Unraveling the mechanisms of selenite reduction and selenium nanoparticle biosynthesis in the highly selenite-tolerant yeast Trichosporon asahii I30.

Selenite contamination poses a significant environmental risk due to its high toxicity, mobility, and bioavailability, and further threatens ecological stability and human health via biological accumulation in trophic chains. Microbial transformation of selenite into selenium nanoparticles (SeNPs) represents a promising and sustainable bioremediation strategy. However, the underlying mechanisms in environmentally prevalent yeasts remain largely uncharacterized.

In-Situ hydrothermal growth of gallic acid-derived MOF on electrospun nanofibers for simultaneous oil and heavy metal removal.

The increasing discharge of complex wastewater, which poses a significant risk to the environment and health, requires the development of an efficient and versatile treatment technology. In this study, we present a more environmentally friendly bifunctional membrane made by in-situ hydrothermal growth of metal-organic frameworks (MOFs) on electrospun nanofibers that can be used for the simultaneous removal of emulsified oils and heavy metal ions. The electrostatically spun fiber substrate consisting of polyacrylonitrile (PAN) and polyimide (PI) provided a high surface scaffold for the uniform deposition of gallic acid biobased MOFs, which ensured highly efficient adsorption and filtration properties as well as the advantage of facilitating secondary recycling.

Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes.

Silver nanoparticles (AgNPs), a promising class of metallic nanomaterials with strong antibacterial properties and biomedical potential, are increasingly being used in a variety of consumer products. The widespread application of AgNPs has raised concerns about their toxicological effects, particularly their accumulation in the liver and the associated oxidative stress. However, the precise molecular mechanisms driving these effects remain unclear.

Pseudo-distribution elite critics: Enhancing accuracy in reinforcement learning value estimation.

Reinforcement learning has succeeded significantly in developing intelligent agents capable of adeptly navigating complex environments, yet it often encounters limitations due to persistent biases in state-action value estimation. To address this challenge, we introduce the Pseudo-distribution Elite Critics (PEC), an innovative framework designed to enhance sample efficiency and effectively balance overestimation and underestimation biases in Q-value approximations. PEC revolves around the innovative concept of pseudo-distribution representation, which enriches Q-value approximations with distributional characteristics, capturing nuanced variations in Q-values without increasing the number of critics, leading to more refined and precise estimations.

Mapping the interactions of critical factors in China's first-contact healthcare systems using causal loop diagrams.

Background: Primary healthcare plays a pivotal role in optimizing healthcare resource allocation and ensuring equitable access to services. In China, first-contact care within the tiered medical care system is essential for alleviating pressure on large hospitals and enhancing healthcare equity. However, challenges such as uneven resource distribution and low patient trust in primary institutions limit the effectiveness of first-contact care.

TGF-β1 Promotes Angiogenesis via Endothelial-to-Mesenchymal Transition in Infantile Hemangioma.

Background: Infantile hemangioma (IH) is the most common benign tumor in infancy and severely affects aesthetics and function. Hemangioma-derived endothelial cells (HemECs) are the main cellular component of IH and contribute to angiogenesis in IH. TGF-β1 (transforming growth factor β1) can induce endothelial-to-mesenchymal transition (EndoMT).

Enhanced curcumin delivery behavior of starch-based emulsion-filled gel by granular and molecular starch transformation: From gel formation to controlled release.

An elastic hydrophobic ingredient-loaded starch-based emulsion-filled gel with high formability was developed in this study. The effect of granular/molecular starch transformation in emulsion-filled gel on its curcumin delivery functionality was focused on for the first time. Curcumin was dissolved in oil droplets, further tightly wrapped by a starch gel three-dimensional network.

Early acetaminophen Use and 90-day mortality in ICU patients with ischemic stroke.

Introduction: The impact of acetaminophen on the prognosis of ischemic stroke patients admitted to intensive care units remains unclear. Although acetaminophen is commonly used for fever and pain management, its potential benefits beyond temperature control require further investigation.

Methods: Using the MIMIC-IV database, we retrospectively identified 494 ICU-admitted ischemic stroke patients, of whom 362 (73.

Prenatal Exposure to PM2.5 Components and Preterm Birth: A Case-Crossover Study in Shijiazhuang, China.

Objective: The aim of the study was to study maternal exposure to PM2.5 components and preterm birth.

Methods: Counts of hospitalizations due to preterm birth at the Fourth Hospital of Shijiazhuang City were collected from 2014 to 2019.

Overexpression of SiGSTU24 enhances salt tolerance in transgenic Arabidopsis.

Background: Soil salinization can lead to reduced soil activity, damage to the plant root system, stunted crop growth and reduced yield. Foxtail millet, an important cereal crop, has high nutritional and economic value but is affected by salt stress during growth. During long-term evolution, foxtail millet has developed various regulatory mechanisms to cope with salt stress.

The construction and analysis of a prognostic model based on CD8 T cell immune-related genes in hepatocellular carcinoma.

The effector functions of CD8 T cell significantly influence the immunosuppressive microenvironment in hepatocellular carcinoma (HCC), which is intricately associated with HCC prognosis. Nevertheless, a comprehensive investigation into the relationship between CD8 T cell immune-related genes and HCC prognosis remains lacking. This study aimed to construct a prognostic model for HCC using CD8 T cell immune-related genes to provide insights for clinical management and prognosis.

Effect of telemedicine-supported structured exercise program in patients with chronic low back pain: a randomized controlled trial.

Background: Structured exercise programs delivered via telemedicine have the potential to benefit patients with chronic low back pain (CLBP). However, evidence-practice gaps exist, such as low exercise adherence and lack of attention to the mental health of CLBP, so further research is needed to investigate the impact of telemedicine-supported structured exercise program on patients with CLBP.

Objectives: To compare the clinical outcomes of patients with CLBP following a telemedicine intervention versus usual care therapy.

A Systematic Study of Lysine Succinylation in the Pathogenic Bacterium in Aquatic Animals.

a pathogenic vibrio, is ubiquitous and the most prevalent disease infecting tropical and subtropical mariculture animals in marine and estuarine environments. It presents a major risk to mariculture companies worldwide and can cause serious disease problems in aquaculture. Recent studies have shown that various pathogens employ post-translational modifications (PTMs) to regulate cellular processes.

Magnetic Biochar Derived from Waste Bamboo as a Peroxymonosulfate Activator for Tetracycline Hydrochloride Degradation.

Magnetic Fe and N-doped biochar (FeN-BC) was synthesized from waste bamboo through microwave pyrolysis and used as a catalyst for the degradation of tetracycline hydrochloride (TC) with peroxymonosulfate (PMS). The results showed that doping with Fe improved the recovery performance of biochar and the N-doping enhanced the activity of PMS. Simultaneously, it achieved a high degradation efficiency for TC (93%) under optimized conditions within 30 min.

Effect of Telemedicine-Supported Structured Exercise Program in Patients with Chronic Low Back Pain: Study Protocol for a Randomized Controlled Trial.

Purpose: Telemedicine-based structured exercise programs have the potential to benefit patients with chronic low back pain (CLBP). However, evidence-practice gaps persist, including low exercise adherence and insufficient focus on mental health. Consequently, further research is warranted to clarify the impact of telemedicine-supported structured exercise programs on patients with CLBP.

Mapping benthic habitats in Bohai Bay, China.

Marine benthic habitat mapping is increasingly recognized as an essential tool in integrating available data to inform marine ecosystem-based management. This study presents the first comprehensive and detailed marine benthic habitat map of Bohai Bay, China, utilizing a classification scheme that incorporates both abiotic and biotic features. A total of 20 distinct marine benthic habitat types were identified, reflecting the spatial distribution of reef biota, semi-terrestrial plants, ecologically and economically important benthic communities, as well as areas impacted by anthropogenic activities.

Progress in silicon-based reconfigurable and programmable all-optical signal processing chips.

Taking the advantage of ultrafast optical linear and nonlinear effects, all-optical signal processing (AOSP) enables manipulation, regeneration, and computing of information directly in optical domain without resorting to electronics. As a promising photonic integration platform, silicon-on-insulator (SOI) has the advantage of complementary metal oxide semiconductor (CMOS) compatibility, low-loss, compact size as well as large optical nonlinearities. In this paper, we review the recent progress in the project granted to develop silicon-based reconfigurable AOSP chips, which aims to combine the merits of AOSP and silicon photonics to solve the unsustainable cost and energy challenges in future communication and big data applications.

Study on dynamic control structure of hazardous chemical accidents based on STAMP-24 model.

Aiming at the complex problem of multi-organization interaction accident analysis, this study combines the STAMP model with the 24Model, applies the new model to the accidents at Xiangshui Jiangsu on March 21, 2019, and verifies the feasibility of the model. First of all, the cause of the accident is analyzed from four perspectives. Secondly, it analyzes the failure of safety restraints at the time of the accident.

Identifying leading anti-inflammatory dietary determinants of depression and loneliness in older adults.

Objectives: The study aims to explore the association between anti-inflammatory dietary variables and prevalence of depression and loneliness in older adults.

Design: A cross-sectional secondary data analysis was performed using data from the English Longitudinal Study of Ageing (ELSA), targeting adults aged 50 and over.

Method: Data from wave 9 of ELSA were utilised.

Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starving .

Unlabelled: In starving bacteria the initiation of two survival programs-biofilm formation and sporulation-is controlled by the same phosphorylated master regulator, Spo0A~P. Its gene, is transcribed from two promoters, P and P that are, respectively, regulated by RNA polymerase (RNAP) holoenzymes bearing σ and σ. Notably, transcription is directly autoregulated by Spo0AP binding sites known as 0A1, 0A2, and 0A3 box, located in between the two promoters.

Stabilizing high-rate potassium storage by ferromagnetism.

In this work, pre-magnetized ε-FeO was used as prototype electrode material to reveal the synergetic effect between ferromagnetism and electrochemical performance. Upon high-rate potassiation, ε-FeO was unable to fully participate in conversion reaction due to "potassiation retardation". The higher the rate was, the less complete the conversion reaction became.

C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1-mediated lipid metabolism.

Altered lipid metabolism is an emerging hallmark of cancer, which is involved in various aspects of the cancer phenotypes. C12ORF49 has recently been identified as a pivotal regulator of sterol regulatory element binding proteins (SREBPs), a family of transcriptional factors that govern lipid biosynthesis. Nevertheless, the function of C12ORF49 in human cancers has not been studied.

Genome-wide identification and expression analysis of the DREB gene family in foxtail millet (Setaria Italica L.).

Background: Dehydration response element binding factors (DREBs) are a family of plant-specific transcription factors that regulate plant responses.

Results: In this study, members of the SiDREB gene family were identified and analyzed in terms of their physicochemical properties, phylogeny, and structure of the encoded proteins. The expression patterns of the DREB transcription factors in foxtail millet under stress were analysed by combining the qRT-PCR data for foxtail millet after exposure to low temperature, abscisic acid (ABA), and osmotic stress (20% PEG 6000).

Monitoring melanoma immunotherapeutic efficacy through successive metabolic labeling and PD-L1-confined signal amplification based on membrane characteristics of the newly generated circulating tumor cells.

Unlike conventional detection, monitoring membrane characteristics of circulating tumor cells (CTCs) within a specific time frame can effectively indicate tumor progression, yet the challenge lies in selectively isolating CTCs generated during this period and precisely identifying subtle progression-related changes. This study focuses on CTCs newly generated during melanoma immunotherapy, utilizing a strategic combination of tumor-specific glycometabolic engineering, phenotypic protein-confined biotinylation and lanthanide luminescence to enrich and detect these spatiotemporally specific CTCs. First, AcManNAz-associated cellular glycometabolic engineering selectively developes azide groups on the membranes of these CTCs, providing clickable artificial tags to distinguish them from pre-existing CTCs and blood cells.

Exploring glucagon-like peptide-1 receptor agonists as potential disease-modifying agents in autoimmune diseases.

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are emerging with therapeutic agents for the treatment of two of the most prevalent metabolic disorders: diabetes and obesity. However, the causal relationship between GLP-1R agonists and autoimmune diseases is still unclear.

Methods: The available cis-eQTLs for drug target genes (GLP-1Rs) were used as proxies for exposure to GLP-1R agonists.