Letrozole ovulation regimen for frozen-thawed embryo transfer in women with polycystic ovary syndrome: a muti-centre randomised controlled trial.

Background: Polycystic ovary syndrome (PCOS) patients typically undergo either an ovulation induction regimen or a programmed regimen for endometrial preparation before frozen embryo transfer (FET). However, the superiority of one approach over the other remains controversial. While previous studies suggest that the letrozole regimen may improve pregnancy outcomes, prospective studies are insufficient.

Role and mechanism of RPA1 in the development and progression of glioma.

Glioma is a highly malignant primary tumor of the central nervous system, characterized by highly invasive behavior and a high recurrence rate. The current treatment options for gliomaoften have unsatisfactory outcomes. Replication protein A1 (RPA1), a component of the RPA heterotrimer, has been identified as a potential oncogene implicated in the development and clinical prognosis of various types of solid tumors, including liver cancer, nasopharyngeal carcinoma and gastrointestinal cancer.

Carefix hexaxial spatial frame versus Ilizarov circular external fixator in treating high-energy tibial shaft fractures: a retrospective study.

Background: External fixation is an effective treatment for high-energy tibial shaft fractures (HETSFs), often with severe soft tissue damage. The purpose of this study was to provide preliminary insights into potential differences in clinical outcomes between the Carefix Hexaxial Spatial Frame (CHSF) and the Ilizarov Circular External Fixator (ICEF) in the definitive treatment of HETSFs.

Methods: We retrospectively analyzed 46 HETSFs patients, treated with CHSF ( = 26) or ICEF ( = 20), in our department from January 2019 to July 2022.

Intestinal KLHL12 is dispensable for lipid absorption and chylomicron metabolism.

Kelch-like protein 12 (KLHL12) has been shown to regulate coat complex II (COPII)-mediated endoplasmic reticulum (ER)-to-Golgi trafficking of large cargos carrying procollagen or apolipoprotein B-100 containing very-low-density lipoprotein (VLDL). It is known that lipid absorption and chylomicron metabolism in enterocytes are dependent on apolipoprotein B-48 (ApoB48) and COPII-mediated trafficking. This study aimed to investigate whether KLHL12 in the intestine regulates dietary lipid absorption, chylomicron assembly, and metabolic phenotypes in mice.

Corrigendum to "Multiple lymph nodes enlargement and fever as main manifestations of nocardiosis in immunocompetent individuals: Two case reports" [Heliyon Volume 10, Issue 15, 15 August 2024, e35681].

[This corrects the article DOI: 10.1016/j.heliyon.

LDL regulates intestinal stem cell homeostasis via PPAR pathway.

Epidemiological studies have highlighted a strong association between hyperlipidemia and an increased risk of cancer in the gut. Intestinal stem cells (ISCs) have been demonstrated as the cells of origin for tumorigenesis in the gut. However, the impact of hyperlipidemia on ISC homeostasis remains unclear.

New-onset diabetes worsens prognosis of patients with pancreatic ductal adenocarcinoma after R0 resection: A multicenter study.

Background: The risk of pancreatic ductal adenocarcinoma (PDAC) is increased in patients with diabetes mellitus (DM), particularly in new-onset diabetes (NOD). This study aimed to analyze the effect of NOD on the outcomes of patients with PDAC after R0 resection.

Methods: PDAC patients from six centers in China undergoing R0 resection from 2015 to 2022 were included.

A Comparative Study of Taylor Spatial Frame and Monolateral External Fixator for Treating Infected Tibial Defects With Concomitant Soft Tissue Loss.

Objective: The management of infectious tibial defects with concomitant soft tissue loss (ITD-STL) continues to pose substantial clinical challenges in orthopedic practice. This study aimed to compare the clinical efficacy of the Taylor Spatial Frame (TSF) versus the Monolateral External Fixator (MEF) in achieving bone and soft tissue reconstruction for ITD-STL.

Methods: A retrospective cohort study was performed on 49 consecutive patients with ITD-STL admitted between July 2010 and September 2022.

Relationship between endothelial activation and stress index and all-cause mortality in rheumatoid arthritis patients: a moderating effect of gamma-glutamyl transferase.

Aim: This study aimed to explore the relationship between endothelial activation and stress index (EASIX) and all-cause mortality in patients with rheumatoid arthritis (RA), and to further examine whether gamma-glutamyl transferase (GGT) influences this association.

Methods: We included 2,543 participants with RA from the National Health and Nutrition Examination Survey (NHANES) in this retrospective cohort study. The study outcome was considered to be all-cause mortality.

Analysis of influencing factors on the rate of high-quality embryos induced by rectangular plan during in vitro fertilization.

Objective: To explore factors influencing high-quality embryo rate in long protocols for controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF).

Methods: It was a retrospective case-control study including patients receiving assisted pregnancy treatment at the Reproductive Medicine Department of the Maternal & Child Care Center of Qinhuangdao from January 2018 to October 2023. This study adopted 724 treatment cycles using COH involving intermediate-acting and long-acting protocols.

Robotic distal pancreatectomy using the Warshaw technique demonstrated superior short-term prognosis compared to the laparoscopic approach: propensity-matched cohort study.

Background: Minimally invasive spleen-preserving distal pancreatectomy (SPDP) presents technical challenges and remains a topic of debate. This study seeks to compare the splenic preservation techniques, especially the Kimura and Warshaw methods, with distal pancreatectomy with splenectomy (DPS) and to examine factors influencing short-term patient prognostic outcomes.

Methods: A retrospective analysis was undertaken of all consecutive cases of minimally invasive distal pancreatectomy, both with and without spleen preservation, conducted at our center from January 2020 to May 2024.

Macromolecule-Enriched Solvation Enabling High-Voltage Sodium-Ion Batteries.

Sodium-ion batteries (SIBs) are emerging as a viable alternative for sustainable and cost-effective energy storage, yet their energy density is curtailed by relatively low voltage outputs (< 4 V) due to the lack of high-voltage electrolytes. Here, for the first time, we describe a high-voltage Na electrolyte featuring a macromolecule-enriched solvation architecture. The vulnerable small molecules in the Na solvation shell are replaced by macro polyamide (PA) molecules with high thermodynamic resilience, ensuring a wide electrochemical stability window for the electrolytes with suppressed oxidative/reductive decomposition.

Hyperbaric oxygen treatment for chronic insomnia at high altitude: A prospective, randomized, open-label, parallel-group trial.

Background: Hyperbaric oxygen (HBO) has been proposed to be effective for treating chronic insomnia at high altitudes.

Methods: Patients suffering from chronic insomnia at high altitude were randomly assigned at a 1:1 ratio to either the hyperbaric oxygen (HBO) treatment group or the control group for a 10-day procedure. The primary outcome was insomnia status, which was assessed via the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI).

MPCD Index for Hepatocellular Carcinoma Patients Based on Mitochondrial Function and Cell Death Patterns.

Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer with a poor prognosis. During the development of cancer cells, mitochondria influence various cell death patterns by regulating metabolic pathways such as oxidative phosphorylation. However, the relationship between mitochondrial function and cell death patterns in HCC remains unclear.

The dynamic patterns of metabolic-associated fatty liver disease and its severity and risk of cardiovascular disease.

Background: While metabolic-associated fatty liver disease (MAFLD) is widely recognized as a risk factor for cardiovascular disease (CVD), the connection between the dynamic patterns of severity of hepatic steatosis and the associated CVD risk remains uncertain.

Method: This study included 71,098 participants from the Kailuan Study without CVD or cancer who underwent two consecutive biennial health screenings between 2006 and 2008 and were followed up until 2022. MAFLD and its severity were assessed using ultrasound.

A Comprehensive Bibliometric Analysis and Visualization of Publication Trends in Hip-Spine Syndrome.

Objective: Hip-spine syndrome (HSS) was first described in 1983 as a syndrome characterizing the concurrent symptoms of lumbar and hip joint degenerative disease. This study aims to elucidate the research trends, hot topics, and influential publications in HSS through bibliometric analysis.

Methods: The Web of Science database was used to search for all literature on HSS from 1983 to 2024.

The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities.

Objective: To investigate the differences in headache and comorbidity symptoms between migraine patients with negative and positive food specific IgG antibodies, and explore the correlation between these symptoms with food specific IgG antibodies.

Methods: A total of 129 migraine patients were enrolled. Seven questionnaires were used to gather information regarding the symptoms of migraine, gastrointestinal, depression, anxiety, and sleep.

Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males.

Testosterone deficiency can cause abnormal lipid metabolism in men, leading to hyperlipidemia. We identified the testosterone-degrading bacterium Pseudomonas nitroreducens in the fecal samples of male patients with hyperlipidemia. Gastric administration of P.

Research progress of gene therapy combined with tissue engineering to promote bone regeneration.

Gene therapy has emerged as a highly promising strategy for the clinical treatment of large segmental bone defects and non-union fractures, which is a common clinical need. Meanwhile, many preclinical data have demonstrated that gene and cell therapies combined with optimal scaffold biomaterials could be used to solve these tough issues. Bone tissue engineering, an interdisciplinary field combining cells, biomaterials, and molecules with stimulatory capability, provides promising alternatives to enhance bone regeneration.

Five miRNAs identified in fucosylated extracellular vesicles as non-invasive diagnostic signatures for hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer that presents significant challenges for early detection. This study introduces the GlyExo-Capture method for isolating fucosylated extracellular vesicles (Fu-EVs) from serum. We analyze microRNA (miRNA) profiles from Fu-EVs in 88 HCC patients and 179 non-HCC controls using next-generation sequencing (NGS) and identify five miRNAs (hsa-let-7a, hsa-miR-21, hsa-miR-125a, hsa-miR-200a, and hsa-miR-150) as biomarkers for HCC diagnosis.