Development of New Blood Immunoassay and Biomarkers for Tau in the Diagnosis of Alzheimer's Disease.

Post-translational modifications, such as truncation facilitated by proteases and phosphorylation mediated by protein kinases, play pivotal roles in Tau protein function and cellular processes. The detection of distinct Tau forms in plasma has garnered significant interest in the scientific and translational communities. We discovered monoclonal antibodies (mAbs) using the hybridoma technique by immunizing mice with different Tau proteins.

Assessment of adipokine and inflammation biomarkers with cancer risk among Chinese men: A prospective cohort study.

Background: Obesity and chronic inflammation are associated with cancer risk. We investigated the association between adipokines, inflammation markers, and cancer risk among Chinese men.

Methods: Using pre-diagnosis fasting plasma samples from 4,051 (6.

Occurrence, dissemination, and inactivation technologies of pathogens in the process of common solid waste treatment and disposal.

Solid waste is an important source of pathogens. During the process of collection, transportation, and treatment, pathogens may spread through direct contact, aerosol transmission, leachate discharge, and waste-derived by-products, posing threats to human health and ecological environment. The types and abundance of pathogens vary across different waste types and treatment methods.

Radiation-sensitive circRNA promotes intestinal regeneration.

Background: The intestine is one of the most sensitive organs to ionizing radiation (IR), and radiation-induced intestinal injury (RIII) impacts the quality of life of patients undergoing radiotherapy. There are limited early diagnostic biomarkers and specific medicines clinically approved for RIII. Therefore, we sought to identify new theranostic targets to prevent RIII and to facilitate the reestablishment of the intestinal epithelium.

Associations of Pre-diagnostic Serum Liver Enzyme Levels with Lung Cancer Risk in Predominantly Low-income African and European Americans.

Previous studies have linked liver diseases to lung cancer (LC) risk; however, few studies evaluated the associations of circulating liver enzyme levels with LC risk. We conducted a study of 353 incident LC cases and 646 matched controls with baseline serum alanine aminotransferase (ALT) and of 552 cases and 1039 matched controls with baseline serum alkaline phosphatase (ALP) nested within the Southern Community Cohort Study. Conditional logistic regression and generalized linear models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) among all study participants and by stratification of potential effect modifiers.

The safety and feasibility of telerobotic cholecystectomy via a 5G network: a prospective controlled clinical trial.

Background: Since advances in the fifth-generation (5G) communication technology have effectively facilitated the development of robotic telesurgery, the popularity of telerobotic operations has increased. The purpose of this study was to evaluate the safety and feasibility of robotic telecholecystectomy with a 5G wireless network using a new domestic robotic surgical system.

Methods: This study is a prospective controlled clinical trial.

Photochemical reaction of 4-chlorobiphenyl with nitrous acid in atmospheric aqueous solution.

The photochemical reaction of 4-chlorobiphenyl (4-PCB) and HONO in atmospheric aqueous phase was studied by 355 nm laser flash photolysis combined with 365 nm UV steady-state irradiation technique. The steady-state study showed that the conversion rate of 4-PCB was affected by the initial concentration of 4-PCB, pH value and HONO concentration, while chloride ions had little effect on the conversion of 4-PCB. HONO produces an HO˙ attack on 4-PCB to form a 4-PCB-OH adduct with the second-order reaction rate constant of (9.

Identification of uridine phosphatase 1 as a potential therapeutic target in gastric cancer by integrated bioinformatics analysis and experimental validation.

Gastric cancer remains a major global health challenge, and its early diagnosis and prognosis prediction pose significant challenges to the current clinical treatment of gastric cancer. Finding gastric cancer biomarkers is essential to comprehending its pathophysiology and creating novel targeted treatments. Following the acquisition and processing of the gastric cancer sample, the single-cell RNA sequencing data, monocyte subpopulation characterization, and cell type identification were performed.

CBX2 and EZH2 cooperatively contribute to 5-Fu resistance in gastric cancer by suppressing ferroptosis via trimethylation of H3k27.

Background And Objective: Chromobox 2 (CBX2) plays a pivotal role in the malignant phenotypes of several cancers, which has been found to up-regulated in gastric cancer (GC). This study aimed to investigate the specific function and underlying mechanism of CBX2 in GC.

Methods: The potential role of CBX2 in GC was uncovered based on online bioinformatic analysis.

Sex-Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild-Based Analysis and Implications for Healthy Aging.

Gut microbial stability typically decreases with physiological aging. This decline may vary between sexes and can potentially be mitigated by adopting a healthy lifestyle. Microbial guilds, defined as functionally coherent groups of bacteria, may serve as meaningful ecological indicators of aging.

Unlocking ESCC Progression: CCL15-CCR1 Axis Activates AKT/ERK1/2/c-Jun/CDK2 Pathway.

Globally recognized as a major oncological concern, esophageal squamous cell carcinoma (ESCC) exhibits a high incidence rate among malignancies originating from the digestive system's epithelial lining. Tumor cells can secrete chemokine (C-C motif) ligand 15 (CCL15) to recruit C-C motif chemokine receptor 1 (CCR1)-positive macrophages, thereby facilitating immune evasion and promoting tumor progression. However, it remains unclear whether CCL15 secreted by tumor cells can also act directly on CCR1 expressed on the same tumor cells to exert tumor-regulatory effects.

Overlooked risk of antibiotic resistance genes in typical landfill plumes and their influencing factors.

Landfills are one of the primary reservoirs of antibiotic resistance genes (ARGs). Previous studies always focus on the distribution of ARGs in landfill leachate, while the distribution of ARGs in groundwater around the landfill and the corresponding influencing factors are always overlooked. In this study, seven groundwater samples and one leachate sample were collected from a typical landfill in Yueqing, China.

Predictors of testicular salvage failure in pediatric testicular torsion: a retrospective analysis of clinical and imaging risk factors.

Objectives: This study aimed to construct preoperative nomograms for predicting testicular necrosis in pediatric patients with testicular torsion (TT).

Methods: This retrospective study analyzed clinical data from 176 patients diagnosed with TT at the Department of Pediatric Surgery, Ningxia Medical General Hospital, between January 2010 and January 2023. To identify independent risk factors for testicular necrosis, both univariate as well as multivariate logistic regression analyses were used.

Actg2 mutation cause megacystis-microcolon-intestinal hypoperistalsis syndrome by impairing smooth muscle contractility.

Purpose: Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS; OMIM:619431) is a congenital disorder of the urinary and digestive systems that is caused by contractile dysfunction of smooth muscles. Recent studies have shown that ACTG2(HGNC:145) is the main gene involved in the pathogenesis of this disease. Herein, we aimed to investigate the correlation between the Actg2 mutation and disease phenotypes.

Acute exogenous lipoid pneumonia leading to severe ARDS: a case report.

Background: Exogenous lipoid pneumonia, a form of pneumonia caused by the aspiration of lipid substances, is often associated with the use of mineral oil. Historically, cases have predominantly been reported in young children, elderly, or individuals with compromised physical strength or neurological disorders, with the majority presenting as mild or chronic conditions. Upon cessation of exposure to lipids, symptoms typically showed improvement.

Circulating gut microbial metabolites and risk of coronary heart disease: a prospective, multi-stage study.

Background: Despite growing evidence linking gut microbiota and microbial metabolites to human cardiometabolic health, few studies have systematically examined circulating microbial metabolites with incident coronary heart disease (CHD).

Methods: We conducted a multi-stage metabolomics study involving five prospective cohorts. Discovery involved an untargeted plasma metabolite profiling among 896 incident cases and 896 age-/sex-/race-matched controls (∼300 pairs per race: Black, White, Asian) from the Southern Community Cohort Study (SCCS) and Shanghai Women's Health Study and Shanghai Men's Health Study (SWHS/SMHS).

Urinary metabolites in association with kidney cancer risk.

Kidney cancer incidence has increased worldwide in recent decades. While metabolomic studies have shown promise in unveiling mechanisms underlying disease development, few studies have investigated prediagnostic urinary metabolites and kidney cancer risk. We conducted a case-control study nested within the Shanghai Women's and Men's Health Studies to prospectively investigate the association between urinary metabolites and kidney cancer risk to understand its etiology and the underlying biological mechanisms.

Lipschitz-Nonlinear Heterogeneous Multi-Agent Adaptive Distributed Time-Varying Formation-Tracking Control with Jointly Connected Topology.

This paper studies the problem of time-varying formation-tracking control for a class of nonlinear multi-agent systems. A distributed adaptive controller that avoids the global non-zero minimum eigenvalue is designed for heterogeneous systems in which leaders and followers contain different nonlinear terms, and which relies only on the relative errors between adjacent agents. By adopting the Riccati inequality method, the adaptive adjustment factor in the controller is designed to solve the problem of automatically adjusting relative errors based solely on local information.

Corrigendum to "Multiple lymph nodes enlargement and fever as main manifestations of nocardiosis in immunocompetent individuals: Two case reports" [Heliyon Volume 10, Issue 15, 15 August 2024, e35681].

[This corrects the article DOI: 10.1016/j.heliyon.

LncRNA SNHG14 Regulated by ZNF460 Promotes Gastric Cancer Progression and Metastasis by Targeting the miR-206/FNDC3A Axis.

The current study investigated the functional role of long non-coding RNA SNHG14 (lncRNA SNHG14) in gastric cancer (GC) progression and its underlying mechanisms. Compared with para-carcinoma tissues, SNHG14 was upregulated in GC tissues, correlating with a poor prognosis in GC patients. SNHG14 knockdown significantly weakened the proliferation, migration and invasion capabilities of GC cell lines while enhancing the apoptosis ability of GC cells.

Association of depression, anxiety with asthma outcomes and allergic comorbidities: results from the National Health Interview Survey.

Background: Depression and anxiety are common among asthmatic patients and are associated with asthma control. However, there is limited research on the nationwide prevalence of mental disorders and the association of depression/anxiety with asthma outcomes, remission and allergic comorbidities.

Objective: Our study aimed to evaluate the effect of depression/anxiety on asthma outcomes and allergic comorbidities.

Real-Time Single-Particle Tracking of Intracellular pH Dynamics during Ferroptosis Using Plasmonic Core-Satellite Nanostructures.

Ferroptosis, an iron-dependent regulated cell death process, is characterized by lysosomal membrane permeabilization and pH dysregulation. Here, we report a DNA-programmed plasmonic nanoprobe based on i-motif-mediated gold core-satellite nanostructures (Au CSNSs) for single-particle resolution mapping of intracellular pH dynamics during ferroptosis. The i-motif DNA linker undergoes pH-dependent conformational switching, dynamically tuning the interparticle gap between 45 nm gold core nanoparticles (Au core NPs) and 15 nm gold satellite nanoparticles (Au satellite NPs).

Deletion of gene leads to autistic-like behavior in mice by inhibiting AMPK signal pathway.

Introduction: Autism Spectrum Disorder (ASD) is a hereditary neurodevelopmental condition influenced by genetic alterations, particularly in genes regulating neural development and synaptic plasticity. Emerging evidence suggests that the gene plays a role in energy metabolism and neuronal development, indicating its potential relevance to ASD pathogenesis.

Methods: To investigate the role of in ASD, we generated knockout (KO) mice and conducted a series of behavioral tests, histological analyses, and molecular assays.

Primary Alkyl Amine-Mediated ZnSe@ZnS QDs from Giant Flowers to Nanorods.

Understanding the relationship between surface ligands and colloidal quantum dots (QDs) is crucial for precisely controlling their size, morphology, and composition. Compared to traditional Cd- or Pb-based II-VI QDs, the precise synthesis of zinc-based colloidal ZnSe@ZnS QDs remains challenging due to zinc's high oxytropism and diffusion tendencies. Herein, we introduce a primary alkyl amine-mediated surface engineering strategy that enables morphology control: from giant flowers and clovers to branches and nanorods (NRs).