[Pediatric salivary pleomorphic adenoma: report of 30 cases].

To summarize the clinical characteristics, diagnosis and treatment experience of salivary pleomorphic adenoma in children. Thirty patients with salivary pleomorphic adenomas treated in Beijing Childrens Hospital from January 2008 to December 2022 were retrospectively reviewed, including 11 boys and 19 girls, with the age ranging from 0.3 to 14.

Incidence and risk factors of pulmonary complications after lumbar spine surgery, 2010-2019.

Background: The occurrence of pulmonary complications is common following major surgery, resulting in a diversity of detrimental outcomes. Nevertheless, there is a dearth of documentation examining the occurrence rate of pulmonary complications and related hazard factors following lumbar spine surgery by using a large-scale national database.

Methods: We conducted a retrospective database analysis from 2010 to 2019 by using the Nationwide Inpatient Sample (NIS).

Prevalence and the Mutual Relationship Between Chronic Obstructive Pulmonary Disease and Arbovirus: A Comprehensive Systematic Review and Meta-Analysis of Current Evidence.

Chronic obstructive pulmonary disease (COPD) is a progressive condition affecting the lungs, marked by persistent respiratory symptoms. The prevalence and the risk of COPD in arboviruses types is not fully addressed clinically. We aim to determine the prevalence and the risk of COPD in arboviruses by a systematic review and meta-analysis.

Cavitation-enhanced disrupts the agglomeration of carbon nanotubes to construct dry electrodes with high-rate and high-loading.

Driven by the urgent demand for high-energy-density lithium-ion batteries, conventional wet slurry-coating processes suffer from critical limitations. Although dry electrode manufacturing emerges as a promising alternative for energy density enhancement, challenges persist in achieving uniform active material dispersion and long-term cycle life. In this study, a dry electrode material composite strategy based on the ultrasonic microbubble cavitation-enhanced (UMC) effect was proposed.

Patient characteristics and adverse effects of allogeneic blood transfusion following lower extremity joint replacement in rheumatoid arthritis: a nationwide inpatient sample database study.

Objectives: Allogeneic blood transfusion is a common therapeutic intervention for patients with rheumatoid arthritis (RA) undergoing lower extremity joint replacement (LEJR). Despite the potential for adverse outcomes associated with blood transfusion, the risks related to this procedure in RA patients remain underexplored, particularly within the framework of a large-scale national dataset.

Methods: This study analyzed data from the National Inpatient Sample (NIS) database from 2010 to 2019, identifying 66,674 patients diagnosed with RA who underwent LEJR.

Research on temporal-spatial distribution differences and formation mechanisms of NPP in the Lanzhou section of the yellow river mainstream.

The Lanzhou section of the Yellow River mainstem is a typical area for vegetation restoration in the ecologically fragile region of Northwest China. The spatiotemporal differences in Net Primary Productivity (NPP) of vegetation in this area serve as an important criterion for measuring the effectiveness of assessing vegetation growth. We analyze the spatiotemporal differentiation characteristics and driving mechanisms of NPP in the northern and southern mountain along the Lanzhou section of the Yellow River mainstream from 2000 to 2020 with the methods of the CASA model, Sen-MK trend analysis, and geographical detector.

Incidence and Risk Factors for Femoral Malrotation Following Intramedullary Nailing of Trochanteric Fractures: A CT-Based Analysis.

Objective: To quantify rotational displacement following intramedullary nail fixation for intertrochanteric femoral fractures using three-dimensional (3D) CT imaging, analyze associated risk factors, and evaluate its clinical significance.

Methods: This study enrolled a cohort of 252 patients who underwent intramedullary nail fixation for intertrochanteric femoral fractures between 2019 and 2023. All participants underwent postoperative three-dimensional computed tomography (3D CT) and were followed for a minimum of 1 year.

Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis.

Metabolic dysfunction-associated steatohepatitis (MASH), an advanced stage of metabolic dysfunction-associated steatotic liver disease, is characterized by significant hepatic fibrosis and inflammation. The pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist IVA337 (lanifibranor) has shown potential as an anti-MASH therapeutic, although its mechanisms of action remain incompletely understood. This study explores the effects and mechanisms of IVA337 using two distinct MASH models: two-dimensional (2D) primary human hepatic stellate cells (HSCs) stimulated with transforming growth factor β1 (TGF-β1), and three-dimensional (3D) liver spheroids comprising primary hepatocytes, HSCs, and non-parenchymal cells.

Erratum to: Lycorine attenuates lipopolysaccharide-induced inflammation and intestinal epithelial barrier dysfunction in Caco-2 cells through inhibiting the STING/NF-κB pathway.

The Pakistan Journal of Pharmaceutical Sciences declares the first co-author ship of Weiwei Gao, and Peng Guan, due to their equal contribution, claimed by the authors. doi: 10.36721/PJPS.

Evidence-Based Weight Management for Fertility Preservation in Endometrial Cancer Patients: Developing a Complex Intervention Based on the Medical Research Council Framework.

: This study aims to develop a standardized weight management intervention program for patients with endometrial cancer (EC) undergoing fertility preservation treatment and to provide a scientific foundation for midwives to implement weight management initiatives in the domains of oncology and reproduction. : The weight management intervention program for patients with EC undergoing fertility preservation treatment was crafted following the directives of the Medical Research Council framework for developing and assessing complex interventions and the World Health Organization handbook for guideline development. The development process encompassed four distinct stages: (1) establishing the intervention development group, (2) identifying a theoretical basis and forming a content framework, (3) gathering and synthesizing evidence, and (4) refining and modeling the practice program.

Association of dietary index for gut microbiota with frailty in middle-aged and older Americans: a cross-sectional study and mediation analysis.

Background: While frailty poses significant challenges in aging populations, evidence regarding gut microbiome-targeted nutritional strategies remains limited. The novel Dietary Index for Gut Microbiota (DI-GM), quantifying microbial-pertinent dietary patterns, provides a framework for personalized frailty mitigation.

Methods: This cross-sectional study analyzed 12,914 middle-aged and older Americans (≥45 years) from National Health and Nutrition Examination Survey 2005-2018.

Rotational changes and associated risk factors following intramedullary nail fixation for intertrochanteric femoral fractures in elderly patients.

Objective: To quantify rotational displacement following intramedullary nail fixation for intertrochanteric femoral fractures using three-dimensional (3D) CT imaging, analyze associated risk factors, and evaluate its clinical significance.

Methods: A total of 210 patients who underwent intramedullary nail fixation for intertrochanteric femoral fractures between 2020 and 2022 were included. All patients received postoperative 3D CT scans and were followed for at least 1 year.

S100A8 regulated by estrogen improves injured endometrial epithelium reconstruction by promoting tight junction formation and stromal cell transformation.

Estrogen is used for endometrial repair; however, it has limited effectiveness. Cytokine S100A8 expression is affected by estrogen and is involved in regulating the damage repair. We aimed to confirm the effects of S100A8 and explore its mechanisms during the reconstruction of the injured endometrium.

Bosutinib Restores the Sensitivity of Colistin against Mcr-1-Positive .

Plasmid-mediated transmission of the gene significantly impairs the antimicrobial activity of colistin, limiting clinical therapeutic options. In this study, we evaluated the potential of bosutinib in restoring the susceptibility of colistin to mcr-1-positive drug-resistant using a "drug repurposing" strategy and explored its mechanism of action to develop a new combination therapy regimen. We found that bosutinib combined with colistin significantly restored the susceptibility of mcr-1-positive to colistin and showed strong bactericidal and antibiofilm activities, confirmed by drug sensitivity assays, viable bacterial counts, and biofilm assays.

Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation.

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy driven by metabolic reprogramming, including dysregulated aerobic glycolysis and reactive oxygen species (ROS) signaling, which promote disease progression and therapeutic resistance. Although baicalein (BC) has demonstrated anti-tumor potential in various cancers, its specific role and molecular mechanisms in AML remain unclear. This study aimed to elucidate the effects and regulatory mechanisms of BC in AML.

A study on multi-objective optimization for the location selection of smart underground parking facilities in high-density urban areas of megacities: A case study of Jing'an district, Shanghai.

The acceleration of global urbanization and the rapid growth of urban populations have intensified the complexity and urgency of parking demand. In megacities with limited land resources, efficiently addressing diverse parking needs has become a critical issue for sustainable urban development. Multi-objective optimization methods are widely applied to tackle such challenges, providing decision-makers with a set of optimal solutions that balance multiple objectives.

Inflammatory Macrophage-Targeted Atherosclerosis Treatment by miRNA-Delivered, MRI-Visible, and Anti-Inflammatory Nanomedicine.

Atherosclerosis, a principal cause of fatal cardiovascular diseases, is fundamentally a chronic inflammatory disease. Addressing this, the combined regulation of oxidative stress and inflammation through synergistic modalities offers an efficient therapeutic avenue. In this work, we rationally designed and engineered a highly efficient functional nanosystem, referred to as polydopamine nanoparticles doped with arginine and gadolinium ions (AGPDAR-146a), for the targeted delivery of therapeutic oligonucleotides, specifically microRNA-146a (miR-146a), to inflammatory macrophages within atherosclerotic plaques.

Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.

The mechanisms underlying transcriptional dysregulation in tumorigenesis have received considerable attention as promising therapeutic targets to combat human cancer. Cyclin-dependent kinase 9 (CDK9) and class I histone deacetylases (HDACs) are significant therapeutic targets due to their pivotal roles in the dysregulated transcriptional programs characteristic of many cancers. Furthermore, the combinatorial transcriptional therapy with CDK9 and class I HDAC inhibitors has been shown to have a synergistic anticancer effect.

Multifunctional cascade theranostic agents for synergistic photothermal/ferroptosis/immuno antitumor therapy.

Photothermal therapy (PTT) has achieved tremendous advances against various cancers. However, it encounters uneven heat distribution caused by the limited penetration of the excitation light. Besides, the intrinsic heat resistance mechanisms in the tumor microenvironment limit antitumor efficacy and impose the potential risks of metastasis.

The E3 ubiquitin ligase SlATL2 suppresses tomato immunity by promoting SlCSN5a degradation during pv. DC3000 infection.

Plant immunity involves complex regulatory mechanisms that mediate the activation of defense responses against pathogens. Protein degradation via ubiquitination plays a crucial role in modulating these defenses, with E3 ubiquitin ligases functioning as central regulators. This study investigates the role of SlATL2, an ARABIDOPSIS TÓXICOS EN LEVADURA (ATL)-type E3 ubiquitin ligase localized in the plasma membrane, in the immune response of tomato plants against pv.

Comparison of Closed Irrigation and Drainage vs Repeated Wound Dressing Changes for Iliac Crest Bone Donor Site Infection in Spine Surgery.

Objective: Bone donor site infection (BDSI) is a main complication of bone harvest in spine surgery. Traditionally, repeated wound dressing changes (RWDC) after debridement are commonly used to treat BDSI but are associated with significant pain and largely prolonged hospitalization. This study retrospectively compared the effectiveness of closed irrigation and drainage (CIAD) with RWDC in treating BDSI.

Synergistic Comprehensive Activation Methods for Dual-Modality PDT and Hypoxia-Triggered Chemotherapy Guided by NIR-II Imaging beyond 1700 nm in Deep Tumors.

Although photodynamic therapy (PDT) holds great promise for applications in cancer treatment, it has limited effectiveness against deep hypoxic tumors. Moreover, the lack of visualization guidance for precision theranostics poses additional challenges, hindering its broader clinical adoption. By combining NIR-IIc (1800 nm) imaging guidance with internally and externally activatable dual-modality PDT and hypoxia-triggered chemotherapy, this study proposes a conceptual framework to overcome these limitations.

α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice.

Nicotine addiction is a serious global public health problem, so there is an urgent necessity to develop novel effective smoking cessation treatments with fewer adverse effects. Spontaneous behavioral sensitization induced by repeated intermittent exposure to the addictive substance represents a classical animal model of addiction research. A significant contributor to nicotine addiction is its interaction with α6β2* nAChRs located on midbrain dopaminergic neurons, which leads to an increase in dopamine (DA) release.

Depression as a Risk Factor for Gynecological Cancers: Evidence from NHANES Data.

Purpose: Depression is one of the leading sources of disease burden globally and plays a significant role in the occurrence and development of many cancers, representing an important health risk. However, the relationship between depression and the risk of gynecologic cancers has not been fully assessed. This study aims to explore the association between depression and the risk of gynecologic cancers.