Crystal Structures and Promising Superconductivity in Sc-S System under High Pressure.

In this work, we performed systematic simulations on the crystal structures and electronic properties of Sc-S crystalline system at a pressure range of 20 to 200 GPa. Our results reveal several stable stoichiometries, such as ScS3, ScS2, Sc2S, and Sc3S. The further electron-phonon simulations indicate that Sc3S exhibits a superconducting critical temperature (Tc) of approximately 25 K at 200 GPa.

Efficacy of Nonpharmacological Interventions and Combination With Pharmacological Interventions for Gastroesophageal Reflux Disease: A Systematic Review and Network Meta-Analysis.

Background: The efficacy of nonpharmacological therapies for patients with gastroesophageal reflux disease (GERD) has been progressively proved. However, the specific differences in effectiveness among various nonpharmacological interventions and their combinations with pharmacological interventions remain unclear, and the optimal intervention strategy has yet to be conclusively determined.

Methods: Systematic searches were conducted in PubMed, Web of Science, Embase, Cochrane, and CNKI from inception to November 6, 2024.

Soy Sauce Fermentation with : Process Optimization and Functional Profiling.

This study presents the development and optimization of a functional soy sauce fermented with (), a medicinal fungus known for its high cordycepin and polysaccharide content. Using as the sole starter culture, the process aimed to improve both nutritional and functional properties. Response surface methodology was employed to optimize the entire fermentation process.

Near-infrared light-driven metabolic reprogramming of synoviocytes for the treatment of rheumatoid arthritis.

Rheumatoid arthritis is a common autoimmune disease characterized by chronic synovial inflammation and joint destruction, primarily driven by an imbalanced cellular metabolism and inflammatory microenvironment. While gene therapy offers a promising therapeutic approach, its effectiveness is limited by the challenges of non-specific gene expression in healthy tissues. Here, we develop a gene delivery system (namely APPC), in which near-infrared (NIR)-responsive gold nanorods are coated with chondroitin sulfate-modified polyethyleneimine to facilitate the heat-responsive targeted delivery of heme oxygenase 1 (HO-1) gene.

Integrative omics analysis of plant-microbe synergies in petroleum pollution remediation.

As the petrochemical industry continues to advance, the exacerbation of ecological imbalance and environmental degradation due to petroleum pollution is increasingly pronounced. The synergistic interaction between plants and microorganisms are pivotal in the degradation of petroleum hydrocarbons; however, the underlying degradation mechanisms are not yet fully understood. This study aims to contribute to understanding these mechanisms by employing a multi-omics approach, integrating transcriptomics, 16S rRNA gene sequencing, and metabolomics, to analyze key differential genes, dominant microbial strains, and root-secreted metabolites involved in petroleum hydrocarbon degradation in alfalfa.

Lymphatic-immune interactions in the musculoskeletal system.

Traditionally, the role of lymphatic vessels has been understood as primarily involving fluid transport and immune surveillance. In addition to these roles, recent studies have revealed a paracrine function of lymphatics through the dissemination of inductive factors, known as lymphangiocrine signals including in musculoskeletal physiology and diseases. These signals play diverse roles, including maintaining tissue equilibrium and facilitating regeneration.

Research on driver injuries in vehicle rear-end collisions considering different overlap rate and speed difference.

Rear-end collisions involving passenger vehicles often result in significant injuries and fatalities, with the driver of the trailing vehicle being particularly vulnerable to severe harm. This study analyzes regulations related to rear-end collisions and their necessity, and develops finite element models of the vehicle, dummy, and airbags. The positioning of the dummy is based on C-NCAP standards, and the Primer software is utilized to model and integrate the seatbelt and airbags.

[Response Characteristics and Influencing Mechanism of Soil Enzyme Activity During Secondary Forest Succession in Loess Hilly Region].

Soil extracellular enzymes are regulated by a range of biotic and abiotic factors, such as soil moisture and nutrients. In vegetation restoration, due to the heterogeneity of ecosystems and vertical spatial environments of soils, the differences in the response of soil surface and substrate enzyme activities to different stages of succession and the driving mechanisms are unclear. Therefore, using the method of "space instead of time," we analyzed the characteristics of four extracellular enzymes and their influencing factors in the soil surface and bottom layers during the succession of secondary forests in loess hilly areas.

Ultrahigh-pressure crystallographic passage towards metallic hydrogen.

The structural evolution of molecular hydrogen H under multi-megabar compression and its relation to atomic metallic hydrogen is a key unsolved problem in condensed-matter physics. Although dozens of crystal structures have been proposed by theory, only one, the simple hexagonal-close-packed (hcp) structure of only spherical disordered H, has been previously confirmed in experiments. Through advancing nano-focused synchrotron X-ray probes, here we report the observation of the transition from hcp H to a post-hcp structure with a six-fold larger supercell at pressures above 212 GPa, indicating the change of spherical H to various ordered configurations.

Incidence Rates of Cutaneous Immune-Related Adverse Events in Patients with Lung Cancer: A Systematic Review and Meta-Analysis.

Objective: Cutaneous immune-related adverse events (cirAEs) represent a prevalent manifestation of adverse reactions linked to immune checkpoint inhibitors (ICIs) therapy, substantially affecting patients' quality of life. This systematic review and meta-analysis aimed to quantify the pooled incidence of cirAEs in this population and strengthen clinical awareness for early recognition and management.

Methods: A comprehensive search of PubMed, Embase, CINAHL, Cochrane Library, CBM, CNKI, and Wanfang databases was conducted from inception to December 2022.

Sensitive Detection of Acoustic Vibration at Nanometer Scale.

The detection of vibrations at nanometer scale is crucial for a variety of applications. The spatial resolution of acoustic detection is limited to micrometers due to its long wavelength. Single-molecule probes with a gold nanorod (GNR) have been proposed to detect an acoustic wave at the nanometer scale at room temperature.

DNA Methylation Patterns and Transcriptomic Data Were Integrated to Investigate Candidate Genes Influencing Reproductive Traits in Ovarian Tissue from Sichuan White Geese.

Ovarian tissue is critical for goose reproduction. This study aimed to investigate gene regulation by DNA methylation in relation to the reproductive traits of geese. We performed whole-genome bisulfite sequencing (WGBS) on ovarian tissues from Sichuan white geese (high-laying-rate group: HLRG, ♀ = 3; low-laying-rate group: LLRG, ♀ = 3) during the laying period.

Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment.

The tumor microenvironment (TME) orchestrates cancer progression by fostering a complex interplay between cancer cells and the surrounding cellular and acellular elements. Through dynamic interactions with cancer cells, vascular and stromal cells not only promote tumor growth but also enhance metastatic potential and restrict therapeutic responses. Vascular and stromal cells play a critical role in regulating epithelial-mesenchymal transition (EMT) and sustaining resistance pathways, making them compelling targets for innovative therapies.

Soil carbon stability regulate carbon dynamics following large-scale afforestation.

Large-scale afforestation is considered an effective measure to mitigate climate change. However, due to the differences in the properties of soil organic carbon (SOC), the dynamic response of SOC to large-scale afforestation remained unclear. Therefore, we conducted paired sampling (farmland and afforestation) in plantation areas across northern China to evaluate the relationship between SOC stability and SOC increments (ΔSOC) resulting from afforestation.

Hydrogen-Vacancy-Induced Stable Superconducting Niobium Hydride at High Pressure.

In recent years, the discovery of unconventional polyhydrides under high pressure, including notable instances like CaH, YH, and LaH, with superconducting critical temperature () above 200 K, has ignited considerable interest in the quest for high-temperature superconductivity in hydrogen-based materials. Recent studies have suggested the highly probable existence of hydrogen vacancies in these high- superconducting hydrides, although there is no conclusive evidence. In this study, taking niobium (Nb) hydride as a model, we showcase the observation of nonstoichiometric face-centered cubic () NbH (δ∼0.

GATI-RS model using Bi-LSTM and multi-head attention mechanism to enhance online shopping experience for the elderly with accurate click-through rate prediction.

With the rapid development of e-commerce and the increasing aging population, more elderly people are engaging in online shopping. However, challenges they face during this process are becoming more apparent. This article proposes a recommendation system based on click-through rate (CTR) prediction, aiming to enhance the online shopping experience for elderly users.

Joint modeling histology and molecular markers for cancer classification.

Cancers are characterized by remarkable heterogeneity and diverse prognosis. Accurate cancer classification is essential for patient stratification and clinical decision-making. Although digital pathology has been advancing cancer diagnosis and prognosis, the paradigm in cancer pathology has shifted from purely relying on histology features to incorporating molecular markers.

Etchless InSe Cavities Based on Bound States in the Continuum for Enhanced Exciton-Mediated Emission.

Recently, fervent research interest is sparked to indium selenide (γ-InSe) due to its dazzling optical and electronic properties. The direct bandgap in the near-infrared (NIR) range ensures efficient carrier recombination in InSe, promoting impressive competency for lavish NIR applications. Nevertheless, the photoluminescence (PL) efficiency of InSe is significantly limited by out-of-plane (OP) excitons, adverse to practical devices.

S-ketamine alleviates morphine-induced hyperalgesia via decreasing the gut Enterobacteriaceae levels: Comparison with R-ketamine.

Background: Opioid-induced hyperalgesia (OIH) is a serious complication during the pain treatment. Ketamine has been commonly reported to treat OIH, but the mechanisms remain unclear. Gut microbiota is recently recognized as one of the important mechanisms underlying the occurrence and treatment of OIH.

pH-Dependent Electrocatalytic Aqueous Ammonia Oxidation to Nitrite and Nitrate by a Copper(II) Complex with an Oxidation-Resistant Ligand.

The electrocatalytic aqueous ammonia oxidation (AO) represents a more sustainable alternative to accessing nitrite (NO) and nitrate (NO). We now report that Cu(pyalk) {pyalk = 2-(pyridin-2-yl)propan-2-oate}, previously employed as a homogeneous water oxidation (WO) catalyst, is also active for selective AO in aqueous environments. The traditional Griess analytical test for NO/NO was modified to permit the operation in the presence of the otherwise interfering Cu ion.

Extraction of lignin from lignocellulosic biomass (bagasse) as a green corrosion inhibitor and its potential application of composite metal framework organics in the field of metal corrosion protection.

With increasing awareness of environmental protection, additional attention has been given to environmentally friendly metal anticorrosion research. In this paper, the green organic corrosion inhibitor sodium lignosulfonate (SLS) was extracted from bagasse waste, and a Ce-MOF@SLS smart anticorrosive film containing the inhibitor was prepared on the surface of an aluminum alloy by in situ electrodeposition. The material was characterized by SEM, EDS, FT-IR, XRD and XPS, and its corrosion resistance was tested with EIS and neutral salt spray tests.

Manipulating ambient pressure superconductivity in metal borocarbides through hole doping.

A Ca2B4C4 ternary compound obtained by using a machine learning (ML) guided structure search is found to be metastable with a formation energy of only 18 meV/atom above the convex hull but exhibits only marginal superconducting transition temperature (Tcc). By replacing Ca with Na, the electronic density of states (DOS) at the Fermi level is significantly enhanced, increasing the predicted Tc to 21.9 K.

Risk factors for psychiatric disorders following traumatic brain injury: a multivariate logistic regression analysis.

Objective: This study aimed to investigate the incidence and risk factors of psychiatric disorders following traumatic brain injury (TBI).

Methods: A total of 232 patients with closed TBI admitted to our hospital from January 2021 to January 2023 were included. Basic demographic data, injury circumstances, and psychiatric conditions during hospitalization were collected.

Relationship between stroke and estimated glucose disposal rate: results from two prospective cohort studies.

Background: Insulin resistance (IR) is a recognized contributor to stroke association, and the estimated glucose disposal rate (eGDR) is a dependable indicator of IR. However, the specific connections between eGDR, stroke prevalence, and overall mortality have not been thoroughly investigated. This study aimed to examine how eGDR correlates with stroke and overall death rate.

An Acid-Resistant Lanthanide Metal-Organic Framework Based on Tetraphenylethylene as an Electrochemical Nitrite Sensor.

Nitrite (NO) is attracting increasing attention due to its harmful effect on human health. Thus, it is highly desirable to construct effective electrochemical sensors to detect the presence of NO. The majority of electrochemical NO detection is focused on alkaline or neutral electrolyte solutions and is rarely reported under acidic conditions.