Maternal oxidative stress throughout pregnancy and early childhood neurodevelopment at different stages: insights from a prospective cohort study.

Background: Maternal oxidative stress during pregnancy plays a role as a hazardous factor of offspring neurodevelopment in animal models. However, epidemiological evidence remains limited. In this prospective cohort, we aimed to investigate the associations between maternal oxidative stress biomarkers (OSBs) across pregnancy and neurodevelopmental outcomes in different stages across early childhood.

Small molecule barrier empowered high-efficiency green electrospinning of fully bio-based nanofibrous membrane for antibacterial and UV-shielding air filtration.

Green electrospinning of fully bio-based nanofibrous membranes holds significant promise for sustainable development. However, the complex molecular structures and functional groups inherent in bio-based materials often lead to strong intermolecular interactions. It may cause nozzle clogging and hinder the stretching and thinning of electrospinning jets, thereby adversely affecting performance optimization and scalable manufacturing of fibers.

Green and efficient electrospinning of ethyl cellulose-based nanofibrous membrane for high-performance and antibacterial air filtration.

The environmentally friendly, economical, and efficient production of high-performance and multifunctional bio-based air filter membranes is crucial for the protection of human health and sustainable development. However, this endeavor is significantly limited by the current gap in material selection and process routes. This study proposes a strategy for advanced functionalization and structural optimization of ethyl cellulose (EC) to effectively develop a high-performance, fully bio-based air filter membrane exhibiting superior antibacterial properties.

Benzotriazoles and Benzothiazoles, Maternal and Neonatal Thyroid Hormones, and Childhood Growth: A Longitudinal Cohort Study.

Prenatal exposure to benzotriazoles and benzothiazoles (BTs) has been associated with pregnancy complications, but their effects on childhood development remain unclear. We investigated these associations and examined the mediating role of maternal and neonatal thyroid hormones in a Chinese birth cohort consisting of 501 mother-child pairs. We found that exposure to 2-hydroxy-benzothiazole (2-OH-BTH) in early pregnancy was inversely associated with childhood body mass index (BMI) (β = -0.

Green electrospinning ethyl cellulose/chitosan bimodal nanofiber membrane based on internal-external synergistic enhancement strategy for high-flux air filtration.

The preparation of electrospinning air filtration membranes based on fully bio-based materials is the key to alleviate the energy and environmental crises. However, for the lack of reasonable materials matching and structural design strategies, it is difficult to balance the mechanical and filtration properties of bio-based fiber membranes. In this study, ethyl cellulose (EC)/chitosan (CS) bimodal nanofiber membrane was prepared by one-step electrospinning.

Traits and economic spectrum of different-aged leaf of in Minjiang River estuary, China.

To elucidate the adaptive mechanisms and strategies of different-aged leaves of in response to resource limitations in the Minjiang River Estuary Wetland Nature Reserve, we measured 21 leaf functional traits from current-year and previous-year leaves, and compared the traits between the two leaf types to construct leaf economic spectrum. The results showed that the fresh and dry weight of in the previous-year leaves was 2.3 times of current-year leaves.

Excess Neprilysin in Placental EVs Impairs CNP-NPRB-Mediated Vasodilation to Trigger Preeclamptic Hypertension.

Background: Preeclampsia is a placenta-origin pregnancy complication. Although its development has long been divided into 2 stages: abnormal placentation (stage I) and the release of factors from the hypoperfused placenta into circulation, triggering preeclampsia due to endothelial dysfunction (stage II), the placenta-derived substances coupling the 2 stages remain unclear.

Methods: Extracellular vesicles (EVs) from normal and preeclampsia-complicated placentas were intravenously administered to pregnant mice, and blood pressure was recorded throughout pregnancy.

Trimester-specific associations of exposure to epoxide alkanes, alkenals, and 1,3-butadiene with preschool children's intellectual development: A birth cohort study in Wuhan, China.

The impact of prenatal exposure to contaminants with neurotoxicity like epoxide alkanes (ethylene oxide, propylene oxide), alkenals (acrolein, crotonaldehyde), and 1,3-butadiene on children's intellectual development remains underreported, and related sensitive window is of interest. In this cohort study, metabolites of these contaminants were measured in 3,081 urine samples from 1,027 pregnant women across three trimesters. Children's intelligence quotient was evaluated at 4-6 years old.

FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in early-onset preeclampsia.

This investigation examined focal adhesion kinase (FAK)'s role in trophoblast cellular processes during early-onset preeclampsia (EOPE). We analyzed FAK and its phosphorylated form (pY397FAK) expression patterns in both normal (n = 15) and EOPE (n = 15) placental tissues, including first trimester samples, using immunohistochemistry and Western blot techniques. Next, Y15 was used to inhibit FAK activity.

Conditional diffusion model for recommender systems.

Recommender systems are used to filter personalized information for users, as it help avoid information overload. The diffusion model is an advanced deep generative model that has been used in recommender systems due to its effectiveness in reconstructing users' interaction vectors and predicting their preferences. The conditional diffusion model is an improvement of the diffusion model that introduces the guidance information in the reverse diffusion process, where the guidance information is usually labels or features related to the reconstructed vector.

METTL3 and IGF2BP2 coordinately regulate FOSL1 mRNA via m6A modification, suppressing trophoblast invasion and contributing to fetal growth restriction.

Fetal growth restriction (FGR) increases the risk of short-term and long-term complications. Widespread N6-methyladenosine (m6A) modifications on mRNAs have been found to be involved in various biological processes. However, the role of m6A modification in the pathogenesis of FGR remains elusive.

G-Diff: A Graph-Based Decoding Network for Diffusion Recommender Model.

The recommendation system is an effective approach to alleviate the information overload caused by the popularization of the Internet. Existing recommendation methods often use advanced deep learning algorithms to predict user preferences. The diffusion model is a deep generative model that has received much attention in recent years and has been successfully applied in recommendation systems.

GLABRA3-mediated trichome branching requires transcriptional repression of MICROTUBULE-DESTABILIZING PROTEIN25.

Microtubules play pivotal roles in establishing trichome branching patterns, which is a model system for studying cell-shape control in Arabidopsis (Arabidopsis thaliana). However, the signaling pathway that regulates microtubule reorganization during trichome branching remains poorly understood. In this study, we report that MICROTUBULE-DESTABILIZING PROTEIN25 (MDP25) is involved in GLABRA3 (GL3)-mediated trichome branching by regulating microtubule stability.

Low-grade systemic inflammation links heavy metal exposures to mortality: A multi-metal inflammatory index approach.

Certain heavy metals have been correlated to an elevated risk of inflammation-related diseases and mortality. Nevertheless, the intricate relationships between metal exposure, inflammation and mortality remain unknown. We included 3741 adults with measurements of ten urinary heavy metals in the National Health and Nutritional Examination Survey (NHANES) 2005-2010, followed up to December 31, 2019.

Preparation of ethyl cellulose bimodal nanofibrous membrane by green electrospinning based on molecular weight regulation for high-performance air filtration.

Preparing bio-based air filtration membrane through green electrospinning strategy is a vital approach to alleviating environmental and energy crises. However, the development of related biomaterials and method for regulating membrane structure are still lacking. In this study, ethyl cellulose (EC) bimodal nanofibrous membrane was prepared by electrospinning using ethanol and water as solvents to achieve high-performance air filtration.

Research waste among randomized controlled trials in ovarian cancer: A cross-sectional study.

Objective: To examine the association between trial characteristics and research waste in randomized controlled trials (RCTs) on ovarian cancer over the past two decades.

Methods: ClinicalTrials.gov was searched for RCTs registered between 2000 and 2020 using the keyword ovarian cancer.

Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.

Premature rupture of membrane (PROM) refers to the rupture of membranes before the onset of labor which increases the risk of perinatal morbidity and mortality. Recently, circular RNAs (circRNAs) have emerged as promising regulators of diverse diseases. However, the circRNA expression profiles and potential circRNA-miRNA-mRNA regulatory mechanisms in PROM remain enigmatic.

High level 27-HC impairs trophoblast cell invasion and migration via LXR in pre-eclampsia.

Introduction: To explore the potential impact of 27-hydroxycholesterol (27-HC) on trophoblast cell function in pre-eclampsia.

Results: The levels of 27-HC and the expression of CYP27A1 are upregulated in clinical samples of PE. Furthermore, high concentrations of 27-HC can inhibit the invasion and migration ability of trophoblast cells in vitro, and this inhibitory effect is weakened after LXR silencing.

An innovative Z-type SbS/InS/TiO heterostructure: superior performance in the photocatalytic removal of levofloxacin and mechanistic insight.

In this study, SbS/InS/TiO (SIT) heterojunction photocatalysts were prepared by a simple two-step hydrothermal method and applied to the photocatalytic degradation of levofloxacin (LEV). After 160 min of reaction under visible light, the SIT heterojunction photocatalyst degraded 10 mg L LEV at a rate of 86.7%.

Synthesis of Bis-Heterocycles Bearing Methyleneindole Motifs by Pd-Catalyzed Domino Reaction.

A highly robust, general, and practically simple palladium-catalyzed domino bicyclization strategy is presented to synthesize nitrogen-containing bis-heterocycles bearing methylene indole motifs from alkyne-tethered carbamoyl chlorides and β,γ- or γ,δ-unsaturated hydrazones. The salient features of this transformation include broad substrate scope, good functional group tolerance, ease for scale-up, and convenient conversion.

Nitrogen-rich carbon nitride (CN) coupled with oxygen vacancy TiO arrays for efficient photocatalytic HO production.

Developing efficient and facilitated recycling photocatalysts for HO formation is an ideal strategy for solar-to-chemical energy conversion. In this work, we synthesized ultrathin CN nanosheets through the process of thermal polymerization and polyvinylpyrrolidone (PVP)-assisted solvent exfoliation. Subsequently, the obtained ultrathin CN nanosheets were tightly attached to the surface of TiO arrays, resulting in an enhanced photocatalytic HO production rate.

Au nanoparticle sensitized blue TiO nanorod arrays for efficient Gatifloxacin photodegradation.

TiO nanorod arrays have been widely used in photocatalytic processes, but their poor visible light absorption and rapid carrier recombination limit their application. Both introducing oxygen vacancies and using precious metals as surface plasmon resonance (SPR) stimulators are effective strategies to enhance their photocatalytic performance. Herein, Au nanoparticle sensitized blue TiO nanorod arrays (Au/B-TiO) were successfully fabricated for efficient Gatifloxacin photodegradation.

The genetic variation in drought resistance in eighteen perennial ryegrass varieties and the underlying adaptation mechanisms.

Background: Drought resistance is a complex characteristic closely related to the severity and duration of stress. Perennial ryegrass (Lolium perenne L.) has no distinct drought tolerance but often encounters drought stress seasonally.

Developments in small-angle X-ray scattering (SAXS) for characterizing the structure of surfactant-macromolecule interactions and their complex.

The surfactant-macromolecule interactions (SMI) are one of the most critical topics for scientific research and industrial application. Small-angle X-ray scattering (SAXS) is a powerful tool for comprehensively studying the structural and conformational features of macromolecules at a size ranging from Angstroms to hundreds of nanometers with a time-resolve in milliseconds scale. The SAXS integrative techniques have emerged for comprehensively analyzing the SMI and the structure of their complex in solution.