Beyond Density: Unveiling the Trade-Off in Catalytic Site Optimization Using Defect-Engineered UiO-66.

Enhancing intrinsic activity and increasing catalytic site density are two widely employed strategies to improve catalytic performance. Although typically considered independently, their interplay remains poorly understood. Here, two UiO-66 metal-organic frameworks (MOFs) with distinct catalytic site densities-linker-defective UiO-66L and cluster-defective UiO-66C-are synthesized and systematically compared.

Efficacy of bleomycin and sirolimus in inhibiting CD31 endothelial cell proliferation in noninvoluting congenital hemangiomas.

Objective: Congenital hemangiomas are rare vascular anomalies that manifest at birth. Noninvoluting congenital hemangiomas present significant clinical challenges due to their persistence and associated complications. The mechanisms underlying congenital hemangiomas remain poorly understood, and current treatments have shown limited efficacy.

Stakeholders' Perceptions of the Nature-Based Healing Industry in South Korea: A Q Methodology Study.

This study explores the subjective perceptions of stakeholders in South Korea's nature-based healing industry and employs Q methodology to classify their viewpoints. As the healing industry continues to evolve across sectors such as forest therapy, marine healing, and healing agriculture, understanding diverse stakeholder perspectives is essential for informing coherent and inclusive policy development. A total of 25 participants-including policymakers, practitioners, and service users-sorted 39 statements derived from academic and media sources.

A randomized controlled trial on the efficacy and safety of vitamin A supplementation in children with sepsis.

Background: Our previous research confirmed that vitamin A (VA) deficiency commonly occurs in children with sepsis, and serum VA levels negatively correlate with disease severity. This study aimed to evaluate the efficacy and safety of VA supplementation (VAS) in children with sepsis.

Methods: A randomized, single-blind, single-center trial was conducted from June 2020 to March 2024 involving children diagnosed with sepsis.

TGF-β1 Promotes Angiogenesis via Endothelial-to-Mesenchymal Transition in Infantile Hemangioma.

Background: Infantile hemangioma (IH) is the most common benign tumor in infancy and severely affects aesthetics and function. Hemangioma-derived endothelial cells (HemECs) are the main cellular component of IH and contribute to angiogenesis in IH. TGF-β1 (transforming growth factor β1) can induce endothelial-to-mesenchymal transition (EndoMT).

A Starch Molecular Explanation for Effects of Ageing Temperature on Pasting Property, Digestibility, and Texture of Rice Grains.

Alterations in rice qualities during ageing are related to changes in starch molecular structures. However, if and how storage temperature determines starch structure-function relations remain unknown. This study applied four storage temperatures to investigate the effects of ageing on starch structure-function relations.

Biomedical graduate outcomes unlocked: LinkedIn as a powerful tracking tool.

Biomedical Science is a popular multi-vocational degree that exposes students to body systems knowledge and scientific research skills, preparing them for work or further study in biomedical research and industry or health professions. With a diverse range of graduate outcomes, biomedical students report feeling uncertain about their career prospects. To date, there is limited data on the employment outcomes of Australian Biomedical Science graduates.

Altered dynamic functional network connectivity patterns in Alzheimer's disease: insights into neural dysfunction.

Background: Dynamic functional network connectivity (dFNC) assesses temporal fluctuations in functional connectivity (FC) during magnetic resonance imaging (MRI), capturing transient changes in neural activity. Investigating dFNC may provide valuable insights into the complex clinical manifestations of Alzheimer's disease (AD). However, research on dynamic FC alterations in AD remain limited.

Comparison of Infantile Hemangiomas in Male and Female Infants: A Prospective Study.

Infantile hemangioma (IH) predominantly occurs in females, yet few studies have compared the clinical characteristics of IH between girls and boys. This study compared the clinical characteristics of females and males with IH. This prospective study included 1016 patients with IHs for whom complete clinical data were available.

Dual-mode sensing of Staphylococcus aureus in food via fluorescent Apt@Fe/Zr MOF with peroxidase-like activity.

Staphylococcus aureus, a prevalent foodborne pathogenic bacterium, poses a significant threat to human health. Herein, a dual-mode sensing method is proposed for detecting S. aureus in food using aptamer-modified Fe/Zr metal organic framework (Apt@Fe/Zr MOF).

Assessing the Impact of Wildfire Smoke Transport Through Chemical Transport Modeling, Satellite Retrievals, and Ground-Based Observations of Ozone in Rural Nevada.

Wildfires emit a large amount of ozone precursors, nitrogen oxides, and particulate matter into the troposphere and sometimes the stratosphere. With the increasing wildfire events in recent years, the western U.S.

PHACE syndrome: looking backward and forward.

PHACE syndrome rarely occurs in patients with infantile hemangioma (IH) but is common in patients with segmental IH involving the head and face. PHACE syndrome involves at least one system abnormality, including arterial abnormalities, structural brain abnormalities, cardiovascular abnormalities, eye abnormalities, and ventral or midline abnormalities. The pathogenesis of PHACE syndrome remains unclear, and it affects various systems in diverse ways.

Standardization transformation of C-lignin to catechol and propylene.

Standardization transformation of lignin to high-value-added chemicals requires precise control of the reaction process based on the elaborate catalytic strategy design and lignin structure optimization. Here we report the selective and efficient preparation of bio-catechol and bio-propylene from the ideal C-lignin via a one-pot hydrogenolysis-dealkylation cascade catalysis. The optimized catalyst Ni/HY could orderly cleave the corresponding C-OAr bonds and C-C bonds in the uniform benzodioxane units of C-lignin, which could directionally and selectively provide a 49 mol% yield of catechol and a 45 mol% yield of propylene from C-lignin under 200°C.

Radiomics-Based Machine Learning for Determining Amplification Status in Childhood Neuroblastoma: A Systematic Review and Meta-Analysis.

IntroductionThe oncogene promotes tumor cell proliferation in neuroblastoma, and its amplification is a well-established marker of poor prognosis. Radiomics-based approaches have shown promise in noninvasively determining amplification status; however, their diagnostic performance has varied significantly across studies. This systematic review and meta-analysis aimed to quantitatively evaluate the diagnostic accuracy of radiomics-based machine learning models for determining amplification in neuroblastoma and to critically assess the methodological quality of the included studies.

Integrative application of bloodletting and cupping for refractory herpes zoster in an immunocompromised patient with ovarian cancer.

Background: Refractory herpes zoster in immunocompromised patients, particularly those receiving chemotherapy, poses significant clinical challenges due to limited responsiveness to standard antiviral and analgesic therapies. Traditional Chinese medicine (TCM) has been explored as an adjunctive modality to enhance analgesic efficacy and support lesion resolution.

Case Report: A 79-year-old patient with ovarian cancer undergoing chemotherapy developed severe HZ affecting the T10-L2 dermatomes.

A web-based dynamic nomogram for predicting readmission in patients with heart failure with preserved ejection fraction.

Background: The study aims to evaluate the efficacy of a web-based dynamic nomogram predicting the risk of heart failure (HF)-related rehospitalization within 1 year in patients with HF with preserved ejection fraction (HFpEF).

Methods: The data of patients from two centers were categorized into training and test sets. Least absolute shrinkage and selection operator and multivariate logistic regression analysis were conducted on the training set data after selecting risk factors described in previous studies, and they were used to set up a nomogram.

Gray Matter Volume Abnormalities in Schizophrenia: Comparisons Between P-Value and Effect Size Inference Frameworks Using Mega- and Meta-Analyses.

Background And Hypothesis: Identifying generalizable brain imaging markers from large multi-center datasets remains challenging due to varying statistical aggregation approaches and p-hacking with increasing big data. We hypothesized that effect size (ES) inference surpasses P-value-based inference in reliably identifying core brain damage of schizophrenia, regardless of whether Mega- or Meta-analyses are used.

Study Design: We examined voxel-wise inter-group differences in gray matter volume (GMV) based on individual data from 976 schizophrenia patients and 801 healthy controls across 16 datasets, along with published coordinates data from 103 studies involving 5151 patients and 5438 controls, using Mega-analysis (Mega), Image-Based Meta-analysis (IBMA), and Coordinate-Based Meta-analysis (CBMA) under P-value and ES inference frameworks, respectively.

Preferred Parallel Alignment of Sulfonamide Enables High-performance Inverted Perovskite Solar Cells.

Molecule additives emerge as a highly effective strategy for enhancing the performance and stability of perovskite solar cells (PSCs), owing to their potential in suppressing intrinsic defects in perovskite. However, the influence of atomic configuration and electronic properties of additives on their passivation performance receives little attention. Here, two benzenesulfonamide derivatives, 4-carboxybenzenesulfonamide (CO-BSA) and 4-cyanobenzenesulfonamide (CN-BSA) are investigated, examining the effects of molecules with different electron‑acceptor functional groups on the defect passivation of perovskite layer and the photovoltaic properties of perovskite solar cells (PSCs.

Hypo-connected pattern in Parkinson's disease with pure apathy: A dynamic functional connectivity perspective.

Background: Apathy, a decline in goal-directed motivated behavior, is a common non-motor symptom in Parkinson's disease (PD). The dynamic information interaction between multiple brain functional networks, crucial for goal-directed behavior, remains unknown in patients with PD and pure apathy (PD-PA). This study thus used the dynamic functional network connectivity (dFNC) analysis to explore the dynamic brain networks changes of apathy in PD.

Identifying common genes and immune infiltration characteristics between systemic sclerosis and atherosclerosis.

Background: Clinical and epidemiological studies suggest a notably higher incidence of atherosclerosis (AS) in systemic sclerosis (SSc) patients, yet their shared molecular mechanisms remain unclear. Therefore, this research was designed to investigate the shared pathogenic mechanisms underlying both SSc and AS.

Methods: SSc and AS datasets were acquired from the Gene Expression Omnibus (GEO) database to identify common differentially expressed genes (DEGs).

Multimodal retinal imaging by visible light optical coherence tomography and phosphorescence lifetime ophthalmoscopy in the mouse eye.

Significance: Oxygen metabolism is important to retinal disease development, but current imaging methods face challenges in resolution, throughput, and depth sectioning to spatially map microvascular oxygen.

Aim: To develop a multimodal system capable of simultaneous phosphorescence lifetime imaging scanning laser ophthalmoscopy (PLIM-SLO) and visible light optical coherence tomography (VIS-OCT) to capture capillary-level oxygen partial pressure (pO) and structural volumes in rodents.

Approach: C57BL/6 mice were imaged by VIS-OCT with high-definition (10 kHz raster) and Doppler (100 kHz circular) protocols.