A solo-LTR insertion in the CreTPS3a promoter enhances γ -terpinene biosynthesis and affects consumer preference for tangerine-like aroma in citrus fruits.

Aroma differentiation is a key trait distinguishing citrus and other horticultural crops from staple crops. However, the mechanisms and sensory features by which distinctive and various citrus-like aroma in citrus remain poorly understood. In this study, we demonstrated that γ-terpinene determines tangerine-like aroma, affects consumer preference, and has pest-repellent properties.

Construction of a Surface Hydroxyl Group on ZnInS Promotes Photocatalytic CO Reduction.

Photocatalysis holds significant promise for the reduction of CO to valued chemicals under mild conditions. However, its potential is severely limited by weak CO adsorption and slow proton-coupled electron transfer (PCET) rates. In this work, ZnInS-based catalysts with varying hydroxyl contents were synthesized via the solvothermal method.

U-shaped association of body roundness index with all-cause and cardiovascular mortality in individuals with chronic kidney disease.

Purpose: This study aimed to investigate the association between body roundness index (BRI) and deaths from all causes and cardiovascular disease (CVD) in participants with chronic kidney disease (CKD).

Materials And Methods: The data was sourced from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Cox proportional hazards regression along with restricted cubic splines were applied to assess the associations of BRI with deaths from all causes and CVD in individuals with CKD.

m1A methylase TRMT6 promotes neuroblastoma development by demethylating SST mRNA in an m1A/YTHDF2-dependent manner.

Background: m1A, a prevalent RNA modification found in various RNA species, has recently been reported to modulate cancer progression. However, its effects on neuroblastoma remain uninvestigated.

Methods: The PCAT database was utilized to analyze the mRNA levels and survival probabilities of m1A regulator genes (TRMT6, TRMT61A, ALKBH1, and ALKBH3) in neuroblastoma patients.

Elucidating the underlying therapeutic mechanism of Feikang prescription on chronic obstructive pulmonary disease: insights from a comprehensive analysis.

Background: Ranking fourth highest mortality rate globally, chronic obstructive pulmonary disease (COPD) exerts a heavy burden on both economies and healthcare systems. The Feikang prescription, a traditional Chinese herbal remedy, is utilized for its potential in managing COPD symptoms. Still,the primary components and underlying mechanisms of the Feikang prescription remain inadequately understood.

MHR Was Associated with Hyperuricemia Risk in Patients with Type 2 Diabetes Mellitus: The Mediating Effect of Body Mass Index.

Background: The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) reflects systemic inflammation, combining the pro-inflammatory role of monocytes with the anti-atherogenic and anti-inflammatory properties of HDL-cholesterol. Prior studies have established MHR as an independent predictor of hyperuricemia (HUA) prevalence. Emerging evidence further identifies MHR as a potential biomarker for early type 2 diabetes mellitus (T2DM) screening, likely mediated through its association with insulin resistance.

Selective P450 Hydroxylation of the Spiro[3.3]heptane Core as a Route to Potential Drug Fragment Molecules.

Engineered P450 enzyme variants, developed from an initial screening panel of 42 enzymes, convert benzyl spiro[3.3]heptane-2-carboxamide into three distally monohydroxylated regioisomers with essentially complete enantioselectivity. Two α-hydroxyamide derivatives are also produced.

Molecular and functional characterization of an antenna-enriched glutathione S-transferase, LoryGSTd1, with cinnamaldehyde and cis-jasmone degradation ability in the Lissorhoptrus oryzophilus.

Background: Glutathione S-transferases (GSTs) play a vital role in maintaining olfactory sensitivity. However, their roles in odorant inactivation in the rice water weevil (RWW, Lissorhoptrus oryzophilus) remain largely unknown.

Results: Through antennal transcriptome analysis of the RWW, this study identified 20 LoryGSTs.

Correction: Association between genetically proxied glucosamine and risk of cancer and non-neoplastic disease: a mendelian randomization study.

[This corrects the article DOI: 10.3389/fgene.2024.

SpaOmicsVAE: A deep learning framework for integrative analysis of spatial multi-omics data.

Spatial multi-omics technologies have revolutionized our understanding of biological systems by enabling simultaneous measurement of multiple molecular features while preserving spatial information. However, the effective integration and analysis of these complex datasets remain challenging. Here we introduce SpaOmicsVAE, a novel computational framework that combines variational autoencoder architecture with a dual graph neural network to address these challenges.

CAFs exosomal miR-21-5p suppresses ferroptosis and promotes proliferation and migration in osteosarcoma.

Background: Osteosarcoma is one of the malignant tumors in children and adolescents patients. Uncontrolled and unlimited proliferation and metastasis lead to poor overall survival. CAFs play a pivotal role in the osteosarcoma tumor microenvironment, exerting significant influence on prognosis and treatment outcomes.

The FLATCAN Model: A Novel Score for Predicting Mortality Risk in Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis.

Background And Objective: Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 + DM) exhibits the worst prognosis among all subtypes of idiopathic inflammatory myopathies, with substantial heterogeneity in patient outcomes. This study aimed to investigate prognostic factors for MDA5 + DM and develop a scoring system to determine mortality risk.

Methods: This retrospective study included 621 patients with MDA5 + DM.

Exploring the pathogenesis of acute lung injury and its treatment through Traditional Chinese Medicine: a state-of-the-art review.

Acute Lung Injury (ALI) is a severe and progressive condition characterized by hypoxic respiratory failure, often triggered by multiple contributing factors. It is associated with high morbidity and mortality rates and can advance to Acute Respiratory Distress Syndrome (ARDS) in severe cases. The pathogenesis of ALI involves a complex interplay of pathological mechanisms, including immune-inflammatory responses, disruption of the alveolar-capillary barrier, damage to mesenchymal stem cell organelles, metabolic dysregulation, ferroptosis, and alterations in gut microbiota.

Mechanisms underlying the role of FeO in enhancing antibiotic degradation and mitigating the spread of antibiotic resistance in aquaculture sediment: Coupling dissimilatory iron reduction with methanogenesis.

Ferric oxides play a critical role in transforming organic contaminants within anaerobic aquaculture sediments; however, their effect on the removal of antibiotics and antibiotic resistance genes (ARGs) remains unexplored. This study revealed that the addition of FeO significantly promoted microbial Fe(III) reduction, SMX degradation, and methanogenesis by enhancing metabolic activity and facilitating electron transfer. While nutrient supplementation similarly improved SMX removal, it notably increased ARG abundance, unlike FeO, which effectively suppressed ARGs.

The impact of digital payments on sports lottery consumption decisions based on the moderating role of the business environment.

Introduction: The purpose of this paper is to examine the relationship between digital payment and sports lottery consumption decisions and to explore the underlying mechanism.

Methods: Based on panel data from 31 Chinese provinces spanning 2011-2023, this study employs a fixed-effects panel model and a moderation analysis to investigate the relationship between digital payment and sports lottery consumption decisions, along with the moderating role of the business environment.

Results: Digital payment significantly contributes to sports lottery consumption decisions.

Macroscopic effects on the Terahertz generation from the two-color filamentation.

We recently investigated the influence of laser propagation in gas medium on Terahertz (THz) yield. The dependence of THz yield on the distance between two spatially discrete foci was reproduced when the two collimated driver beams were focused separately. In this study, we further account of the THz field propagation and the interference of local THz sources in the far field; thus, the THz spectra are even reproduced successfully.

METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA.

Colorectal cancer (CRC) is a prevalent digestive system malignancy accompanied by peritoneal metastasis occurring in 7% of cases. Methyltransferase-like 3 (METTL3) promoted the progression of CRC whereas its function in peritoneal metastasis was incompletely understood. Here, we found that METTL3 was upregulated in peritoneal metastasis tissues of CRC patients compared with CRC tissues.

Melatonin as an anti-inflammatory hormone bridging migraine relief and cancer immunity enhancement: a literature review.

Melatonin, once relegated to the circadian periphery, has resurfaced as a pleiotropic immunomodulator capable of quelling neurogenic inflammation while invigorating antitumour defence. Migraine-and its disabling, episodic neurovascular pain-shares an "inflammatory genome", defined here as a conserved danger-response gene set (NF-κB, NLRP3, IL1B, NOS2), with the metabolic chaos that subdues cytotoxic immunity in solid cancers; both ignite NF-κB, NLRP3 and reactive-oxygen cascades that erode tissue homeostasis. Emerging evidence shows that endogenous melatonin declines precede migraine attacks, and nightly supplementation rivals first-line preventives in shrinking monthly headache burden while restoring sleep architecture.

Functional Zoning for Integrated Management of Transboundary Lake Basins from a Sustainable Development Perspective: A Case Study of Lake Victoria in East Africa.

From the perspective of sustainable development, multi-objective collaborative governance plays a vital role in the integrated management of transboundary lake basin systems. However, regionally differentiated governance solutions, based on the systematic identification of spatial use functions within the basin, remain undefined. Based on an analysis of regional evolution patterns, this study establishes a coupled zoning framework to identify conflict types and synergetic relationships while quantifying the characteristics of the three spatial use functions: agricultural production, urban development, and ecological conservation.

Exploration and Application of Malignant Cell Heterogeneity Analysis with Single-Cell Transcriptome Sequencing Technology.

Cancer remains a formidable global health burden owing to its persistently high incidence and mortality, highlighting the need to elucidate its underlying biological mechanisms. Such insights are crucial for refining diagnostic precision and therapeutic efficacy. Notably, human tumors represent highly heterogeneous ecosystems, comprising a dynamic interplay between malignant cells and non-malignant components, such as immune infiltrates and stromal elements.

Legacy and Novel Per- and Polyfluoroalkyl Substances in Tap Water from East China: Impact from Water Sources and Risk Mitigation by Household Purifiers.

The growing regulatory focus on per- and polyfluoroalkyl substances (PFAS) in drinking water raises the urgent need for comprehensive monitoring and effective removal strategies. Herein, we analyzed 81 PFAS in tap water produced from three major water bodies in East China, a global PFAS emission hub. Such systematic quantitative analyses detected 64 PFAS, representing the highest reported number to date and including 28 novel species first quantified in Chinese tap water.

Identification of rs2036527 as a cis-regulatory variant for CHRNA3 and CHRNA5 by allele-specific expression and implications for nicotine dependence and lung cancer.

Background And Objectives: Numerous genome-wide association studies suggest that rs1051730 is significantly associated with nicotine dependence and further lung cancer in Caucasian. Since rs1051730 is a synonymous variant at CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit), it might be hypothesized that the causal variant might be other SNP(s) in strong linkage disequilibrium (LD).

Methods: LD analysis and functional genomics work, including chromosome conformation capture (3C), luciferase assay, and chromatin immunoprecipitation (ChIP), were performed.

Non-invasive light flickering reinstates visual plasticity in adult mice via lipocalin 2.

Background: Light flickering, a non-invasive stimulation technique over recent years, has shown a promising therapeutic potential for brain dysfunctions. However, the mechanisms by which this visual stimulus exerts its beneficial effects are largely unknown.

Results: Here, we found that 7 days of 1 h 20 and 40 Hz light flickering promoted visual plasticity in primary visual cortex of adult mice.

Attitudes toward seeking professional psychological help among patients with colorectal cancer: A latent profile analysis.

Objective: This study aimed to explore the attitudes of patients with colorectal cancer (CRC) toward seeking professional psychological help and to identify latent profiles and associated influencing factors.

Methods: A total of 236 patients with CRC were recruited through convenience sampling. Participants completed validated instruments assessing attitudes toward seeking professional psychological help, mental health literacy, and stigma related to psychological help-seeking.

Trigeminal nerve-driven neurogenic inflammation linking migraine to glioblastoma invasion: a literature review.

Migraines are among the most common neurological disorders, disabling nearly one in seven people worldwide, whereas glioblastoma (GBM) is the most aggressive primary brain tumour, with median survival scarcely beyond 15 months. Historically considered distinct, these conditions are increasingly linked by trigeminal nerve-driven neurogenic inflammation. Activation of trigeminovascular afferents provokes antidromic release of calcitonin gene-related peptide (CGRP), substance P (SP), and pituitary adenylate cyclase-activating polypeptide (PACAP); beyond mediating migraine pain, these peptides remodel vasculature, immune infiltrates, and extracellular matrix to facilitate GBM invasion.