Hybrid feature fusion in cervical cancer cytology: a novel dual-module approach framework for lesion detection and classification using radiomics, deep learning, and reproducibility.

Objective: Cervical cancer screening through cytology remains the gold standard for early detection, but manual analysis is time-consuming, labor-intensive, and prone to inter-observer variability. This study proposes an automated deep learning-based framework that integrates lesion detection, feature extraction, and classification to enhance the accuracy and efficiency of cytological diagnosis.

Materials And Methods: A dataset of 4,236 cervical cytology samples was collected from six medical centers, with lesion annotations categorized into six diagnostic classes (NILM, ASC-US, ASC-H, LSIL, HSIL, SCC).

Radiomics and deep learning methods for predicting the growth of subsolid nodules based on CT images.

The growth of subsolid nodules (SSNs) is a strong predictor of lung adenocarcinoma. However, the heterogeneity in the biological behavior of SSNs poses significant challenges for clinical management. This study aimed to evaluate the clinical utility of deep learning and radiomics approaches in predicting SSN growth based on computed tomography (CT) images.

The spatiotemporal evolution and contributing factors of PM and O concentrations in Shandong Province from 2014-2023.

Comprehensive control of fine particulate matter (PM) and ozone (O) is essential for improving environmental quality. In this study, spatiotemporal pattern mining methods were used to study the spatiotemporal evolution of PM and O in Shandong Province, and Kolmogorov‒Zurbenko (KZ) filtering and stepwise regression methods were integrated to study their influencing factors. The results revealed that (1) from 2014-2023, the PM concentrations in Shandong were high in winter and low in summer, forming a "U"-shaped pattern, and the O concentration showed a seasonal pattern of summer > spring > fall > winter, revealing an inverted "U"-shaped pattern.

Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.

Background: The hematopoietic ecosystem comprises both cellular components such as hematopoietic stem cells (HSCs) and immune cells as well as non-cellular components including iron. Systemic iron overload, which leads to serious complications and affects both patients' quality of life and overall survival, is a common clinical challenge in patients with acute myeloid leukemia (AML). We previously elucidated the direct effects of iron overload on AML cells.

Nursing care of a patient with negative symptoms of schizophrenia who underwent tracheotomy: A case report.

Background: Patients with schizophrenia may lack awareness of the importance of post-tracheotomy care due to the impact of their condition, often showing resistance or misunderstanding of care measures. When coupled with the impact of negative symptoms and the risk of complications after tracheotomy, patients may experience emotional fluctuations, restlessness, anxiety, and hostile behaviors, which pose significant challenges to nursing work.

Case Summary: We have reported the case of an 87-year-old male patient who was admitted to the hospital because of negative symptoms of schizophrenia and who underwent tracheotomy for severe pneumonia.

Association between number of missing teeth and stroke risk: an analysis of NHANES 2011-2020 data.

Background: Stroke is the second leading cause of death globally and the third leading cause of disability, severely impacting quality of life and increasing healthcare costs. Identifying underlying causes is critical for effective management. Oral health is closely linked to stroke occurrence, and tooth loss is a common oral health issue.

High-confidence reconstruction for Laplace inversion in NMR based on uncertainty-informed deep learning.

Laplace-related techniques in nuclear magnetic resonance (NMR), including both standalone Laplace NMR and combined Laplace-Fourier NMR, provide detailed insights into molecular dynamics and spin interactions through the measurement of relaxation and diffusion parameters, offering complementary chemical resolution to Fourier NMR. Spectrum reconstruction with accurate diffusion coefficients or relaxation time is essential for the Laplace-related NMR experiments, but existing processing methods generally yield varying results because of the ill-posed nature of inverse Laplace transform, making it challenging to assess the accuracy and reliability of estimations without ideal references. To address this, we developed a deep learning-based method that not only recovers parameter distributions from exponential signals with improved accuracy but also provides an uncertainty estimation for each reconstruction result.

Impact of postoperative complications on patient-reported outcomes in deep inferior epigastric perforator flap breast reconstruction.

Objective: This study aims to investigate the factors that influence the occurrence of complications following deep inferior epigastric perforator (DIEP) flap breast reconstruction, and to determine whether these complications have an impact on the patient's quality of life in China.

Methods: We collected clinical data from patients who underwent DIEP flap breast reconstruction at the Department of Breast, Affiliated Cancer Hospital of Zhengzhou University between December 2019 and December 2023. We analyzed the incidence of postoperative complications and their relationship with patient clinical data and surgical parameters.

Effects of dietary cinnamic acid supplementation on growth performance, meat quality, muscle development and antioxidant capacity of Yuedong black pigs.

Cinnamic acid (CA) is a natural bioactive substance with antimicrobial, anti-inflammatory and antioxidant properties, which has potential value as a novel feed additive. This study investigated the effects of CA supplementation on growth performance, carcass characteristics, meat quality, energy metabolism and antioxidant capacity in muscle of Yuedong black pigs. A total of 100 3-month-old Yuedong black pigs with an initial body weight of 35 kg were selected and randomly assigned to two treatment groups: the control group and the 0.

Development and validation of screening tools for motoric cognitive risk syndrome in community settings.

Background: Motoric cognitive risk (MCR) syndrome represents an "ultra-early" stage of dementia prevention, highlighting the need for effective screening tools.

Aim: To develop and validate a novel tool for MCR identification, comparing its effectiveness with existing methods.

Methods: As part of a community study on healthy aging, a cross-sectional study recruited 1189 Chinese participants aged 50 years and older between May 1, 2022, and March 15, 2023.

Application of multi-perspective nursing based on the whole-course ERAS concept during laparoscopic fundoplication in patients with PPI-dependent gastroesophageal reflux disease.

Background: To examine the impact of a multi-perspective nursing approach using the whole-course Enhanced Recovery After Surgery concept on laparoscopic fundoplicationoutcomes for patients with proton pump inhibitor-dependent gastroesophageal reflux disease.

Methodology: This study was a randomized controlled trial. 98 proton pump inhibitor -dependent gastroesophageal reflux disease patients who underwent aparoscopic fundoplication in our hospital from Jan 2020 to Dec 2022 were randomly divided into two groups using a random number table.

The association between walking speeds and osteoarthritis risk based on the National Health and Nutrition Examination Survey and Mendelian randomization study.

Objectives: To investigate the association between walking speed and osteoarthritis (OA) risk using nationally representative data and Mendelian randomization analysis to infer potential causality.

Study Design: A cross-sectional study combined with a two-sample Mendelian randomization analysis.

Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES), including information on walking speed, OA status, and covariates.

Photochemistry of Sulfur Dioxide Mediated by Charge Transfer through Intermolecular Chalcogen Bonds.

The photochemistry of sulfur dioxide (SO) plays a crucial role in the Earth's atmosphere. In contrast to the well-established photochemistry of free SO, the electronic properties and reactivity of SO complexes with other atmospherically relevant gas molecules are barely known. Herein, we demonstrate that the photochemistry of SO can be dramatically influenced by the first formation of charge-transfer (CT) prereaction complexes through intermolecular chalcogen bonds.

Effect of finerenone on urinary protein and inflammatory factor levels in type 2 diabetes mellitus patients with diabetic kidney disease.

Aims: This study aimed to investigate the efficacy and safety of finerenone in the treatment of diabetic kidney disease (DKD) in the real-world medical setting and explore the underlying mechanism of its kidney-protecting effects from the perspective of the inflammatory response.

Materials And Methods: Forty-eight DKD patients were selected and completed a 6-month finerenone treatment. Renal parameters, inflammatory cytokines, other related indicators and adverse effects were collected at every visit.

Primary adrenal CD56-negative extranodal NK/T-cell lymphoma: Case report and literature review.

Primary adrenal extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is exceptionally rare, and it remains unclear whether this subtype of ENKTL exhibits distinct clinicopathological features. This case report describes a later 30s female patient who presented with 6 months of back pain. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) revealed a hypermetabolic left adrenal mass.

Spatiotemporal distribution and detection of spatial clusters of tuberculosis in Hubei Province, China using FleXScan (2017-2023).

Background: This study investigates the spatiotemporal distribution and spatial clustering of tuberculosis(TB) in 103 counties of Hubei Province, China, using spatial scan statistics. By identifying high-risk areas and temporal trends, the findings will provide a scientific foundation for targeted TB prevention and control strategies.

Methods: This study employed the FleXScan method to detect spatial clusters of pulmonary tuberculosis cases in Hubei Province and identify statistically significant high-risk areas.

Metabolic divergence between healthy and conditional presenilin-1/2 knockout dementia model mice under chronic nicotine exposure.

BackgroundNicotine's complex physiological effects vary significantly between healthy and neurodegenerative states, yet the underlying metabolic mechanisms remain poorly understood.ObjectiveTo investigate the differential metabolic responses to chronic nicotine administration in healthy versus neurodegenerative conditions and elucidate the underlying biochemical pathways that govern these genotype-dependent effects.MethodsEight-month-old presenilin-1/2 double knockout (DKO) mice and wild-type (WT) controls underwent three-month oral nicotine administration (100 μg/mL).

Fabry-Perot interference optical fiber biosensor based on the ECF for label-free DNA detection.

A fiber-optic biosensor based on self-reference parallel Fabry-Perot interference (FPI) is proposed for label-free DNA detection. The parallel FPI is formed by fusing a section of exposed core fiber (ECF) in SMF and MMF. Adopting the air cavity of the ECF as a reference, a self-reference differential phase demodulation technique is designed to improve the stability and resolution of the demodulation system.

Research on temporal-spatial distribution differences and formation mechanisms of NPP in the Lanzhou section of the yellow river mainstream.

The Lanzhou section of the Yellow River mainstem is a typical area for vegetation restoration in the ecologically fragile region of Northwest China. The spatiotemporal differences in Net Primary Productivity (NPP) of vegetation in this area serve as an important criterion for measuring the effectiveness of assessing vegetation growth. We analyze the spatiotemporal differentiation characteristics and driving mechanisms of NPP in the northern and southern mountain along the Lanzhou section of the Yellow River mainstream from 2000 to 2020 with the methods of the CASA model, Sen-MK trend analysis, and geographical detector.

Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents.

Neuroimmune signals can regulate neuronal function and affect behavior through mechanisms that are not yet fully understood. Here we investigated the action of interleukin 13 (IL-13), a cytokine that can be produced in the brain by both microglia and neurons. We show that dopamine-containing neurons in the ventral tegmental area (VTA) predominantly express the IL-13 receptor alpha 1 (IL-13Rα1) and exhibit presynaptic vesicular localization of neuronal IL-13.

Shared and unique therapeutic targets of KarXT and clozapine for schizophrenia treatment revealed by network pharmacology and molecular docking analyses: Implications for differential clinical responses.

Xanomeline plus trospium (KarXT) is a combination drug targeting muscarinic receptors with demonstrated efficacy against positive, negative, and cognitive symptoms of schizophrenia, although therapeutic effects on positive and negative symptoms do not differ significantly from risperidone and olanzapine. Clozapine remains the most effective treatment for schizophrenia unresponsive to other antipsychotics and demonstrates superior efficacy for positive and negative symptoms compared to risperidone and olanzapine. However, the common and distinct molecular targets underlying these different clinical responses to KarXT and clozapine are not fully understood.

Economic insecurity increases high earners' preference for risk.

This study examines how economic insecurity and income level influence individuals' preferences for risk in decision-making. Economic insecurity was experimentally manipulated in a laboratory setting, and participants' risk preference was subsequently assessed using the Balloon Analogue Risk Task (BART). Participants completed the BART under either a gain frame, where inflating a virtual balloon increased potential monetary gains (Experiment 1), or a loss frame, where ballon inflation was necessary to avoid monetary loss (Experiment 2).

The Impact of Azithromycin on Lung Function in Children And Adolescents with Cystic Fibrosis: A Systematic Review And Meta-Analysis.

Purpose: This study aims to evaluate the effects of azithromycin on lung function in children with cystic fibrosis (CF) through a systematic review and meta-analysis of randomized controlled trials (RCTs). The study primarily focuses on its impact on FEV1 (forced expiratory volume in 1 second), FVC (forced vital capacity), and the progression of lung function decline.

Methods: Electronic searches were conducted across PubMed,Cochrane Central, Embase, Web of Science, and China National Knowledge Infrastructure databases, including studies published up to November 1, 2024.

Transformational leadership, psychological empowerment, work engagement and intensive care nurses' job performance: a cross-sectional study using structural equation modeling.

Background: The global nursing shortage has intensified the need for effective leadership strategies to enhance nurse performance and retain skilled staff, particularly in high-stress environments like intensive care units Transformational leadership has been recognized as a critical factor in improving nurses'job performance. However, the mechanisms underlying this relationship remain underexplored. This study investigates the direct impact of transformational leadership on ICU nurses'job performance and examines the mediating roles of psychological empowerment and work engagement.