IF-MMCL: an individual focused network with multi-view and multi-modal contrastive learning for cross-subject emotion recognition.

Electroencephalography (EEG) usage in emotion recognition has garnered significant interest in brain-computer interface (BCI) research. Nevertheless, in order to develop an effective model for emotion identification, features need to be extracted from EEG data in terms of multi-view. In order to tackle the problems of multi-feature interaction and domain adaptation, we suggest an innovative network, IF-MMCL, which leverages multi-modal data in multi-view representation and integrates an individual focused network.

An MRI study of pancreatic atrophy in children with type 1 diabetes: Heterogeneity, disease duration effects, and progression prediction models.

Aim: To investigate the heterogeneity of pancreatic alterations in children with T1D and the effect of disease duration on the pancreas. To develop predictive models based on clinical and imaging parameters at baseline to determine whether pancreatic atrophy will progress at follow-up.

Methods: This retrospective study included 90 children with T1D and 82 control children.

SIRT6 Lysine-Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE-Cadherin Pathway Regulating Vascular Endothelial Barrier.

Cardiovascular diseases (CVDs) progression is significantly modulated by epigenetic mechanisms, particularly through Sirtuin 6 (SIRT6), a key NAD⁺-dependent deacetylase in the sirtuin family. Though essential for cardiovascular homeostasis, the effects of SIRT6-mediated lysine myristoylation on CVDs progression remain largely unexplored due to detection limitations. This study developes an innovative lysine-myristoylated peptide enrichment technique, identifying mutant SIRT6 (H133Y) with high myristoyl affinity but deficient demyristoylase activity.

Graphene-based wearable biosensors for point-of-care diagnostics: From surface functionalization to biomarker detection.

The growing demand for non-invasive, real-time health monitoring has driven the development of graphene-based wearable biosensors for point-of-care (POC) diagnostics. This review explores the surface functionalization of graphene and its critical role in enhancing the performance of wearable biosensors for biomarker detection. Leveraging graphene's exceptional electrical, mechanical, and biocompatible properties, we discuss how surface functionalization-such as covalent and non-covalent functionalization, biomolecular probes, and passivation layers-enable highly sensitive and selective detection of biomarkers in biofluids.

Coupling ozone-based AOPs with DLLME for simultaneous determination of trace free antimony and total antimony in surface water.

The traditional standard method for the determination of the heavy metal pollutant antimony (Sb) in water, 5-Br-PADAP spectrophotometry, involves the consumption of many kinds of chemical reagents and has low sensitivity. For highly toxic liquid and gas containing Sb(iii), this paper presents a green determination method based on UV/O synergistic oxidation-malachite green-dispersive liquid-liquid microextraction (DLLME)-spectrophotometry, which can achieve the enrichment of a trace amount of antimony in water and high-precision detection. Using the selective complexation and color development of protonated alkaline dye and the solubility difference of the complexes involved, an enrichment and determination method for trace Sb(v) in surface water was established for the first time.

Effects of diabetic ketoacidosis, islet cell function, and age of onset on pancreas size, morphology, and exocrine function in children with type 1 diabetes: an abdominal MRI study.

Objective: To investigate pancreatic MRI parameters changes in children with T1D and to assess the effects of DKA, islet cell function, and onset age on the pancreas size, morphology, and exocrine function.

Methods: 176 children with newly diagnosed T1D and 100 age- and sex-matched controls were enrolled in this retrospective study. Clinical metrics and pancreatic MRI parameters were collected and compared, and correlation analyses were performed to explore the relationships.

Altered spontaneous neural activity and its association with cognition, abdominal fat and liver function in children with obesity.

Background: The spontaneous neural activity alterations and their correlations with cognition, abdominal fat, and liver function in children with obesity remains unclear. This study examined the spontaneous neural activity variations in children with obesity using fractional amplitude of low-frequency fluctuation (fALFF) analysis and correlated the findings with clinical data.

Methods: Fifty-nine children with obesity and forty-eight healthy controls underwent resting-state functional MRI.

Early Time Spreading Dynamics of Nanobubble-Laden Drops.

Nanobubbles, when dispersed in a liquid phase, may enhance mass transport, adsorption, and reactions in many industrial applications, such as fabrication of functional materials, drug delivery, water treatment, carbon dioxide capture, and surface decontamination. Here, we experimentally study the early time spreading dynamics of nanobubble-laden surfactant drops on a hydrophilic solid surface submerged in an oil phase. Along with recovering the retarding effects of surfactants on the early time wetting dynamics, we report that nanobubbles can weaken Marangoni stresses and consequently reduce the duration of the retardation regime.

Two novel SH3TC2 mutations predispose to Charcot-Marie-Tooth disease type 4C by mistargeting away from TFRC.

Charcot-Marie-Tooth disease type 4C (CMT4C) is an autosomal recessive form of demyelinating neuropathy caused by the biallelic pathogenic mutations in the SH3TC2 gene and characterized by progressive scoliosis, muscular atrophy, distal weakness, and reduced nerve conduction velocity. Here, we report two novel SH3TC2 mutations (c.452dupT and c.

Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity.

Hepatocellular carcinoma is one of the leading causes of cancer deaths globally and a key hindrance to extending life expectancy. Celastrol (CEL) demonstrates excellent antitumor activity, but faces challenges like low solubility and a narrow therapeutic window, limiting its clinical application. To address these limitations, drug combinations and nano-delivery systems have emerged as effective solutions.

Cortisol regulates neonatal lung development via Smoothened.

Background: Neonatal respiratory distress syndrome (NRDS), one of the main causes of neonatal death, is clinically characterized by progressive dyspnea and cyanosis 1 to 2 h after birth. Corticosteroids are commonly used to prevent NRDS in clinical. However, the protective mechanism of the corticosteroids remains largely unclear.

A structure-based approach to discover a potential isomerase Pin1 inhibitor for cancer therapy using computational simulation and biological studies.

Peptidyl-prolyl cis/trans isomerase Pin1 occupies a prominent role in preventing the development of certain malignant tumors. Pin1 is considered a target for the treatment of related malignant tumors, so the identification of novel Pin1 inhibitors is particularly urgent. In this study, we preliminarily predicted eight candidates from FDA-approved drug database as the potential Pin1 inhibitors through virtual screening combined with empirical screening.

G-Diff: A Graph-Based Decoding Network for Diffusion Recommender Model.

The recommendation system is an effective approach to alleviate the information overload caused by the popularization of the Internet. Existing recommendation methods often use advanced deep learning algorithms to predict user preferences. The diffusion model is a deep generative model that has received much attention in recent years and has been successfully applied in recommendation systems.

Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model.

Background: There is an urgent need to develop an efficient therapeutic strategy for heart failure with preserved ejection fraction (HFpEF), which is mediated by phenotypic changes in cardiac macrophages. We previously reported that vitamin B-6 inhibits macrophage-mediated inflammasome activation.

Objectives: We sought to examine whether the prophylactic use of vitamin B-6 prevents HFpEF.

Altered Brain Glymphatic Function at Diffusion-Tensor MRI in Pre-cirrhotic Metabolic Dysfunction-Associated Fatty Liver Disease.

Rationale And Objectives: To evaluate glymphatic function changes and their relationships with clinical features in patients with metabolic dysfunction-associated fatty liver disease (MAFLD), thereby facilitating early intervention before this disease progresses to cirrhosis.

Materials And Methods: A cross-sectional cohort of 46 pre-cirrhotic MAFLD patients and 30 age-, sex-, and education-matched controls was enrolled, with diffusion-tensor imaging (DTI) data, laboratory and neurocognitive scores collected. The DTI analysis along the perivascular space (DTI-ALPS) index was computed for qualifying glymphatic function.

Abnormalities in spontaneous brain activity and functional connectivity are associated with cognitive impairments in children with type 1 diabetes mellitus.

Background: It remains unclear whether alterations in brain function occur in the early stage of pediatric type 1 diabetes mellitus(T1DM). We aimed to examine changes in spontaneous brain activity and functional connectivity (FC) in children with T1DM using resting-state functional magnetic resonance imaging (rs-fMRI), and to pinpoint potential links between neural changes and cognitive performance.

Methods: In this study, 22 T1DM children and 21 age-, sex-matched healthy controls underwent rs-fMRI.

Association between paravertebral muscle radiological parameter alterations and non-alcoholic fatty liver disease.

Purpose: To assess changes in laboratory indices, paravertebral muscle (PVM) fat infiltration and multi b-value DWI parameters and their potential correlation with NAFLD.

Methods: This retrospective analysis included 178 patients with histopathologically confirmed NAFLD, incluiding 76 with non-alcoholic steatohepatitis (NASH). Differences in PVM fat infiltration ratio (FIR), DWI parameters, and laboratory indices were compared between two groups.

Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review.

Inflammation can be triggered by any factor. The primary pathological manifestations can be summarized as the deterioration, exudation, and proliferation of local tissues, which can cause systemic damage in severe cases. Inflammatory lesions are primarily localized but may interact with body systems to cause provocative storms, parenchymal organ lesions, vascular and central nervous system necrosis, and other pathologic responses.

Therapeutic effects and molecular mechanisms of natural products in thrombosis.

Thrombotic disorders, such as myocardial infarction and stroke, are the leading cause of death in the global population and have become a health problem worldwide. Drug therapy is one of the main antithrombotic strategies, but antithrombotic drugs are not completely safe, especially the risk of bleeding at therapeutic doses. Recently, natural products have received widespread interest due to their significant efficacy and high safety, and an increasing number of studies have demonstrated their antithrombotic activity.

Improved detection of aortic dissection in non-contrast-enhanced chest CT using an attention-based deep learning model.

Rationale And Objectives: This study investigated the effects of implementing an attention-based deep learning model for the detection of aortic dissection (AD) using non-contrast-enhanced chest computed tomography (CT).

Materials And Methods: We analysed the records of 1300 patients who underwent contrast-enhanced chest CT at 2 medical centres between January 2015 and February 2023. We considered an internal cohort of 200 patients with AD and 200 patients without AD and an external test cohort of 40 patients with AD and 40 patients without AD.

Effects of Foliar Selenium Application on Oxidative Damage and Photosynthetic Properties of Greenhouse Tomato under Drought Stress.

Both drought stress and exogenous selenium (Se) cause changes in plant physiological characteristics, which are key factors affecting crop yield. Although Se is known to be drought-resistant for crops, its internal physiological regulatory mechanisms are not clear. This study analyzed the effects of selenium application (SeA) on antioxidant enzyme activities, osmoregulatory substance contents, and photosynthetic characteristics of greenhouse tomatoes under drought stress and related physiological mechanisms.

Gli1 marks a sentinel muscle stem cell population for muscle regeneration.

Adult skeletal muscle regeneration is mainly driven by muscle stem cells (MuSCs), which are highly heterogeneous. Although recent studies have started to characterize the heterogeneity of MuSCs, whether a subset of cells with distinct exists within MuSCs remains unanswered. Here, we find that a population of MuSCs, marked by Gli1 expression, is required for muscle regeneration.

Construction of curcumin-fortified juices using their self-derived extracellular vesicles as natural delivery systems: grape, tomato, and orange juices.

Different fruit and vegetable juices were first used to encapsulate curcumin to improve its solubility, stability, and bioaccessibility, which is expected to enable designing of polyphenol-enriched beverages and impact human health and well-being. Briefly, fruit and vegetable-derived extracellular vesicles usually serve as transport and communication tools between different cells, which means they also may be utilized as delivery carriers for other bioactive agents. Curcumin, as a model polyphenol with many physiological activities, typically has low water-solubility, stability, and bioaccessibility.