The impact of the ratio of renal parenchyma to renal volume on stone-free rates after RIRS: a retrospective study.

Renal parenchyma thickness and hydronephrosis degree may predict stone-free rate (SFR) after lithotripsy. This study combined these factors and introduced a new index, the ratio of renal parenchymal volume to renal volume (RPRV) to investigate its prediction role of SFR after retrograde intrarenal surgery (RIRS). We collected data from 119 adult patients with upper ureteral or kidney stones who underwent RIRS from March to September 2023.

Multi-omics analysis revealing the taste characteristics and formation mechanism of Ocimum.

Ocimum, a plant of significant economic value, finds extensive applications in the food, spice, and pharmaceutical industries. This study integrated sensory evaluation, metabolomics, and transcriptomics to systematically analyze taste differentiation in four Ocimum accessions (G126, G081, G096, G124). Standardized quantitative descriptive analysis (QDA) revealed distinct taste profiles: G126 (O.

RCN3 functions as a tumor promoter in colorectal cancer by modulating the GRP78-PI3K-AKT signaling pathway.

Colorectal cancer (CRC) remains a significant global health concern, highlighting the urgent need for novel therapeutic targets and prognostic biomarkers. This study investigates the role of Reticulocalbin-3 (RCN3) in CRC development, focusing on its regulatory influence on calcium ion homeostasis and transport proteins, critical factors in cancer progression. We employed bioinformatics databases, qRT-PCR, Western blotting, and immunohistochemistry to evaluate RCN3 expression levels, revealing that RCN3 is upregulated in CRC tissues and correlates with poorer patient outcomes.

An MRI study of pancreatic atrophy in children with type 1 diabetes: Heterogeneity, disease duration effects, and progression prediction models.

Aim: To investigate the heterogeneity of pancreatic alterations in children with T1D and the effect of disease duration on the pancreas. To develop predictive models based on clinical and imaging parameters at baseline to determine whether pancreatic atrophy will progress at follow-up.

Methods: This retrospective study included 90 children with T1D and 82 control children.

Efficacy of Nonpharmacological Interventions and Combination With Pharmacological Interventions for Gastroesophageal Reflux Disease: A Systematic Review and Network Meta-Analysis.

Background: The efficacy of nonpharmacological therapies for patients with gastroesophageal reflux disease (GERD) has been progressively proved. However, the specific differences in effectiveness among various nonpharmacological interventions and their combinations with pharmacological interventions remain unclear, and the optimal intervention strategy has yet to be conclusively determined.

Methods: Systematic searches were conducted in PubMed, Web of Science, Embase, Cochrane, and CNKI from inception to November 6, 2024.

Extracellular Vesicles Containing MDP Derived from Lactobacillus rhamnosus GG Inhibit HSV-2 Infection by Activating the NOD2-IFN-I Signalling Pathway.

The immune evasion strategies and lifelong latency of herpes simplex virus type 2 (HSV-2) present significant challenges for effective treatment. Recent studies have demonstrated that the commensal microbiota plays an important role in regulating immunity against viral infections. We previously reported that Lactobacillus rhamnosus GG (LGG) activates the expression of type I interferons (IFN-I) to inhibit HSV-2 infection.

Activation of molecular oxygen over MnO/CeO for catalytic wet air oxidation of high-concentrated phenolic pollutants.

Catalytic wet air oxidation (CWAO) is an efficient and environmentally friendly technology for treating high concentrations of organic compounds. However, the efficient activation of molecular oxygen remains a great challenge, particularly over non-noble metal catalysts. This study developed a series of MnO/CeO catalysts with different Mn loadings for CWAO of phenolic pollutants via oxygen activation.

Asynchronous changes in precipitation and soil water content decelerate vegetation greening on the Qinghai-Tibetan Plateau.

Climate warming and precipitation generally enhance greening on the Qinghai-Tibetan Plateau (QTP). However, recent studies suggested that the greening trend is decelerating, while its underlying driving mechanisms remain unclear. We speculate that this may be related to an asynchrony between precipitation and soil water content in certain regions, but this is poorly understood.

The bidirectional regulatory network between ATF4 and lncRNAs in systemic diseases.

Long non-coding RNAs (lncRNAs) are pivotal regulators of gene expression across multiple biological contexts, including stress responses and cellular adaptation. Activating transcription factor 4 (ATF4) is a key transcriptional effector of the integrated stress response (ISR), modulating genes involved in redox balance, amino acid metabolism, autophagy, and apoptosis. Emerging evidence has uncovered complex interactions between ATF4 and lncRNAs in systemic diseases, where lncRNAs can act as either downstream targets or upstream modulators of ATF4 signaling.

Case Report: A rare case of tuberculous otitis media mimicking chronic suppurative otitis media - an ongoing challenge.

Ear tuberculosis, a rare form of extrapulmonary tuberculosis caused by , predominantly affects the middle ear. The common symptoms of ear tuberculosis include otorrhea, hearing loss, and facial nerve paralysis, and if left untreated, it can lead to complete deafness. Diagnosing ear tuberculosis can be challenging, as its symptoms often overlap with those of otitis media, leading to potential misdiagnosis.

Evaluation of the effects of fermentation on the non-volatile compounds in semi-dry coffee beans using widely targeted metabolomics analysis.

This study was the first to investigate the differences in non-volatile metabolites and their relationships with the sensory attributes of Hainan Robusta coffee by yeast fermentation [four single strains (HK, JK, GK and ZK), one mixed strain (MK), and natural fermentation (CK)] via widely targeted metabolomics. The results indicated that GK led to a change in the brew coffee color and obtained the highest scores for mouthfeel (7.67), aftertaste (7.

A meta-analysis of the efficacy of fractional CO2 laser combined with acupuncture for acne scars.

Background: To systematically evaluate the efficacy of fractional carbon dioxide (CO2) laser combined with acupuncture in acne scars based on the available evidence.

Methods: China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, Chinese Biomedical Database, China Science and Technology Journal Database, PubMed, Embase, the Cochrane Library, Web of Science databases were searched for published articles on fractional CO2 laser combined with acupuncture for acne scars from their inception to March 22, 2024. Meta-analysis of the articles was performed using Stata/SE 15.

Kirenol relieves rheumatoid arthritis by targeting the TWEAK/Fn14 pathway.

Fibroblast‑like synoviocytes (FLSs) are the primary drivers of synovial tissue hyperplasia in rheumatoid arthritis (RA). Activation of the tumor necrosis factor‑like weak inducer of apoptosis (TWEAK)/fibroblast growth factor‑inducible immediate‑early response protein 14 (Fn14) pathway significantly contributes to the pathogenesis of RA. Kirenol (Kir), a compound with anti‑inflammatory and antirheumatic properties, has an unclear mechanism of action.

Genetic diversity, population structure and quality-trait associations in Blumea balsamifera revealed by EST-SSR markers.

Blumea balsamifera is a widely used ancient medicinal herb in tropical and subtropical Asia. Studying the genetic diversity of B. balsamifera germplasm resources and developing molecular markers related to the content of active constituents in B.

Identification of the serum uric acid threshold with increasing risk for diabetic nephropathy in type 1 diabetes.

Purpose: To investigate the correlation between serum uric acid (SUA) levels and the risk for diabetic nephropathy (DN) in Chinese patients with type 1 diabetes mellitus (T1DM) and determine the potential optimal SUA threshold.

Methods: In this case-control study, 913 T1DM patients were matched 1:1 with healthy controls by age and sex. Multivariable adjusted logistic regression analysis was used to investigate the association between SUA levels and the risk of developing DN.

Implied gravity promotes coherent motion perception.

Gravity, a constant in Earth's environment, constrains not only physical motion but also our estimation of motion trajectories. Early studies show that natural gravitational acceleration facilitates the manual interception of free-falling objects. However, whether implied gravity affects the perception of coherent motion patterns from local motion cues remains poorly understood.

A 3D point cloud and deep learning based automated process for quantifying multi-scale phenotypes in sliced bread.

In response to the current focus on two-dimensional phenotypic analysis of sliced bread evaluation parameters, this study developed an innovative technology using an inexpensive 3D laser scanner to accurately capture and analyze the three-dimensional structure of both the entire bread slice and the pore surface of the slice. A 3D line-scan laser profiling sensor integrated with a three-axis motion platform was used to efficiently acquire 3D point cloud data of bread surfaces. For the pre-processed point cloud data, a segmentation model called 3D-PoreSegNet was proposed to separate the bread surface and pore regions within the point cloud.

Hepatitis B virus promotes liver cancer by modulating the immune response to environmental carcinogens.

Hepatitis B virus (HBV) infection is associated with hepatitis and hepatocellular carcinoma (HCC). Considering that most HBV-infected individuals remain asymptomatic, the mechanism linking HBV to hepatitis and HCC remains uncertain. Herein, we demonstrate that HBV alone does not cause liver inflammation or cancer.

Neural correlates of rumination in remitted depressive episodes: Brain network connectivity and topology analyses.

Background: Rumination is a critical psychological factor contributing to the relapse of major depressive episodes (MDEs) and a core residual symptom in remitted MDEs. Investigating its neural correlations is essential for developing strategies to prevent MDE relapse. Despite its clinical importance, the brain network mechanisms underlying rumination in remitted MDE patients have yet to be fully elucidated.

Pyodermatitis-Pyostomatitis Vegetans: The Role of Langerin Deficiency in Disease Pathogenesis.

Pyodermatitis-pyostomatitis vegetans (PPV) is a rare, chronic inflammatory mucocutaneous disorder. However, the etiology of PPV remains controversial. : A review of online PPV case studies from PubMed, Wanfang database, Web of Science, and books has been performed.

Associations of Plasma and CSF Osteocalcin Levels With CSF ATN Biomarkers and Cognitive Functions in Alzheimer's Disease.

Animal studies have shown that osteocalcin (OCN), a hormone derived from bone, plays a vital role in brain development and cognitive function. However, its potential connection to Alzheimer's disease (AD) pathology in humans remains largely unexplored. This cross-section study included 238 cognitively unimpaired participants, 26 mild cognitive impairment (MCI) patients, 54 AD dementia patients, and 32 patients with non-AD neurodegenerative diseases.

Overexpression of the eukaryotic translation initiation factor FveIF3h represses CER4/FAR3 translation and attenuates the synthesis of cuticular wax in strawberry leaves.

The cuticle layer serves as the first protective barrier against environmental biotic and abiotic stresses for plants. Although transcriptional and post-transcriptional regulation of cuticle biosynthesis genes has been extensively studied, the translational control remains poorly understood. The eukaryotic translation initiation factor (eIF3h) is a known regulator in protein translation.

Efficacy of polyphenols in adjuvant treating ulcerative colitis: A meta-analysis of randomized controlled trials.

Background: The effectiveness and safety of polyphenols in treating ulcerative colitis remain controversial. This study aimed to evaluate the efficacy and safety of polyphenols in the treatment of ulcerative colitis.

Methods: This study followed the preferred reporting items for systematic reviews and meta-analyses 2020 guidelines.

Application and effectiveness study of tripartite linkage nursing in prediabetes type 2 diabetes: A retrospective study.

This study aimed to evaluate the tripartite linkage nursing model's effectiveness in prediabetic patients at risk of type 2 diabetes mellitus, assessing its impact on glycemic control, metabolic outcomes, diabetes prevention, and treatment adherence. In this retrospective cohort study, 400 patients (2020-2022) were allocated via medical record review to control (standard care) and experimental groups (tripartite model integrating hospital-community-home management). Clinical parameters (fasting plasma glucose, 2-hour postprandial glucose, glycated hemoglobin, body mass index, lipid profiles, blood pressure) were monitored at baseline and 6-month intervals over 24 months, with diabetes incidence and adherence rates concurrently evaluated.