Diabetes is associated with impaired skeletal muscle quality, not quantity, in older adults, based on CT-derived chest muscle metrics.

Objective: The study assessed the association between diabetes and both the quantity and quality of skeletal muscle among older adults, based on an analysis of chest computed tomography (CT) scans.

Methods: In this cross-sectional study of 1225 adults aged 65 years or more, 255 had type 2 diabetes mellitus. All participants had chest CT scans.

Phosphorylation of the transcription factor PoWRKY31 by PoKIN10 activates lignin biosynthesis to improve tree peony drought tolerance.

The SNF1-Related Protein Kinase 1 (SnRK1) signaling cascade is highly conserved and plays a crucial role in coordinating various cellular processes in plants. However, its regulatory mechanisms in stress responses remain largely unclear. Here, we started from the perspectives of transcriptional regulation, protein-protein interaction, and posttranslational modification, and through the integration of multiple molecular biology approaches and functional validation methods, we conducted a detailed analysis of the mechanisms by which PoKIN10 (SnRK1 catalytic subunit), PoWRKY31, PoWRKY75, and PoCCoAOMT participate in drought tolerance in tree peony.

The mechanism of NK cell expression of RANKL/RANK/OPG pathway in mouse models of femoral head necrosis.

This study aimed to investigate the role of natural killer (NK) cells in the RANKL/RANK/OPG pathway in osteonecrosis of the femoral head (ONFH). C57 mice were categorized into a control group, an observation group (10 mice each), and an experimental group comprising 4 NK cell knockout mice. A hormone-induced femoral head necrosis model was created by administering lipopolysaccharide combined with methylprednisolone for 8 weeks to the experimental and control groups.

Evaluating the operational efficiency of the compact urban medical group in Qiqihar based on the three-stage DEA and Malmquist index model.

Background: Since the establishment of medical alliances, a key issue regarding their ability to better address the imbalance in China's medical resources lies in the changes in operational efficiency before and after their formation. This study focuses on urban medical groups, a reform model of medical alliances, and systematically analyzes the changes in operational efficiency before and after the group-based reform, aiming to provide empirical evidence for improving the group-based management model.

Methods: This study employs a dual-method framework combining three-stage DEA for static efficiency evaluation and Malmquist index analysis for dynamic assessment.

Thermodynamic regulation of aerosol pH by temperature and humidity: The role of gas-particle partitioning of semi-volatile inorganic species in a subtropical region.

Aerosol acidity (pH) plays a critical role in atmospheric chemical processes, secondary aerosol formation, and urban air quality. Based on five years of hourly observations (2019-2023) in subtropical Dongguan, this study investigates the variability and thermodynamic regulation of aerosol pH, with a focus on aerosol liquid water content (ALWC), hydrogen ion (H) concentrations, and their interactions. Secondary inorganic aerosols (SIA), including NH, SO, NO and Cl, accounted for 92 ± 4 % of total water-soluble inorganic ions (WSIIs), with sufficient total NH (TNH) and non-volatile cations (NVCs) available to neutralize acidic species.

Integrating HIV prevention services into care settings for people with opioid use disorder (OUD): a study protocol for implementation strategy development and modeling.

Background: The overlapping epidemics of opioid use disorder (OUD) and HIV present a critical public health challenge. Although people with OUD frequently engage with healthcare settings, uptake of HIV prevention services such as pre-exposure prophylaxis (PrEP) remains low. Integrating HIV prevention into routine OUD care could reduce new infections, but scalable, evidence-based strategies are lacking.

Malnutrition and Muscle Loss Mediate the Association Between NT-proBNP and Mortality in Hospitalized Older Adults.

Background & Aims: Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP), a biomarker of cardiac stress, predicts mortality in heart failure. Its association with outcomes in older hospitalized patients without overt heart failure, and potential mediation by malnutrition and muscle loss, remains unclear. The purpose of this study was to assess the association between NT-proBNP and mortality in hospitalized oldest-old adults (≥80 years) and to explore the mediating role of malnutrition and muscle loss.

Risk of lymphomas among people with HIV in the United States during 2001-2019.

Introduction: Lymphomas are among the most common malignancies in people with HIV (PWH). Although the widespread use of combination antiretroviral therapy has significantly reduced the risk of lymphoma among PWH, data on specific lymphoma subtypes remain limited and outdated.

Methods: Using data from the HIV/AIDS Cancer Match Study, a U.

Bibliometric analysis of immunogenic cell death in hepatocellular carcinoma.

Objectives: This study aimed to delineate global research trends in immunogenic cell death (ICD) within hepatocellular carcinoma (HCC) by mapping collaborative networks, thematic shifts, and high-impact findings. Using VOSviewer network visualisation and R-bibliometrix quantitative metrics, we sought to show how scientific output has evolved and to pinpoint research gaps that may guide future investigations.

Methods: We retrieved 568 publications from the Web of Science Core Collection (2000-2024) using a tailored keyword strategy encompassing "Hepatocellular carcinoma" and "Immunogenic cell death.

Hierarchically functionalized PCL/CS with synergistic PDA-mediated antioxidant therapy and NGF-activated neurogenesis for spinal cord injury regeneration.

Spinal cord injury (SCI) is a common disease worldwide. Tissue engineering scaffolds are considered a promising strategy for SCI treatment, but their efficacy is significantly limited by the local abundance of MSC (mesenchymal stem cell) and a highly inflammatory microenvironment. In this study, a multifunctional composite scaffold of polycaprolactone/chitosan (PCL/CS) loading polydopamine (PDA)-coated nerve growth factor (NGF) loaded onto was prepared using a freeze-drying method.

A Study of Data Augmentation for Learning-Driven Scientific Visualization.

The success of deep learning heavily relies on the large amount of training samples. However, in scientific visualization, due to the high computational cost, only few data are available during training, which limits the performance of deep learning. A common technique to address the data sparsity issue is data augmentation.

N6-methyladenosine RNA landscape in the aged mouse hearts.

Objective: Cardiac aging is a major risk factor for the development of cardiovascular diseases. Although evidence suggests an association between N6-methyladenosine (m6A) modification and numerous cardiovascular diseases, its role in cardiac aging remains unclear. This study was conducted to elucidate the role of m6A modification in cardiac aging and the molecular mechanisms involved.

Sexually Transmitted Infections and Risk of Human Immunodeficiency Virus Transmission.

Purpose Of The Review: Sexually transmitted infections (STIs) include a diverse set of bacteria, viruses, parasites, and other pathogens that can facilitate transmission of Human Immunodeficiency Virus (HIV). However, the extent to which STIs increase HIV risk and public health approaches to address this are still evolving.

Recent Findings: Compelling evidence suggests STIs increase the risk of HIV acquisition and transmission.

The association of calf circumference with nutritional risk and mortality in type 2 diabetes aged over 80 years inpatient Chinese.

Objective: The aim of this study was to determine whether low calf circumference (CC) could predict nutritional risk and the cut-off value of CC in type 2 diabetes (T2D) older patients. We also aimed to evaluate the risk factors for predicting mortality in T2D.

Methods: A total of 296 older patients with T2D were enrolled in this study and followed for 2.

Chinese expert consensus on failure and revision after anterior cruciate ligament reconstruction.

Background: With the recent rise in anterior cruciate ligament (ACL) reconstruction surgeries in China, a corresponding increase in surgical failures has been observed. Variability in primary surgical techniques and the intricacies of failure mechanisms have introduced significant challenges in diagnosing failures, planning procedures, and conducting revision surgeries.

Methods: In response to these challenges, the Chinese Association of Orthopaedic Surgeons (CAOS) and the Chinese Society of Sports Medicine (CSSM) initiated the development of an expert consensus on ACL reconstruction failure and revision.

M1 Macrophage is a Novel Potential Trigger for Endothelial Senescence: Role of Exosomal miR-155 Targeting SOCS1 Signal.

Age-related proinflammatory microenvironment induced by infiltration of M1 macrophages promotes endothelial senescence-mediated vascular diseases. Macrophages exert their immunomodulatory effects by releasing exosomes. However, the underlying mechanisms governing endothelial cell senescence induced by exosomes derived from M1 macrophages (M1-Exo) remain elusive.

Identification of Key Genes and Potential Therapeutic Targets in Sepsis-Associated Acute Kidney Injury Using Transformer and Machine Learning Approaches.

Sepsis-associated acute kidney injury (SA-AKI) is a life-threatening complication of sepsis, characterized by high mortality and prolonged hospitalization. Early diagnosis and effective therapy remain difficult despite extensive investigation. To address this, we developed an AI-driven integrative framework that combines a Transformer-based deep learning model with established machine learning techniques (LASSO, SVM-RFE, Random Forest and neural networks) to uncover complex, nonlinear interactions among gene-expression biomarkers.

Multichannel Magnetic Switching Observed in a Fe(II) Spin-Crossover Compound Bearing Rotatable Ligands.

The magnetic properties of materials can be modulated by external stimuli through either spin-state transition or modification of the coordination environment. However, achieving both mechanisms in a single-phase system via sophisticated molecular design remains a formidable challenge. In this work, we present an Fe(II) spin-crossover (SCO) complex incorporating rotatable isoxazole ligands, which exhibits a three-step reversible magnetic transition from 120 to 300 K.

A cross-sectional survey on the relationship between metacognitive ability and completion ability among Chinese nursing students: the mediating role of perceived campus atmosphere ability and the moderation of simulation teaching method.

Background: With the continuous development of medical technology, the demand for high-quality of nursing student training is increasing, and nursing, as an important part of health care service work, is facing new challenges. In recent years, the proportion of nursing undergraduates among registered nurses in China has been increasing year by year. Enhancing the completion ability of nursing students and improving the quality of undergraduate nursing training is a need for the development of nursing education.

Preoperative computed tomography-guided localization pulmonary nodules: comparison between accura and soft anchored wires.

Background: Both Accura wire and soft anchored wire strategies can be employed for the preoperative computed tomography (CT)-guided localization of pulmonary nodules (PNs). The relative outcomes associated with these two distinct localization strategies, however, remain uncertain. This study thus sought to explore the relative safety and efficacy of preoperative CT-guided Accura wire and soft anchored wire localization for PNs.

Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy.

Dilated cardiomyopathy (DCM) is a severe cardiac condition characterized by ventricular dilation and systolic dysfunction, often leading to heart failure. While the DNA damage response (DDR) pathway is increasingly implicated in DCM pathogenesis, the precise mechanisms linking DDR activation to specific pathological features like adverse extracellular matrix (ECM) remodeling and fibrosis remain poorly understood. Interferon-inducible protein 16 (IFI16), a known DNA sensor involved in DDR and inflammatory signaling, emerges as a potential mediator in this process.

Association of proBNPage with all-cause and cardiovascular mortality among US adults: an analysis of data from the National Health and Nutrition Examination Survey.

Objective: Biological age assessed by the Klemera and Doubal method (KDM) and phenotypic age (PhenoAge) was considered as a marker for ageing-related outcomes because it reflects different aspects of biological ageing and health, which are associated with increased risk of death. proBNPage based on N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a novel index for biological age estimation. However, the independence of its relationship with clinical outcomes from established risk factors, KDM or PhenoAge remains uncertain.

Unlocking the molecular secrets of plants: advances in key gene mining and molecular breeding technology.

plants are famous for their ornamental, medicinal, and oil values. Due to the popularity of seed oil and cut flowers in the market, the mechanisms underlying related traits of plants have been fascinating, and the research work on them has increased rapidly in recent years, urging a comprehensive review of their research progress. To unlock the molecular secrets of plants, we first summarize the latest advances in their genome research.

Multimodal Synergistic Strategies for Diabetic Wound Healing Using Glucose Oxidase Nanocomposites: Therapeutic Mechanisms and Nanomaterial Design.

Diabetic wounds (DWs) are characterized by high blood glucose levels, and one of the primary strategies for regulating blood glucose is the use of glucose oxidase (GOx). This enzyme catalyzes the oxidation of glucose to produce D-gluconic acid, consuming oxygen and generating hydrogen peroxide (H₂O₂) in the process. In DWs, this reaction not only effectively reduces glucose concentrations at the wound site but also provides an antibacterial effect through the release of H₂O₂.