Machine Learning-Guided Construction of Cobalt Hexacyanoferrate Space-Confined in Hollow Carbon with Yolk-Shell Structure for Advanced Aqueous Zinc-Ion Batteries.

Carbon-modified materials have shown great promise as cathode candidates for aqueous zinc-ion batteries (AZIBs). However, the indistinctness of screening standards along with the time-consuming experimental procedures inevitably restricts their practical uses. With the increasing prevalence of artificial intelligence, machine learning (ML) offers an avenue to enhance the performance of energy storage devices.

Relationship between heart rate variability parameters and inflammatory activity in patients with Crohn's disease: a retrospective study.

Background: It is widely recognized that individuals with Crohn's disease (CD) often experience impaired autonomic nervous system (ANS) function. However, the specific relationship between autonomic activity and inflammatory processes in CD remains uncertain. The objective of this study was to investigate the association between autonomic nervous function, as assessed through heart rate variability (HRV) parameters, and the Crohn's disease activity index (CDAI).

Novel enzymes involved in the biotransformation of oxytetracycline by OTC-16.

Current research on the microbial degradation of antibiotic residues primarily focuses on isolating degrading bacteria and characterizing their metabolites. The enzymatic mechanisms underlying these biotransformation processes remain poorly understood. Here, we investigated the molecular mechanisms involved in the biodegradation of oxytetracycline (OTC) by OTC-16 using integrated transcriptomic and proteomic sequencing analyses.

Prediction model for chemical explosion consequences via multimodal feature fusion.

Chemical explosion accidents represent a significant threat to both human safety and environmental integrity. The accurate prediction of such incidents plays a pivotal role in risk mitigation and safety enhancement within the chemical industry. This study proposes an innovative Bayes-Transformer-SVM model based on multimodal feature fusion, integrating Quantitative Structure-Property Relationship (QSPR) and Quantitative Property-Consequence Relationship (QPCR) principles.

Neuroinflammation and hypertensive cardiac hypertrophy: mechanisms, pathways, and therapeutic perspectives.

Hypertensive cardiac hypertrophy is a major pathological consequence of chronic hypertension, leading to heart failure and increased cardiovascular morbidity. Emerging evidence highlights the critical role of neuroinflammation in the development and progression of hypertensive cardiac hypertrophy. This review provides a comprehensive overview of the interplay between neuroinflammation and hypertensive cardiac hypertrophy, focusing on the roles of the sympathetic nervous system (SNS), immune activation, and central nervous system (CNS) dysregulation.

Nitrogen-doped carbon coated NiFeNnanosheet arrays for efficient glycerol electrooxidation coupled with hydrogen evolution.

Water splitting represents a pivotal technology for green hydrogen generation, yet its practical application remains constrained by the sluggish kinetics of the oxygen evolution reaction (OER). To address this challenge, we propose a hybrid electrolysis system that replaces OER with the thermodynamically favorable glycerol oxidation reaction, thereby enabling energy-efficient hydrogen production coupled with value-added chemical synthesis. In this work, we reported a bifunctional self-supporting electrocatalyst for the growth of nitrogen-doped carbon shell NiFeNnanosheets on carbon fibers (NC@NiFeN) that can be applied to efficient hydrogen production and formate generation.

Association between sleep disorder and delirium in adult patients undergoing cardiac surgery: a retrospective cohort study.

Background: Compared to non-cardiac surgical patients, those undergoing cardiac surgery exhibit a higher prevalence of sleep disturbances and delirium, yet limited research has specifically examined this association in the cardiac surgical population. This study investigates the association between sleep disorders and the risk of delirium in patients after cardiac surgery, aiming to raise public awareness of the relationship.

Methods: This retrospective cohort study utilized data from the MIMIC-IV database.

Graph Spiking Attention Network: Sparsity, Efficiency and Robustness.

Existing Graph Attention Networks (GATs) generally adopt the self-attention mechanism to learn graph edge attention, which usually return dense attention coefficients over all neighbors and thus are prone to be sensitive to graph edge noises. To overcome this problem, sparse GATs are desirable and have garnered increasing interest in recent years. However, existing sparse GATs usually suffer from high training complexity and are also not straightforward for inductive learning tasks.

Atractylenolide III as a novel therapeutic strategy for gastric ulcer: mechanistic insights and investigation of molecular targets.

Purpose: Atractylenolide III (AT-III) exhibits notable anti-inflammatory, neuroprotective, and gastroprotective properties; however, its protective mechanisms in the gastric mucosa remain unclear. This study aimed to investigate the protective effects and mechanism of action of AT-III against indomethacin (IND)-induced gastric mucosal injury in rats.

Methods: Network pharmacological approaches were used to predict the therapeutic potential and underlying mechanisms of AT-III in gastric ulcers (GU).

Fe₂O₃/Fe-NCA heterojunction nanozyme with oxidase-peroxidase activities for dual-mode simultaneous detection of rutin and puerarin.

A 3D Fe₂O₃/Fe-N-doped carbon aerogel nanozyme (Fe₂O₃/Fe-NCA) was constructed via a spatial confinement strategy. The synergistic effect between Fe₂O₃/Fe heterojunctions and the N-doped carbon matrix endows the material with dual enzyme-like activities: oxidase (OXD) and peroxidase (POD). By leveraging the high reactivity of its OXD, we have developed a colorimetric electrochemical sensing platform for the simultaneous detection of rutin (RU) and puerarin (PU).

Integrated network pharmacology and experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis.

Background: Uveitis is a complex intraocular inflammatory disease and pathology results from the continuous production of proinflammatory cytokines in the optical axis. Qinghuo Rougan Formula (QHRGF), a traditional Chinese medicine (TCM) is now used to treat uveitis with desirable effect. However, the mechanism of action is still unclear.

Simple, sensitive and specific detection method for polystyrene nanoplastics in food matrix based on peptide-modified FeO@Au magnetic nanoparticles.

Microplastics (MPs) and nanoplastics (NPs) are emerging hazardous pollutants that pose a significant threat to the global environment and human health. MPs and NPs have been detected in water sources and food products. Due to the wide variety of NPs, and low concentrations in environment and food samples, the rapid and selective detection of NPs still remains a challenge.

Frequency dependence of complex permittivity of thick samples tested with an end-loaded cylindrical resonant cavity.

This paper presents a permittivity measurement system for materials using an improved end-loaded cylindrical resonator. Compared with the conventional cylindrical resonator cavity, the improved resonator expands the operating frequency by opening a slit at the top of the cavity. The resonator operates at 10-25 GHz with the TE01p (p = 1-9) operating mode and has a maximum Q-factor of 5.

Effectiveness and Cost-Effectiveness of a Mobile Psychoeducation Program (OkeyMind) for Social Anxiety Symptoms Among Youths: Protocol for a Randomized Controlled Trial.

Background: Social anxiety is increasingly prevalent among youths, leading to social withdrawal, isolation, and heightened depression risk. Mobile health (mHealth) interventions offer anonymity, accessibility, and personalized support, but their effectiveness and cost-effectiveness for young individuals with social anxiety remain unclear.

Objective: This randomized controlled trial aims to evaluate the effectiveness and cost-effectiveness of a mobile-based psychoeducation program (OkeyMind) for mitigating social anxiety symptoms among youth.

Real-Time Monitoring Supramolecular Disassembly by Nanoconfinement Engineering-Tuned Electrochemiluminescence.

Understanding the disassembly process is significant for constructing well-defined and multifunctional supramolecular structures. Nowadays, fluorescent microscopy is used as a common technique to observe a real-time disassembly process. However, the addition of the fluorescent probes into nonfluorescent systems might influence the disassembly due to the weak supramolecular interactions.

Analysis of factors influencing endometrial polyp recurrence after hysteroscopic polypectomy.

Objective: To analyze the factors influencing the recurrence of endometrial polyps after hysteroscopic polypectomy.

Methods: A retrospective analysis was conducted on the clinical data of 925 patients who underwent hysteroscopic polypectomy for endometrial polyps at the Affiliated Hospital of Shaanxi University of Chinese Medicine from January 2017 to December 2023. All patients were followed up for 6 months, and the factors influencing the recurrence of endometrial polyps after hysteroscopic polypectomy were analyzed.

Effects of postoperative antifungal therapy on the recurrence of Aspergillus infection after pulmonary aspergilloma resection: a prospective, randomized, controlled, single-center, 24-month, open-label, parallel group trial.

Background: Surgical resection is considered the most effective therapeutic method for pulmonary aspergilloma (PA), while the necessity of postoperative antifungal therapy remains controversial. Previous studies have several shortcomings such as retrospective design and inadequate follow-up durations. In this study, we aim to address these evidence gaps by evaluating the effects of postoperative antifungal therapy on both Aspergillus infection recurrence and drug-related side effects.

The interplay between oxytocin receptor and YAP in regulating gastric cancer progression.

Gastric cancer (GC) remains a lethal malignancy with limited therapeutic targets, while recent studies revealed YAP could be a promising target for GC treatment. In our study, we identify oxytocin receptor (OXTR) as an important regulator of Hippo/YAP axis. Through bioinformatics analysis, RNA sequencing analysis, functional research, and molecular mechanism research, we found that OXTR could facilitate Hippo/YAP axis, while YAP were shown to bind the OXTR promoter, enhancing its expression and establishing an interesting positive feedback loop.

Bile acid receptors regulate the role of intestinal macrophages in inflammatory bowel disease.

Many factors, including genetic vulnerability, barrier function, intestinal immune cells, and intestinal microbiota, may combine to affect the occurrence and progression of inflammatory bowel disease (IBD). Through targeting bile acid receptors (BARs), bile acids have been demonstrated to have a range of regulatory effects on intestinal immune responses in recent decades. As the basis of intestinal immunity, macrophages play an indispensable role in intestinal homeostasis.

The effect of acupuncture on blood glucose control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Purpose: This meta-analysis aimed to ascertain the effectiveness of acupuncture in treating clinical symptoms of type 2 diabetes mellitus (T2DM) and to summarize the acupoints and meridians involved.

Methods: PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang were thoroughly retrieved to acquire randomized controlled trials (RCTs) evaluating acupuncture as an adjunct treatment for T2DM. Outcome measures focused on improvements in T2DM clinical symptoms.

[Analysis of association of IL-23R gene polymorphisms with susceptibility for psoriasis].

Objective: To assess the association of single nucleotide polymorphisms (SNPs) of interleukin-23 receptor (IL-23R) gene with susceptibility to psoriasis.

Methods: Two hundred and ten psoriasis patients admitted to Xinxiang Central Hospital from January 2019 to December 2024 were selected as the study group, and 210 healthy individuals undergoing physical examination during the same period were selected as the control group. 3 mL of peripheral venous blood sample was collected from each individual from the two groups, and PCR-Restriction fragment length polymorphism (PCR-RFLP) assay was used to determine the polymorphisms of the IL-23R gene at rs2201841, rs1004819, rs10889677, rs1343151 and rs1495965 loci.

Worldwide burden of metabolic risk-related cardiovascular disease from 1990 to 2021, with projections to 2050: A systematic analysis for the Global Burden of Disease Study 2021.

Aims: This study presents a detailed examination of specific metabolic risk factors for various types of cardiovascular disease (CVD) from 1990 to 2021, stratified by sex, age and socio-demographic index (SDI) levels, and to predict the future trajectory up to 2050.

Materials And Methods: Data from the Global Health Data Exchange were utilized to estimate the burden of metabolic risk-related CVD, including high low-density lipoprotein cholesterol (LDL-c), high systolic blood pressure (SBP), high fasting plasma glucose (FPG), high body mass index (BMI) and kidney dysfunction, across different types of CVD. The study employed the age-standardized death rate (ASDR)/crude death rate and its estimated annual percentage change (EAPC) to measure the burden, and a Bayesian age-period-cohort model (BAPC) to forecast future trends.

Differentiating Molecular Weights of Supramolecular Polymers in Lower Monomer Concentrations by Coreaction Accelerator-Regulated Electrochemiluminescence.

Nuclear magnetic resonance is the most conventional approach to characterizing the molecular weight () of supramolecular polymers (SPs) at high monomer concentrations. However, it remains a great challenge to determine SPs with lower values because the increased monomer concentrations will assemble dynamically to larger SPs. In this contribution, we developed an SP-regulated electrochemiluminescence (ECL) strategy for differentiating the of SPs in low monomer concentrations.

Novel drug-inducible CRISPRa/i systems for rapid and reversible manipulation of gene transcription.

CRISPR activation and interference (CRISPRa/i) are highly effective tools to regulate transcription by fusing dead Cas9 (dCas9) with transcriptional regulatory factors guided by small guide RNA (sgRNA) in mammalian cells and mice. Still, a controllable gene regulation system is desired to investigate and manipulate dynamic biological processes. Here, we reported flexible drug-responsive CRISPRa/i systems by fusing mutated human estrogen receptor (ERT2) domains, which responded to estrogen analogue tamoxifen or its active metabolite 4-hydroxy-tamoxifen (4OHT), to CRISPRa/i components for transcriptional regulation.

Clinical comparison of arthroscopic double-row rotator cuff repair with or without long head of biceps tendon transposition.

Background: Long head of biceps tendon (LHBT) transposition is a novel technique based on the double-row suture bridge method, utilizing autologous reconstruction to treat massive rotator cuff tears.

Aim: To evaluate the mid-to-long-term clinical outcomes following the double-row repair method for massive rotator cuff tears.

Methods: This retrospective analysis included data from 53 patients with massive rotator cuff tears treated at our hospital between 2020 and 2021.