabismus at 12 months of age, with photographs taken before 6 months of age revealing no ocular misalignment. Despite the absence of typical inflammatory signs, the temporal discrepancy, characterized by delayed onset inconsistent with congenital DRS, prompted further investigation.

Cigarette Tar Enhanced ECs Pyroptosis via CAMKII/Drp1/mtDNA: Novel Insight Into the Mechanism of Plaque Erosion.

Smoking is the only cardiovascular risk factor for plaque erosion. We found cigarette tar resulted in erosion-like lesion development in apolipoprotein E mice, with mural thrombosis, discontinuous endothelium, platelet activation, smooth muscle cell proliferation, and hyaluronic acid accumulation in the aorta. Single-cell transcriptomics revealed that genes relating to pyroptosis, platelet activation, and leukocytes adhesion were significantly increased in an endothelial cell subset.

Targeting KEAP1/NRF2 interaction with oleuropein ameliorates atherosclerosis by inhibiting macrophage ferroptosis.

Atherosclerosis (AS) is a chronic inflammatory arterial disease. Oleuropein (OL), extracted from olive leaves, has demonstrated broad cardioprotective properties. However, the effects of OL on AS remain to be fully elucidated.

Sulfur-Mediated Microenvironment Modulation of High-Density Fe-N Sites for High-Efficiency Oxygen Reduction and Cryotolerant Quasi-Solid-State Zinc-Air Batteries.

Single-atom catalysts (SACs) featuring Fe-N active sites hold significant potential for the oxygen reduction reaction (ORR). However, achieving high-density Fe-N active sites while precisely modulating their microenvironment to enhance ORR activity remains a formidable challenge. Here, an S-mediated strategy is presented for the preparation of Fe single-atom-loaded S,N-doped carbon (FeNSC).

Alterations of the skin microbiome in multiple system atrophy: a pilot study.

Multiple system atrophy (MSA) alters skin physiology, potentially impacting skin microbiota. This pilot study investigated whether skin microbiota differs in MSA and whether these differences relate to disease severity. Using 16S rRNA sequencing of cervical and axillary sites in MSA, Parkinson's disease, and controls, we identified distinct microbial patterns among groups.

The effect of follow-up reexamination on the long-term prognosis of patients with acute coronary syndrome undergoing coronary angiography.

Background: Patients with acute coronary syndrome (ACS) remain at high risk for recurrent adverse cardiovascular events after discharge. Patient adherence to secondary prevention is poor. This study proposes a follow-up center-based secondary prevention program to assess whether a structured cardiologist-led follow-up and reexamination protocol influences ACS patient prognosis.

IGF2BP1-mediated methylation of ABCA1 facilitates tumor progression by affecting cholesterol metabolism in lung adenocarcinoma.

ABCA1 is a key protein in maintaining cholesterol homeostasis, and its abnormal expression is associated with the progression of many cancers. Nonetheless, the specific molecular mechanisms by which ABCA1 facilitates the development of LUAD remain largely unexplored, necessitating further in-depth investigation. The TCGA-LUAD database was used to analyze the expression of ABCA1 in LUAD tissues.

Pollution and health risk assessment of potentially toxic elements in soil-crop systems near a pyrite mining area, China.

Mining activities have increasingly contributed to soil contamination by potentially toxic elements (PTEs), which pose significant environmental and health risks, especially in historically under-regulated regions. This study investigated PTE contamination and associated risks in Longyou, a typical pyrite mining area in southeastern China. A total of 42 site-matched soil and crop samples were collected for the analysis of PTE total content and chemical fractions.

Integrated Helical Fiber Electrode for Stable Ah-Level Fast-Charging Fiber Lithium-Ion Batteries.

Fiber lithium-ion batteries (FLIBs) represent a significant advancement in energy storage technology for wearable electronics, yet still suffer from unsatisfactory rate capability and power output due to the sluggish Li diffusion kinetics. Herein, the integrated helical fiber electrode (IHFE) configuration is proposed to optimize the Li transport path within the high-loading fiber electrode, thus promoting the Li diffusion kinetics. The IHFE design features a helical-wound ultrafine metal wire around a solid skeleton, which increases the specific surface area by 71.

Efficacy and safety of neoadjuvant toripalimab plus chemotherapy in localized deficient mismatch repair/microsatellite instability-high gastric or esophagogastric junction adenocarcinoma (NICE): a multicentre, single-arm, exploratory phase 2 study.

Background: In locally advanced gastric or gastroesophageal junction adenocarcinoma (GC/EGJC), deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H) tumors exhibit high responsiveness to immunotherapy. The synergistic efficacy of neoadjuvant immunotherapy combined with chemotherapy in dMMR/MSI-H GC/EGJC remains uncertain.

Methods: The NICE trial is a multicentre, single-arm, exploratory phase 2 study conducted at six hospitals in China, evaluating the safety and efficacy of toripalimab in combination with CapeOX as perioperative therapy for locally advanced GC/EGJC across three biomarker-defined cohorts.

Distinguishing the impact of river discharge and submarine groundwater discharge on phytoplankton community in coastal water.

Primary production in coastal embayment is largely shaped by terrestrial influences, with river discharge and submarine groundwater discharge (SGD) playing pivotal roles. However, distinguishing the effects of terrestrial inputs from different sources on phytoplankton growth remains a challenge. Through integrated field investigations, laboratory experiments, and long-term data analysis, this study examines how these terrestrial inputs structure phytoplankton communities in Tolo Harbor, Hong Kong.

Establishing a clinical prediction model of neurosyphilis via a lumbar-puncture-free nomogram.

Objectives: Neurosyphilis (NS) can cause a range of central nervous system (CNS) damage, from asymptomatic states to severe mental disorders. While lumbar puncture is a reliable diagnostic method for NS, it is often poorly accepted due to its invasive nature, particularly by patients with mild symptoms. This study aims to develop a prediction model for the early diagnosis of NS that without requiring lumbar puncture.

Combining Soft-Templating and Post-Synthetic Methods for the Rational Design of an Amidoximated Metal-Organic Framework with Mesopores for Efficient Uranium Extraction.

Recently, metal-organic frameworks (MOFs) have been widely studied for uranium extraction from seawater to resolve the shortage of uranium resources. However, traditional MOF-based adsorbents are microporous structures, which are unfavorable to the mass transfer of guest molecules and the modification of functional groups. Herein, a novel mesoporous MOF (meso-UiO-66-NH-CN) is designed by the synergy of perchlorate and Pluronic F127, which gives meso-UiO-66-NH-CN with more accessible active sites and high mass transfer rates.

Ce(III)-Doped Mixed-Valence Metal-Organic Frameworks Boosting Ligand-To-Metal Charge Transfer for Photooxidation of a Mustard-Gas Simulant.

Due to the high toxicity and potential threats to society, extensive efforts are devoted to developing catalysts for efficient photodegradation of mustard gas. Metal-organic frameworks (MOFs) are considered as promising candidates for photooxidation, but the limited charge separation efficiency of the pristine MOFs restricts their further applications. Herein, through a one-pot synthesis strategy, Ce(III) ions are incorporated in a Ti-based porphyrin MOF (DGIST-1), leading to a mixed-valence MOF with enhanced charge transfer efficiency.

A Redox-Active Manganese Nanocluster Reverses Depression-Impaired Bone Regeneration via Targeting Cellular Senescence, Lymphangiogenesis, and the Muscle-Bone Metabolic Axis.

Depression, a prevalent chronic psychological disorder in aging populations, is increasingly recognized for its deleterious impact on bone regeneration; yet its pathological mechanisms and targeted therapies remain underexplored. Here, a rationally engineered tetranuclear manganese nanocluster (Mn), supported by a heptadentate chelating ligand (TPDP), as a multifunctional nanozyme platform to combat depression-induced skeletal dysfunction, is introduced. Utilizing a murine chronic restraint stress model combined with tibial drill-hole injury, it is demonstrated that depression impairs bone healing through a complex interplay of cellular senescence, inflammatory dysregulation, compromised lymphatic vessel proliferation, and disruption of the muscle-bone metabolic axis.

Intravenous Multifunctional Nanotherapy for Treating Dry Age-Related Macular Degeneration.

Retinal pigment epithelium (RPE) degeneration is the pathological hallmark of multifactorial dry age-related macular degeneration (dAMD). Mounting evidence implicates oxidative stress and aberrant activation of mammalian target of rapamycin (mTOR) as key drivers of this process. Recent studies have shown that simultaneous modulation of these pathways may offer therapeutic benefit.