Combination Therapy for Simple Obesity: Acupoint Needling and Auricular Acupressure Effects.

Introduction: To evaluate the efficacy and safety of acupoint-embedded needling combined with auricular acupressure in treating simple obesity associated with spleen deficiency and dampness accumulation.

Methods: Ninety-six patients with simple obesity were randomized into two groups. The intervention group received acupoint-embedded needling and auricular acupressure, while the control group received conventional acupuncture.

DNA methylation of the ABCA1 and ABCG1 genes contribute to stroke risk.

Introduction: Stroke is a major cause of death in China. The epigenetic factors, especially the methylation of ABCA1/G1 genes implicated in cholesterol regulation, are being examined to comprehend their association with stroke.

Methods: In this nested case-control study, we examined data from the North-west China Cohort (CNC-NX) initial phase, involving 53 pairs of stroke cases and controls.

Gut Microbiota-Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers.

Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes mellitus, characterized by myocardial structural and functional abnormalities in the absence of overt coronary artery disease or hypertension. A growing body of evidence implicates the gut microbiota and its metabolites as key modulators of systemic metabolic homeostasis, influencing energy metabolism, inflammation, and oxidative stress. The gut microbiota emerges as a novel regulator of cardiac remodeling and metabolic reprogramming in DCM through the gut-heart axis.

[Comparison of the efficacy of sigmoid sinus constriction plus cartilage reconstruction and sigmoid sinus return surgery in sigmoid sinus-related pulsatile tinnitus].

To investigate the efficacy of sigmoid sinus constriction plus cartilage reconstruction technique for sigmoid sinus related pulsatile tinnitus. The clinical data of 31 patients with Sigmoid Sinus Diverticulum（SSD） who underwent surgical treatment from January 2020 to December 2023 were retrospectively analyzed. The surgical methods include transmastoid sigmoid sinus constriction and cartilage reconstruction, transmastoid sigmoid sinus（bone wax） return surgery.

A magneto-responsive nanomesh biosensor for simultaneous mechanical stimulation and electrochemical detection.

Mechanical cues are critical regulators of cell fate and behavior through the orchestrated and continual conversion of physical forces into biochemical responses. However, due to the poor compatibility between mechanical and biochemical techniques, existing methods are often limited in characterizing the occurring biochemical signals during mechanical stimulation. Herein, this work presents a magneto-responsive nanomesh (MRnM) biosensor capable of mechanically stimulating cells in vitro and tissues in vivo and simultaneously detecting the triggered biomolecules.

Acupuncture for cancer-related insomnia: An evidence mapping.

Background: Acupuncture shows promise in treating cancer-related insomnia (CRI); however, the evidence level for its effectiveness remains low. This study systematically examined research quality and used evidence mapping (EM) to map and present evidence information to identify gaps and inform future research.

Methods: Two reviewers searched eight databases from inception to May 2024, screened eligible randomized controlled trials (RCTs), and extracted key characteristics from included studies.

Blades and barriers: Oral vaccines for conquering cancers and warding off infectious diseases.

Global public health faces substantial challenges from malignant tumors and infectious diseases. Vaccination provides an approach for treating and preventing these diseases. Oral vaccinations are particularly advantageous in disease treatment and prevention due to their non-invasive nature, high patient compliance, convenience, cost-effectiveness, and capacity to stimulate comprehensive and adaptive immune responses.

Sensitivity-driven control strategy and analysis of operating parameter MLSS in the stacking total nitrogen prediction model.

The operation of wastewater treatment plants (WWTPs) is frequently characterized by complexity, largely attributable to the properties of the influent and the nonlinear fluctuations that occur throughout the wastewater treatment process. Accurate modeling of wastewater quality within WWTPs is essential for informed decision-making. In this research, we utilized a stacking model to amalgamate five foundational models, thereby enhancing the precision of the total nitrogen (TN) prediction model for effluent.

Utilisation of artificial intelligence to enhance the detection rates of renal cancer on cross-sectional imaging: protocol for a systematic review and meta-analysis.

Introduction: The incidence of renal cell carcinoma has steadily been on the increase due to the increased use of imaging to identify incidental masses. Although survival has also improved because of early detection, overdiagnosis and overtreatment of benign renal masses are associated with significant morbidity, as patients with a suspected renal malignancy on imaging undergo invasive and risky procedures for a definitive diagnosis. Therefore, accurately characterising a renal mass as benign or malignant on imaging is paramount to improving patient outcomes.

IL-7-PD-L1 nano-antibody mediated "zipper" effect augments the tumoricidal activity of tumor-infiltrating lymphocytes.

Cancer represents a pressing global health concern, characterized by a substantial number of unmet clinical needs. Cell therapy has emerged as a promising and efficacious approach for cancer treatment, particularly tumor-infiltrating lymphocytes (TILs), which have demonstrated remarkable improvements in patients' overall survival rates across various clinical studies. However, the tumor microenvironment exerts a adverse effect on TILs, leading to their rapid exhaustion and functional disorder.

Regulatory Effect of PGE-EP2/EP4 Receptor Pathway on -Induced Inflammatory Factors in Dairy Cow Neutrophils.

Naturally occurring prostaglandin E (PGE) influences cytokine production regulation in bovine neutrophils exposed to Rosenbach. Here, we employed bovine neutrophils as the primary experimental system, and administered specific inhibitors targeting various receptors, which were subsequently exposed to . Cytokine expression levels in dairy cow neutrophils induced by via the endogenous PGE-EP2/4 receptor pathway were investigated, and its effects on P38, extracellular signal-regulated kinase (ERK), P65 activation, and phagocytic function in Rosenbach-induced dairy cow neutrophils, were examined.

Exploring the role of hyperreflective walls as a biomarker for the management of cystoid macular edema.

Aim: To investigate the prevalence and clinical implications of hyperreflective walls (HRW) in foveal cystoid spaces in patients with cystoid macular edema (CME) caused by retinal diseases and noninfectious uveitis (NIU).

Methods: This retrospective cross-sectional study included 443 eyes with CME secondary to diabetic macular edema (DME), retinal vein occlusion (RVO), retinitis pigmentosa (RP), neovascular age-related macular degeneration (nAMD), and NIU. Demographic data, HRW features, and other spectral domain optical coherence tomography (SD-OCT) biomarkers were analyzed.

Different Response Criteria and Response Rates for Biologic Therapy in Patients With Chronic Rhinosinusitis With Nasal Polyps: A Systematic Review and Meta-Analysis.

Objective: Different criteria have been proposed for the response to biologic treatment to evaluate the efficacy of treatment among patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This review aimed to summarize current response criteria and evaluate response rates of patients with CRSwNP after biologic therapies.

Methods: We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library from the inception to July 2024 to identify clinical studies exploring the response to biologic treatment in patients with CRSwNP.

IF-MMCL: an individual focused network with multi-view and multi-modal contrastive learning for cross-subject emotion recognition.

Electroencephalography (EEG) usage in emotion recognition has garnered significant interest in brain-computer interface (BCI) research. Nevertheless, in order to develop an effective model for emotion identification, features need to be extracted from EEG data in terms of multi-view. In order to tackle the problems of multi-feature interaction and domain adaptation, we suggest an innovative network, IF-MMCL, which leverages multi-modal data in multi-view representation and integrates an individual focused network.

Exogenous prostaglandin D as a modulator in bovine endometritis: implications for reducing antibiotic use in dairy cattle.

Introduction: Bovine endometritis is a common postpartum uterine infection that significantly impacts the health and production performance of dairy cows, leading to economic losses for farms. Bovine endometritis is closely associated with pathogenic microorganisms, disturbances in uterine microecology, and localized inflammatory damage. () is the primary pathogenic bacterium responsible for bovine endometritis.

Interplay of the structures and viscoelastic properties of polyampholyte gels with the interlude of neutral blocks.

Polyampholyte gels with hierarchical structures due to the microphase separation are good candidates for biomaterials and bioengineering due to their unique properties such as self-healing and anti-biofouling. However, how to precisely control their microstructures and viscoelastic properties is yet to be explored. By introducing the acrylamide neutral blocks, we have quantitively tuned the microstructures and viscoelastic properties of polyampholyte gels.

3D Printing of Conductive Polymer via Photo-Oxidation Polymerization inside Metal-Organic Framework.

Despite the crucial role of conductive polymers in flexible microelectronics, current 3D fabrication of conductive polymers is plagued by solubility problems and low precision. Femtosecond laser direct writing (FsLDW) offers a potential solution, yet complex 3D structures constructing of conductive polymers remains challenging. Here, an innovative approach that utilizes inorganic microporous metal-organic framework (MOF) crystals as supporting substrates for 3D printing of polypyrrole (PPy) is developed.

Synthesis and highly selective adsorption of hydroxyapatite in situ self-Co-doped by magnesium-fluorine in phosphate tailings.

The main components of waste phosphate tailings (WPT) were used in this study for high-value purposes. In particular, these tailings were utilized as raw materials to create magnesium-fluoride self-co-doped hydroxyapatite (abbreviated Mg-F-HAP), a material with a high adsorption capacity and selectivity. Notably, fluorine doping raises the materials' adsorption capacity, whereas magnesium doping improves selectivity.

Mycophenolate mofetil plus methotrexate versus cyclophosphamide with sequential azathioprine for treatment of Takayasu arteritis.

Objectives: Study the efficacy and safety of mycophenolate mofetil (MMF) combined with methotrexate (MTX) compared to cyclophosphamide (CYC) followed by azathioprine (AZA) to treat active Takayasu arteritis (TAK).

Methods: Adults with active TAK were randomised in a 2:1 ratio to receive oral MMF plus MTX or intravenous CYC followed by oral AZA. All subjects also received high-dose oral glucocorticoids with a predefined taper.

Synthesis of 2-Aminodihydrobenzofurans through Copper-Catalyzed -Alkenylation/[3,3]-Rearrangement of Aryloxyamines with Alkenyl Boronic Acids.

A variety of 2-amino-2,3-disubstituted dihydrobenzofurans were prepared in good yields and high diastereoselectivity through copper-catalyzed -alkenylation and sequential [3,3]-rearrangement of aryloxyamines with alkenyl boronic acids under mild reaction conditions. Control experiments revealed that the monophosphine ligand played important roles in the C-N coupling reaction. More importantly, this -alkenylation and [3,3]-rearrangement could be easily applied into the modification of natural products and drugs.

Voltage-Programmed Sequential Fluorescence Encoding (VPSFE) Enables Multiplexed In Situ Proteo-Imaging with Electric-Field Turing Patterns.

DNA barcode-based immunolabeling has revolutionized single-cell protein profiling. However, conventional multiplexed imaging methods are hindered by laborious probe exchange procedures involving buffer washing-based probe removal and prolonged hybridization cycles (requiring tens of minutes to 1.5 h per cycle), which limit throughput, specificity, and universality.

The efficacy of acupuncture in the treatment of chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review and meta-analysis.

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect in cancer patients, often emerging within the first month of chemotherapy. Severe CIPN can disrupt daily life, necessitating chemotherapy adjustments or discontinuation, which may increase cancer mortality. No standardized treatment exists, but acupuncture is widely used in China for CIPN.

SIRT3 promotes mitophagy to attenuate fumonisin B1-induced chicken hepatocyte senescence and antagonism of lycopene.

Fumonisins are a class of mycotoxins produced by molds of the genus Fusarium, and fumonisin B1 (FB1) is the most toxic and common fumonisins. As a carotenoid with natural powerful antioxidant capacity found in plants, lycopene (LYC) can enhance immunity, modulate blood lipids, and prevent liver diseases. Sirtuin 3 (SIRT3) is a versatile molecule in modulating mitochondrial function with the significance in mitophagy and cellular senescence.