Trimester-specific associations of exposure to epoxide alkanes, alkenals, and 1,3-butadiene with preschool children's intellectual development: A birth cohort study in Wuhan, China.

The impact of prenatal exposure to contaminants with neurotoxicity like epoxide alkanes (ethylene oxide, propylene oxide), alkenals (acrolein, crotonaldehyde), and 1,3-butadiene on children's intellectual development remains underreported, and related sensitive window is of interest. In this cohort study, metabolites of these contaminants were measured in 3,081 urine samples from 1,027 pregnant women across three trimesters. Children's intelligence quotient was evaluated at 4-6 years old.

Exploring the relationships between prenatal phthalate exposure and neonatal thyroid function: A prospective cohort study.

Previous studies have reported the thyroid disruptive effects of prenatal phthalate exposure; however, evidence on the impact of prenatal phthalate alternative exposure on neonatal thyroid function is still limited. We aimed to investigate the associations between prenatal exposure to phthalates and phthalate alternatives (individually and as a mixture) and neonatal thyroid function, based on longitudinal data from the Wuhan Healthy Baby Cohort Study. We measured concentrations of phthalate and phthalate alternative metabolites (mPAEs) in urine samples, provided by 1202 mothers at three trimesters, and neonatal thyroid stimulating hormone (TSH) levels in heel-prick blood samples.

Effects of prenatal vanadium exposure on neurodevelopment in early childhood and identification of critical window.

The increased environmental vanadium exposure levels have drawn widespread attention to its health risks. However, the specific impacts of vanadium exposure during pregnancy on child neurodevelopment are unknown. Prenatal vanadium exposure was assessed using 3777 urine samples from 1259 mothers over three stages of pregnancy, and child neurodevelopment at 2 years old was evaluated using the Bayley Scales of Infant Development to get mental development index (MDI) and psychomotor development index (PDI) scores.

The relationship between autoimmune disorders and intracranial aneurysms in East Asian and European populations: a bidirectional and multivariable two-sample Mendelian randomization study.

Background: It remains unclear about the pathogenesis of intracranial aneurysms (IAs) in the setting of autoimmune disorders (ADs). However, the underlying systemic inflammatory characteristics of ADs may affect IAs through shared inflammatory pathways. Therefore, this study was conducted to explore the relationship between ADs and IAs and assess causal effects.