Prevalence, risk factors, and metabolic implications of alcohol use disorders among male workers in Hebei Province, China: a cross-sectional study.

Background: Alcohol is a psychoactive substance that can lead to alcohol use disorders (AUDs), which encompass a spectrum of conditions including alcohol dependence and abuse, causing significant mental and physical health issues. Excessive drinking is linked to various diseases, such as liver damage, metabolic disorders, and mental health conditions, with notable gender differences in drinking patterns, particularly among workers. This study investigates the prevalence, risk factors, and metabolic implications associated with AUDs among male workers in China.

Autophagy and glycolysis synergistically mediate Cd²⁺ transport to enhance Cd tolerance in Arabidopsis.

Cadmium (Cd), as a widely investigated heavy metal, demonstrates severe toxicity to plant growth and development. However, the roles of energy metabolism, and protein degradation caused by autophagy in plant Cd tolerance remain poorly characterized. This study reveals that Cd-exposure simultaneously affects both the glycolytic and autophagic in Arabidopsis thaliana.

[Study on the effects of telomerase reverse transcriptase in alleviating doxorubicin induced cardiotoxicity].

Objective: To investigate the role of telomerase reverse transcriptase (TERT) in alleviating doxorubicin (DOX)-induced cardiotoxicity.

Methods: (1) Cell experiments: rat H9c2 cardiomyocytes were divided into control group (CON group), null adenovirus transfection group (NC group), TERT overexpression adenovirus transfection group (TERT group), DOX group (treated with 1 μmol/L DOX for 12 hours), DOX+NC group, and DOX+TERT group (null adenovirus or TERT overexpression adenovirus were transfected for 24 hours and then treated with 1 μmol/L DOX for 12 hours). The mRNA expression of TERT in cardiomyocytes was detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR).

A semi-supervised Bayesian approach for marker gene trajectory inference from single-cell RNA-seq data.

Motivation: Trajectory inference methods are essential for extracting temporal ordering from static single-cell transcriptomic profiles, thus facilitating the accurate delineation of cellular developmental hierarchies and cell-fate transitions. However, numerous existing methods treat trajectory inference as an unsupervised learning task, rendering them susceptible to technical noise and data sparsity, which often lead to unstable reconstructions and ambiguous lineage assignments.

Results: Here, we introduce BayesTraj, a semi-supervised Bayesian framework that incorporates prior knowledge of lineage topology and marker-gene expression to robustly reconstruct differentiation trajectories from scRNA-seq data.

Traditional Chinese Medicine Formulas for the Treatment of Sepsis-Induced Acute Lung Injury: A Review.

Background: Sepsis, a severe infectious systemic syndrome with high morbidity and mortality, is pathologically characterized by multi-organ dysfunction, with pulmonary involvement predominating as acute lung injury (ALI) or its severe progression to acute respiratory distress syndrome (ARDS). Contemporary therapeutic strategies exhibit limited efficacy, while Traditional Chinese Medicine (TCM)-grounded in millennia of clinical empiricism demonstrates unique pharmacological advantages through multi-component and multi-target regulation.

Summary: The mechanism underlying sepsis-induced ALI centers on dysregulated inflammatory response, redox imbalance, and coagulopathy.

Effect of Preoperative Education Provided by Operating Room Nurses on the Preoperative and Postoperative Anxiety Levels of Patients Undergoing Radical Prostatectomy.

Background: Prostate cancer is a common malignancy amongst males worldwide. Radical prostatectomy (RP) is a standard treatment, but preoperative anxiety, which affects about 69.5% of patients, negatively affects postoperative outcomes.

Wearable electrochemical immunosensor based on ultra-thin flexible stainless steel sheets for detection of methyl jasmonate in tomato leaves.

Methyl jasmonate (MeJA), a key plant hormone, plays essential roles in plant growth, development, biotic stress responses, and wound-induced defense. Monitoring dynamic changes in MeJA in situ is vital for botanical research. Herein, coupling with paper-based analytical devices, the ultra-thin flexible stainless steel sheets with the excellent flexibility and conductivity were used to develop wearable electrochemical immunosensor for in situ and continuous detection of MeJA in plants.

Identification and validation of ANXA3 and SOCS3 as biomarkers for acute myocardial infarction related to sphingolipid metabolism.

Background: Sphingolipid metabolism (SM) is linked to acute myocardial infarction (AMI), but its role remains unclear. This study explored SM-related genes (SMRGs) in AMI to support clinical diagnosis.

Methods: We analyzed datasets GSE48060 and GSE123342 to identify differentially expressed genes (DEGs) and key module genes.

Kawasaki disease: insights into the roles of T cells.

Kawasaki disease (KD) is a systemic immune vasculitis characterized by fever and is a common cause of acquired heart disease in children. The etiology of KD remains unclear, but it is generally believed to be an amplified inflammatory cascade caused by the combined action of infection and genetic susceptibility factors. Changes in T lymphocyte subsets and their abnormal activation play an important role in the immune response to KD.

Simple, sensitive and specific detection method for polystyrene nanoplastics in food matrix based on peptide-modified FeO@Au magnetic nanoparticles.

Microplastics (MPs) and nanoplastics (NPs) are emerging hazardous pollutants that pose a significant threat to the global environment and human health. MPs and NPs have been detected in water sources and food products. Due to the wide variety of NPs, and low concentrations in environment and food samples, the rapid and selective detection of NPs still remains a challenge.

The role of immune mechanisms in hypertension and advances in immunomodulatory research.

Hypertension is one of the major risk factors for cardiovascular diseases and end-organ damage worldwide. Traditionally, it has been linked to factors such as genetics, diet, and lifestyle. However, increasing research indicates that the immune system also plays an important role in the initiation and progression of hypertension.

Correlation between serum inflammatory factors and psychosomatic syndrome in patients with chronic obstructive pulmonary disease: an observational study.

Background: Chronic obstructive pulmonary disease (COPD) is increasingly prevalent in respiratory medicine, with rising incidence and mortality rates annually. Beyond respiratory implications, it leads to cardiovascular events, osteoporosis, muscle loss, and psychosomatic syndrome, often overlooked yet pivotal in COPD prognosis. Despite this, the relationship between COPD and psychosomatic syndrome remains unclear.

Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism.

Background: Drug-induced Parkinsonism (DIP) is a secondary Parkinsonism with limited research on its hippocampal structural changes. This study explores hippocampal subfield volumes in DIP compared to Parkinson's disease (PD) and healthy controls (HCs), investigating correlations with cognitive (Montreal Cognitive Assessment, MoCA), emotional (Hamilton Depression Rating Scale, HAMD; Hamilton Anxiety Rating Scale, HAMA), and motor (Unified Parkinson's Disease Rating Scale, UPDRS) symptoms.

Methods: A total of 19 DIP patients, 20 PD patients, and 20 HCs were enrolled.

Intracardiac echocardiography improves lesion quality and ablation efficiency of pulmonary vein isolation in atrial fibrillation patients: a propensity score-matched analysis.

Background: Pulmonary vein isolation (PVI) is a cornerstone of catheter ablation for atrial fibrillation (AF). Intracardiac echocardiography (ICE) offers real-time imaging that may enhance procedural outcomes compared to traditional x-ray guidance. This study evaluates the impact of ICE on PVI lesion quality and efficiency using a novel Ablation Index Functional Validation (AIFV) system.

DNA methylation and hydroxymethylation combined with transcriptional profiling identify key regulators of hyperoxia-induced bronchopulmonary dysplasia.

Background: Hyperoxia-induced bronchopulmonary dysplasia (BPD) is a major cause of lung injury in premature infants. Epigenetics, particularly DNA (hydroxy)methylation, has been identified as a crucial regulator of BPD pathogenesis. This study aimed to reveal key regulators and pathogenic genes involved in hyperoxia-induced BPD via DNA (hydroxy)methylation and transcriptional analysis.

The VDAC3/DHODH Axis Ameliorates Sepsis-induced Myocardial Injury by Regulating Ferroptosis.

Background: Sepsis-induced myocardial injury (SIMI) represents a major contributor to prolonged hospitalization in intensive care units (ICUs) and is associated with increased mortality rates. Mitochondria serve as the primary energy source for cardiomyocytes and are also essential for various other cell functions. The essential voltage-dependent anion channel 3 (VDAC3) protein located in the outer mitochondrial membrane plays a crucial role in preserving mitochondrial homeostasis by controlling metabolite transport and the shape of cristae.

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.

Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life's Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions.

A novel iron bioresorbable scaffold: a potential strategy for pulmonary artery stenosis.

A big diameter bioresorbable scaffold is expected to be used for treatment of vessel stenosis of children with congenital heart disease to adapt the growth characteristics of vessel of children and avoid the late adverse events of permanent stent implanted in children. However, it is challenging to fabricate a big diameter bioresorbable scaffold that is appropriate for percutaneous implantation with enough mechanical performance and can be smoothly delivered in children's small vessel. In this study, a novel iron big and bioresorbable Scaffold (BBS) for pulmonary artery stenosis of children with congenital cardiovascular diseases was fabricated and evaluated.

Diagnostic dynamic contrast-enhanced magnetic resonance imaging blood-brain barrier assessment combined with plasma biomarkers for mild cognitive impairment.

Background: The role of cerebral microvascular dysfunction in early cognitive impairment and dementia has become increasingly recognized. Furthermore, pathological changes in both Alzheimer's disease and vascular dementia are almost always associated with cerebral hemodynamic deficits.

Aim: To investigate the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) assessment of the blood-brain barrier (BBB) in combination with relevant plasma biomarkers for mild cognitive impairment (MCI).

Polymorphous corneal dystrophy subtype 3 and keratoconus aggravation after corneal refractive surgery in a three-generation family carrying both and pathogenic variant.

Background: This study reports a three-generation Chinese family with polymorphous corneal dystrophy subtype 3 (PPCD3) and keratoconus (KC) aggravation induced by corneal refractive surgery, specifically small incision lenticule extraction (SMILE), in the context of genetic variations.

Methods: The history of illnesses and blood samples of all family members were collected. One hundred healthy individuals served as normal controls.

Neutrophil heterogeneity in Kawasaki disease and multisystem inflammatory syndrome in children.

Neutrophils, specialized cells of the early innate immune response, are important for maintaining the body's internal homeostasis. Upon invasion by foreign microbes, neutrophils are swiftly activated and recruited to the infection site, where they perform bactericidal functions through phagocytic clearance, degranulation-mediated toxin release, and NADPH oxidase-dependent killing. While their presence is crucial in the early stages of inflammation to combat infection, the prolonged engagement of neutrophils at the infection site can cause tissue damage due to apoptosis and the release of cytotoxic mediators.

Association Between Cardiometabolic Index and Blood Pressure: A Cross-Sectional Analysis of the NHANES 2015-2018 Data.

Background: Hypertension is a major risk factor for cardiovascular diseases (CVDs) and is closely related to metabolic abnormalities. The cardiometabolic index (CMI) integrates lipid profiles and anthropometric indicators, reflecting overall cardiometabolic health. However, the CMI and blood pressure (BP) relationship is poorly understood.

Malakoplakia mimicking malignant rectal carcinoma with bone erosion in a SLE patient: diagnosis insights from a case report and literature review.

Malakoplakia, an uncommon granulomatous inflammatory disease, is frequently associated with impaired immune function in adults, and its occurrence in patients with systemic autoimmune diseases such as SLE has not been widely studied. The variable clinical manifestations and sometimes non - specific radiological findings of malakoplakia can be misleading, thereby posing a challenge for diagnosis. We report a case of colon and bone malakoplakia mimicking malignant colonic carcinoma in an 18-year-old male with systemic lupus erythematosus (SLE).