An Explainable Two-Stage Machine Learning Model for Predicting the Post-Thrombolysis Complications in Stroke Patients: A Multi-Center Study.

Current tools for predicting the thrombolysis risk in patients after stroke exhibit limited event prediction in early post-thrombolysis hemorrhagic events. This highlights an unmet medical need to improve the tools for stroke management. We developed an explainable 2-stage machine learning model for stroke risk stratification to predict the risk of bleeding, composite complications, and all-cause death in patients before and after thrombolysis therapy.

Artificial intelligence in neurodegenerative diseases research: a bibliometric analysis since 2000.

This bibliometric review examines the evolving landscape of artificial intelligence (AI) in neurodegenerative diseases research from 2000 to March 16, 2025, utilizing data from 1,402 publications (1,159 articles, 243 reviews) indexed in the Web of Science Core Collection. Through advanced tools - VOSviewer, CiteSpace, and Bibliometrix R - the study maps collaboration networks, keyword trends, and knowledge trajectories. Results reveal exponential growth post-2017, driven by advancements in deep learning and multimodal data integration.

Insulin resistance and Alzheimer's disease: Exploring research hotspots and frontiers from a bibliometric and visual analysis (2005-2024).

Background: Alzheimer's disease (AD) and insulin resistance (IR) share intersecting pathological pathways, with IR increasingly implicated in AD pathogenesis. Systematic bibliometric analyses mapping the evolution of this interdisciplinary field remain limited.

Objective: To quantify global research trends, collaboration networks, knowledge structures, and emerging frontiers in IR-AD research from 2005-2024.

Research Progress on the Hydrogen Embrittlement Resistance Performance of High-Entropy Alloys.

The concealment and delayed characteristics of hydrogen embrittlement (HE) pose significant challenges for the development of hydrogen-resistant materials. As a novel category of multi-principal-element alloys, high-entropy alloys (HEAs) have emerged as ideal candidates for the next generation of hydrogen-resistant alloys due to their unique design philosophy, which endows them with excellent mechanical properties, corrosion resistance, high-temperature stability, and hydrogen embrittlement resistance. In recent years, research on the hydrogen embrittlement resistance of HEAs has attracted extensive attention.

Solid-state screening and dry powder inhaler development of ziyuglycoside II sodium salt for enhanced bioavailability.

The pharmacological effects of ziyuglycoside II (ZYG II), a saponin derived from Sanguisorba officinalis L., were partially limited by low oral bioavailability (< 5 %) attributable to its poor water solubility, low membrane permeability and extensive first-pass metabolism. To enhance solubility, salt form was selected as ZYG II sodium salt (ZYG-II-Na) in this study, with systematic screening and characterization of its solid forms.

Supramolecular cyclodextrin-based reservoir as nasal delivery vehicle for rivastigmine to brain.

The purpose of this study involved the synthesis of supramolecular reservoir (i.e. cyclodextrin metal-organic framework, MOF) using cyclodextrins as building blocks, followed by cross-linking to obtain crosslinked CD framework (CDF) using CD-MOF as template and functionalized with borneol (BO) to enhance rivastigmine (RIV) permeation and facilitate brain targeting via intranasal administration.

Enhanced Stability and Solidification of Volatile Eugenol by Cyclodextrin-Metal Organic Framework for Nasal Powder Delivery.

Eugenol (Eug) holds potential as a treatment for bacterial rhinosinusitis by nasal powder drug delivery. To stabilization and solidification of volatile Eug, herein, nasal inhalable γ-cyclodextrin metal-organic framework (γ-CD-MOF) was investigated as a carrier by gas-solid adsorption method. The results showed that the particle size of Eug loaded by γ-CD-MOF (Eug@γ-CD-MOF) distributed in the range of 10-150 μm well.

Clonorchis sinensis on the prognosis of patients with spontaneous rupture of Hepatocellular Carcinoma: An inverse probability of treatment weighting analysis.

Background: We examined the impact of the Clonorchis sinensis (C. sinensis) infection on the survival outcomes of spontaneous rupture Hepatocellular Carcinoma (srHCC) patients undergoing hepatectomy.

Methods: Between May 2013 and December 2021, 157 consecutive srHCC patients who underwent hepatectomy were divided into an no C.

Quantitative proteomics based on TMT revealed the response of PK15 cells infected PEDV wild strain.

Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), is an acute and highly contagious enteric disease with a high mortality rate in suckling piglets. Identification of proteins associated with PEDV infection may provide insights into the pathogenesis of this viral disease. In this study, we employed tandem mass tag (TMT) quantitative protein analysis to investigate proteomic changes in PK15 cells following PEDV infection, and differential protein expression profiles were obtained at 0 h, 24 h, and 48 h post-infection.

Analysis of Energy Loss Characteristics of Vertical Axial Flow Pump Based on Entropy Production Method under Partial Conditions.

The energy loss of the vertical axial flow pump device increases due to the unstable internal flow, which reduces the efficiency of the pump device and increases its energy consumption of the pump device. The research results of the flow loss characteristics of the total internal conduit are still unclear. Therefore, to show the internal energy loss mechanism of the axial flow pump, this paper used the entropy production method to calculate the energy loss of the total conduit of the pump device to clarify the internal energy loss mechanism of the pump device.

Pore Strategy Design of a Novel NiTi-Nb Biomedical Porous Scaffold Based on a Triply Periodic Minimal Surface.

The pore strategy is one of the important factors affecting the biomedical porous scaffold at the same porosity. In this work, porous scaffolds were designed based on the triply periodic minimal surface (TPMS) structure under the same porosity and different pore strategies (pore size and size continuous gradient distribution) and were successfully prepared using a novel NiTiNb alloy and selective laser melting (SLM) technology. After that, the effects of the pore strategies on the microstructure, mechanical properties, and permeability of porous scaffolds were systematically investigated.

MicroSPECT Imaging-Guided Treatment of Idiopathic Pulmonary Fibrosis in Mice with a Vimentin-Targeting Tc-Labeled -Acetylglucosamine-Polyethyleneimine.

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease with poor prognosis. Evidence has shown that vimentin is a key regulator of lung fibrogenesis. Tc-labeled -acetylglucosamine-polyethyleneimine (NAG-PEI), a vimentin-targeting radiotracer, was used for the early diagnosis of IPF, and NAG-PEI was also used as a therapeutic small interfering RNA (siRNA) delivery vector for the treatment of IPF in this study.

Brain network analyses of diffusion tensor imaging for brain aging.

The approach of graph-based diffusion tensor imaging (DTI) networks has been used to explore the complicated structural connectivity of brain aging. In this study, the changes of DTI networks of brain aging were quantitatively and qualitatively investigated by comparing the characteristics of brain network. A cohort of 60 volunteers was enrolled and equally divided into young adults (YA) and older adults (OA) groups.

Experimental investigation of shale oil recovery from Qianjiang core samples by the CO huff-n-puff EOR method.

CO Huff-n-Puff (HnP) is an effective technique for enhancing oil recovery (EOR) that can be applied to shale oil reservoirs faced with poor natural productivity and low water injectivity. The main objective of this study is to investigate the interactions of CO and formation crude oil, and evaluate the CO HnP performance in shale oil reservoirs in the Qianjiang depression in China. In this study, the variation rules of oil phase behavior, viscosity, saturation pressure, and swelling factor at different CO contents of 0 to 65% were studied.

Gradient Microstructures and Mechanical Properties of Ti-6Al-4V/Zn Composite Prepared by Friction Stir Processing.

In this work, a biomedical Ti-6Al-4V (TC4)/Zn composite with gradient microstructures was successfully prepared by friction stir processing (FSP). The microstructures and mechanical properties of the composite were systematically studied using scanning electron microscope (SEM), X-ray diffractometer (XRD), transmission electron microscope (TEM), atom probe tomography (APT), and microhardness test. The results show that TC4/Zn composite can be successfully prepared, and gradient microstructures varying from coarse grain to nanocrystalline is formed from the bottom to the upper surface.

Microstructures, mechanical, and biological properties of a novel Ti-6V-4V/zinc surface nanocomposite prepared by friction stir processing.

Background: The interaction between the material and the organism affects the survival rate of the orthopedic or dental implant in vivo. Friction stir processing (FSP) is considered a new solid-state processing technology for surface modification.

Purpose: This study aims to strengthen the surface mechanical properties and promote the osteogenic capacity of the biomaterial by constructing a Ti-6Al-4V (TC4)/zinc (Zn) surface nanocomposites through FSP.

Proliferation and osteogenic differentiation of rat BMSCs on a novel Ti/SiC metal matrix nanocomposite modified by friction stir processing.

The aims of this study were to fabricate a novel titanium/silicon carbide (Ti/SiC) metal matrix nanocomposite (MMNC) by friction stir processing (FSP) and to investigate its microstructure and mechanical properties. In addition, the adhesion, proliferation and osteogenic differentiation of rat bone marrow stromal cells (BMSCs) on the nanocomposite surface were investigated. The MMNC microstructure was observed by both scanning and transmission electron microscopy.