Semiology and neurophysiology of clonic seizures in children: a retrospective study.

Objectives: To identify and quantify clonic seizures in children, we retrospectively reviewed the clinical symptoms and neurophysiology of them.

Methods: Data were obtained from 24 patients presenting with 34 clonic seizures, and their video-electroencephalography (EEG) recordings were examined for symptomatology and ictal EEG characteristics. Additionally, synchronous electromyography (EMG) data from 17 patients were analyzed.

Targeted inhibition of macrophage STING signaling alleviates inflammatory injury and ventricular remodeling in acute myocardial infarction.

Mitochondrial DNA (mtDNA) acts as a damage-associated molecular pattern to activate the stimulator of interferon genes (STING) signaling in macrophages, promoting tissue inflammation. However, its role in acute myocardial infarction (AMI) remains unclear. Macrophage-specific knockout mice were used to validate STING's pathological role in AMI.

Tumor-associated macrophages in colon cancer immunotherapy: mechanisms, natural product interventions, and microenvironment remodeling.

Colon cancer persists as a major global health burden due to therapy resistance and metastasis, with tumor-associated macrophages (TAMs) in the microenvironment driving progression through immune evasion and angiogenesis. This review highlights plant-derived therapeutics targeting TAMs to disrupt protumor signaling. Key phytochemicals (e.

Clinical nurses' evidence-based healthcare competence and associated factors: a regional cross-sectional study.

Background: Evidence-Based Healthcare is essential for enhancing the quality of care and improving patient outcomes in contemporary healthcare. As the largest professional group in the healthcare sector, nurses are critical in all phases of the EBHC process. The purpose of the study was to investigate clinical nurses' evidence-based healthcare competence and explore the associated factors.

Programmable DNA Nanocages Enable Adaptive Spatiotemporal Organization of Biomimetic Organelle Networks.

Synthetic organelles have emerged to simulate the multicompartmental organization and communication within cells. However, current synthetic organelles (e.g.

Jiedu Quyu Ziyin prescription alleviated renal injury in MRL/lpr by inhibiting PPP-mediated oxidative stress through regulating p53/G6PD/NOX pathway.

Ethnopharmacological Relevance: Jiedu Quyu Ziyin prescription (JP), derived from classical Chinese medicinal formulations (Shengma Biejia Tang), alleviates systemic lupus erythematosus (SLE) progression by modulating immunological derangements. The underlying mechanism by which JP regulates metabolism to retard SLE progression has not yet been fully elucidated.

Aim Of The Study: This study aims to investigate whether JP attenuates renal injury in MRL/lpr lupus-prone mice by suppressing hyperactivation of the pentose phosphate pathway (PPP) and its mediated oxidative stress.

The Association Between Elevated Estimated Glomerular Filtration Rate and Poor Clinical Outcomes of Pediatric Patients with Community-Acquired Bacterial Meningitis Receiving Vancomycin: A Ten-Year Retrospective Cohort Study.

Introduction: This study aimed to explore the association between elevated estimated glomerular filtration rate (eGFR) and poor prognosis in pediatric patients with community-acquired bacterial meningitis (BM) receiving vancomycin.

Methods: This retrospective cohort study included children aged 1 month to 18 years with community-acquired BM admitted to the Department of Neurology, Children's Hospital of Chongqing Medical University (CHCMU) from 2013 to 2023. Relevant information for all patients was collected, and clinical outcomes were assessed using the Glasgow Outcome Scale (GOS) at the time of discharge.

Triptonoterpene promotes the mitochondrial translocation of cofilin-1 to induce apoptosis in gastric cancer cells by regulating actin dynamics.

The pharmacological effects of the natural product triptonoterpene have been scarcely documented. In our preliminary investigations, we identified that triptonoterpene possesses the capacity to impede the invasion and migration of gastric cancer (GC) cells. We are committed to further exploring the potential extensive effects of triptonoterpene on GC and to clarifying its exact mechanism of action.

Effects of different incremental treadmill exercise protocols on the autonomic nervous system in healthy college students: a comparative study based on heart rate variability analysis.

Objectives: This study aimed to examine the acute regulatory effects of three different incremental load treadmill exercise protocols on autonomic nervous system (ANS) function in healthy college students. The ultimate goal was to inform evidence-based training strategies and enhance cardiopulmonary function assessment in this population.

Methods: Forty healthy male college students were recruited to complete three incremental treadmill protocols: Ellestad A, Ellestad B, and Bruce.

Effects of stroboscopic visual training on reaction time and movement accuracy in collegiate athletes: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the effects of stroboscopic training on sport-specific performance in collegiate athletes and examined the moderating influence of key training parameters. A comprehensive literature search was conducted across multiple databases. The risk of bias in the included studies was assessed using the Cochrane Risk of Bias tool.

Steroid-responsive autoimmune psychosis with cerebrospinal fluid-restricted oligoclonal bands and positive tissue-based assay findings: a case series of three patients.

Background: Partial psychotic disorders such as autoimmune psychosis do not respond adequately to conventional antipsychotic drugs or psychotherapy. Autoimmune psychosis presents with isolated psychiatric symptoms, responds to immunotherapy, and differs from typical autoimmune encephalitis. Previous study has proposed an approach to identifying autoimmune psychosis, however, further research remains necessary to enhance our understanding of this condition.

Status and Influencing Factors of Fatigue-Pain-Sleep Disturbance Symptom Cluster in Patients With Lung Cancer: A Latent Profile Analysis.

In this cross-sectional study, we aimed to explore the latent profiles of fatigue-pain-sleep disturbance symptom cluster in patients with lung cancer and analyze its influencing factors. A total of 310 patients with lung cancer who received systemic anticancer therapy were recruited as the research participants by convenience sampling. The fatigue-pain-sleep disturbance symptom cluster was assessed using the Cancer Fatigue Scale, Brief Pain Inventory, and Pittsburgh Sleep Quality Index.

The clinical spectrum associated with ERCC5 mutations: Is there a relationship between phenotype and genotype?

Mutations in the gene can lead to different clinical phenotypes, few articles have reported the clinical phenotypes in detail and explained the relationship between genotype and phenotype. The clinical data of cases with gene mutations diagnosed in our center and reported in previous studies were collected. The cases were divided into three groups based on phenotype; the differences of clinical manifestation and genotype among groups were analyzed.

Force-driven base recognition programs DNA origami-based supramolecular networks.

This study proposes a force-driven recognition strategy that anchors conformationally constrained short loops at DNA origami edges, leveraging entropy compensation to enable large-scale nanostructure assembly. Precise thermoresponsive control across distinct temperature regimes is achieved by modulating nucleobase types and ultraviolet (UV) irradiation.

Minimally invasive myofascial closure device in combination with laparoscopy for pediatric linea alba hernia repair: a new approach.

Background: We assessed the safety, feasibility, and efficacy of a new minimally invasive technique for pediatric linea alba hernia repair, using a fascial closure device with laparoscopic support. The surgical procedure and technical details are outlined.

Methods: Clinical data of 15 pediatric patients (6 males, 9 females; ages ranging from 2 to 12 years inclusive) who underwent repair of linea alba hernias using a minimally invasive fascial closure device with laparoscopic assistance at the Guangzhou Medical University Women and Children’s Medical Center between June 2023 and June 2024 were retrospectively reviewed.

A web-based dynamic nomogram for predicting readmission in patients with heart failure with preserved ejection fraction.

Background: The study aims to evaluate the efficacy of a web-based dynamic nomogram predicting the risk of heart failure (HF)-related rehospitalization within 1 year in patients with HF with preserved ejection fraction (HFpEF).

Methods: The data of patients from two centers were categorized into training and test sets. Least absolute shrinkage and selection operator and multivariate logistic regression analysis were conducted on the training set data after selecting risk factors described in previous studies, and they were used to set up a nomogram.

Association between the serum Klotho levels and diabetic kidney disease: results from the NHANES 2007-2016 and Mendelian randomization study.

Objectives: The purpose of this research is to clarify the connection between the serum Klotho levels and diabetic kidney disease (DKD) in American adults with diabetes.

Methods: Statistic from the 2007-2016 National Health and Nutrition Examination Survey was used to explore correlation between Klotho levels and the risk of diabetic kidney disease (DKD) with multivariate linear regression models. Smoothed curve fitting was conducted to find potential non-linear relationships.

AuPtNPs/hydrogel based multichannel bionic sensor for rapid evaluation of food flavor.

Flavor is one of the important indicators of food quality, and the development of rapid detection methods for key flavor substances is crucial for the intelligent evaluation of food flavor. Herein, umami receptor T1R1-VFT and olfactory receptor Mor1-1 were used as sensitive elements to specifically recognize umami substances and hexanal molecules. Combining the excellent biocompatibility and electrochemical activity of AuPtNPs and hydrogels, the receptors are well immobilized in the three-dimensional network structure, thereby a multichannel biomimetic sensor for multiple detection of umami and hexanal was constructed.

CATIONIC AMINO ACID TRANSPORTER 1 modulates amino acid distribution between stem and leaf in new shoots: A case study of theanine distribution in tea plants (Camellia sinensis).

Theanine, a tea plant (Camellia sinensis)-specific non-proteinogenic amino acid, is one of the most important components conferring the taste quality and health benefits of tea. It is primarily synthesized in roots of tea plants and transported to new shoots, where it is mainly distributed to the young stem; however, tea is predominantly produced from young leaves. To promote more theanine allocation to young leaves, the molecular mechanism underlying theanine distribution between stems and leaves requires elucidation.

Efficacy and Safety of Botulinum Toxin Type A in Primary Axillary Hyperhidrosis: A Meta-analysis and Systematic Review.

Background: The clinical efficacy of botulinum toxin type A (BTX-A) injections for the treatment in primary axillary hyperhidrosis is a subject of ongoing debate. This study aims to consolidate and analyze the available evidence regarding the use of BTX-A as a therapeutic intervention for this conclusion.

Method: This study was conducted in accordance with PRISMA guidelines and registered with PROSPERO.

Diagnosis and therapy of recurrent renal metastases after surgery for testicular seminoma: a rare case report and review of the literature.

Background: Seminoma is a malignant tumor arising from testicular germ cells, with cryptorchidism recognized as a major risk factor for its development. Although retroperitoneal lymph node metastasis is common, renal metastasis is exceedingly rare. Testicular seminomas are generally highly sensitive to chemotherapy; however, the treatment and prognosis become significantly more challenging in cases of distant metastasis.

High-Throughput Monitoring of 323 Pharmaceuticals and Personal Care Products (PPCPs) and Pesticides in Surface Water for Environmental Risk Assessment.

The ubiquity of pharmaceuticals and personal care products (PPCPs) and pesticides in aquatic environments has raised significant ecological concerns due to their potential to disrupt aquatic ecosystems. This study presents a high-throughput ultraperformance liquid chromatography-tandem mass spectrometry method without sample enrichment to monitor 323 PPCPs and pesticides in the surface water of the Jingmi Water Diversion Canal in Beijing, China. One hundred and three PPCPs and pesticides were detected, with the highest detection frequency observed for antibiotics, which constituted 25.

Electroclinical features of myoclonic absence epilepsy: A single-center cohort analysis in Southwest China.

Background And Objective: To date, few analyses of the electroclinical features and prognosis of patients with epilepsy with myoclonic absences (EMA) have been performed. We reviewed the clinical and electroencephalography (EEG) features, response to antiseizure medications, and long-term prognosis of patients with EMA in a single center in Southwest China, with the goal of increasing the understanding of the disease, strengthening early clinical diagnosis and treatment, and improving prognosis.

Methods: We retrospectively analyzed the data of 11 children with EMA at the Epilepsy Center of Children's Hospital of Chongqing Medical University.

Baricitinib for Takayasu arteritis refractory to TNF-α inhibitors: a multi-centre, single-arm trial.

Objective: This study aimed to assess the efficacy and safety of baricitinib in Takayasu arteritis (TAK) refractory to TNF-α inhibitors.

Methods: We conducted a multicentre, single-arm trial between February 2021 and August 2023. Patients with TAK unresponsive to at least 6 months of TNF-α inhibitors were treated with baricitinib 4 mg daily for up to 48 weeks, while continuing of immunosuppressants and glucocorticoids.

Delta 4-desaturase sphingolipid 2 enhances prostate cancer stem-like traits through phytoceramide-mediated PI3K-AKT signaling pathway.

Cancer stem cells (CSCs) are the initiating cells of tumorigenesis, metastasis, and recurrence and play a crucial role in androgen deprivation therapy resistance, yet how sphingolipid metabolism promotes CSC maintenance remains exclusive. Here, we conducted gene expression profiling of sphere-derived castration-resistant prostate cancer stem cells (PCSCs) and identified enhanced sphingolipid de novo biosynthesis with upregulated DEGS2 expression in PCSCs. Silencing of DEGS2 significantly suppressed prostate cancer stem-like traits, cell growth, clonogenicity, and metastasis, while ectopic overexpression of DEGS2 showed the opposite effects.