Superelastic and Washable Micro/Nanofibrous Sponges Based on Biomimetic Helical Fibers for Efficient Thermal Insulation.

Extreme cold weather seriously harms human thermoregulatory system, necessitating high-performance insulating garments to maintain body temperature. However, as the core insulating layer, advanced fibrous materials always struggle to balance mechanical properties and thermal insulation, resulting in their inability to meet the demands for both washing resistance and personal protection. Herein, inspired by the natural spring-like structures of cucumber tendrils, a superelastic and washable micro/nanofibrous sponge (MNFS) based on biomimetic helical fibers is directly prepared utilizing multiple-jet electrospinning technology for high-performance thermal insulation.

HDAC2 enhances the antimicrobial activity of neutrophils by promoting the formation of neutrophil extracellular traps (NETs) in sepsis.

Introduction: Sepsis is characterized as a life-threatening organ dysfunction resulting from a dysregulated host response to infection, representing a critical clinical syndrome. Uncontrolled infection and inflammation are two main characteristics of sepsis. Neutrophil extracellular traps (NETs) is a major mechanism by which neutrophils resist pathogens invasion, but the mechanism of the NETs formation remain completely unclear.

Epidemiological Study of Childhood Idiopathic Epilepsy from 1990 to 2021 at Global, Regional, and National Scales.

Objective: To address the long-term impact of childhood idiopathic epilepsy on health and families, and to provide epidemiological evidence for developing effective prevention and treatment strategies, this study aimed to explore the trends in incidence, deaths, and disability-adjusted life years (DALYs) of childhood idiopathic epilepsy globally and across regions from 1990 to 2021.

Patients And Methods: This cross-sectional analysis utilized data from the 2021 Global Burden of Disease database, covering idiopathic epilepsy cases among children aged 0-14 years across 204 countries and regions. The study period was from September 15, 2024, to October 31, 2024.

Impact of Post-Procedural Atrial Arrhythmia on Long-Term Cardiac Function and Quality of Life Following Patent Foramen Ovale Closure.

Background: Patent foramen ovale (PFO) is a common remnant of the embryonic development of the heart with an underestimated potential for morbidity and mortality. This study aimed to investigate the long-term impact of atrial arrhythmia (AA), a common complication after PFO closure, on cardiac function and quality of life (QoL) through a retrospective clinical analysis.

Methods: Patients who underwent percutaneous PFO closure between January 2022 and June 2024 were retrospectively identified.

Numerical Simulation Research on Lateral Explosion Venting of Pipeline Gasoline Vapor-Air Mixture under Different Opening Pressures.

In the research on lateral vented explosions of gasoline vapor-air mixtures in pipelines with different opening pressures, the paper conducts a numerical simulation study of gasoline vapor-air mixture explosions in a rectangular pipeline with a length-to-diameter ratio of 15. By analyzing the explosion flame morphology, unburned fuel gas distribution, flow field structure, and overpressure variation characteristics, the results reveal that there are two different explosion modes with and without constraints, forming five typical overpressure peaks: , , , , and . There is a strong dynamic coupling relationship among explosion flame behavior, unburned fuel gas distribution, and flow field structure.

Presence and sources of antibiotics in Dongzhai Harbor, Hainan Island.

Dongzhai Harbor Mangrove forest, which is one of the largest mangrove forests in China, is currently contaminated by antibiotics from aquaculture and human activities in the vicinity. However, insufficient research has been conducted on antibiotic pollution in Dongzhai Harbor, which could affect the antibiotic pollution levels in the mangrove forest. In this study, the occurrence, distribution and risk assessment of 37 antibiotics in the seawater and sediment of Dongzhai Harbor were analyzed.

Reticular framework materials as versatile platforms for controllable polymer synthesis.

Polymers play a crucial role in a wide range of applications, and achieving precise control over their primary structures (, molecular weight, tacticity) and higher-order architectures (, cross-linking density, macroscopic morphology) remains a significant challenge in modern materials science. Traditional polymerization methods often fall short in achieving the necessary structural precision, limiting the development of advanced functional polymers. The emergence of reticular framework materials, such as metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and hydrogen-bonded organic frameworks (HOFs), offers promising solutions to these limitations.

Reconstruction of cobalt magnesium aluminum hydrotalcite loaded ruthenium using the memory effect for selective oxidation of 5-hydroxymethylfurfural under alkali-free conditions.

The hydrotalcite CoMgAl-LDH was prepared using a hydrothermal method. The calcined hydrotalcite was rehydrated utilizing its "memory effect", and the catalyst Ru/CoMgAl-RLDH was prepared by loading ruthenium nanoparticles through the impregnation reduction method. The pristine hydrotalcite CoMgAl-LDH exhibited a specific surface area of 9.

ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling.

Background & Aims: The extracellular matrix protein 1 (ECM1) is essential for liver homeostasis by keeping latent transforming growth factor-beta quiescent. Upon hepatocyte damage, ECM1 is significantly downregulated, facilitating fibrosis and chronic liver disease (CLD) progression. We investigated the mechanism of ECM1 regulation in hepatocytes under pathophysiological conditions.

Robust and Versatile OPH-Cu Phosphate Hybrid Nanoflower for Organophosphorus Compound Degradation.

Organophosphorus hydrolase (OPH), a promising biocatalyst for the degradation of organophosphorus compounds, faces application limitations due to its structural fragility. To address this, we developed a novel bioinorganic hybrid nanoflowers (HNFs) system by integrating OPH with copper phosphate via a self-assembly strategy. The HNFs exhibited significant catalytic robustness across a broad pH and temperature range.

An intelligent colorimetric paper-based hypoxanthine biosensor enabled by smartphone and dual-enzyme system for efficient shrimp freshness monitoring.

Monitoring the freshness of aquatic foods is essential to ensure their quality and safety. Hypoxanthine (Hx), degraded from adenosine triphosphate, emerges as an early indicator during shrimp spoilage. There is no paper-based biosensor to monitor shrimp freshness via Hx detection.

Calcium-responsive phosphorylation of SlLHP1b epigenetically suppresses auxin synthesis to control drought-induced flower drop in tomato.

Drought causes the abscission of flowers and fruits, thereby reducing yields. Although trimethylation of histone H3 in the lysine 27 (H3K27me3)-dependent pathway has been shown to control drought responses, the mechanisms underlying drought-induced abscission remain unknown. In this study, we showed that drought-induced calcineurin B-like11 (SlCBL11) upregulation activated the CBL-interacting protein kinase10 (SlCIPK10) to phosphorylate like heterochromatin protein 1b (SlLHP1b) at Thr387 and Thr389, respectively, in stamens of tomato (Solanum lycopersicum).

Innovations in smart enzyme biosensors: Advancing the detection of antibiotic residues in aquaculture.

In aquaculture, the presence of antibiotic residues is an escalating concern that poses significant risks to human health. Establishing efficient and user-friendly detection methods for antibiotic residues has become crucial to mitigate these potential hazards. To address the limitations of traditional techniques, novel enzyme biosensors, offering high sensitivity and specificity and rapid response, has been introduced for monitoring a wide range of antibiotics in food safety applications.

Enhanced stability and efficiency of enzyme-inorganic hybrid nanoflowers for organophosphate degradation.

Enzyme catalysis is characterized by high efficiency and selectivity; however, the natural enzymes are prone to inactivation once removed from their native environment. The immobilization of enzyme using solid-phase carriers presents an effective strategy to enhance the structural stability of natural enzymes. In this study, organophosphate hydrolase (OPH) was utilized as the organic component, while ferrous phosphate served as the inorganic component, leading to the synthesis of enzyme-inorganic hybrid nanoflower materials through biomimetic mineralization.

Artificial Light-Driven Ion Pumps.

Nature's molecular machinery has long provided inspiration for the development of functional materials, with natural ion pumps exemplifying the efficient conversion of solar energy into directional ion transport. This process is crucial for cellular signaling, bioenergy conversion, and photosynthesis. Motivated by these biological systems, artificial light-driven ion pumps have emerged as transformative technologies for sustainable energy harvesting, desalination, and bioelectronic innovations.

Machine learning model to predict sepsis in ICU patients with intracerebral hemorrhage.

Patients with intracerebral hemorrhage (ICH) are highly susceptible to sepsis. This study evaluates the efficacy of machine learning (ML) models in predicting sepsis risk in intensive care units (ICUs) patients with ICH. We conducted a retrospective analysis on ICH patients using the MIMIC-IV database, randomly dividing them into training and validation cohorts.

Improving lower-extremity artery depiction and diagnostic confidence using dual-energy technique and popliteal artery monitoring in dual-low dose CT angiography.

To assess the utility of dual-energy CT scanning (DECTs) with popliteal artery (PA) monitoring in dual low-dose (radiation and contrast) lower-extremity CT angiography (LE-CTA). 135 patients undergoing LE-CTA were prospectively included and divided into three groups of 45 each. Group-A: conventional scanning, 105 mL of contrast, abdominal aorta monitoring; Group-B: low-dose DECTs, 95 mL of contrast, AA monitoring; Group-C: low-dose DECTs, 85 mL of contrast, PA monitoring.

Aptamers capable of simultaneously identifying multiple targets and corresponding applications in medical diagnosis-A review.

Aptamers, a unique class of nucleic acid sequences recognized for their specific binding capabilities, have found widespread application in biomedical field. While traditional aptamers are typically designed to target a single molecule recognition, recent attention has been directed towards multifunctional aptamers capable of simultaneously identifying multiple targets. In this review, the latest advancements in multifunctional aptamers and their applications in medical diagnosis are presented for the first time.

Comparison of blood viscosity models in different degrees of carotid artery stenosis.

Background: Carotid atherosclerotic vascular disease significantly contributes to strokes, presenting a heightened risk of early recurrent ischemia. Computational fluid dynamics (CFD) has shown potential in predicting subsequent stroke recurrence in patients with carotid stenosis.

Objective: This study aims to investigate the differences in computational time and accuracy of four key hemodynamic indices-wall shear stress (WSS), time-averaged wall shear stress (TAWSS), Oscillatory Shear Index (OSI), and relative residence time (RRT)-across different viscosity models, thereby providing optimal model selection for clinical cases and offering guidance for clinicians' decision-making.

Engineering Bipolar Covalent Organic Framework Membranes for Selective Acid Extraction.

Nitric acid (HNO) is a vital industrial chemical, and its recovery from complex waste streams is essential for sustainability and resource optimization. This study demonstrates the effectiveness of bipolar covalent organic framework (COF) membranes with tunable ionic site distributions as a solution for this challenge. The membranes are fabricated by layering anionic COF nanosheets on cationic COF layers, supported by a porous substrate.

The circular RNA circANK suppresses rice resistance to bacterial blight by inhibiting microRNA398b-mediated defense.

Circular RNAs (circRNAs) are prevalent in eukaryotic cells and have been linked to disease progressions. Their unique circular structure and stability make them potential biomarkers and therapeutic targets. Compared with animal models, plant circRNA research is still in its infancy.

Prevalence and 10-Year Risk of Intracerebral Hemorrhage in Central China Using Estimates From the 1 Million Cross-Sectional Study.

Background And Objectives: Intracerebral hemorrhage (ICH) is a common and fatal type of stroke, especially in central China. However, recent epidemiologic data are scarce. The study aimed to investigate the latest prevalence of ICH in central China and assess the risk of ICH in the next 10 years based on the Resident Health Records (RHR) data.

The function of CC-type glutaredoxins in salt-induced flower drop in tomato.

Salt stress significantly induces the abscission of flowers and fruits, resulting in a reduction in crop yields and posing a threat to food security. Nonetheless, the molecular mechanisms underlying the abscission triggered by salt stress remain poorly understood. In our study, the effects of different NaCl concentrations on the growth of tomato plants and flower drop were investigated.

Ultralight and Flame-Retardant Nanofiber/Aerogel Microfiber Sponges with Dual-Network Structures for Warmth Retention.

Long-term exposure to cold conditions can cause damage to the body, which makes cold prevention equipment urgently needed. However, the most commonly used fibrous warmth retention materials have drawbacks of heavy weight, poor mechanical properties, flammability, and inefficient thermal insulating performance. Herein, we propose a simple and feasible strategy to prepare nanofiber/aerogel microfiber sponges (NAMS) with dual-network structures for warmth retention by direct electrospinning.

Anlotinib for the treatment of recurrent and refractory hemangioblastomas: a case report and review of literature.

Hemangioblastomas (HBs) are rare, highly vascular tumors that present significant treatment challenges, especially in cases of multiple recurrences. Here we present our experience treating one patient with recurrent and refractory HBs, aiming to provide preliminary data on the use of anlotinib in treating this disease. An 18-year-old woman with recurrent and refractory HBs, treated at the Henan Provincial Hospital of Traditional Chinese Medicine, achieved disease remission through oral anlotinib treatment after recurrence.