Niujiaodihuang Detoxify Decoction Inhibits D-GalN/LPS-induced Hepatocyte Ferroptosis by Maintaining Mitochondrial Homeostasis Via OMA1-OPA1 Pathway.

Niujiaodihuang Detoxify Decoction (NDD) has been shown to attenuate liver injury during acute liver failure by inhibiting ferroptosis, whereas the specific mechanism regulating ferroptosis remains to be elucidated. The LO2 liver cell injury model was induced with a combination of D-Galactosamine hydrochloride (D-GaIN) and lipopolysaccharide (LPS), followed by treatment with NDD-medicated serum. Hepatocyte injury, ferroptosis, and mitochondrial function homeostasis were assessed by measuring cell viability, inflammatory factors levels, lipid peroxidation, oxidative stress, expression of ferroptosis-related proteins, mitochondrial membrane potential, and expression of mitochondrial injury-related proteins.

Antibiotic-induced perturbations in C-N metabolic networks, and associated gene pathways in soybean (Glycine max) seedlings.

Antibiotic contamination in agricultural systems via organic fertilizer application and livestock wastewater irrigation are threats to crop physiology. However, the phytotoxic mechanisms affecting the pivotal carbon-nitrogen (C-N) metabolic nexus remain unclear. In this study, we investigated florfenicol-induced perturbations in C-N metabolic networks and associated gene regulatory pathways in soybean (Glycine max) seedlings.

Appealing smoky flavor formation and flavor quality enhancement in soy sauce: Synergistic ferulic acid metabolism by a yeast consortium (Starmerella etchellsii, Wickerhamiella versatilis, Debaryomyces hansenii).

Soy sauce, a traditional condiment, derives its characteristic smoky aroma from 4-vinylguaiacol (4-VG) and 4-ethylguaiacol (4-EG), formed by yeast metabolism of ferulic acid (FA). However, controlling the production of these compounds remains challenging. This study isolated four yeasts from soy sauce: Starmerella etchellsii was identified as a key 4-VG producer (28.

Developing and Applying RNA Empirical Models With Secondary Structure Insights for Orthoptera Phylogenetics.

The evolutionary patterns exhibited by the ring and stem regions of the RNA secondary structure are distinct. Incorporating RNA secondary structure information into evolutionary models can improve the reliability of phylogenetic trees constructed using RNA sequences. However, empirically derived RNA evolutionary models remain scarce.

Anti-Swelling Dual-Network Zwitterionic Conductive Hydrogels for Flexible Human Activity Sensing.

Conventional conductive hydrogels are susceptible to swelling in aquatic environments; which compromises their mechanical integrity; a limitation that poses a potential challenge to their long-term stability and application. In this study, a zwitterionic ion-conductive hydrogel was fabricated from polyvinyl alcohol (PVA), acrylic acid (AA), and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SMBA), forming a dual-network structure. A copolymer of zwitterionic SBMA and AA formed the first network, and PVA formed the second network by repeated freeze-thawing.

AoChk1 Is Required for Sporulation, Trap Formation, and Metabolic Process in .

Chk1, a highly conserved serine/threonine protein kinase, functions as a critical regulator of fungal cell cycle progression, mitotic fidelity, and DNA damage response. In this study, we characterized an orthologous Chk1 (AoChk1) in a ubiquitous nematode-trapping fungus, through targeted gene knockout coupled with integrated phenotypic, metabolomic, and transcriptomic analyses. This study aims to elucidate the function and potential regulatory networks of AoChk1 in .

Tunnel-structured IrO unlocks catalytic efficiency in proton exchange membrane water electrolyzers.

Proton exchange membrane water electrolyzers face challenges due to high iridium loading and sluggish oxygen evolution reaction kinetics when using conventional rutile-structured iridium oxide nanocatalysts. Here we find that iridium oxide catalysts with a specific tunnel-type crystal structure exhibit highly localized reactivity, where regions at tunnel mouths drive oxygen evolution far more efficiently than tunnel-wall regions. The intrinsic activity of tunnel mouths is 25-fold higher than that of tunnel walls, with shorter nanorods achieving a better balance between active site exposure and electron/mass transport efficiency.

3D reconstruction of a highly reflective surface based on multi-view fusion and point cloud fitting with a structured light field.

In this paper, a three-dimensional (3D) reconstruction method based on multi-view fusion and point cloud fitting is proposed to accurately reconstruct the highly reflective surface, which can effectively restore the highlight regions with only a single shot. A multi-view image fusion method based on the characteristics of microlens array cameras is used to remove unsaturated highlights. A new adaptive method, to our knowledge, based on binary images is designed to quickly extract the highlight regions.

Functional Zoning for Integrated Management of Transboundary Lake Basins from a Sustainable Development Perspective: A Case Study of Lake Victoria in East Africa.

From the perspective of sustainable development, multi-objective collaborative governance plays a vital role in the integrated management of transboundary lake basin systems. However, regionally differentiated governance solutions, based on the systematic identification of spatial use functions within the basin, remain undefined. Based on an analysis of regional evolution patterns, this study establishes a coupled zoning framework to identify conflict types and synergetic relationships while quantifying the characteristics of the three spatial use functions: agricultural production, urban development, and ecological conservation.

Efficient and complete biodegradation of Poly (butylene adipate-co-terephthalate) by a novel dual-member bacterial consortium from compost: Metabolic division of labor between BDP053 and BDT04.

Poly (butylene adipate-co-terephthalate) has been widely used, but its natural degradation is sluggish and microbes degrading PBAT efficiently are still limited. Herein, two novel bacteria BDP053 and BDT04 were isolated from compost and formed a PBAT-degrading consortium through metabolic complementation. They represent novel genus and species in families Steroidobacteraceae and Alcaligenaceae, respectively.

Hierarchically functionalized PCL/CS with synergistic PDA-mediated antioxidant therapy and NGF-activated neurogenesis for spinal cord injury regeneration.

Spinal cord injury (SCI) is a common disease worldwide. Tissue engineering scaffolds are considered a promising strategy for SCI treatment, but their efficacy is significantly limited by the local abundance of MSC (mesenchymal stem cell) and a highly inflammatory microenvironment. In this study, a multifunctional composite scaffold of polycaprolactone/chitosan (PCL/CS) loading polydopamine (PDA)-coated nerve growth factor (NGF) loaded onto was prepared using a freeze-drying method.

Carboxylate-Directed Self-Assembly of [MoO] Units for Enhanced Proton Conduction.

Three new polyoxomolybdate-based complexes functionalized with organic carboxylic acid ligands were synthesized and structurally characterized: Na[CNH][(MoO)(MoO)(HCO)(HO)]·2HO (complex ); [CNH][(MoO)(MoO)(HCO)] (complex ); and [CNH][(MoO)(HCO)]·2HO (complex ). Complexes - were obtained via condensation reactions between the organic carboxylic acid ligands and the [MoO(HO)] precursor. Each complex features [MoO(HO)] cores, organic carboxylate moieties, and protonated guanidiniums ([CNH]) as structural components.

Lateral quadratus lumborum block versus transversus abdominis plane block for perioperative analgesia in patients undergoing laparoscopic colorectal cancer surgery: a randomized, controlled clinical trial.

Background: Lateral quadratus lumborum block (QLB) and transversus abdominis plane block (TAPB) have been widely used in abdominal surgeries. This study aimed to compare the intraoperative analgesic effect, hemodynamic changes and postoperative complications of the two blocks in patients undergoing laparoscopic colorectal cancer surgery.

Methods: This was a randomized controlled trial that enrolled 189 patients scheduled for laparoscopic colorectal cancer surgery.

Effects of soy isoflavones on menopausal symptoms in perimenopausal women: a systematic review and meta-analysis.

Soy isoflavones are phytoestrogens found mainly in soy and its derivatives. Given their estrogen-like and antioxidant-inhibiting inflammatory effects, they have been hypothesized to be effective in treating menopausal symptoms. We conducted a systematic review in accordance with the PRISMA guidelines.

[Acupuncture inhibits cuproptosis to prolong the time window of thrombolysis by down-regulating cerebral FDX1 and DLAT in rats with cerebral infarction].

Objectives: To observe the effect of acupuncture on neuronal cuproptosis after thrombolytic treatment in rats with cerebral infarction (CI), so as to explore its underlying mechanisms in prolonging the time window of thrombolysis therapy for CI.

Methods: In the first part of the present study, 40 male SD rats were randomly divided into 5 groups:sham operation, model, 4.5 h thrombolysis, 6 h thrombolysis and acupuncture+6 h thrombolysis groups, with 8 rats in each group.

Insulin resistance and Alzheimer's disease: Exploring research hotspots and frontiers from a bibliometric and visual analysis (2005-2024).

Background: Alzheimer's disease (AD) and insulin resistance (IR) share intersecting pathological pathways, with IR increasingly implicated in AD pathogenesis. Systematic bibliometric analyses mapping the evolution of this interdisciplinary field remain limited.

Objective: To quantify global research trends, collaboration networks, knowledge structures, and emerging frontiers in IR-AD research from 2005-2024.

The Predictive Value of the Cholesterol-to-Natural Killer Cell Ratio in Colorectal Cancer.

We constructed a novel biomarker cholesterol (C)-to-natural killer (NK) cell ratio (CNR) to reflect the synergistic effect of cholesterol metabolism and inflammation on colorectal cancer (CRC) outcomes. This study aimed to investigate the clinical significance and predictive value of CNR in CRC and develop a simple and reliable prognostic model for predicting OS in CRC patients. We retrospectively collected the hematology data and medical records of 213 patients with CRC at Renji hospital and the histological data and medical records of 94 patients with CRC included in a tissue microarray.

Hydrogel-based biomaterials for brain regeneration after stroke: Gap to clinical translation.

Due to the limited effects of current treatments on brain repair and regeneration, stroke continues to be the predominant cause of death and long-term disability on a global scale. In recent years, hydrogel-based biomaterials combined with stem cells and extracellular vesicles have emerged as promising new treatments to improve brain regeneration after stroke. However, the clinical translation of hydrogel-based biomaterials for the treatment of brain injury is still far from satisfactory.

Wheat transcription factor TaSIP1 participates in plant response to osmotic stress and abscisic acid.

Environmental stresses, including drought and high salinity, induce osmotic stress that severely impairs plant growth and agricultural productivity. TaSIP1, a membrane-associated NAC transcription factor interacting with TaSRO1 (Triticum aestivum Similar to RCD-one 1), participates in salinity responses through mitochondria retrograde signaling. Here, we report a critical role of TaSIP1 in osmotic stress as well as abscisic acid (ABA) signaling in wheat and Arabidopsis (Arabidopsis thaliana).

Integrative application of bloodletting and cupping for refractory herpes zoster in an immunocompromised patient with ovarian cancer.

Background: Refractory herpes zoster in immunocompromised patients, particularly those receiving chemotherapy, poses significant clinical challenges due to limited responsiveness to standard antiviral and analgesic therapies. Traditional Chinese medicine (TCM) has been explored as an adjunctive modality to enhance analgesic efficacy and support lesion resolution.

Case Report: A 79-year-old patient with ovarian cancer undergoing chemotherapy developed severe HZ affecting the T10-L2 dermatomes.

CT imaging in differentiating non-solid lung adenocarcinoma with cycstic airspaces: a clinical and diagnostic study.

Objective: To investigate the correlation between clinical features, CT imaging manifestations and histopathology of cystic cavity-containing nodular lung adenocarcinomas, and to provide a basis for improving the diagnostic accuracy and therapeutic decision-making in this type of lung adenocarcinoma.

Methods: In total, 2146 patients with pathologically confirmed nodular lung adenocarcinoma in 3 hospitals in Anhui and Zhejiang were retrospectively analyzed from July 2017 to June 2023. The patients were divided into three groups according to their status of lung adenocarcinoma associated with cystic airspaces (LACA): the LACA0 group (no cystic airspaces, 1821 patients), the LACA1 group (cystic airspace diameter of < 5 mm, 208 patients), and the LACA2 group (cystic airspace diameter of ≥ 5 mm, 117 patients).

Effects of the quorum-sensing system on the phenotypic features and virulence of WH1.

mailto:Soft rot caused by is an important bacterial disease affecting rice and other plants around the world. Several studies found that the specific virulence factor-modulating quorum sensing (-QS) system is present in bacteria. is the key member encoding a two-component system sensor histidine kinase.

The RAB GTPase RABA1E regulates stomatal movement and drought stress response in Arabidopsis.

Plant growth and development are severely affected by drought in the external environment. The phytohormone abscisic acid (ABA) is involved in cellular signaling to regulate stomatal movement in response to drought. Here, we show that RAB GTPASE HOMOLOG A1E (RABA1E) is regulated by ABA signaling and is abundantly expressed in guard cells.

Regulation of Intestinal Inflammation in Large Yellow Croaker (Larimichthys crocea) by Soybean Globulin via Toll-Like Receptor Signaling.

Larimichthys crocea, an economically significant fish species, has experienced significant resource depletion due to overfishing, prompting the expansion of aquaculture. However, the utilization of plant-based protein sources, like soybean globulin, in aquafeeds may induce intestinal inflammation, compromising fish health. In this study, models of Toll-like receptor (TLR) gene expression were constructed using dual-luciferase reporter vectors.

TIGIT blockade improves anti-Mycobacterium tuberculosis immunity.

Despite the therapeutic benefit of immune checkpoint blockade in cancers, there is no consensus on its effect in infectious diseases. Here we investigated whether blocking the immune checkpoint T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) increases T cell immunity in active Mycobacterium tuberculosis infection. TIGIT expression in both peripheral blood and lung lesions in tuberculosis patients was assessed, and the correlation with clinical features analyzed.