Publications by authors named "Xingqian Shen"

Intralabyrinthine schwannoma (ILS) is a rare benign tumor of the inner ear, often presenting with nonspecific symptoms such as hearing loss, tinnitus and vertigo. Vestibular function in ILS patients remains underexplored. This study aims to evaluate vestibulo-ocular reflex (VOR) function and inner ear magnetic resonance imaging (MRI) signal changes in ILS, and to provide insights into potential mechanisms underlying vestibular dysfunction.

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Purpose: To explore functional connectivity alterations in idiopathic tinnitus patients at the integrity, network, and edge levels through resting-state functional magnetic resonance imaging (rs-fMRI), and elucidating central plasticity changes in idiopathic tinnitus from the perspective of central functional connectivity patterns.

Method: Collect rs-fMRI data from 74 patients with idiopathic tinnitus and 98 healthy volunteers, analyze the functional connectivity differences between the two groups at the integrity, network, and edge levels, and explore the correlation between these differences and the clinical characteristics of idiopathic tinnitus patients.

Result: Patients with idiopathic tinnitus significantly reduce node degree in the left parahippocampal gyrus, left amygdala, and bilateral Heschl gyrus.

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Background: Endolymphatic hydrops (ELH) can be identified by electrophysiological and radiological examinations.

Objectives: We aimed to investigate the relationship between audiometric glycerol test and delayed magnetic resonance imaging (MRI) of the inner ear after intratympanic gadolinium in patients with unilateral Ménière's disease (MD).

Material And Methods: Forty-two patients with unilateral definite MD underwent audiometric glycerol test and delayed MRI following intratympanic gadolinium application.

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: To explore the neuroanatomical abnormalities in idiopathic tinnitus patients by voxel-based morphometry (VBM) and surface-based morphometry (SBM) techniques. To elucidate the central plasticity in tinnitus patients with normal or mild hearing loss from the neuroanatomical insights. : A total of 74 patients with idiopathic tinnitus (43 with normal hearing and 31 with mild hearing loss) and 98 healthy subjects were enrolled.

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BackgroundRamsay Hunt syndrome with dizziness (RHSD), vestibular neuritis (VN), and idiopathic sudden sensorineural hearing loss with vertigo (SHLV) all present with acute vestibular symptoms, and no study has compared the semicircular canal (SCC) deficits among them.ObjectiveThis study aimed to use video head impulse test (vHIT) to compare the SCC injury patterns in RHSD, VN, and SHLV.MethodsTwenty-three RHSD patients, 44 VN patients, and 70 SHLV patients were enrolled.

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Background: The pathological hallmark of Ménière's disease is endolymphatic hydrops, which can lead to an increase in basilar membrane stiffness and, consequently, an acceleration of the traveling wave of sound. The cochlear hydrops analysis masking procedure (CHAMP), which is an auditory brainstem response test masked at various frequencies with high-pass noise masking, uses the principle of the traveling wave velocity theory to determine the presence of endolymphatic hydrops.

Purpose: This study aimed to review the previous results of the CHAMP, expound the principles and key indicators, and discuss its clinical significance in diagnosing Ménière's disease.

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To explore the effect of mild hearing loss on cognitive function by evaluating the Montreal Cognitive Assessment(MoCA) in idiopathic tinnitus patients with mild hearing loss. 102 patients with idiopathic tinnitus(68 patients with normal hearing and 34 patients with mild hearing loss) whose first complaint is tinnitus and 34 healthy volunteers(control group) were included. All subjects were asked to fill the MoCA, Tinnitus Handicap Inventory(THI), Self-rating Anxiety Scale(SAS), Self-rating Depression Scale(SDS), and Pittsburgh Sleep Index(PQSI) after collecting medical history, pure tone audiometry, tinnitus matching and masking test.

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Background: The eustachian tube (ET), a critical conduit connecting the middle ear and nasopharynx, is essential for normal middle ear function. However, it remains one of the least understood anatomical structures due to its complexity and the challenges of in vitro manipulation. Historically, these challenges have hindered research into the morphology and function development of the ET.

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