Restrictive strabismus caused by infantile myositis masquerading as Duane retraction syndrome.

We report a rare case of restrictive strabismus in a pediatric patient who was initially misdiagnosed with Duane retraction syndrome (DRS) because she had large-angle exotropia, restricted adduction, globe retraction, narrowing of the palpebral fissure, and downshoot on attempted adduction. Notably, the parents first observed strabismus at 12 months of age, with photographs taken before 6 months of age revealing no ocular misalignment. Despite the absence of typical inflammatory signs, the temporal discrepancy, characterized by delayed onset inconsistent with congenital DRS, prompted further investigation.

Quantitative analysis of microvasculature in macular and optic disc regions in keratoconus patients: A systematic review and meta-analysis.

Background: Studies have utilized optical coherence tomography angiography (OCTA) to assess vessel density in the macular and optic disc regions among patients with keratoconus (KC); however, the findings have been incongruent. This study aimed to systematically investigate the retinal macular and optic disc microvascular characteristics in patients with KC compared to healthy controls using OCTA.

Methods: A comprehensive literature search was performed across multiple electronic databases, including PubMed, Embase, Web of Science, and the Cochrane Library, up to April 2025.

Psychiatric screening tools in asthma and their barriers to clinical utilization: a systematic review.

Background: Chronic airway diseases such as asthma are often associated with psychiatric disorders like anxiety, depression, and posttraumatic stress disorder (PTSD), which occur 1.5-2.4 times more frequently in individuals with asthma.

Efficacy and safety of augmented-reality pathway-specific binocular training in patients with unilateral amblyopia (ARPSBT): study protocol for a multicenter randomized controlled trial.

Background: Amblyopia is a common developmental disorder with reduced visual acuity and impairment in binocular functions. Patching the fellow eye, as the gold standard therapy in amblyopia, sometimes fails to achieve satisfactory outcomes because of poor adherence or delayed intervention. Recently, dichoptic/binocular digital therapy in amblyopia has been developed, but no evidence-based binocular treatments with superiority are available.

3,4-Diaminobenzophenone as an Effective Reactive MALDI Matrix for Simple and Sensitive Detection of α-Ketoacid Compounds.

Determination of α-ketoacids is very important for disease diagnosis as well as for quality control of food and pharmaceuticals. In order to determine α-ketoacids by a simple, rapid, and simultaneous method in complex samples, a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method has been reported herein through the development of an efficient reactive matrix. In this method, a MALDI matrix, 3,4-diaminobenzophenone (DABP), is first used to generate imidazole derivatives through its rapid reaction with α-ketoacids, which enables simple, rapid, sensitive, and selective detection of α-ketoacids by MALDI-TOF MS.

Health and well-being comparison between residents of serviced housing for older people and community-dwelling older adults in japan: a propensity score matching analysis.

Purpose: Serviced Housing for Older People (SHOP) in Japan offers barrier-free living environments and supportive services to enhance the health and well-being of older adults. This study aimed to compare the health and well-being of SHOP residents with community-dwelling older adults and to compare factors that may influence them.

Methods: This cross-sectional study utilized propensity score matching to compare the health and well-being of 1,080 SHOP residents (69.

[Expression and Function of miR-144 in β-Thalassemia].

Objective: To explore the expression and function of microRNA-144 (miR-144) in β-thalassemia (β-thal).

Methods: The expression of miR-144 during the differentiation of murine erythroleukemia (MEL) cells and mouse embryonic liver-derived erythroid precursor cells was analyzed by real-time fluorescence quantitative PCR (qRT-PCR); The expression levels of miR-144 in peripheral blood and day-14.5 embryonic hepatocytes of wild-type (WT) and β-thal mice, as well as the expression levels of miR-144 in peripheral blood of β-thal patients, was also measured by qRT-PCR.

Space temperature traceability based on near-site transfer of miniature fixed points.

Long-term remote sensing precision depends on real-time radiation calibration, challenging the stability and accuracy of spaceborne calibrators in harsh space environments. Miniature fixed points offer a solution for International System of Units traceability of space radiation values. However, traditional in-situ calibration methods face difficulties due to location mismatches between miniature fixed points and radiation surface.

A Surface-Enabled Computational Homogenization Method for Variable-Density Polymer Lattice Metastructures.

The current limitations in predicting mechanical properties arise from an incomplete understanding of surface-induced size effects in variable-density polymer lattice metastructures. Through large-scale, high-fidelity finite element simulations, we identify a novel variable-density surface law governing the surface intrinsic length at the macroscopic scale. Capitalizing on this surface law discovery, we propose a surface-enhanced computational homogenization framework.

Joint effects of rice straw-derived biochar and microcystin-LR on splenic histopathological injuries, inflammation, and innate immune responses in male zebrafish.

Microcystin-LR (MC-LR), a toxin produced by cyanobacterial blooms, poses a significant threat to aquatic animals and humans. Biochar (BC), known for its high adsorption capacity, is increasingly being utilized to remove hazardous pollutants from aquatic environment. In the present study, we conducted a full factorial experiment to investigate the potential immunotoxicity in male zebrafish (Danio rerio) exposed to environmentally relevant levels of MC-LR (0, 1, 5, 25 μg/L) and rice straw-derived BC (0, 100 μg/L) for 30 d.

Benchmarking spatial transcriptomics technologies with the multi-sample SpatialBenchVisium dataset.

Background: Spatial transcriptomics allows gene expression to be measured within complex tissue contexts. Among the array of spatial capture technologies available is 10x Genomics' Visium platform, a popular method which enables transcriptome-wide profiling of tissue sections. Visium offers a range of sample handling and library construction methods which introduces a need for benchmarking to compare data quality and assess how well the technology can recover expected tissue features and biological signatures.

Rhizobacterium streptomyces sp. NEAU-383 as a potential biocontrol agent to control tomato bacterial wilt.

The global tomato plants are seriously threatened by soilborne bacterial wilt, which is caused by Ralstonia solanacearum. Biological control agents (BCAs) are considered as a promising strategy. In this study, strain NEAU-383, which exhibited significant inhibitory activity against R.

BuZhong YiQi Formula Alleviates Postprandial Hyperglycemia in T2DM Rats by Inhibiting α-Amylase and α-Glucosidase In Vitro and In Vivo.

BuZhong YiQi Formula (BZYQF) can alleviate type 2 diabetes mellitus (T2DM). However, its efficacy in managing postprandial hyperglycemia in T2DM needs to be further confirmed, and its underlying mechanism and pharmacodynamic material basis have not been sufficiently investigated. A T2DM rat model was induced to measure postprandial glycemic responses following glucose and starch ingestion.

Discovery of (+)-Methyl Nonactate as a Potential Fungicide against Gummy Stem Blight.

Gummy stem blight (GSB), which is caused by , threatens pumpkin yields and agriculture. Effective, safe antifungal agents are urgently needed. In this study, fermentation broth supernatant of sp.

Asthma.

Asthma is one of the most common respiratory disorders in Canada, however, many Canadians with asthma remain poorly controlled. In most patients, control can be achieved through appropriate therapy, including: inhaled corticosteroids (ICS), combination ICS/long-acting beta-agonists (LABA), "triple therapy" with ICS/LABA/long-acting muscarinic receptor antagonist (LAMA), and biologic therapies. The medical management of severe asthma, in particular, has changed dramatically with the incorporation of biologics in asthma treatment plans.

Combined effects of co-exposure to microcystin-LR and polystyrene microplastics on growth, brain pathology and thyroid hormone homeostasis in adult zebrafish.

The concurrent presence of algal blooms and microplastics pollution in natural water bodies poses a novel threat. However, the joint effects of microcystin-LR (MCLR) in combination with polystyrene microplastics (PSMPs) on the thyroid endocrine system of adult fish remains unclear. In our study, male zebrafish (Danio rerio) were exposed to environmentally relevant concentrations of MCLR alone (0, 0.

Analysis of Risk Factors for Hemorrhagic Transformation of Cerebral Infarction and Recurrence of Cerebral Infarction: A Retrospective Study on Cerebral Infarction Patients with or without Hemorrhagic Transformation.

Background: Acute ischemic stroke, especially hemorrhage cerebral infarction (HCI), resulted in the leading causes of mortality and long-term disability across populations. However, fewer researches have focused on the risk factors of first admission and recurrence of HCI.

Methods: The study included 1857 patients who underwent cerebral infarction with or without hemorrhagic transformation.

CAR/CSACI Practice Guidance for Contrast Media Hypersensitivity.

Contrast media, including iodinated contrast media and gadolinium-based contrast agents, are commonly administered pharmaceuticals with excellent safety profiles. However, a minority of the population may experience a hypersensitivity reaction following intravenous administration. Hypersensitivity reactions can be immediate or delayed, and range from mild, such as urticaria, to severe, including anaphylaxis.

A combined proteomic and metabolomic analysis of the early aborted embryonic tissues with maternal COVID-19 infection.

COVID-19 still spreads worldwide, and repeated infections are hard to avoid. Maternal infection during pregnancy is associated with adverse maternal and neonatal outcomes. Our study used a multi-omics profiling method to explore the proteome and metabolome alteration in early embryonic development after COVID-19 infection.

Lesion Topography and Clinical Features Associated With Respiratory Failure in Patients With Medullary Infarction.

Background: Respirator failure (RF) is a severe malignant complication in both lateral medullary infarction (LMI) and medial medullary infarction (MMI) patients. However, the differences in clinical and radiological manifestations associated with RF between patients with LMI and MMI have not been fully elucidated.

Methods: A total of 435 consecutive patients with MI within 7 days of onset in our institute were retrospectively enrolled from January 2017 to January 2024.

Predictors of treatment failure of tubal pregnancy with single-dose methotrexate regimen - a systematic review and meta-analysis.

Background: Ectopic pregnancies represent a potentially life-threatening medical emergency, with 95% being tubal. This meta-analysis aimed to identify early predictors for single-dose methotrexate (MTX) treatment failure in tubal pregnancies.

Methods: A literature search was conducted across several databases from their inception to December 2023, with references in the selected studies manually reviewed.

Integrating Chemoselective Labeling and Laser-Cleavable Mass Tagging for Determination of Sialic Acids in Glycoconjugates.

Sialic acids are the terminal units of glycans in glycoproteins or glycolipids. The determination of sialic acids in glycoconjugates is crucial since they regulate essential biological functions and have a significant nutritional value. To achieve a specific and high-throughput in situ determination of sialic acids in glycoconjugates, a laser-desorption/ionization mass spectrometry (LDI-MS)-based strategy is reported by integrating chemoselective labeling and laser-cleavable mass tagging.

Mutations in AMBRA1 aggravate β-thalassemia by impairing autophagy-mediated clearance of free α-globin.

Accumulation of free α-globin is a critical factor in the pathogenesis of β-thalassemia. Autophagy plays a crucial role in clearing toxic free α-globin, thereby reducing disease severity. However, the impact of natural mutations in autophagy-related genes (ATGs) on the phenotypic variability of β-thalassemia remains unclear.