Diminished rest-activity rhythm is associated with postoperative complications and mortality: A prospective cohort study of UK Biobank participants.

Background: Circadian rhythm disruption, as a modifiable risk factor, has been increasingly recognised for its potential impact on adverse health outcomes, particularly in surgical populations where its implications warrant further investigation.

Objectives: To investigate associations between postoperative outcomes and preoperative rest-activity rhythm metrics from accelerometry.

Design: A cohort analysis of UK Biobank participants undergoing major surgery within 1 year of accelerometer monitoring.

Association of disrupted circadian rhythms with self-reported periodontal diseases: Insights from 94,305 UK biobank participants.

Background: This study investigates the association of circadian rhythmicity, physical activity, and chronotype with periodontal diseases, focusing on both the independent and combined effects.

Methods: A cross-sectional study was conducted among 94,305 participants from the UK Biobank. Circadian rhythmicity, measured by relative amplitude from the accelerometer, was the primary exposure, with physical activity and chronotype (morning/evening preference) as secondary exposures.

Risk factors for traumatic fracture related infection in surgically treated ankle fracture: A multicenter retrospective study.

Purpose: Infection after ankle fracture fixation is a serious complication, leading to a prolonged healing period and dysfunction in a long-term follow-up. Identifying risk factors for ankle fracture-related infection (FRI) is beneficial in preventing complications and reducing the risk of treatment. The study aims to retrospectively analyze clinical risk factors for ankle FRI.

Outcomes of surgically treated traumatic neuromas of cutaneous nerves as complications of ankle arthroscopy: A 5-year follow-up.

Objectives: To investigate the long term result of traumatic neuromas as complications of ankle arthroscopy treated by neuroma resection.

Methods: Twenty-five patients diagnosed with traumatic neuroma as complications of ankle arthroscopy were included. The standard procedure of microsurgical neuroma resection and nerve release was performed in all patients.

Precision design of highly sensitive luminescent thermometers via crystal field splitting engineering.

Rare earth-doped up-conversion luminescent materials have attracted considerable attention in the field of optical temperature sensing due to their superior spatial resolution and fast response. However, their practical application has been fundamentally hindered by their low relative sensitivity (S), which inherently restricts the accuracy of temperature measurement, and conventional optimization strategies, which predominantly rely on empirical trial-and-error approaches, and lack systematic theoretical guidance for rational material design. To address these critical challenges, we propose a novel thermometric paradigm based on the energy splitting factor (K) to theoretically determine the energy gap (ΔE) between thermally coupled excited states.

Global, regional, and national burden of varicella-zoster infections in adults aged 70 years and older from 1997 to 2021: Findings from the Global Burden of Disease Study.

Background: Varicella-zoster virus (VZV) infection gives rise to varicella (chickenpox) and herpes zoster (HZ, shingles). Primary VZV infection results in varicella, while HZ occurs as a consequence of latent VZV reactivation. Older adults are at a significantly elevated risk of HZ because of age-related immune senescence.

Association between maternal smoking during pregnancy and smoking behaviors in adult offspring.

Background: Maternal smoking during pregnancy (MSP) is associated with offspring smoking. However, there is still scant evidence to support the association between MSP and smoking behaviors in adult offspring.

Methods: This is a prospective cohort study based on the UK Biobank.

Multi-omics assessment of gut microbiota in circadian rhythm disorders: a cross-sectional clinical study.

Background: The interaction between the host and microbiota is influenced by host circadian rhythm. However, it is unknown what the changes of gut microbiota and metabolites.

Methods: We conducted a cross-sectional study (n=72) in which participants' fecal DNA was detected by macrogenomic sequencing analysis.

enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8 T cells.

Background: Immune checkpoint therapy for colorectal cancer (CRC) has been found to be unsatisfactory for clinical treatment. Fecal microbiota transplantation (FMT) has been shown to remodel the intestinal flora, which may improve the therapeutic effect of αPD-1. Further exploration of key genera that can sensitize cells to αPD-1 for CRC treatment and preliminary exploration of immunological mechanisms may provide effective guidance for the clinical treatment of CRC.

Association of Oxygenation Targets and Mortality in Critical Care Patients Following Cardiac Surgery: A Retrospective Cohort Study.

Objective: To investigate the relationship between arterial oxygen partial pressure (PaO) and all-cause mortality of post-cardiac surgery patients.

Design: A retrospective cohort study based on the Medical Information Mart in Intensive Care-III (MIMIC-III) database.

Setting: The MIMIC-III database is a dataset comprising the clinical data of patients admitted to intensive care units (ICUs) at the Beth Israel Deaconess Medical Center.

Factors influencing disease-free survival after radical endometrial cancer surgery: an analysis of the competitive risk prediction mode.

Objective: To investigate the factors influencing disease-free survival (DFS) of patients with endometrial cancer after surgery and construct a competing risk prediction model.

Methods: Clinical data of endometrial cancer patients admitted to the First People's Hospital of Qinzhou City from October 2015 to January 2021 were retrospectively analyzed. A total of 280 patients were included, randomly split into a training set (202 cases) and a validation set (78 cases) in a 7:3 ratio using RStudio software.

Causal association between metabolic syndrome and ovarian dysfunction: a bidirectional two-sample mendelian randomization.

Background: The relationship between Metabolic Syndrome (MetS) and ovarian dysfunction has been widely reported in observational studies, yet it remains not fully understood. This study employs genetic prediction methods and utilizes summary data from genome-wide association studies (GWAS) to investigate this causal link.

Methods: We employed a bidirectional two-sample Mendelian Randomization (MR) analysis utilizing MetS and ovarian dysfunction summary data from GWAS.

Dimeric natural product panepocyclinol A inhibits STAT3 di-covalent modification.

Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. Here, we screened an in-house dimeric natural product collection, and panepocyclinol A (PecA) emerged as a selective and potent STAT3 inhibitor with profound anti-tumor efficacy. Through cross-linking C712/C718 residues in separate STAT3 monomers with two distinct Michael receptors, PecA inhibits STAT3 DNA binding affinity and transcription activity.

Development and validation of non-invasive prediction models for assessing kidney histopathological activity index in lupus nephritis.

Objective: To develop and validate prediction models for estimating the activity index (AI) of kidney histopathology in lupus nephritis (LN) using clinical and laboratory data.

Methods: This study used single-center data from patients with kidney biopsy-confirmed LN between January 2012 and March 2022. The development and validation datasets were temporally cut.

Engineering dual-mode near-infrared ratiometric thermometers based on rare earth-doped molybdates.

Near-infrared optical thermometers have sparked great interest for their ability to provide non-destructive testing and high-resolution. However, the restricted relative sensitivity and single temperature measurement mode represent the current limitations of luminescent thermometers. Herein, near-infrared dual-mode ratiometric thermometers with high sensitivity in La(MoO): Yb, Ln (LMO: YbLn, Ln = Er, Ho, Nd) phosphors were designed.

Correction: Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study.

[This corrects the article DOI: 10.1371/journal.pone.

Achieving Near-Infrared Highly Sensitive Temperature Sensing in Lanthanide-Doped Lead-Free Double Perovskite NaLaMgWO with Significant Thermal Enhancement.

The significant temperature response of lanthanide-doped up-conversion luminescent materials is typically characterized by a severe thermal quenching of the luminescence intensity at elevated ambient temperatures, which severely restricts materials' capability in temperature sensing. Herein, the influence of matrix phonon properties on the remarkable thermal enhancement effect in the thermosensitive material NaLaMgWO:Yb/Nd is reported. It is elucidated that achieving a significant thermal enhancement of Nd with a higher phonon energy oxide matrix is easier than a halide matrix, which has lower phonon energy by comparison with previous findings.

RNA Surveillance Factor SMG5 Is Essential for Mouse Embryonic Stem Cell Differentiation.

Nonsense-mediated mRNA decay (NMD) is a highly conserved post-transcriptional gene expression regulatory mechanism in eukaryotic cells. NMD eliminates aberrant mRNAs with premature termination codons to surveil transcriptome integrity. Furthermore, NMD fine-tunes gene expression by destabilizing RNAs with specific NMD features.

Toward Ultra-High Sensitivity Optical Thermometers and Bright Yellow LEDs Based on Phonon-Assisted Energy Transfer in Rare Earth-Doped LaZnTiO Double Perovskite.

Double perovskites, a class of ceramic oxides with unique crystal structures and diverse physical properties, show promise for various technological applications including solar cells, photodetectors, and light-emitting diodes (LEDs). Despite limited research on rare earth-doped double perovskites, leveraging their ultrahigh luminous efficiency to achieve bright yellow LED emission and addressing energy transfer challenges between Yb and Nd ions in double perovskite LaZnTiO with moderate phonon energy are explored in this work. Through phonon-assisted energy transfer, an ultrasensitive optical thermometer covering a wide temperature range is developed by utilizing the different temperature responses of Er emission in the visible light region and Nd emission in the near-infrared region based on the luminescence intensity ratio (LIR).

Endoscopic Combined Drainage of One Giant and Multiple Small Pancreatic Pseudocysts: A Case Report.

A pancreatic pseudocyst (PPC) is a frequent complication of pancreatitis, often stemming from alcohol, gallstones, or hyperlipidemia. Endoscopic treatment of PPC has become the mainstream treatment. A case of one giant and multiple small PPCs was observed, manifesting as repeated abdominal bloating, abdominal pain, nausea, and vomiting after meals.

Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study.

Background And Aims: Few studies have examined the relationship between daytime napping and risk of kidney diseases. We aimed to investigate the association of daytime napping with the incidence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD). We also examined whether sleep duration modified the association of nap with CKD or ESKD.

Sensitive, Low-Background-Signal miRNA Analysis via the Self-Priming-Initiated Color Reaction Loaded on a Rolling Circle Amplification Product.

MicroRNAs (miRNAs) have been regarded as potential biomarkers in evaluating various diseases, such as pregnancy-induced hypertension and cancers. However, sensitive and reliable miRNA detection is still a challenge due to the low amplification efficiency and high background signal. Herein, we developed a colorimetric method for miRNA detection utilizing the self-priming-initiated color reaction loaded on a rolling circle amplification (RCA) product.

Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design.

The occurrence and development of Parkinson's disease (PD) have been demonstrated to be related to gut dysbiosis, however, the impact of fecal microbiota transplantation (FMT) on microbiota engraftment in PD patients is uncertain. We performed a randomized, placebo-controlled trial at the Department of Neurology, Army Medical University Southwest Hospital in China (ChiCTR1900021405) from February 2019 to December 2019. Fifty-six participants with mild to moderate PD (Hoehn-Yahr stage 1-3) were randomly assigned to the FMT and placebo group, 27 patients in the FMT group and 27 in the placebo group completed the whole trial.