The associations between prenatal rare earth elements exposure and preterm birth: integrate insights from birth cohort and in vitro study.

Rare earth elements (REEs) are emerging environmental contaminants, yet their effects on preterm birth (PTB) remain poorly understood. This study integrates epidemiological and mechanistic evidence to evaluate REEs-associated PTB risk and potential biological pathways. We analyzed 4,897 mother-child pairs from a large cohort in China and 13 REEs in maternal urine were measured.

HPV negative conversion following Hiporfin PDT for HPV associated HSIL in the female lower reproductive tract.

Currently, there is no relevant literature specifically discussing the human papillomavirus (HPV) negative conversion rate following Hiporfin photodynamic therapy (PDT) in HPV-associated high-grade squamous intraepithelial lesion (HSIL) of the female lower reproductive tract. Our study aims to fill this gap. Prospective study of 91 patients aged 37.

Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice.

Experimental studies suggest that the probiotic yeast Saccharomyces boulardii can mitigate the symptoms of inflammatory bowel disease. However, these results are equivocal and S. boulardii probiotic therapy has not gained widespread acceptance in clinical practice.

Study on the Regulatory Effect of Water Extract of L. on Antioxidant Function of Mutton Sheep via the Keap1/Nrf2 Signaling Pathway.

This study was conducted through in vivo and in vitro experiments and aimed to reveal the regulatory effect of water extract of L. (WEAA) on the antioxidant function of mutton sheep and the underlying mechanism. In the in vivo experiment, 32 Dorper × Han female sheep (3 months old; avg.

Effect of CYP2D6 and ABCB1 polymorphisms on pharmacokinetics and efficacy of aripiprazole in pediatric tic disorders.

Background: Aripiprazole (ARI) is the first-line treatment for tic disorders (TD). Cytochrome P450(CYP)2D6 (CYP2D6) and ATP-binding cassette, sub-family B, member 1 (ABCB1) transporter are involved in the metabolism of ARI. However, whether CYP2D6 and ABCB1 genetic polymorphisms influence clinical efficacy and pharmacokinetics of ARI remains unclear.

Implementation of simulated driving tests and interviews to investigate the impact of gender on rail transit driving tasks.

BackgroundThe rail transit sector is experiencing growing gender diversity and increasing system automation. Understanding how gender influences drivers' trust in automation, operational performance, and perceived workload is crucial for ensuring safe and equitable development.ObjectiveThis study aimed to investigate gender differences in automation trust, task performance, and subjective workload in rail transit driving tasks and to explore the interrelationships among these factors.

Calcium-responsive phosphorylation of SlLHP1b epigenetically suppresses auxin synthesis to control drought-induced flower drop in tomato.

Drought causes the abscission of flowers and fruits, thereby reducing yields. Although trimethylation of histone H3 in the lysine 27 (H3K27me3)-dependent pathway has been shown to control drought responses, the mechanisms underlying drought-induced abscission remain unknown. In this study, we showed that drought-induced calcineurin B-like11 (SlCBL11) upregulation activated the CBL-interacting protein kinase10 (SlCIPK10) to phosphorylate like heterochromatin protein 1b (SlLHP1b) at Thr387 and Thr389, respectively, in stamens of tomato (Solanum lycopersicum).

Achieving high nitrogen removal rates in partial nitritation/anammox system treating low-ammonium wastewater by optimizing microbial growth environments via sludge settling-driven spatial segregation.

Achieving a high nitrogen removal rate (NRR) in partial nitritation/anammox (PN/A) systems under low-ammonium conditions remains challenging due to conflicting oxygen requirements and substrate competition among functional microbes. To overcome these limitations, a novel spatial segregation strategy driven by sludge settling was proposed to establish niche separation between ammonia-oxidizing bacteria (AOB) and anaerobic ammonia-oxidation bacteria (AnAOB) within a sequencing batch reactor (SBR). AOB-rich flocs were maintained in the aerobic upper zone, while AnAOB-enriched granules settled in the anoxic bottom zone, and an internal reflux ensured efficient nitrite transfer.

Quantitative Analysis of Tomato Flower Pedicel Abscission and Single-Cell Transcriptome Analysis.

Plant organ abscission is a highly organized biological process in response to developmental and environmental cues. The understanding of the regulation of abscission is of great importance for the improvement of crop productivity and quality. The abscission process can be quantitatively analyzed by investigating the abscission of the tomato flower pedicel of different genotypes at a specific period.

The function of CC-type glutaredoxins in salt-induced flower drop in tomato.

Salt stress significantly induces the abscission of flowers and fruits, resulting in a reduction in crop yields and posing a threat to food security. Nonetheless, the molecular mechanisms underlying the abscission triggered by salt stress remain poorly understood. In our study, the effects of different NaCl concentrations on the growth of tomato plants and flower drop were investigated.

A KNOTTED1-LIKE HOMEOBOX PROTEIN1-interacting transcription factor SlGATA6 maintains the auxin-response gradient to inhibit abscission.

The KNOTTED1-LIKE HOMEOBOX PROTEIN1 (SlKD1) is a master abscission regulator in tomato (). Here, we identified an SlKD1-interacting transcription factor GATA transcription factor 6 (SlGATA6), which is required for maintaining the auxin-response gradient and preventing abscission. SlGATA6 up-regulates the expression of and .

Comparative analysis of photodynamic therapy and conization for cervical high-grade squamous intraepithelial lesion: A systematic review and meta-analysis.

Objectives: This review aims to compare the effectiveness of photodynamic therapy (PDT) with conization, including loop electrosurgical excision procedure (LEEP) and cold-knife conization (CKC), in treating cervical high-grade squamous intraepithelial lesions (HSIL).

Methods: PubMed, Cochrane Library, Google Scholar, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched. The outcomes assessed were complete response (CR) rate, human papillomavirus (HPV) eradication rate, recurrence rate, and adverse events (AEs).

Low-intensity-pulsed-ultrasound-treated menstrual-blood-derived mesenchymal stem cells repair endometrial injury by PI3K/AKT pathway inhibition.

Research Question: What is the effect and underlying mechanism of low-intensity-pulsed-ultrasound (LIPUS)-treated menstrual-blood-derived mesenchymal stem cells (MenSC) on intrauterine adhesions (IUA)?

Design: First, MenSC were identified and exposed to LIPUS. The proliferation, migration, invasion, cytokine secretion, and ability to differentiate into human endometrial epithelial cells (HEEC) of LIPUS-treated MenSC were characterized. In vitro, human endometrial stromal cells (HESC) were treated with 10 ng/ml transforming growth factor-β1 (TGF-β1) to simulate IUA, and then co-cultured indirectly with LIPUS-treated MenSC.

A regulatory network involving calmodulin controls phytosulfokine peptide processing during drought-induced flower abscission.

Drought stress substantially decreases crop yields by causing flowers and fruits to detach prematurely. However, the molecular mechanisms modulating organ abscission under drought stress remain unclear. Here, we show that expression of CALMODULIN2 (CaM2) is specifically and sharply increased in the pedicel abscission zone in response to drought and plays a positive role in drought-induced flower drop in tomato (Solanum lycopersicum).

Association between gut microbiota and short-chain fatty acids in children with obesity.

The gut microbiome and its metabolites may be important role in regulating the pathogenesis of obesity. This study aimed to characterize the gut microbiome and short-chain fatty acid (SCFA) metabolome in obese children. This case-control study recruited children aged 7‒14 years and divided them into a normal group (NG) and an obese group (OG) based on their body mass index.

Safety profile of isocitrate dehydrogenase inhibitors in cancer therapy: a pharmacovigilance study of the FDA Adverse Event Reporting System.

Background: Isocitrate dehydrogenase (IDH) inhibitors hold promise for IDH-mutated cancer patients and demonstrated favorable clinical efficacy. Nonetheless, a comprehensive understanding of the associated toxicities of IDH inhibitors remains notably lacking.

Research Design And Methods: This pharmacovigilance analysis utilized the FDA Adverse Event Reporting System (FAERS) database to assess notable adverse events (AEs) attributed to IDH inhibitors (enasidenib and ivosidenib) from January 2018 to December 2023.

Carbon dot-based molecularly imprinted polymer fluorescent sensor for the detection of propranolol in plasma.

Propranolol, a medication used to treat cardiovascular diseases, can be harmful when overdosed and hazardous to ecosystems if released into the environment. Here, a new molecularly imprinted fluorescent sensor was developed from carbon dots through a sol-gel method. Carbon dots served as both the fluorescent signal and the carrier, with propranolol as the template molecule and 3-aminopropyltriethoxysilane as the functional monomer to be grafted on carbon dots' surface.

Hiporfin photodynamic therapy for early-stage cervical cancer: A case report.

A 28-year-old female patient, diagnosed with stage IA1 cervical cancer, received PDT treatment with intravenous injection of Hiporfin, a HpD type photosensitizer. The patient's human papillomavirus (HPV) and cytology testing results were negative at the 3-month. At 6 months, the lesions on the cervical surface and within the cervical canal had completely resolved.

Hiporfin-photodynamic therapy for high-grade squamous intraepithelial lesions of the endocervical canal in young women.

The objective of this prospective study was to assess the efficacy of Hiporfin-photodynamic therapy (PDT) int the treatment of young women diagnosed with high-grade squamous intraepithelial lesions (HSIL) of the endocervical canal. This study included 14 patients aged 30 ± 4.2 years (range 21-37) with HSIL of the cervical canal, treated at our hospital from August 2021 to June 2023.

Photodynamic therapy compared with loop electrosurgical excision procedure in patients with cervical high-grade squamous intraepithelial lesion.

The study aimed to compare the effectiveness between Hiporfin-photodynamic therapy (PDT) and loop electrosurgical excision procedure (LEEP) in treating cervical high-grade squamous intraepithelial lesion (HSIL). We conducted a retrospective analysis of 104 women diagnosed with cervical HSIL at our hospital from April 2019 to July 2023. With 1:1 matched case-control, 52 cases received Hiporfin-PDT and 52 cases underwent LEEP.

Risk factors for regional lymph node metastasis in rectal neuroendocrine tumors: a population-based study.

Introduction: The identification of risk factors for regional lymph node (r-LN) metastasis in rectal neuroendocrine tumors (R-NETs) remains challenging. Our objective was to investigate the risk factors associated with patients diagnosed with R-NETs exhibiting r-LN metastasis.

Methods: Patient information was obtained from the Surveillance, Epidemiology, and End Results (SEER) database, complemented by data from the West China Hospital (WCH) databases.