Radiation-sensitive circRNA promotes intestinal regeneration.

Background: The intestine is one of the most sensitive organs to ionizing radiation (IR), and radiation-induced intestinal injury (RIII) impacts the quality of life of patients undergoing radiotherapy. There are limited early diagnostic biomarkers and specific medicines clinically approved for RIII. Therefore, we sought to identify new theranostic targets to prevent RIII and to facilitate the reestablishment of the intestinal epithelium.

Effects of Intracellular Polysaccharides and Proteins of on Water Quality, Floc Formation, and Microbial Composition in a Biofloc System.

The use of (formerly ) and its intracellular substances (ISs) to promote biofloc development has been extensively studied. To identify the key components of the ISs of that drive biofloc formation, algal-extracted polysaccharides (AEPSs) and algal-extracted proteins (AEPTs) were isolated from the ISs. In this study, we established four groups: ISs, AEPSs, AEPTs, and tap water (TW, control), to investigate the effects of AEPSs and AEPTs on biofloc formation dynamics, water quality parameters, and microbial community composition.

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis is poor due to distant metastasis. Thus, there is an urgent need to discover novel therapeutic targets and strategies to overcome metastasis. A series of in vitro and in vivo phenotype experiments were performed to investigate the role of phosphodiesterase 1A (PDE1A) in NSCLC.

Assessment of prostate cancer aggressiveness through the combined analysis of prostate MRI and 2.5D deep learning models.

Objective: Prostate cancer is prevalent among older men. Although this malignancy has a relatively low mortality rate, its aggressiveness is critical in determining patient prognosis and treatment options. This study therefore aimed to evaluate the effectiveness of a 2.

[Analysis of association of IL-23R gene polymorphisms with susceptibility for psoriasis].

Objective: To assess the association of single nucleotide polymorphisms (SNPs) of interleukin-23 receptor (IL-23R) gene with susceptibility to psoriasis.

Methods: Two hundred and ten psoriasis patients admitted to Xinxiang Central Hospital from January 2019 to December 2024 were selected as the study group, and 210 healthy individuals undergoing physical examination during the same period were selected as the control group. 3 mL of peripheral venous blood sample was collected from each individual from the two groups, and PCR-Restriction fragment length polymorphism (PCR-RFLP) assay was used to determine the polymorphisms of the IL-23R gene at rs2201841, rs1004819, rs10889677, rs1343151 and rs1495965 loci.

Research progress on nitrogen-removal characteristics and mechanisms in salt-tolerant microorganisms.

Nitrogen pollution in wastewater from industrial effluents contains various substances, including salts and organic matter, that pose potential threats to aquatic ecosystems and human health. Denitrification microorganisms therefore play crucial roles in nitrogen bioremediation. This review focuses on salt-tolerant denitrification microorganisms, including their definition and classification.

Waste valorization of ovum protein isolates versus commercially available proteins isolates from physicochemical, structural, and functional properties to stabilizing Pickering emulsions.

Unlabelled: This study demonstrated the commercialization potential of ovum protein isolates (RCOPI) by comparing it with commercially available proteins from physicochemical, structural, and functional properties to stabilizing Pickering emulsions. The size of RCOPI colloids nanoparticles reached 65 nm which is much smaller than the commercially available proteins. Besides, RCOPI exhibited incredible emulsion ability with the emulsion drop around 22 μm diameters and the zeta potential approximately - 50 mV.

Boosting microbial nitrogen removal through green-engineered iron nanocomposites: A sustainable strategy for high-strength inorganic nitrogen wastewater treatment.

Heterotrophic nitrification and aerobic denitrification are critical biochemical pathways for nitrogen removal in wastewater treatment systems. These processes are predominantly mediated by microorganisms, whose bioremediation capacity is often constrained when treating wastewater with high concentrations of inorganic nitrogen. In this study, a novel zeolite (Ze)-supported sulfurized nanoscale zerovalent iron (NZVI) with tea polyphenols (TP) (TP-Ze-NZVI/S) was synthesized through an innovative, low-energy green vacuum reduction method, utilizing TP as the reducing agent.

Melatonin regulates proline metabolism by modulating CmDREB1A/E to enhance cold tolerance in cantaloupe fruit.

The potential regulatory mechanisms of 100 μM melatonin (MT) treatment on proline accumulation in cantaloupe fruit under cold stress were investigated. The results showed that MT treatment increased the content of free proline in cold-stored cantaloupe fruit by upregulating the expressions of the Δ1-pyrroline-5-carboxylate synthase (P5CS) and ornithine δ-aminotransferase (OAT) genes and decreasing the transcripts and enzyme activity of proline dehydrogenase (ProDH). Furthermore, the yeast one-hybrid assay screened for CmDREB1A and CmDREB1E that bind CmP5CS, and electrophoretic mobility shift analysis and dual luciferase reporter gene verified that these two transcription factors could bind the CmP5CS promoter.

Complete genome sequence of strain R isolated from Antarctic soil.

We report the complete genome sequence of strain R, isolated from Antarctic soil. The genome consists of a 6,361,549-bp chromosome and two plasmids (99,385 bp and 312,136 bp). The genome encodes 5,915 protein-coding sequences, 56 tRNAs, and five copies each of the 5S, 16S, and 23S rRNA genes.

Alterations of DNA Repair and Immune Infiltration in Radiation-Induced Intestinal Injury.

Objectives: The intestine exhibits high radiosensitivity and is susceptible to damage during radiotherapy for abdominal or pelvic tumors, especially at radiation doses exceeding 5 Gy, which can lead to severe gastrointestinal complications. This study aims to elucidate the mechanisms of DNA repair and immune responses in radiation-induced intestinal injury, with the goal of enhancing radiotherapy efficacy.

Methods: We employed weighted correlation network analysis (WGCNA) to analyze RNA sequencing data from intestinal tissues collected at various time points following irradiation, as well as from mice with targeted disruption of the NFE2-like bZIP transcription factor 2 (Nrf2) gene and their wild-type counterparts.

Effect of Linn. on the Physicochemical Properties and Microbial Community Structure of Inter-Rhizosphere Soils.

Aims: The aim of this study was to elucidate the effect of Linn. ( L.) on the structure and abundance of the soil microbial community.

CRY1-GAIP1 complex mediates blue light to hinder the repression of PIF5 on AGL5 to promote carotenoid biosynthesis in mango fruit.

Carotenoids are essential natural pigments that not only determine the commercial value of horticultural crops through colouration but also serve as vital antioxidants and provitamin A precursors in the human diet. Our previous research has demonstrated that blue light induces carotenoid biosynthesis in mango fruit. However, a critical knowledge gap remains regarding how blue light regulates carotenoid biosynthesis in fruit.

An Ultra-High Performance Liquid Chromatography-Mass Spectrometry Method Based on Solid-Phase Extraction Developed for the Analysis of Polyphenols in Prunus Mume Sieb. et Zucc.

Background: Prunus mume Sieb. et Zucc. (P.

Pharmacokinetics, Tissue Distribution, and Excretion of 9-Methylfascaplysin, a Potential Anti-Alzheimer's Disease Agent.

9-Methylfascaplysin, a derivative of the marine natural product fascaplysin, has shown promising anti- Alzheimer's disease (AD) potential through its anti-β-amyloid (Aβ) neuroprotective effects. However, the pharmacokinetics (PK) of 9-methylfascaplysin, crucial for its preclinical evaluation, have not been thoroughly studied. In this study, we developed and validated a sensitive and accurate ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the quantification of 9-methylfascaplysin in rat plasma.

New Insight Into the Mechanism of Nitrite Enhancement on Heterotrophic Nitrification and Aerobic Denitrification Bacterium in Gene Expression.

The growth and nitrogen metabolism of heterotrophic nitrification-aerobic denitrification (HN-AD) bacteria are affected by nitrite, but the mechanisms underlying this for strain Acinetobacter johnsonii EN-J1 are unclear. In this study, the addition of 10 mg/L nitrite increased the reduction rate of ammonium by 1.0 mg/L/h, and 20 mg/L nitrite increased the reduction rate of nitrate by 3.

Impact of Activation Conditions on the Electrochemical Performance of Rice Straw Biochar for Supercapacitor Electrodes.

Biochar, derived from agricultural waste, has gained significant attention as a sustainable material for energy storage applications due to its high surface area, tunable porosity, and environmental benefits. This study investigates the electrochemical performance of rice straw biochar (RSBC) as an electrode material, with a focus on the effects of activation temperature, activation ratio, and activation time. Among the prepared samples, RSBC-2, activated at 800 °C with a 1:2 KOH ratio for 0.

Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis.

Radiotherapy is a method of treating cancer through radiation aimed at killing cancer cells or inhibiting their growth. However, radiotherapy has numerous side effects because it kills tumors while causing damage to normal cells or tissues. The literature shows that radiation can cause damage to heart tissue.

Efficient adsorption of Sb(III/V) by zirconium-functionalized cellulose microspheres and their application in actual underground water of mine cavern.

At present, with the mining of antimony, highly toxic antimony has seriously threatened the safety of water sources and jeopardized human health. It remains a challenge to create adsorbents that are easy to separate, efficient and have high adsorption capacity. In this study, the zirconium-functionalized MCC microspheres (MCC-g-GMA-IDA-ZrOCl) have been successfully synthesized using radiation grafting technique and applied for Sb(III/V) capture.

Structural characterization and anti-inflammatory activity of a neutral polysaccharide from Dendrobium huoshanense C. Z. Tang et S. J. Cheng.

A neutral polysaccharide (NDHP-2-1) was isolated from Dendrobium huoshanense C. Z. Tang et S.

Recent advances in the nitrogen cycle involving actinomycetes: Current situation, prospect and challenge.

Actinomycetes are essential for sustaining the ecosystem's nitrogen balance and stimulating plant development. In contrast, existing detection and culture techniques for actinomycetes are still limited, making it difficult to fully assess their role in the nitrogen cycle. This review emphasized the advantages of actinomycetes in ecological restoration, outlined the current status and challenges of research on nitrogen cycling by actinomycetes.