Triatomines outside the Americas: a comprehensive dataset for the global surveillance of Chagas disease vectors.

Chagas disease is caused by , which is transmitted to mammals, including humans, mainly by insects of the subfamily Triatominae (Hemiptera: Reduviidae). Also known as "kissing bugs", the subfamily includes 159 species in 18 genera and five tribes. Although most species are in the Americas, here we present the first compilation of non-American triatomine occurrences.

Genotype for hypocretin receptor (hcrtr2) affects appetite in zebrafish.

We investigated the role of hypocretin receptor in signaling appetite in zebrafish (Danio rerio). Hypocretin is a small neuropeptide known for its effects on circadian rhythm and appetite. Wild-type and heterozygous hu2098 (knockout for hcrtr2) zebrafish were raised to adulthood (3-4 months post fertilization) and genotyped.

The impact of reading trauma literature on Chinese undergraduates' PTSD: the mediating roles of social support and empathy.

Trauma literature has emerged as a powerful medium for exploring collective and individual psychological experiences. However, its the potential psychological risks—particularly its association with PTSD symptoms among students—have not been thoroughly examined, especially in the context of Chinese undergraduates who face unique academic and social pressures. This study investigates the impact of trauma literature on PTSD symptoms, with a focus on the mediating roles of social support and empathy.

Weight adjusted waist index is a superior obesity index for predicting arterial stiffness in type 2 diabetes mellitus.

Obesity is a key risk factor for arterial stiffness (AS) and a strong predictor of cardiovascular diseases (CVD). In patients with type 2 diabetes mellitus (T2DM), the risk of AS is further exacerbated due to metabolic dysregulation and chronic inflammation, especially when both conditions coexist. Traditional obesity indices such as Body Mass Index (BMI) and Waist Circumference (WC) have limitations in assessing fat distribution and metabolic risk.

Vestibulo-Ocular Reflex Results in Patients with Intralabyrinthine Schwannomas: Case Series with a Literature Review.

Intralabyrinthine schwannoma (ILS) is a rare benign tumor of the inner ear, often presenting with nonspecific symptoms such as hearing loss, tinnitus and vertigo. Vestibular function in ILS patients remains underexplored. This study aims to evaluate vestibulo-ocular reflex (VOR) function and inner ear magnetic resonance imaging (MRI) signal changes in ILS, and to provide insights into potential mechanisms underlying vestibular dysfunction.

Chromosome-Level Genome Announcement of the Monokaryotic Strain PC80.

is a widely cultivated edible fungus in China, renowned for its rich nutritional composition and diverse medicinal compounds. However, the quality of the currently published genomes remained suboptimal, which limited in-depth research on its evolution, growth, and development. In this study, we conducted a chromosome-level genome assembly of the monokaryotic basidiospore strain PC80.

Improved Hypoxic Microenvironment By Nanoformulation For Effective T Cell Therapy In Mice Model.

Introduction: Adoptive cell therapy (ACT) has emerged as a powerful strategy for eliciting tumor regression. However, its efficacy in solid tumors remains limited, primarily due to the immunosuppressive tumor microenvironment (TME). We developed a tumor microenvironment-responsive mesoporous silica nanosphere (MSN) formulation co-loaded with the immunostimulant imiquimod (R837), zinc peroxide (ZnO), and manganese peroxide (MnO) to alleviate hypoxia and enhance dendritic cell (DC)-mediated antitumor immunity.

Innovative approaches to melanoma treatment: a spotlight on stimuli-responsive biomaterials.

Melanoma presents as an increasingly prevalent and intricate skin cancer, characterized by a complex tumor microenvironment that features various mutations and the activation of melanogenesis pathways. Dynamic changes within this microenvironment, including increased ROS levels, acidity, and enzyme expression, specifically upregulation of glutaryl-CoA dehydrogenase and MMP2, amongst other enzymes, further contribute to its complexity. Despite advancements in melanoma treatment and FDA approval of therapies targeting specific pathways and employing immune checkpoint inhibitors, challenges persist in melanoma treatment, particularly in optimizing drug delivery and navigating the intricate tumor microenvironment.

Digital transformation and environmentally sustainable innovation: Based on machine learning and text analysis methods.

As global environmental challenges intensify, environmentally sustainable innovation (ESI) has emerged as a critical factor in firms' pursuit of green development strategies. Although traditional literature has emphasized the potential value of digital technologies, less attention has been paid to the transformative role of both internal and external digital transformation in driving ESI. We employ the bidirectional encoder representations from transformers (BERT) and bag of words (BoW) models to construct the ESI and digital transformation variables, facilitating an in-depth examination of the impact of digital transformation on environmental sustainability.

The role of Siglec-15 in tumor immunity: mechanism and therapy.

Siglec-15, a member of the sialic acid-binding immunoglobulin-like lectins (Siglecs) family, has emerged as a pivotal immunosuppressive mediator and a promising therapeutic target in cancer immunotherapy. This transmembrane glycoprotein orchestrates multifaceted biological processes, such as osteoclastogenesis regulation, bone remodeling, and tumor-associated macrophage (TAM)-mediated T cell immunosuppression. Notably, Siglec-15 exhibits non-redundant expression with programmed death-ligand 1 (PD-L1), suggesting its compensatory role in immune evasion mechanisms within PD-L1-negative tumor microenvironment (TME).

Compliant, Tough, Fatigue-Resistant, and Biocompatible PHEMA-Based Hydrogels as a Breast Implant Material.

Breast reconstruction remains hindered by the limitations of conventional implant materials such as silicone, which exhibit hydrophobicity and poor tissue integration, often leading to complications, including capsular contracture. Here, we report the development of a poly-(HEMA-MA)/Fe (PHM/Fe) hydrogel as a next-generation soft implant material. This hydrogel is synthesized via copolymerization of 2-hydroxyethyl methacrylate (HEMA) and maleic acid (MA), followed by immersion in FeCl to induce secondary cross-linking through Fe-carboxyl coordination.

Biomineralized engineered -based in situ vaccination enhances antitumor immunity via sequential activation of chemo-immunotherapy.

Background: Combining chemotherapy with immunotherapy is a promising strategy to enhance in situ immunity by increasing antigen exposure and inflammation in the tumor microenvironment (TME). However, the inconvenience of separate administration and the randomness of delivery can diminish the synergistic effect of these treatments. An efficient co-delivery system to optimize chemo-immunotherapy is urgently needed.

SOX4-ZIP14-zinc metabolism mediates oncogenesis and suppresses T cell immunity in nasopharyngeal carcinoma.

Subtle variations of micronutrients in the tumor microenvironment often coincide with tumor progression and immune disorders. Nevertheless, the underlying mechanisms of how micronutrients, such as metal ions, influence tumor-intrinsic properties and tumor-immune crosstalk remain inadequately characterized. Here, our integrative analysis of multi-center single-cell, spatial transcriptome sequencing, and bulk RNA sequencing (RNA-seq) cohorts reveals that nasopharyngeal carcinoma (NPC)-specific SRY-box transcription factor 4 (SOX4) governs microenvironmental and cellular zinc metabolism through its downstream target, SLC39A14 (ZIP14), a membrane zinc uptake transporter.

A Chromosome-Level Genome Assembly and Annotation for the Beauty Snake Elaphe taeniura.

The genus Elaphe Fitzinger, a large species clade within Colubridae, comprises 18 non-venomous snake species. Among them, Elaphe taeniura serves as a representative species due to its wide distribution and strong adaptability. However, genomic studies on this group remain limited.

Whole-genome resequencing unveils the phylogeographic coevolution of Oncomelania hupensis with Yangtze River dynamics in China.

The freshwater snail Oncomelania hupensis is the only intermediate host of Schistosoma japonicum and is currently mainly distributed in the middle and lower reaches of the Yangtze River in China. To explore the evolutionary history and adaptations of O. hupensis, we re-sequenced 283O.

RNAi-Induced Disruption of Life Cycle Using shRNA-Cell-Penetrating Poly(disulfide) Nanocarriers.

RNA interference (RNAi) efficacy in lepidopterans faces challenges. Here, a chemically engineered nanocarrier system was developed for efficient RNAi in the . High-efficacy siRNA sequences targeting two essential genes: chitin synthase () and coatomer subunit beta-like () were selected via in silico screening, engineered into RNase-resistant shRNAs, and complexed with a cell-penetrating poly(disulfide) (CPD) nanocarrier.

Complete chloroplast genomes of three species and comparative analyses with : codon usage bias and phylogeny.

The liverwort genus , a morphologically specialized bryophyte group, holds unique taxonomic and evolutionary significance. This study sequenced and assembled the chloroplast genomes of three species (, , and ), with genome sizes of 118,233 bp, 118,423 bp, and 118,304 bp, respectively. All three genomes exhibit the typical quadripartite structure.

Phenanthrene exposure disrupts puberty onset in SD rats by influencing hypothalamic neural networks.

Polycyclic aromatic hydrocarbons (PAHs) are gaining attention due to their widespread occurrence and serious health risk. Epidemiological survey research discovered that PAHs are associated with compromised pubertal development. To investigate this, weaned rats were administrated to corn oil (control group) or phenanthrene (PHE) for 21 days.

Parents' learning support and school attitudes in relation to adolescent academic identity and school performance in nine countries.

An important question for parents and educators alike is how to promote adolescents' academic identity and school performance. This study investigated relations among parental education, parents' attitudes toward their adolescents' school, parental support for learning at home, and adolescents' academic identity and school performance over time and in different national contexts. Longitudinal data were collected from adolescents and their parents in nine countries (China, Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the United States).

Risk Assessment of Precancers and Cancers in Women with Atypical Glandular Cells of Endocervical, Endometrial, and Unknown Origin.

To assess the risk of precancers [high-grade squamous intraepithelial lesions (HSIL), adenocarcinoma (AIS) and atypical endometrial hyperplasia (AEH)] and cancers [squamous cell carcinoma (SCC) and adenocarcinoma (ADC)] in women with atypical glandular cells (AGC) cytology. : A total of 1,028 women diagnosed with abnormal cervical glandular cytology from January 2019 and December 2023 were enrolled. Of these, 670 underwent both HPV genotyping and cervical biopsy.

EGCG attenuates BPA -induced male reproductive toxicity by regulating the blood-testis barrier by suppressing autophagy via AMPK/AKT/mTOR signaling pathway.

Bisphenol A (BPA) is a typical endocrine disrupting chemical widely distributed in the environment and in food systems. The adverse effects of BPA on reproductive health have posed major concerns worldwide. The aim of this study was to determine the potential of epigallocatechin gallate (EGCG) to protect against BPA-induced male reproductive toxicity and investigate the underlying protective mechanism.

Development of an mRNA vaccine encoding IHNV glycoprotein protects rainbow trout (Oncorhynchus mykiss) from infection.

mRNA vaccines have demonstrated significant potential in preventing human diseases and controlling livestock infections. However, the application of mRNA vaccines in aquaculture, especially on fish, remains limited. Infectious hematopoietic necrosis virus (IHNV) is an RNA virus that mainly affects rainbow trout (Oncorhynchus mykiss), leading to high mortality rates.

Transition metal-doped porous carbon nitride composites serve as highly reactive catalysts for thermal decomposition of ammonium perchlorate.

The performance of composite solid propellants (CSPs) is influenced by the energy release rate and combustion efficiency of ammonium perchlorate (AP), which serves as their core oxidizer. In this research, porous carbon nitride-based composites doped with transition metals (Mn, Fe, Co, Ni, and Cu) (PCN-M) were rapidly fabricated through precipitation and low-temperature calcination, and were comprehensively characterized. It was found that such additives are conducive to regulating the thermal decomposition pathway of AP and enhancing the combustion efficiency of propellants.

Exploring the Role and Potential of Chatbots in Learning From the Perspective of Nursing Students: A Systematic Review of Qualitative Studies.

Aim: This study explores nursing students' experiences and needs regarding chatbot-assisted learning, while evaluating the opportunities and challenges they encounter.

Background: As artificial intelligence (AI) advances, chatbots are increasingly integrated into nursing education, offering real-time feedback and personalized support. While chatbots show promise in enhancing theoretical knowledge and clinical skills, little is known about students' actual experiences and expectations.