Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression.

Protein phosphorylation modification plays an important role in regulating protein activity. Astrocyte elevated gene-1 (AEG-1), an adaptor protein, promotes the progression of various types of cancers by protein-protein interactions. We previously demonstrated that AEG-1 promoted the growth and metastasis of gastric cancer by upregulating the expression of oncogenic eukaryotic translation initiation factor 4E (eIF4E).

Hollow Cu/Pt Interspersed GO Nanosheets Cascade Triggering Catalytic Signal Amplification for Colorimetric/SERS Sensing of in Clinical Samples.

Rapid and precise detection of () is crucial for early diagnosis, treatment of infectious ailments, and controlling outbreaks. Herein, we present a rapid, streamlined, and sensitive method for screening based on a hollow copper/platinum interspersed graphene oxide nanosheets (Cu/Pt-GO)-mediated cascade responsiveness strategy. The Cu/Pt-GO nanozymes were proposed to catalyze the colorless 3,3',5,5'-tetramethylbenzidine (TMB) to colored oxidized TMB (oxTMB) with enhanced SERS signals, achieving colorimetric/SERS dual-model detection.

Sakuranetin inhibits osteoclastogenesis and rescues the ovariectomy-induced bone loss by blocking PI3K/AKT and NF-κB signaling pathway.

Background: Bone remodeling constitutes an intricate physiological process essential for maintaining skeletal integrity. Hyperactivation of osteoclastogenesis precipitates excessive resorption of osseous tissue, consequently engendering osteoporotic pathology. The formulation of effective anti-resorptive therapeutic modalities remains a potential strategy in the clinical management of osteoporosis.

The relationship between depression and academic burnout among undergraduate students majoring in eldercare services: a moderated mediation model.

Objectives: To explore the relationship between depression, self-efficacy, academic burnout, and social support among undergraduate students majoring in eldercare services in China.

Methods: A cross-sectional study was carried out among 957 students majoring in eldercare services across four provinces of China. The study employed questionnaires based on the Center for Epidemiological Studies Depression Scale, General Self-Efficacy Scale, Learning Burnout Scale, and Perceived Social Support Scale.

Immune checkpoint inhibitors use in liver transplantation for hepatocellular carcinoma: a global cohort study.

Background: Hepatocellular carcinoma (HCC) remains a major contributor to global cancer mortality, with liver transplantation (LT) offering curative potential for patients in the early stages. While immune checkpoint inhibitors (ICIs) are effective in managing tumor progression, concerns about graft rejection persist. This study investigates how peri-LT ICIs administration affects rejection rates and survival outcomes in HCC patients.

Risk factors and prevalence of latent tuberculosis infection in rheumatic patients: a meta-analysis.

Objective: This study aims to evaluate the risk factors and prevalence of latent tuberculosis infection (LTBI) in patients with rheumatic diseases.

Methods: Databases including PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, Vip, and Wanfang were searched. Data extraction was performed independently by two authors.

Microneedle-Delivered Multivalent MPXV DNA Vaccines Induce Promising Immunity Profiles and Cross-Protection in Mice.

Traditional DNA vaccines, typically administered via intramuscular injection with electroporation (IM-E), often cause discomfort and require trained personnel. Addressing these challenges, we developed multivalent DNA vaccines targeting both intracellular mature virion (IMV) and extracellular enveloped virion (EEV) proteins of the monkeypox virus (MPXV), designated as M2 (A29L, B6R), M3 (A29L, B6R, M1R) and M4 (A29L, B6R, M1R, A35R). These vaccine constructs were formulated into dissolvable microneedle array patches (D-MAPs) for intradermal delivery.

A predicted structural interactome reveals binding interference from intrinsically disordered regions.

Proteins function through dynamic interactions with other proteins in cells, forming complex networks fundamental to cellular processes. While high-resolution and high-throughput methods have significantly advanced our understanding of how proteins interact with each other, the molecular details of many important protein-protein interactions are still poorly characterized, especially in non-mammalian species, including . Recent advancements in deep learning techniques have enabled the prediction of molecular details in various cellular pathways at the network level.

Identifying indicators and targets for the new World Health Organization global framework on infection and prevention and control: an e-Delphi study.

Background: The World Health Organization (WHO) recently developed the global action plan (GAP) and monitoring framework (MF) for Infection Prevention and Control (IPC). An e-Delphi survey was conducted as part of a consultative process to achieve consensus on IPC MF indicators and targets.

Methods: The study was conducted as an e-Delphi consensus-seeking exercise, with two rounds of sequential surveys.

Research on Disaster Environment Map Fusion Construction and Reinforcement Learning Navigation Technology Based on Air-Ground Collaborative Multi-Heterogeneous Robot Systems.

The primary challenge that robots face in disaster rescue is to precisely and efficiently construct disaster maps and achieve autonomous navigation. This paper proposes a method for air-ground collaborative map construction. It utilizes the flight capability of an unmanned aerial vehicle (UAV) to achieve rapid three-dimensional space coverage and complex terrain crossing for rapid and efficient map construction.

Identification of conservation priority areas on the Qinghai-Tibet Plateau considering habitat, biodiversity, ecosystem services, and human well-being.

The delineation of conservation priority areas may involve both trade-offs and synergies with sustainable development goals, but region-specific and integrative assessments that simultaneously consider habitat, biodiversity, ecosystem services, and human well-being remain limited in high-altitude regions such as the Qinghai-Tibet Plateau. Taking habitat, biodiversity, ecosystem services and human well-being as management objectives, this paper focuses on the Qinghai-Tibet Plateau (QTP) and develops an indicator system that integrates these considerations. The paper: a) uses the zonation model to identify conservation priority areas under both single-objective and multi-objective conditions, b) evaluates the conservation gaps in existing protected areas and c) assesses the synergies and trade-offs among the different objectives by employing various scenarios.

A pilot study investigating the efficiency of an Internet of things (IOT)-aided warehouse management system in the management of consumables for the operating room in a Chinese setting.

The aim of this study was to investigate the value of an Internet of things (IOT)-aided warehouse management system (IAWMS) to improve the efficiency of consumables management for the operating room (OR). Indices in three domains (error alerts, time taken for work, and level of satisfaction) were selected. Records were compared for two groups, namely the IAWMS group (records after implementation of IAWMS from March 2024 to September 2024) and the control group (manual work before implementation of IAWMS from July 2023 to December 2023).

Thoracic paravertebral osteosarcoma induced by radiotherapy for esophageal cancer: A case report.

With the wide application of radiation therapy for malignant tumors and the continuous improvement of comprehensive treatment effect, the survival period of patients has been prolonged, while the incidence of radiation-induced osteosarcoma (RIOS) has gradually increased. Compared with primary osteosarcoma, RIOS has a higher degree of malignancy and poorer prognosis, severely impacting patient survival. Currently, there are relatively few case reports on RIOS and the understanding of its imaging characteristics remains incomplete.

Oncometabolite 5-IP inhibits inositol 5-phosphatase to license E-cadherin endocytosis.

E-cadherin downregulation is an epithelial-mesenchymal transition hallmark canonically attributed to transcriptional repression. Here we delineate a metabolite-driven endocytic route of E-cadherin downregulation in inflammation-associated colorectal cancer (CRC). Specifically, IP kinase-2 (IP6K2), a 5-diphosphoinositol pentakisphosphate (5-IP) synthase upregulated in patients with CRC, is activated via a ROS-Src phosphorylation axis elicited by dextran sulfate sodium (DSS), generating 5-IP around adherens junction (AJ) to promote E-cadherin endocytosis and the transcriptional activities of β-catenin.

Electronic structure modulation of Zn-doped FeNiS nanosheet arrays for alkaline overall water splitting.

Water electrolysis comprises two half-reactions-the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER)-each involving multiple elementary steps. The development of bifunctional electrocatalysts that are simultaneously efficient for both HER and OER remains a significant challenge, as different steps often require distinct catalytic properties. Pentlandite-type materials ((Fe,Ni)S) have emerged as promising candidates for water splitting due to their intrinsic bifunctional activity.

The importance of measuring the endometrial cavity length in deciding the ideal place for embryo transfer: a retrospective cohort study.

Background: The relationship between clinical pregnancy rates and embryo transfer positioning remains a matter of considerable debate, with persistent inconsistencies reported across existing studies. A notable limitation of existing studies is their failure to systematically account for anatomical variations in the endometrial cavity dimensions. The purpose of the present study was to determine the ideal location for embryo transfer according to different endometrial cavity lengths.

A Self-Assembled Protein Platform for Plug-and-Play Customization of Multivalent Artificial Antibodies and Antibody-Drug Conjugates.

Modular assembly of multivalent therapeutics with precise modulation of pharmacokinetic and pharmacological properties remains a critical challenge in drug development. Here, we present ATPlug, a self-assembling protein platform that integrates three crucial functional modules: a trimerization domain to enhance avidity, a SpyCatcher module for efficient conjugation, and an albumin-binding domain to optimize pharmacokinetics and tissue selectivity. This rational design facilitates the modular assembly of multivalent artificial antibodies and antibody-drug conjugates (ADCs), demonstrating remarkable versatility through the successful incorporation of diverse therapeutic modules targeting epidermal growth factor receptor (EGFR), programmed cell death ligand 1 (PD-L1), and vascular endothelial growth factor (VEGF).

The Effects of Accentuated Eccentric Loading Repetition Structures on Muscle Strength and Adaptation.

Yue, C, Xiong, W, Zhang, C, Zhang, R, Deng, K, and Li, Z. The effects of accentuated eccentric loading repetition structures on muscle strength and adaptation. J Strength Cond Res XX(X): 000-000, 2025-The investigators aimed to compare the effects of different accentuated eccentric loading (AEL) repetition structures on lower limb muscle strength and adaptation.

Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice.

Accumulating data demonstrate that bleomycin (BLM), a clinically used antineoplastic drug, induces pulmonary interstitial fibrosis. However, the specific mechanism remains unclear. This study was carried out for the purpose of evaluating the effect of mitochondrial dysfunction-associated senescence on BLM-induced pulmonary fibrosis.

Application of Ago-mediated genome editing in .

is nonpathogenic and fast-growing and is usually used as a model species of . Studying basic metabolic mechanisms is crucial for accelerating mycobacterial research. Although several tools for genome editing in MC 155 () can be used, plasmids are difficult to construct, and the knockout efficiency is still low.

Correction to "Enrichment of 1.0 Nanometer Diameter Single-Chirality Single-Walled Carbon Nanotubes Dictated by Conjugated Polymer Characteristics: Implications for High-Performance Thin-Film Transistors".

[This corrects the article DOI: 10.1021/acsanm.5c00783.