Effect of transcutaneous auricular vagus nerve stimulation on postoperative liver function in patients undergoing partial hepatectomy: a study protocol for a prospective, double-blind, randomized controlled trial.

Background: Partial hepatectomy remains a primary therapeutic intervention for various hepatic diseases. However, several intraoperative factors, including surgical manipulation, substantial blood loss, the need for blood transfusions, and hypoxic stress, can significantly impair liver function. Current perioperative strategies aimed at protecting the liver exhibit certain limitations.

Chromosome-Level Genome Announcement of the Monokaryotic Strain PC80.

is a widely cultivated edible fungus in China, renowned for its rich nutritional composition and diverse medicinal compounds. However, the quality of the currently published genomes remained suboptimal, which limited in-depth research on its evolution, growth, and development. In this study, we conducted a chromosome-level genome assembly of the monokaryotic basidiospore strain PC80.

Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang.

Objective: Obesity has been recognized as a global epidemic and public health crisis. The prevalence of obesity has tripled since 1975, especially in the elderly population. Accumulating preclinical and clinical studies have confirmed that chronic low-grade inflammation of adipose tissues is mechanistically related to metabolic diseases and tissue complications in overweight and obesity patients, as a result of the intricate interplay of various pro-inflammatory and anti-inflammatory signaling cascades.

Genome-wide association study reveals that the SUS domain protein SS7 positively regulates seed storability in rice (Oryza sativa L.).

The rice seed storability gene Seed storability 7 (SS7) encodes a cytosol localized sucrose synthase (SUS) domain protein. SS7 positively regulates seed storability by enhancing the activity of peroxidase and nitrate reductase (NR) in seeds, resulting in the reduction of ROS and NO accumulation during seed storage. Long-term storage of crop seeds is essential for conserving germplasm resources, ensuring food security, and supporting sustainable agriculture.

OsATG1 and OsATG8 exhibit autophagy-independent functions to oppositely regulate ROP GTPase-mediated plant immunity in rice.

ROP GTPases regulate various cellular processes, including plant immunity. While ROP GTPase activation has been reported during plant immune responses, the mechanisms underlying the dynamic deactivation of ROP GTPases remain unclear. In this study, we identified the autophagy kinase OsATG1 as a key regulator that interacts with and phosphorylates SPIN6, a plant-specific ROP GTPase-activating protein (RhoGAP), which in turn deactivates the ROP GTPase OsRac1.

Physiological impairment and metabolic perturbations in Porites cylindrica induced by Hypnea pannosa contact.

Coral reef ecosystems are undergoing accelerated degradation, characterized by phase shifts marked by declining live coral cover and increasing macroalgal proliferation. However, the long-term metabolic adjustments of corals under chronic macroalgal competition remain poorly understood, particularly regarding the integration of physiological changes with metabolic responses resilience mechanisms. This study conducted a 21-day experiment to investigate the physiological and metabolomic response between coral Porites cylindrica and macroalgae Hypnea pannosa.

TWEAK/Fn14 hypomethylation and higher plasma TWEAK and TNF-α levels are related to sarcopenic obesity in community-dwelling elderly in Xinjiang.

Sarcopenic obesity is a primary factor contributing to the decline in the quality of life among the elderly in our country. Studies have shown that hypomethylation of tumour necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) is associated with sarcopenia. Our research primarily explores whether this mechanism also affects the progression of sarcopenic obesity.

A century of advances in molecular genetics and breeding for sustainable resistance to rice blast disease.

Rice blast, caused by the hemibiotrophic filamentous ascomycete fungus Magnaporthe oryzae, seriously limits rice production. Since the pioneering genetic studies in 1922, substantial advancements have been made in understanding the genetic basis of rice-M. oryzae interaction via the advanced molecular genetics studies.

Association Between Sleep and Vertigo Severity in Benign Paroxysmal Positional Vertigo: Mediating Role of Psychological Factors.

Objective: To investigate the relationship between sleep quality and vertigo severity among patients with benign paroxysmal positional vertigo (BPPV) and to elucidate the mediating effects of anxiety and depression on this association.

Methods: We analyzed baseline data from an ongoing cohort study of 1056 BPPV patients in Northwest China. Vertigo severity was assessed using the Dizziness Handicap Inventory (DHI), sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI), and psychological states were evaluated using the Hospital Anxiety and Depression Scale (HADS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS).

Association of Arterial Stiffness with Atrioventricular Coupling and Left Atrial Phasic Function in Patients with Hypertension.

Background: Hypertension (HTN) predisposes individuals to arterial stiffness (AS) and dysfunction of the left atrial (LA) and left ventricular (LV). AS, characterized by increased pulse wave velocity (PWV) may impair LA phasic function. This study investigates the associations of brachial-ankle PWV and the left atrioventricular coupling index (LACI) as well as LA phasic function in hypertensive patients, and to evaluate the predictive value for LA dysfunction.

The "Fe-S wheel": A new perspective on methylmercury production dynamics in subalpine peatlands.

The cycling of iron (Fe) and sulfur (S) in peatland ecosystems plays a pivotal role in modulating methylmercury (MeHg) formation. This study integrates data on Fe and S fractions, geochemical factors, microbial communities, and statistical modeling to propose the novel "Fe-S wheel" conceptual framework. This framework explores the coupled cycling of Fe, S, and Hg in the Dajiuhu peatland (DJH), an exemplary natural laboratory in central China.

Neuroprotective effects and mechanisms of the YiQiWenYangSanHan formula on Parkinson's disease mice.

Background: Parkinson's disease (PD) is a complex neurodegenerative disease, which is often treated with obvious side effects such as dopamine replacement therapy. Our team has validated the unique advantages of the traditional Chinese medicine formula, YiQiWenYangSanHan formula (YQWYSHF), through in vitro experiments, confirming its therapeutic potential for PD. Nevertheless, further research and validation are required to fully understand its protective effects and underlying mechanisms against PD.

Mangrove Against Invasive Snails: Shows a Molluscicidal Effect on Exotic Apple Snails () in Mangroves.

Apple snails (), one of the 100 most serious invasive species in the world, have invaded mangrove wetlands due to their salinity tolerance. We firstly prepared a plant molluscicide against apple snails based on the mangrove in coastal wetland. The effects of four mangrove extracts from , including ethanol extract (EE), petroleum ether extract (PEE), ethyl acetate extract (EAE), and n-butanol extract (BE), were studied for molluscicidal activity against apple snails in a saline environment.

Heat wave, fine particulate matter, and cardiovascular disease mortality: A time-stratified case-crossover study in Shenzhen, China.

Background: In the context of global warming, the frequency of heat wave and the concentration of fine particulate matter (PM) have increased, and more people are co-exposed to air pollution and extreme heat. However, the interaction between heat wave and PM on cardiovascular disease (CVD) mortality remained largely unknown.

Methods: We conducted a time-stratified case-crossover study of 40,169 CVD deaths in Shenzhen, China between 2013 and 2022.

Metabolic Activity of Invasive Apple Snails Negatively Affects the Survival of Native Benthic Snail in Mangrove.

The golden apple snail (GAS, ) has invaded mangrove forests. The effect of water contaminated by metabolic activity of GAS feeding on (T1), (T2), and without food (CK) on the native mangrove black helmet snail (BHS, ) was investigated under salinity conditions. The GAS deteriorated saline water quality (2.

Influence of metabolic factors on systemic sclerosis complicated with severe interstitial lung disease based on high-resolution computed tomography grading.

Objectives: Systemic sclerosis complicated with interstitial lung disease (SSc-ILD) is a rare autoimmune disease with a dismal prognosis. To analyze the common clinical indicators of systemic sclerosis (SSc) complicated with severe interstitial lung disease (ILD) patients based on the grading of lung high-resolution computed tomography (HRCT) and to explore the risk factors of severe (ILD).

Methods: A retrospective analysis was performed on 72 newly diagnosed and treated SSc-ILD patients in the Affiliated Hospital of Xuzhou Medical University from June 2013 to August 2023.

Pure data correction enhancing remote sensing image classification with a lightweight ensemble model.

The classification of remote sensing images is inherently challenging due to the complexity, diversity, and sparsity of the data across different image samples. Existing advanced methods often require substantial modifications to model architectures to achieve optimal performance, resulting in complex frameworks that are difficult to adapt. To overcome these limitations, we propose a lightweight ensemble method, enhanced by pure data correction, called the Exceptionally Straightforward Ensemble.

The relationship between marital status and survival in primary bone cancer: a population-based study.

Background: Previous studies have demonstrated a significant impact of marital status on the prognosis of various cancers; however, its specific influence on the prognosis of primary bone cancer remains insufficiently investigated. In this study, we aimed to investigate the survival differences between male and female in patients diagnosed with primary bone cancer.

Methods: Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify suitable patients.

Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians.

BACKGROUNDLeft ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking.METHODSUsing liquid chromatography-mass spectrometry (LC-MS), we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending 2 exams (mean, 5 years apart).

Association of Mite Molecular Sensitization Profiles with Respiratory Allergies and Asthma Control in Children from East China.

Background: Allergic conditions, identified as a significant global health challenge, are profoundly influenced by indoor allergens, especially house dust mites (HDM). Yet the relationship between mite sensitized components and respiratory allergies and asthma control remains poorly understood.

Methods: A cohort of 96 children, either with allergic rhinitis (AR) or rhinitis with asthma syndrome (ARAS), was assessed.

Three New Steroids from the Roots of Marsdenia tenacissima.

Three undescribed pregnane steroids, 12β-O-4-hydroxybenzoyl tenacigenin D (1), 12β-O-4-hydroxybenzoyl tenacigenin A (2), and 11α-nicotinoyl-17β-marsdenin (3), along with two known analogues (4 and 5), were isolated from the roots of Marsdenia tenacissima. Their structures were elucidated using one- and two-dimensional NMR, high-resolution electron ionization-mass spectrometry, single-crystal X-ray diffraction data, and experimental and density-functional-theory-calculated electronic circular dichroism measurements. All isolated compounds were evaluated for their cytotoxic activities against human lung cancer cells (A549), ovarian carcinoma cells (SKOV-3), gastric cancer cells (MGC 803) and breast cancer cells (MCF-7).

Harnessing sulfur-binding domains to separate Sp and Rp isomers of phosphorothioate oligonucleotides.

Chemical synthesis of phosphoromonothioate oligonucleotides (PS-ONs) is not stereo-specific and produces a mixture of Rp and Sp diastereomers, whose disparate reactivity can complicate applications. Although the current methods to separate these diastereomers which rely on chromatography are constantly improving, many Rp and Sp diastereomers are still co-eluted. Here, based on sulfur-binding domains that specifically recognize phosphorothioated DNA and RNA in Rp configuration, we developed a universal separation system for phosphorothioate oligonucleotide isomers using immobilized SBD (SPOIS).

NADP-malic Enzyme OsNADP-ME2 Modulates Plant Height Involving in Gibberellin Signaling in Rice.

Plants NADP-malic enzymes (NADP-MEs) act as a class of oxidative decarboxylase to mediate malic acid metabolism in organisms. Despite NADP-MEs have been demonstrated to play pivotal roles in regulating diverse biological processes, the role of NADP-MEs involving in plant growth and development remains rarely known. Here, we characterized the function of rice cytosolic OsNADP-ME2 in regulating plant height.

S100a8/a9 regulated by LPS/TLR4 axis plays an important role in Salmonella-based tumor therapy and host defense.

Bacteria are ideal anticancer agents and carriers due to their unique capabilities that are convenient in genetic manipulation, tumor-specific targeting, and deep-tissue penetration. However, the specific molecular mechanisms of bacteria-mediated cancer therapy (BMCT) have not been clarified. In this study, we found that TLR4 signaling pathway is critical for Salmonella-mediated tumor targeting, tumor suppression, and liver and spleen protection.