Integrated nursing and medical management improves outcomes in pediatric lobar pneumonia: a randomized controlled study.

Objective: To evaluate the effectiveness of integrated nursing and medical management in children with lobar pneumonia, focusing on symptom relief, pulmonary function recovery, inflammation control, length of hospital stay, and caregiver satisfaction.

Methods: Fifty pediatric patients with lobar pneumonia were randomly assigned to receive either routine nursing care or an integrated medical and nursing intervention. Key clinical outcomes-including the duration of symptoms, pulmonary function indices, inflammatory markers, length of hospital stay, treatment efficacy, caregiver satisfaction, and adverse events-were compared between groups.

Integrative multi-omics analysis reveals BEST1 as a potential tumor-associated gene in gliomas.

Background: The newest glioma classification in WHO 2021 emphasizes the importance of gene mutations in the glioma molecular pathogenesis. Our research aims to look for new glioma-related genes that have the potential to be therapeutic targets.

Methods: We applied Mendelian randomization and colocalization analysis to identify the target genes.

Detecting a potential causal relationship between plasma metabolites and myocardial infarction using bidirectional and two-step Mendelian randomization.

Some studies have shown that plasma metabolites may be associated with myocardial infarction (MI); however, the causal relationship between plasma metabolites and MI, as well as the potential mediating role of immune cells, remains unclear. This Mendelian randomisation (MR) study utilised large-scale genome-wide association study (GWAS) summary data encompassing 1400 plasma metabolites (n = 8299), 731 immune cell traits from the GWAS Catalog consortium (n = 3757), and MI cases and controls from the FinnGen consortium (cases: n = 26,060; controls: n = 343,079). Using bidirectional MR analysis, we assessed the causal links between plasma metabolites and MI, and between immune cells and MI, excluding reverse causality.

Prognostic value of N-terminal prohormone B-type natriuretic peptide modified by renal function in patients with acute heart failure.

Introduction: It remains unclear whether renal function and follow-up duration impact the prognostic value of N-terminal prohormone B-type natriuretic peptide (NT-proBNP) in patients with heart failure (HF).

Methods: A nationwide prospective cohort study was conducted in 4907 adults hospitalized for acute HF, of whom 4766 were eligible for analysis. We used Cox regression to estimate the relative risks and Poisson regression to assess the absolute risks of adverse outcomes associated with NT-proBNP levels at admission.

Artesunate Nanoplatform Targets the Serine-MAPK Axis in Cancer-Associated Fibroblasts to Reverse Photothermal Resistance in Triple-Negative Breast Cancer.

Cancer-associated fibroblasts (CAFs) play a pivotal role in inducing photothermal therapy (PTT) resistance of triple-negative breast cancer (TNBC), but with unclear mechanism. Herein, aminoethyl anisamide-modified nano-biomimetic low-density lipoprotein (A-aLDL) is used to target deliver the PTT agent and artesunate (ARS) to both CAFs and cancer cells. Though CAFs are sensitive to PTT and notably transition to heat-resistant phenotype, the formed protective barrier is destroyed by ARS.

Dual-Label Single-Molecule Imaging Method for Quantifying Apparent Fluorescence Efficiency of Fluorescent Proteins.

Fluorescent proteins (FPs) are indispensable tools for life science research, crucial for quantitative analyses, such as protein stoichiometry determination, signal transduction, and protein-protein interactions. In this work, we introduce a new method of dual-color single-molecule imaging to assess the apparent fluorescence efficiency of FPs (DC-FEFP). By integrating high signal-to-noise ratio (SNR) FPs or self-labeling tags, this approach enables us to precisely quantify the fluorescence efficiency of various FPs at the single-molecule level in both living and fixed cells.

Superiority of targeted RNA sequencing for fusion detection and subtype diagnosis in Chinese sarcoma patients: a multicenter study.

Sarcomas are rare, heterogeneous mesenchymal malignancies with notably high misdiagnosis rates. Despite sarcoma patients in China representing about one-quarter of the global disease burden, large-scale NGS-based diagnostic studies remain scarce, with limited sample sizes failing to capture the extensive subtype complexity of sarcomas. To address diagnostic gaps, we conducted the largest multicenter study in China involving 788 patients with soft tissue or bone sarcomas.

Efficacy and safety of traditional Chinese medicine Elian Granule for chronic atrophic gastritis: a multi-center, randomized, double-blind, placebo-controlled study.

Objective: This multi-center, randomized, double-blind, placebo-controlled study aimed to evaluate the clinical efficacy and safety of Elian Granule in treating chronic atrophic gastritis (CAG).

Methods: Over a 24-week period, 240 CAG patients were randomized to receive either Elian Granule or placebo. Primary outcomes included histological improvement of gastric mucosa via biopsy, while secondary outcomes assessed dyspepsia symptom scores and quality of life (QOL) scores.

Hyperuricemia and adverse outcomes in patients with cardiorenal syndrome: A nationwide prospective cohort study in China.

Background: Serum uric acid (UA) has been associated with adverse outcomes in patients with heart failure. However, it remains inconclusive whether such association persists in patients with cardiorenal syndrome (CRS).

Methods: In a nationwide prospective cohort from China, 4907 adults hospitalized for heart failure were enrolled.

The Association Between Internet Use and Co-occurring Health Care Needs: Cross-Sectional Study in China.

Background: The need for health care underpins health care service provision and serves as the foundation for enhancing service capacity and allocating resources. Health care needs are influenced by health, social, and economic conditions and may exhibit different characteristics over time. However, previous studies have primarily focused on specific populations or types of needs, overlooking the diversity and complexity of residents' health care requirements.

The m6A RNA demethylase FTO promotes radioresistance and stemness maintenance of glioma stem cells.

Glioblastoma (GBM) was the most common and deadliest malignant brain tumor in adults, with a poor prognosis. Effective targeted drugs are still lacking, and the presence of glioblastoma stem cells (GSC) is a major factor contributing to radiotherapy resistance. Screening for targeted drugs that can sensitize GBM to radiotherapy is crucial.

Correlation Between Fatty Pancreas and Coronary Artery Calcium Score in a Dyslipidemic Population.

Objectives: This study aimed to investigate the clinical value of fatty pancreas (FP) in predicting coronary atherosclerosis by studying the correlation between the extent of pancreatic fat deposition and coronary artery calcification.

Patients And Methods: Totally, 153 patients who underwent dyslipidemic medical check-ups at our hospital were selected and divided into 4 groups of calcification-none, mild, moderate, and severe-based on the coronary artery calcification score (CACS) obtained using low-dose chest computed tomography (CT). Upper abdominal CT was performed using a conventional dose and the pancreas/spleen attenuation ratio was measured.

Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation.

Background: Runchangningshen paste (RCNSP) is a paste made of four medicinal and edible homologous Chinese medicine mixed with honey. It is known for its ability to nourish yin and blood as well as to loosen the bowel to relieve constipation. The pathophysiology of functional constipation (FC) is associated with a reduction in mucin-2 (MUC2) secretion and microbial dysbiosis.

Urinary extracellular vesicle N-glycomics identifies diagnostic glycosignatures for bladder cancer.

Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges. Urinary extracellular vesicles (EVs) are promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. This study pioneers urinary EV N-glycomics for bladder cancer diagnosis.

Chaihushugan powder regulates the gut microbiota to alleviate mitochondrial oxidative stress in the gastric tissues of rats with functional dyspepsia.

Introduction: Functional dyspepsia (FD) is a prevalent functional gastrointestinal disorder associated with oxidative stress (OS) and dysbiosis. Chaihushugan powder (CHSGP) demonstrates efficacy in treating FD; however, the underlying therapeutic mechanism is not yet elucidated. This study aims to investigate the effects of CHSGP on OS and gut microbiota (GM) in FD rats, with a particular emphasis on the role of GM as a potential target for the antioxidant properties of CHSGP.

Behavioral and pathological characteristics of 5xFAD female mice in the early stage.

Alzheimer's disease (AD) is a central nervous system degenerative disease with insidious onset and gradual development caused by selective and progressive loss of neurons. The 5xFAD mouse is a relatively mature disease model of AD. However, the behavioral research on 5xFAD female mouse is more focused on the changes of late memory function, and the exploration of its early behavioral and pathological changes is still incomplete.

Short-term effect of sunshine duration on daily emergency visits for hip fractures in Beijing, China: a time-series study.

Unlabelled: This study employs a time-series analysis to investigate how sunshine duration associates hip fractures in China and found both short and long durations of sunshine increased the risk of hip fractures. The findings can guide strategies for reducing hip fractures and enhance health education on fracture prevention.

Background: Studies on the associations between sunshine duration and emergency visits for hip fractures (HF) are limited.

Photothermal composites for in-situ trace oil detection on ultra-clean surfaces.

Oil is widely used as a lubricant in many industries. However, in the final product, oil is often considered a contaminant. In various production processes, such as semiconductor manufacturing, precision machining, and optical device fabrication, ultra-clean surfaces are crucial.

alleviate Serovar Typhimurium-induced murine inflammatory/oxidative responses via the p62-Keap1-Nrf2 signaling pathway and cecal microbiota.

Background: Serovar Typhimurium (. Typhimurium) infection can cause inflammation and oxidative stress in the body, leading to gastroenteritis, fever and other diseases in humans and animals. More and more studies have emphasized the broad prospects of probiotics in improving inflammation and oxidative stress, but the ability and mechanism of (LA) to alleviate the inflammatory/oxidative reaction caused by pathogens are still unclear.

Exploring the relationship between MGAT2 and glioblastoma: A Mendelian Randomization and bioinformatics approach.

Background: Mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2 (MGAT2) and tumors' relevant research was in full swing recently. Therefore, we employed Mendelian Randomization (MR) alongside bioinformatics to thoroughly investigate the possible relationship between MGAT2 and glioblastoma (GBM).

Methods: We utilized the summary statistics of genome-wide association studies (GWAS) for MGAT2 (N = 35,559 from deCODE) and glioblastoma (N = 379,155 from FinnGen).

Study on the co-occurrence of multiple health service needs throughout the lifecourse of rural residents in China based on association rules.

Objective: To understand the multiple health service needs of rural residents in China and explore the co-occurrence patterns of these needs throughout the entire life course, providing a basis for the formulation and optimization of health service packaging policies.

Methods: This study utilized a stratified random sampling method, resulting in a final sample size of 15,125 individuals. The R statistical software was employed to apply the Apriori algorithm to mine the co-occurrence relationships among multiple health service needs across the life course and to explore the packaging model of these services.

Biopharmaceutical drug delivery and phototherapy using protein crystals.

Biopharmaceutical drugs, including proteins, peptides, and antibodies, are renowned for their high specificity and efficacy, fundamentally transforming disease treatment paradigms. However, their structural complexity presents challenges for their formulation and delivery. Protein crystals, characterized by high purity, high stability and a porous structure for biopharmaceutical drug encapsulation, providing a potential avenue for formulating and delivering biopharmaceutical drugs.

Predicting Health-Related Quality of Life Among Chinese Residents: Latent Class Analysis Based on Panel Survey Data.

Purpose: This study aimed to identify distinct trends among Chinese residents based on their health-related quality of life (HR-QoL) outcomes and to analyze the demographic characteristics that contribute to these trends.

Materials And Methods: The study conducted latent class analysis using baseline data obtained from a survey of health service utilization behaviors (from July to December 2016) among residents of Hubei Province, China (N = 1517). Latent classes were used to implement the HR-QoL grouping of different trends among the respondents.

Multilayer porous poly (vinylidene fluoride)/MXene/cobalt ferrite composites with ternary gradients for electromagnetic wave absorption.

A composite material with a high potential for absorbing electromagnetic waves (EMW) was obtained by selecting poly (vinylidene fluoride) (PVDF) as the matrix, MXene as the conductive filler, and cobalt ferrite (CoFeO) as the magnetic filler. A layer-by-layer assembly strategy involved hot pressing and sequential blade coating, followed by vapor-induced phase separation, was used to implement the preparation of PVDF/MXene/CoFeO (PMC) composites. The process facilitates the formation of a well-organized multilayer porous framework, providing a gradient of positive conductivity, negative magnetism, and porosity within the composites.