Cancer therapy-induced cardiac metabolic reprogramming: A new frontier in cardio-oncology.

With the continuous advancement of cancer treatment technology, cardiotoxicity has gradually become a significant concern regarding the quality of life and long-term prognosis of cancer patients. This review systematically explores the mechanisms of cardiac metabolic reprogramming during cancer treatment, highlighting the impact of chemotherapy, targeted therapy, immunotherapy, and other drugs on the metabolic balance of cardiac cells. The primary manifestation of this impact is the shift from efficient fatty acid oxidation to inefficient glycolysis dependence.

Occurrences and migration characteristics of photoinitiators in paper food packaging: Implication for human exposure.

Photoinitiators (PIs), as an important component of UV inks, are widely used in the printing of paper food packaging. Nevertheless, there is limited information concerning the identification of PIs in food packaging and their potential migration rules under natural storage condition. In this study, 23 target PIs detected in paper food packaging were dominated by benzophenones (BZPs), followed by amine co-initiators (ACIs), thioxanthones (TXs) and phosphine oxides (POs).

SOX4-ZIP14-zinc metabolism mediates oncogenesis and suppresses T cell immunity in nasopharyngeal carcinoma.

Subtle variations of micronutrients in the tumor microenvironment often coincide with tumor progression and immune disorders. Nevertheless, the underlying mechanisms of how micronutrients, such as metal ions, influence tumor-intrinsic properties and tumor-immune crosstalk remain inadequately characterized. Here, our integrative analysis of multi-center single-cell, spatial transcriptome sequencing, and bulk RNA sequencing (RNA-seq) cohorts reveals that nasopharyngeal carcinoma (NPC)-specific SRY-box transcription factor 4 (SOX4) governs microenvironmental and cellular zinc metabolism through its downstream target, SLC39A14 (ZIP14), a membrane zinc uptake transporter.

Single-path interferometric technique for measuring the orbital angular momentum spectrum of a structured light beam.

Accurate and rapid measurement of the orbital angular momentum (OAM) spectrum of structured light beams is essential for high-accuracy optical systems and real-time applications based on OAM. In this Letter, we propose and experimentally demonstrate a single-path interferometric technique for full-field reconstruction and OAM mode decomposition. Compared to the standard interferometric technique, our technique significantly improves measurement efficiency and accuracy.

Integrated modeling method of ultraviolet radiation and transmission in aircraft plume detection.

The radiation characteristics of aircraft plumes provide the basis for target detection and tracking. Radiation simulation of the plume mainly includes the radiation simulation of its flow field and the transmission characteristics during its long-distance propagation. However, current research in this area often focuses on one of these two aspects and fails to integrate an analysis of both processes.

Orbital angular momentum mode crosstalk of asymmetric Laguerre-Gaussian beams in a supersonic wind-induced airflow environment.

The near-field airflow caused by supersonic wind is an important factor affecting the propagation of vortex beams in airborne optical communications. In this random environment, the orbital angular momentum (OAM)-based communication system will cause signal-mode degradation and mode crosstalk. As an unconventional source, asymmetric vortex beams have unique control dimensions and methods, and the coupling characteristics with a turbulent environment are rarely reported.

Recent Advances in Inflammation-Associated Epicardial Adipose Tissue for Atrial Fibrillation Patients.

The relationship between inflammation and atrial fibrillation (AF) has recently attracted significant research interest. Epicardial adipose tissue (EAT) contributes to the pathogenesis of AF through its inflammatory, metabolic, and electrophysiological effects and may also influence AF outcomes. Inflammatory cells within EAT release key proinflammatory cytokines, including interleukin (IL)-1β and tumor necrosis factor-α (TNF-α), which promote cardiomyocyte apoptosis and fibrosis.

Core Symptoms and Dynamic Interactions of Depressive Symptoms in Older Chinese Adults: A Longitudinal Network Analysis.

Depressive symptoms in older adults are associated with adverse psychosocial outcomes. Understanding how depressive symptoms interrelate can enhance intervention strategies. While network analysis has advanced our comprehension of depressive symptom structure, few studies have explored dynamic interactions in older populations.

Risk factors for traumatic fracture related infection in surgically treated ankle fracture: A multicenter retrospective study.

Purpose: Infection after ankle fracture fixation is a serious complication, leading to a prolonged healing period and dysfunction in a long-term follow-up. Identifying risk factors for ankle fracture-related infection (FRI) is beneficial in preventing complications and reducing the risk of treatment. The study aims to retrospectively analyze clinical risk factors for ankle FRI.

Graph Spiking Attention Network: Sparsity, Efficiency and Robustness.

Existing Graph Attention Networks (GATs) generally adopt the self-attention mechanism to learn graph edge attention, which usually return dense attention coefficients over all neighbors and thus are prone to be sensitive to graph edge noises. To overcome this problem, sparse GATs are desirable and have garnered increasing interest in recent years. However, existing sparse GATs usually suffer from high training complexity and are also not straightforward for inductive learning tasks.

Outcomes of surgically treated traumatic neuromas of cutaneous nerves as complications of ankle arthroscopy: A 5-year follow-up.

Objectives: To investigate the long term result of traumatic neuromas as complications of ankle arthroscopy treated by neuroma resection.

Methods: Twenty-five patients diagnosed with traumatic neuroma as complications of ankle arthroscopy were included. The standard procedure of microsurgical neuroma resection and nerve release was performed in all patients.

Prognostic implications of complement C1q-like 4 expression in breast cancer.

Higher expression of Complement C1q-like protein 4 (C1ql4) in breast cancer may be associated with increased tumor malignancy. As a protein involved in immune responses and inflammation, C1ql4 is expressed across all molecular subtypes of breast cancer. We conducted a retrospective analysis and follow-up study involving 111 patients who underwent breast cancer resection at the Department of Breast Surgery, Affiliated Hospital of Chengde Medical College, to investigate the relationship between C1ql4 expression and overall survival, as well as to evaluate the prognostic value of C1ql4 both independently and in combination with conventional clinicopathologic parameters.

Grouping Digital Health Apps Based on Their Quality and User Ratings Using K-Medoids Clustering: Cross-Sectional Study.

Background: Digital health apps allow for proactive rather than reactive health care and have the potential to take the pressure off health care providers. With over 350,000 digital health apps available on the app stores today, those apps need to be of sufficient quality to be safe to use. Discovering the typology of digital health apps regarding professional and clinical assurance (PCA), user experience (UX), data privacy (DP), and user ratings may help in determining the areas where digital health apps can improve.

Long-term climate warming and nitrogen deposition increase leaf epiphytic and endophytic bacterial diversity.

Plant microbiome plays a vital role in plant fitness and ecosystem functioning, yet its response to global environmental change remains poorly understood. Using an 18-year field experiment, we investigated the effects of climate warming and nitrogen deposition on the diversity of leaf epiphytic and endophytic bacterial communities in two dominant plant species (Stipa breviflora and Cleistogenes songorica) of a temperate desert steppe. We found that warming and nitrogen addition increased both epiphytic and endophytic bacterial diversity, but via different mechanisms.

Condensin Accelerates Long-Range Intra-Chromosomal Interactions.

The 3D genome organization plays a key role in regulating interactions among chromosomal loci. While Chromosome Conformation Capture (3C)-based methods have provided static snapshots of chromatin architecture, the kinetics of chromosomal encounters in live cells remain poorly characterized. In this study, we employ Chemically Induced Chromosomal Interaction (CICI) to measure encounter times between multiple loci pairs in G1-arrested budding yeast.

Medial vs. Anterior Malleolar Osteotomy in Osteochondral Autologous Transplantation for Hepple V Talar Lesions: A Retrospective Study.

Aims: To compare clinical outcomes in patients with talar Osteochondral lesions (OLTs) treated with medial malleolar osteotomy (MMO) or anterior malleolar osteotomy (AMO) combined with Osteochondral autologous transplantation (OAT).

Methods: From May 2014 to May 2020, 39 patients with Hepple V OLTs underwent MMO (n = 22) or AMO (n = 19). Functional outcomes were assessed using the American Orthopaedic Foot and Ankle Society ankle-hindfoot scale (AOFAS) and Visual Analog Scale (VAS) pain scores.

Microbial-mediated transformation shapes the molecular diversity of landfill leachate under anthropogenic and natural covariation.

Extensive landfill leachate from human activities is one of the most intractable liquid waste due to the presence of stubborn leachate dissolved organic matter (LDOM) and various pollutants. However, critical driving forces regarding LDOM complexity are still unclear. This study explores relationships between LDOM chemical composition, microbial community, anthropogenic factors and climate conditions based on national-scale landfill leachates in China.

Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis.

Background: Chronic cerebral hypoperfusion (CCH) is a pathophysiological hallmark of vascular dementia, the second most common form of dementia. CCH exerts complex and subtle detrimental effects on both the brain and peripheral systems. Irisin is a polypeptide primarily expressed in contracting skeletal muscle and the brain.

The Effect of the Gene on Swainsonine Biosynthesis in OW7.8, an Endophytic Fungus of .

The gene was cloned in the endophytic fungus OW 7.8 isolated from , and the gene knockout mutant Δ was first constructed in this study. Compared with OW 7.

Identification and validation of extracellular matrix-related genes in the progression of gastric cancer with intestinal metaplasia.

Background: Gastric cancer (GC) is a highly lethal malignancy with a high incidence and mortality rate globally. Its development follows the Correa model, with intestinal metaplasia (IM) being a critical precursor to GC. However, the mechanisms underlying IM progression to GC remain unclear.

Catalytic Asymmetric -Site Dearomatization Enables Kinetic Resolution.

Dearomatization of planar aromatics offers unparalleled opportunities for the construction of three-dimensional stereochemical frameworks. However, the inherent instability of dearomatized intermediates, particularly bearing labile C(sp)-heteroatom bonds, has hindered progress due to competing rearomatization pathways. By capitalizing on arene dearomatization and transforming the rearomatization predicament into a new opportunity, we herein present a stability-driven catalytic asymmetric dearomatization/rearomatization (CADA/RA) cooperative strategy to resolve racemic -stereogenic compounds.

A bibliometric analysis of research trends in mesenchymal stem cell therapy for neonatal bronchopulmonary dysplasia: 2004-2024.

Introduction: Bronchopulmonary dysplasia (BPD) is a chronic lung disease predominantly affecting preterm infants, often requiring mechanical ventilation and supplemental oxygen. The pathogenesis of BPD involves a combination of genetic susceptibility and environmental insults, such as oxidative stress and mechanical ventilation. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option for BPD due to their immunomodulatory, anti-inflammatory, and regenerative properties.

Artesunate Nanoplatform Targets the Serine-MAPK Axis in Cancer-Associated Fibroblasts to Reverse Photothermal Resistance in Triple-Negative Breast Cancer.

Cancer-associated fibroblasts (CAFs) play a pivotal role in inducing photothermal therapy (PTT) resistance of triple-negative breast cancer (TNBC), but with unclear mechanism. Herein, aminoethyl anisamide-modified nano-biomimetic low-density lipoprotein (A-aLDL) is used to target deliver the PTT agent and artesunate (ARS) to both CAFs and cancer cells. Though CAFs are sensitive to PTT and notably transition to heat-resistant phenotype, the formed protective barrier is destroyed by ARS.

Receptor-like cytoplasmic kinases mediated signaling in plant immunity: convergence and divergence.

Receptor-like cytoplasmic kinases (RLCKs) function as a central player in plant receptor kinases-mediated signaling, which regulate various aspects of plant immunity and growth. RLCKs receive signals from pattern recognition receptors (PRRs) to activate pattern-triggered immunity (PTI), including reactive oxygen species (ROS) production, Ca influx, mitogen-activated protein kinase (MAPK) cascades, cellulose synthesis, phosphatidic acid (PA) production, hormone synthesis and signaling, and transcriptional remodeling. Besides, RLCK also participate in effector-triggered immunity (ETI) and the interplay between ETI and PTI.

NLTE-based atmospheric radiance modeling for space-based 4.3μm infrared detection of rocket exhaust flames.

The radiance characteristics of the atmosphere background provide the basis for rocket exhaust flame detection and tracking. The traditional atmospheric radiance model uses the LTE (local thermodynamic equilibrium) model. However, at high altitudes (above 50 km), the number density distribution of molecular is no longer a function of thermodynamic temperature, at which point the molecules are in NLTE (non-local thermodynamic equilibrium).