Metabolic basis of resveratrol biosynthesis in P. megaterium PH3: Key roles of phenylpropanoid precursors and enzymatic feedback inhibition.

Resveratrol, a bioactive polyphenol, has poorly characterized biosynthetic pathways in bacteria. Metabolomic analysis demonstrated that resveratrol biosynthesis in P. megaterium PH3 was primarily driven by the phenylpropanoid pathway, with phenylalanine and tyrosine acting as critical precursors that significantly promoted resveratrol synthesis.

Digital Twin-Based Technical Research on Comprehensive Gear Fault Diagnosis and Structural Performance Evaluation.

In the operation process of modern industrial equipment, as the core transmission component, the operation state of the gearbox directly affects the overall performance and service life of the equipment. However, the current gear operation is still faced with problems such as poor monitoring, a single detection index, and low data utilization, which lead to incomplete evaluation results. In view of these challenges, this paper proposes a shape and property integrated gearbox monitoring system based on digital twin technology and artificial intelligence, which aims to realize real-time fault diagnosis, performance prediction, and the dynamic visualization of gear through virtual real mapping and data interaction, and lays the foundation for the follow-up predictive maintenance application.

Evaluating the efficacy and safety of Anlotinib in conjunction with stereotactic radiosurgery for small cell lung cancer patients with brain metastases.

Background: Small cell lung cancer (SCLC) is characterized by its aggressive nature and high propensity for brain metastases. This study investigates the clinical efficacy and safety profile of Anlotinib in combination with Stereotactic Radiotherapy (SRT) for treating brain metastases in patients with small cell lung cancer (SCLC).

Methods: This research included 98 SCLC brain metastasis patients treated at Chengde Central Hospital from October 2020 to January 2024.

Circ_0008440 Inhibits Proliferation and Promotes Apoptosis of Trophoblast Cells through the miR-194-5p/PFKFB2 Axis.

Preeclampsia (PE), an idiopathic hypertensive disorder that arises during pregnancy, poses a serious threat to the health of expectant mothers. Human chorionic trophoblast cells (HTR-8/SVneo) are associated with the development of PE. It has been reported that circ_0008440 expression is abnormally increased in the placental tissues of PE patients.

Research on Fault Diagnosis of Rolling Bearing Based on Gramian Angular Field and Lightweight Model.

Due to the limitations of deep learning models in processing one-dimensional signal feature extraction, and high model complexity leading to low training accuracy and large consumption of computing resources, this paper innovatively proposes a rolling bearing fault diagnosis method based on Gramian Angular Field (GAF) and enhanced lightweight residual network. Firstly, the one-dimensional signal is transformed into a two-dimensional GAF image, fully preserving the signal's temporal dependency. Secondly, to address the parameter redundancy and high computational complexity of the ResNet-18 model, its residual blocks are improved.

The role of the ubiquitin system in the onset and reversal of neuropathic pain.

Neuropathic pain (NP) remains one of the world's most difficult problems, and people suffering from NP have their quality of life affected to a great extent and constantly suffer from pain. Sensitization of injurious receptors, ectopic firing of afferent nerves after nerve injury, and coupling between sympathetic and sensory neurons are involved in the onset or development of NP, but the pathogenesis of NP is still not well understood. We found that the ubiquitin system is involved in the pathogenesis of NP and has a crucial role in it.

Sensitive, Low-Background-Signal miRNA Analysis via the Self-Priming-Initiated Color Reaction Loaded on a Rolling Circle Amplification Product.

MicroRNAs (miRNAs) have been regarded as potential biomarkers in evaluating various diseases, such as pregnancy-induced hypertension and cancers. However, sensitive and reliable miRNA detection is still a challenge due to the low amplification efficiency and high background signal. Herein, we developed a colorimetric method for miRNA detection utilizing the self-priming-initiated color reaction loaded on a rolling circle amplification (RCA) product.

Preparation and functional characteristics of protein from Ginkgo endophytic Pseudomonas R6 and Ginkgo seed.

Ginkgo seed protein (GSP) has excellent processing characteristics and antioxidant properties. In this study, Gingko endophytic protein (GEP) was synthesized by Ginkgo endophytic Pseudomonas R6. SDS-PAGE analysis indicated that the molecular weights of GSP and GEP were mainly distributed at 17 KDa and 48 KDa, respectively.

Photocatalytic and oxidation mechanisms of Fe-Ag@AgCl: Effect on co-existing arsenic (III) and Escherichia coli.

To address the drinking safety problems associated with high arsenic(III) (As(III)) and bacteria in underground water, core-shell Fe-Ag@AgCl nanowires were synthesized and exhibited excellent photocatalytic oxidation effects on co-existing As(III) and Escherichia coli (E. coli). With the introduction of Fe, the nanowires that were used 5 times could be easily magnetically collected, and the As(III) oxidation effect of these re-chlorinated nanowires increased from 39% to 60%.

Mechanistic Insight into Humic Acid-Enhanced Hydroxyl Radical Production from Fe(II)-Bearing Clay Mineral Oxygenation.

Hydroxyl radical (•OH) production by electron transfer from Fe(II)-bearing clay minerals to oxygen has been increasingly reported. However, the influence of ubiquitous coexisting humic acid (HA) on this process is poorly understood. Here, we investigated the effect of different HA on •OH production during the oxygenation of reduced nontronite NAu-2 (rNAu-2), montmorillonite, and sediment.

Visible light-activated 1-D core-shell paramagnetic Fe-Ag@AgCl as an innovative method for photocatalytic inactivation of E. coli.

Innovative paramagnetic one-dimensional (1-D) core-shell Fe-Ag@AgCl visible light-driven photocatalysts are synthesized through a template-assisted electrodeposition method trailed by FeCl in-situ oxidation. The metallic nature of Fe-Ag@AgCl is confirmed through scanning electron microscopy (SEM) and crystal nature through X-ray diffraction (XRD). The controllable diameter of Fe-Ag is obtained through the selection of hollow size of the polycarbonate (PC) template.

A novel compound wind speed forecasting model based on the back propagation neural network optimized by bat algorithm.

Wind power, a clean and renewable resource, is regarded as one of the most promising and economical resources during the transformation from fossil fuels to new energy resources. Thus, the accuracy of wind speed forecasting work is very important to integrate the wind resource into electrical power system on a large scale. To improve the short-term wind speed forecasting accuracy, a novel compound model is introduced in this paper.

A Multi-Organ Nucleus Segmentation Challenge.

Generalized nucleus segmentation techniques can contribute greatly to reducing the time to develop and validate visual biomarkers for new digital pathology datasets. We summarize the results of MoNuSeg 2018 Challenge whose objective was to develop generalizable nuclei segmentation techniques in digital pathology. The challenge was an official satellite event of the MICCAI 2018 conference in which 32 teams with more than 80 participants from geographically diverse institutes participated.

A Review of PCSK9 Inhibitors and their Effects on Cardiovascular Diseases.

Background: Cardiovascular diseases remain the leading cause of morbidity and mortality in the world, with elevated Low-Density Lipoprotein-Cholesterol (LDL-C) levels as the major risk factor. Lower levels of LDL-C can effectively reduce the risk of cardiovascular diseases. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in regulating the degradation of hepatic LDL receptors that remove LDL-C from the circulation.

Establishment and evaluation of a model for predicting 3-month mortality in Chinese patients with hepatic encephalopathy.

Hepatic encephalopathy (HE) is a serious complication of liver disease. To establish a model for predicting 3-month mortality in patients with HE in China. This retrospective study included 609 patients with HE admitted to the Peoples' Hospital, Liaocheng City, China (August 2006 to January 2016).

Synthesis of AG@AgCl Core-Shell Structure Nanowires and Its Photocatalytic Oxidation of Arsenic (III) Under Visible Light.

Ag@AgCl core-shell nanowires were synthesized by oxidation of Ag nanowires with moderate FeCl, which exhibited excellent photocatalytic activity for As(III) oxidation under visible light. It was proved that the photocatalytic oxidation efficiency was significantly dependent on the mole ratio of Ag:AgCl. The oxidation rate of As(III) over Ag@AgCl core-shell nanowires first increased with the decrease of Ag percentage, up until the optimized synthesis mole ratio of Ag nanowires:FeCl was 2.

Efficiently Visible-Light Driven Photoelectrocatalytic Oxidation of As(III) at Low Positive Biasing Using Pt/TiO2 Nanotube Electrode.

A constant current deposition method was selected to load highly dispersed Pt nanoparticles on TiO2 nanotubes in this paper, to extend the excited spectrum range of TiO2-based photocatalysts to visible light. The morphology, elemental composition, and light absorption capability of as-obtained Pt/TiO2 nanotubes electrodes were characterized by FE-SEM, energy dispersive spectrometer (EDS), X-ray photoelectron spectrometer (XPS), and UV-vis spectrometer. The photocatalytic and photoelectrocatalytic oxidation of As(III) using a Pt/TiO2 nanotube arrays electrode under visible light (λ > 420 nm) irradiation were investigated in a divided anode/cathode electrolytic tank.

The prevalence, clinical correlates and structure of phobic fears in Han Chinese women with recurrent major depression.

Background: Phobic fears are common in the general population and among individuals with major depression (MD). We know little about the prevalence, clinical correlates, and structure of phobic fears in Chinese women with MD.

Methods: We assessed 22 phobic fears in 6017 Han Chinese women with MD.

Age at onset of recurrent major depression in Han Chinese women - a replication study.

Background: The relationship between age at onset (AAO) and major depression (MD) has been studied in US, European and Chinese populations. However, larger sample studies are needed to replicate and extend earlier findings.

Methods: We re-examined the relationship between AAO and the clinical features of recurrent MD in Han Chinese women by analyzing the phase I (N=1848), phase II (N=4169) and total combined data (N=6017) from the CONVERGE project.

Clinical predictors of familial depression in Han Chinese women.

Background: A number of clinical features potentially reflect an individual's familial vulnerability to major depression (MD), including early age at onset, recurrence, impairment, episode duration, and the number and pattern of depressive symptoms. However, these results are drawn from studies that have exclusively examined individuals from a European ethnic background. We investigated which clinical features of depressive illness index familial vulnerability in Han Chinese females with MD.

The impact of educational status on the clinical features of major depressive disorder among Chinese women.

Background: Years of education are inversely related to the prevalence of major depressive disorder (MDD), but the relationship between the clinical features of MDD and educational status is poorly understood. We investigated this in 1970 Chinese women with recurrent MDD identified in a clinical setting.

Methods: Clinical and demographic features were obtained from 1970 Han Chinese women with DSM-IV major depression between 30 and 60 years of age across China.

Electrochemical determination of nitrite using a gold nanoparticles-modified glassy carbon electrode prepared by the seed-mediated growth technique.

Seed-mediated growth of gold nanoparticles on glassy carbon (GC) surfaces was developed. The field emission scanning electron microscopy (FE-SEM) and electrochemical characterization confirmed the effective attachment of gold nanoparticles on GC surface with such a wet-chemical method. The as-prepared gold nanoparticles attached glassy carbon electrode (Au/GCE) presented excellent catalytic ability toward the oxidation of nitrite.

Treatment of nitrophenols by cathode reduction and electro-Fenton methods.

This study deals with the degradation of various nitrophenols by cathode reduction and electro-Fenton methods. Phenols (Poh), 2-nitrophenol (2-NP), 3-nitrophenol (3-NP), 4-nitrophenol (4-NP), and 2,4-dinitrophenol (2,4-DNP) are treated and different degradation sequences are obtained. The relationship between the structure and activities of nitrophenols is discussed.