Nickel exposure aggravates aortic dissection by exacerbating neutrophil recruitment and NETosis to compromise endothelial barrier.

Nickel exposure elevates aortic dissection (AD) risk, yet its pathogenic mechanisms remain unclear. Here, we demonstrate that nickel accelerates AD progression, particularly in hypertensive individuals. Bioinformatics analysis of GEO datasets identified chemokine-mediated endothelial-neutrophil crosstalk as a key pathway.

Advancing Wearable VOC Sensors: A Roadmap for Sustainable Agriculture and Real-Time Plant Health Monitoring.

Plant diseases account for nearly one-third of annual global crop losses, making early and real-time detection essential for safeguarding agricultural productivity. Wearable technology has emerged as a promising real-time plant health monitoring approach that detects specific physiological and chemical changes associated with plant diseases or stresses. In this review, we highlight the role of volatile organic compounds (VOCs) as noninvasive biomarkers for tracking plant health and diagnosing diseases.

Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study.

Purpose: To characterize causes of death in patients with bone metastases and to support data-driven approaches to survivorship planning and clinical decision-making in this population.

Methods: Using data from the SEER registry (2010-2021), we identified 186,404 patients with newly diagnosed bone metastases. Causes of death were classified as related to the cancer-specific, non-cancer, or subsequent cancer.

Integrative machine learning and Mendelian randomization identify causal laboratory biomarkers for coronary artery lesions in Kawasaki disease: a prospective study.

Kawasaki disease (KD) patients could develop coronary artery lesions (CALs) which threatens children's life. We aimed to develop and validate an artificial intelligence model that can predict CALs risk in KD patients. A total of 506 KD patients were included at Children's Hospital of Fudan University.

Rapamycin alleviates neurodegeneration in a Drosophila model of spinocerebellar ataxia type 51.

Spinocerebellar ataxia (SCA) type 51 is a neurodegenerative disease caused by CAG repeat expansions in exon 1 of the THAP11 gene. These repeats are translated into a glutamine-rich protein, THAP11-polyQ, which forms protein aggregates and exhibits toxicity in cell models; however, the underlying mechanism remains unclear. In this study, we generate transgenic Drosophila models expressing varying lengths of THAP11-polyQ using the UAS-GAL4 system and assess neurodegeneration through pathological and behavioral analyses.

Effect of combined salt and microplastic stress on the microbiota structure of the rice-oriental armyworm system.

Salt and microplastic (MP) stress likely co-occur in coastal plains, yet their combined influence on multi-trophic members remains poorly understood. We investigated whether combined salt (120 mM) and polyethylene (PE-MP) (10 mg/L) stress affected biomass and microbial diversity and structure in rice and oriental armyworm. The results showed that rice biomass remained unchanged, armyworm weight decreased under individual stressors (0.

The optimal childbearing age and birth spacing in china: a multicenter retrospective cohort study.

Background: We aimed to comprehensively analyze the impact of both maternal age and birth spacing on adverse maternal and neonatal outcomes.

Methods: A total of 151,301 pregnancies in China from January 1, 2010, to December 31, 2021 were included, and 8,222 subjects matched their primary and second pregnancy information. Join point regression was used to analyze the temporal trends of adverse outcomes with maternal age and birth spacing.

Multigenerational Heat Selection Enhancing Thermal Acclimation and Transcriptional Response of Hsps to Heat Stress in Male Adults.

In this study, using a multigenerational heat selection design, we investigated the possible pattern of thermal acclimation and the background mechanism in . Results show that heat selection significantly shortened the larval and pupal developmental duration, which was maintained in the four tested generations. Significant costs to reproduction were found in the first two generations, but they recovered in the following generations.

Unmasking Phytotoxicity and Interaction Mechanism of Two Phthalate Esters in Lettuce: Evidences from Biotransformation Processes, Metabolic Response and Molecular Network Perturbations.

Vegetables are considerably affected by plasticizer pollution. This study investigated the transformation process and toxic mechanisms of dimethyl phthalate (DMP) and butyl benzyl phthalate (BBP), in lettuce. Six phase I transformation products of DMP and nine phase I transformation products of BBP were screened and identified using UPLC-QTOF-MS, which were primarily generated via hydrolysis, hydroxylation, and decarboxylation.

A heart failure classification model from radial artery pulse wave using LSTM neural networks.

Background: Heart failure (HF) represents a pressing global health issue demanding innovative and accessible approaches for early detection. Non-invasive, rapid, and cost-effective techniques utilizing deep learning (DL) hold significant promise for addressing this challenge.

Methods: This study included 462 participants categorized into healthy, coronary artery disease (CAD), and HF groups.

Thoracic paravertebral osteosarcoma induced by radiotherapy for esophageal cancer: A case report.

With the wide application of radiation therapy for malignant tumors and the continuous improvement of comprehensive treatment effect, the survival period of patients has been prolonged, while the incidence of radiation-induced osteosarcoma (RIOS) has gradually increased. Compared with primary osteosarcoma, RIOS has a higher degree of malignancy and poorer prognosis, severely impacting patient survival. Currently, there are relatively few case reports on RIOS and the understanding of its imaging characteristics remains incomplete.

The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment.

Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, the expression of senescence markers, and the acquisition of senescence-associated secretory phenotype (SASP). In this review, we discuss the role of cellular senescence within the tumor microenvironment. Some senescent innate immune cells fail to sustain their antitumor function and may even promote tumor progression.

Unexpected Spontaneous Generation of Superoxide Radicals: Water-Solid Collision as an Atypical Source.

Spontaneous generation of reactive oxygen species (ROS) driven by water-solid contact electrification was a new source of redox chemistry. However, superoxide radicals (O ), a kind of ROS that was of great significance in both natural and engineering environments, remain overlooked and poorly understood at the water-solid interface. Here, we found O could be generated spontaneously when water collided with the solid interface even under dark conditions, and its production was quantified by CL.

Factors influencing the birth weight of ART-conceived offspring.

Since the birth of the first infant conceived through assisted reproductive technology (ART) in 1978, over 10 million individuals worldwide have been born using these methods. ART has offered hope to many facing infertility. However, concerns remain regarding potential health risks in ART-conceived offspring.

Correction: Adverse childhood experiences and 10-year depressive-symptoms trajectories among middle-aged and older adults in China: a population-based cohort study.

[This corrects the article DOI: 10.3389/fpubh.2024.

Targeting GABA signaling in the tumor microenvironment: implications for immune cell regulation and immunotherapy resistance.

As an important inhibitory neurotransmitter, γ-aminobutyric acid (GABA) not only plays a key role in the central nervous system, but also has attracted wide attention in the tumor immune microenvironment in recent years. Studies have shown that tumor cells can synthesize GABA and use it to remodel the tumor microenvironment, thereby promoting the occurrence, development and metastasis of tumors. Although previous studies have revealed the important role of GABA in tumor immune escape, there are still many unknown areas of its mechanism, especially the heterogeneous manifestations in different tumor types and tissue environments.

Lipid profiling reveals unsaturated lipid reduction in women with Alzheimer's disease.

Introduction: Alzheimer's disease (AD) is a devastating neurological disease that disproportionately affects women. This study aimed to investigate sex-specific single lipids associated with AD.

Methods: Plasma samples from 841 participants, comprising 306 individuals with AD, 165 with mild cognitive impairment (MCI), and 370 cognitively healthy controls were curated from the AddNeuroMed cohort.

The Impact of Comorbidities, EEG Abnormalities, and ASM Use as a Predicting Outcomes in Pediatric Status Epilepticus.

Background: Pediatric patients admitted to the pediatric intensive care unit (PICU) often present with diverse clinical conditions that influence their prognosis. Identifying key prognostic factors is crucial for optimizing treatment strategies and improving patient outcomes.

Methods: A retrospective analysis was conducted on the clinical data of 203 pediatric patients with status epilepticus (SE) admitted to the PICU from January 2020 and December 2024.

Clinical characteristics and caloric testing in patients with light or heavy cupula of the horizontal semicircular canal.

Objectives: Persistent direction-changing positional nystagmus (DCPN) and null point (NP) are characteristic of cupulopathy of the horizontal semicircular canal (HSC). The cupulopathy can manifest as HSC-light cupula (HSC-Lcu) (geotropic DCPN) and HSC-heavy cupula (HSC-Hcu) (apogeotropic DCPN) in the supine roll test (SRT). Whether the affected side of cupulopathy could be based on the nystagmus intensity in the SRT is controversial.

PNAGMDA: A Principal Neighborhood Aggregation Based Graph Neural Network for miRNA-Disease Association Prediction.

Increasing research suggests that microRNAs (miRNAs) serve an essential function as biomarkers in various diseases. The variations in miRNA expression can influence their corresponding mRNAs, which, in turn, regulate the expression of target genes. Recently, graph neural networks (GNNs) have been widely utilized to predict miRNA-disease associations.

Methanol fixation and tagmentation of RNA/DNA hybrids directly enable single-cell transcriptome sequencing.

Objective: Single-cell transcriptome sequencing is a powerful tool for investigating cellular diversity in normal development and disease. However, prevalent methods predominantly employ 3'-end sequencing of transcripts, limiting the analysis of alternative splicing and other post-transcriptional processes. While full-length single-cell transcriptome sequencing methods, such as Smart-seq, offer more comprehensive information, but are restricted by low-throughput.

Zebrafish neurofibromatosis type 1 mutants show disruption of sleep but not of circadian rhythms.

Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder that is associated with several developmental and behavioral phenotypes, including reduced and fragmented sleep at night. Here we describe the role of NF1 in sleep in zebrafish, a diurnal vertebrate whose mechanisms of sleep control are broadly conserved with those of mammals. The zebrafish genome encodes for two nf1 paralogs, nf1a and nf1b, that function in a partially redundant manner.