Niujiaodihuang Detoxify Decoction Inhibits D-GalN/LPS-induced Hepatocyte Ferroptosis by Maintaining Mitochondrial Homeostasis Via OMA1-OPA1 Pathway.

Niujiaodihuang Detoxify Decoction (NDD) has been shown to attenuate liver injury during acute liver failure by inhibiting ferroptosis, whereas the specific mechanism regulating ferroptosis remains to be elucidated. The LO2 liver cell injury model was induced with a combination of D-Galactosamine hydrochloride (D-GaIN) and lipopolysaccharide (LPS), followed by treatment with NDD-medicated serum. Hepatocyte injury, ferroptosis, and mitochondrial function homeostasis were assessed by measuring cell viability, inflammatory factors levels, lipid peroxidation, oxidative stress, expression of ferroptosis-related proteins, mitochondrial membrane potential, and expression of mitochondrial injury-related proteins.

Efficacy of Schisandra chinensis in liver injury: a systematic review and preclinical meta-analysis.

Background: Liver injury is a multifaceted condition marked by oxidative stress, inflammation, and apoptosis. Schisandra chinensis, a traditional Chinese medicinal herb with a history of use spanning over 2,000 years, exhibits significant hepatoprotective, antioxidant, anti-inflammatory, and anti-apoptotic effects. This study aims to review the therapeutic effects and underlying mechanisms of Schisandra chinensis in mitigating liver injury in animal models.

A bearing fault diagnosis method based on hybrid artificial intelligence models.

The working state of rolling bearing severely affects the performance of industrial equipment. Addressing the issue of that the difficulty of incipient weak signals feature extraction influences the rolling bearing diagnosis accuracy, an efficient bearing fault diagnostic technique, a proposition is forwarded for hybrid artificial intelligence models, which integrates Improved Harris Hawks Optimization (IHHO) into the optimization of Deep Belief Networks and Extreme Learning Machines (DBN-ELM). The process employs Maximum Second-order Cyclostationary Blind Deconvolution (CYCBD) to filter out noise from the vibration signals emitted by bearings; secondly, considering the issue with the conventional Harris Hawks Optimization (HHO) algorithm which tends to prematurely converge to local optima, the differential evolution mutation operator is introduced and the escape energy factor is improved from linear to nonlinear in IHHO; then, a double-layer network model based on DBN-ELM is proposed, to avoid the number of hidden layer nodes of DBN from human experience interference, and IHHO is used to optimize DBN structure, which is denoted as IHHO-DBN-ELM method; with the optimal structure is obtained by using a combined IHHO optimized DBN and ELM; in conclusion, the proposed IHHO-DBN-ELM approach is applied to the bearing fault detection using the Western Reserve University's bearing fault dataset.

Application of multi-stage fracturing stimulation based on case study of Chang-7 shale gas formation in Ordos basin.

To address the issue of low production output, additional stimulation measures are always adopted.This study analyzes the complex characteristics of the Chang-7 shale gas reservoir in the central Tianhuan Syncline, Ordos Basin. Facing challenges from reservoir heterogeneity, we implemented a multi-stage fracturing pilot in the first horizontal well (DPX) of the Chang-7 reservoir using drillable bridge plug technology and customized fracturing designs based on horizontal well multi-stage stimulation theory and multi-fracture interference mechanisms.

A Self-Supervised Adversarial Deblurring Face Recognition Network for Edge Devices.

With the advancement of information technology, human activity recognition (HAR) has been widely applied in fields such as intelligent surveillance, health monitoring, and human-computer interaction. As a crucial component of HAR, facial recognition plays a key role, especially in vision-based activity recognition. However, current facial recognition models on the market perform poorly in handling blurry images and dynamic scenarios, limiting their effectiveness in real-world HAR applications.

Effective Bud Induction of and Without KNO and NHNO in Media.

Stem segments of and containing full axillary buds were used to study the effects of reduced amounts of the main nitrogen source in the growth media. This condition, referred to as nitrogen deficiency in this article and denoted as -N, involved the omission of ammonium nitrate and potassium nitrate from MS media, and its impact on bud induction was assessed. The results show that in media lacking nitrogen, the bud induction rate, contamination rate, browning rate, stem length, and leaf number of induced buds of and varied depending on the different culture media used.

sp. nov., a Crucial and Highly-Active Flavor and Protease Producer Isolated from the -Starter of Chinese Baijiu.

In the study presented herein, an aerobic, Gram-stain-positive, spore-forming bacterium, designated as WLY-B-L8, was isolated from a -starter () cultivation facility used for the production of Wuliangye baijiu in Yibin city (Sichuan province, China). The strain comprised short, rod-shape cells of 1.2-1.

Knowledge landscape of macrophage research in liver fibrosis: a bibliometric review of the literature from WoSCC.

Recent insights into the immune response in fibrosis have provided valuable perspectives for the treatment of liver fibrosis. Macrophages, as the most abundant immune cells in the liver, are key drivers of liver fibrosis. They are extensively involved in tissue damage, chronic inflammation, and the progression and regression of liver fibrosis.

The longitudinal influence of cyberbullying victimization on depression, self-esteem and academic burnout among Chinese adolescents: mindfulness as a mediator.

Cyberbullying victimization (CV) has been linked to numerous adverse psychological outcomes among adolescents. While previous research has established associations between CV and negative outcomes including depression, diminished self-esteem, and academic burnout, the potential protective mechanisms in these relationships remain underexplored. This longitudinal study investigated the mediating role of mindfulness in the relationships between CV and these psychological outcomes among Chinese adolescents.

Multidimensional diagnostic features and intervention pathways for youth mental disorders in China's involution society.

This short communication examines the complex relationship between China's intensifying social involution and rising mental disorders among youth. We analyze the multidimensional diagnostic challenges specific to this cultural context and propose evidence-based intervention pathways. Key findings highlight the necessity of culturally-sensitive diagnostic approaches that account for China's unique socioeconomic pressures, the manifestation of "involution anxiety" as a culturally-bound syndrome, and the effectiveness of integrated intervention frameworks combining traditional Chinese approaches with contemporary psychotherapeutic techniques.

Clinical characteristics of MASLD/MetALD/MAFLD/NAFLD and the relative risk analysis on metabolic disorders.

Objectives: Our objective was to compare the clinical features of Metabolic dysfunction-associated steatotic liver disease (MASLD) /metabolic alcohol-related liver disease (MetALD)/metabolic associated fatty liver disease (MAFLD)/nonalcoholic fatty liver disease (NAFLD) and the relative risk analysis of metabolic disorders.

Methods: The National Health and Nutrition Examination Survey for the 2017-2018 cycle was used to screen the participants. Multivariate-adjusted logistic regression models were applied to explore the difference in relative risk analysis between NAFLD/MAFLD/MASLD/MetALD and metabolic disorders.

Natural bioactive compounds reprogram bile acid metabolism in MAFLD: Multi-target mechanisms and therapeutic implications.

Metabolic-associated fatty liver disease (MAFLD) has become an increasingly prevalent liver disorder worldwide, being closely associated with obesity, metabolic syndrome, and insulin resistance. Bile acids (BAs), beyond their traditional role in lipid digestion, play a pivotal part in regulating lipid and glucose metabolism as well as inflammatory responses. Recent investigations have recognized BAs as key factors in the onset and progression of MAFLD, mainly via their interactions with nuclear receptors such as the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor (TGR5).

Paracoccus yibinensis sp. nov., a novel bacterium with astaxanthin producing isolated from the environment of Chinese distilled Baijiu.

An aerobic, Gram-stain-negative bacterium, designated as strain WLY502, was isolated from the environment of Baobaoqu starter production. The strain was with a short rod shape cells 0.5-0.

Ellagic acid alleviates PM-induced senescence of lung epithelial cells by mediating autophagy.

Fine particulate matter (PM) exposure is significantly linked to lung epithelial cell senescence, and autophagy dysfunction being a key contributor to the aging process. Although the anti-aging properties of ellagic acid (EA) are well-documented, its specific protective effect on PM-induced lung epithelial cell senescence still needs to be studied in depth. To investigate the impacts of PM on autophagy and senescence in lung epithelial cells, 16HBE and A549 cells were exposed to PM suspension.

Expression and prognosis of NR3C1 in uterine corpus endometrial carcinoma based on multiple datasets.

Uterine corpus endometrial carcinoma (UCEC), a prevalent malignancy in the female reproductive system, has witnessed a 30% increase in recent year. Recognizing the significance of early treatment in reducing patient mortality, the identification of potential biomarkers for UCEC plays a crucial role in early diagnosis. This study was to identify key genes associated with UCEC utilizing the Gene Expression Omnibus database, followed by validating their prognostic value across multiple databases.

Effect of intraoperative intravenous esketamine on postoperative delirium in older patients undergoing hip fracture surgery: protocol for a randomised, double-blind, placebo-controlled trial.

Introduction: Postoperative delirium (POD) is a common complication after hip fracture surgery in older patients. Esketamine may be beneficial in alleviating the occurrence of POD. Our trial aim is to investigate whether the intravenous administration of esketamine can improve POD in older patients undergoing surgery for hip fracture.

Tailoring monogenic disease carrier screening panels for Chinese populations: The importance of considering regional differences.

Carrier screening for monogenic diseases is becoming increasingly important in preventive medicine, yet selecting appropriate target genes remains a complex task, especially in countries with significant ethnic and geographic diversity such as China. This study aimed to develop a strategy to screen for carrier screening target genes suitable for the Chinese population, considering regional variations in carrier frequencies (CFs). We analyzed a dataset from a large-scale, multicenter carrier screening study, encompassing 33,104 individuals from different regions of China and carrier status for 223 genes.

Palladium-Catalyzed Sequential Assembly of Nucleophilic Lactone-Embedded Benzofulvenes with π-Allylic Species and Nucleophiles.

Compared with previously electrophilic benzofulvenes with exclusive reaction regioselectivity of the exocyclic double bond, novel lactone-embedded benzofulvenes with nucleophilicity and unique chemical properties have been designed and utilized in palladium-catalyzed sequential assembly with π-allylic species and various nucleophiles (including methoxide anion, alcohols, anilines, and alkylamines) through an unprecedented tandem allylation/ester bond cleavage process probably via a key oxocarbenium ion. The protocol featured high chemoselectivity and regioselectivity, constructing an array of densely functionalized indenes in high yields. Furthermore, the biological evaluation revealed that the synthesized indenes exhibited antitumor activity.

Microbial Etiology, Antimicrobial Resistance, and Risk Factors of Surgical Site Infections in Gestational Diabetes Mellitus Patients Undergoing Elective Pre-Labor Cesarean Deliveries.

Background: Gestational Diabetes Mellitus (GDM) significantly increases the risk of adverse pregnancy outcomes, including elective pre-labor cesarean deliveries. Postoperative surgical site infections (SSIs) pose a significant concern, underscoring the need for a detailed investigation into their causes and preventative measures. The aim of this study is to systematically identify and analyze the microbial etiology and antimicrobial resistance profiles of pathogens responsible for SSIs in GDM patients undergoing elective pre-labor cesarean deliveries.

MAFLD-related hepatocellular carcinoma: Exploring the potent combination of immunotherapy and molecular targeted therapy.

Hepatocellular carcinoma (HCC) is a common cause of cancer-related mortality and morbidity globally, and with the prevalence of metabolic-related diseases, the incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) related hepatocellular carcinoma (MAFLD-HCC) continues to rise with the limited efficacy of conventional treatments, which has created a major challenge for HCC surveillance. Immune checkpoint inhibitors (ICIs) and molecularly targeted drugs offer new hope for advanced MAFLD-HCC, but the evidence for the use of both types of therapy in this type of tumour is still insufficient. Theoretically, the combination of immunotherapy, which awakens the body's anti-tumour immunity, and targeted therapies, which directly block key molecular events driving malignant progression in HCC, is expected to produce synergistic effects.

[Expert consensus over genetic counseling for carrier screening of Spinal muscular atrophy].

Spinal muscular atrophy (SMA), an autosomal recessive neuromuscular disease with a carrier frequency of 1/60 ~ 1/40, is characterized by severe clinical symptoms, high mortality rate, and expensive treatment costs. Carrier screening is of paramount importance to detect high-risk couples, and therefore to reduce the occurrence of SMA. In China, SMA carrier screening has become widespread, though there is still a lack of genetic counseling expertise.

The Regulatory Effect of Polysaccharides on Intestinal Microbiota and Metabolites during Fermentation.

polysaccharides (HSPs) have attracted extensive attention recently for their biological activity and physicochemical property. This research investigated the extraction, structural characterization, and prebiotic activity of three different HSPs (HSP40-0, HSP60-0, and HSP80-0) to reveal the scientific support for the high-value utilization of HSPs were heteropolysaccharide with diverse structures and surface morphologies. Comprehensive analysis was conducted through 16S rRNA gene sequencing and metabolite profiling techniques, and results showed that HSPs had different potentials to regulate the gut microbiota due to their different structures; for instance, both HSP40-0 and HSP80-0 could notably increase the relative abundance of Bacteroidota, whereas HSP60-0 could increase the relative abundance of .

The Prebiotic Activity of a Novel Polysaccharide Extracted from by Fecal Fermentation .

A novel polysaccharide, HSP80-2, with an average molecular weight of 13.8 kDa, was successfully isolated by the gradient ethanol precipitation (GEP) method from (HS), the by-product of Chinese Baijiu. It was mainly composed of arabinose, xylose, and glucose with a molar ratio of 4.