Mechanically robust and highly conductive polyacrylamide/carboxymethyl chitosan organohydrogels via synergistic physical interactions for flexible sensing.

Conductive hydrogels have revolutionized wearable electronics due to their biocompatibility and tunable properties. However, it remains a great challenge for hydrogel-based sensors to maintain both conductivity and mechanical integrity in harsh environments. Synergistic dynamic interactions provide a promising strategy to address this issue.

Multiomics analysis of gibberellin involved in far-red light-regulated internode elongation in cucumber seedlings.

GA participates in FR light-induced internode elongation of cucumber by regulating the expression of genes/proteins related to aquaporins, expansins, cell wall biosynthesis, hormone metabolism, and signal transduction. This study investigated the effects of the interaction between far-red (FR) light and gibberellin (GA) on the internode elongation of cucumber (Cucumis sativus L. 'Zhongnong No.

Spatial Disparities in Perfluoroalkyl and Polyfluoroalkyl Substances Exposure and Immunosuppressive Effects on Vaccine Induced Antibody Levels in Guangzhou Children.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants that are widely detected in human serum worldwide, and are associated with reduced vaccine-induced antibody responses. However, existing research has primarily focused on the effects of prenatal and adolescent PFAS exposures on antibody levels or disease incidence. A critical gap remains in understanding the association between serum PFAS concentrations and antibody levels in children.

Remnant Preservation in Anterior Cruciate Ligament Reconstruction Versus Non-Preservation Methods: A Systematic Review and Meta-Analysis.

To manage anterior cruciate ligament (ACL) injury, both remnant-preserving anterior cruciate ligament reconstruction (ACLR) and standard ACLR without remnant preservation are applied. This study aims to systematically evaluate clinical outcomes of remnant-preserving versus standard ACLR techniques by analyzing randomized controlled trials (RCTs). The PubMed, Embase, and Cochrane Library databases were used to identify studies published from January 2000 to November 2024.

Small extracellular vesicles derived from hair follicle neural crest stem cells enhance perineurial cell proliferation and migration via the TGF-β/SMAD/HAS2 pathway.

Peripheral nerve defect repair is a complex process that involves multiple cell types; perineurial cells play a pivotal role. Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling; however, their clinical applications are limited by potential risks such as tumorigenesis and xenogeneic immune rejection, which are similar to the risks associated with other stem cell transplantations. The present study therefore focuses on small extracellular vesicles derived from hair follicle neural crest stem cells, which preserve the bioactive properties of the parent cells while avoiding the transplantation-associated risks.

Mediating effect of moral resilience between good-death perception and coping with death competence of ICU nurses: a cross-sectional study.

Background: Moral resilience can help Intensive Care Unit (ICU) nurses overcome moral dilemmas caused by the death of patients, while enhancing their competence to cope with death. Death-coping competence is also related to the cognitive level of nurses about good death. However, few studies have focused on the relationships among between moral resilience, perception of good death, and death-coping competence.

Preclinical evaluation of antitumor activity and toxicity of TROP2-specific CAR-T cells for treatment of triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) represents a subtype of breast cancer with poorest prognosis due to limited effective targeted therapies. Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable efficacy in treating hematological cancers, but its application in TNBC requires further development. One major obstacle is the lack of suitable tumor-specific target in TNBC.

Pay more attention to the robustness of LLMs on adversarial prompt for instruction data mining.

Instruction tuning has emerged as a paramount method for tailoring the behaviors of LLMs. Recent studies have unveiled the potential for LLMs to achieve high performance through fine-tuning with a limited quantity of high-quality instruction data. Instruction-Following Difficulty is one of the most representative approaches in instruction data mining, which involves selecting samples where LLMs fail to generate response that align with the provided instructions as the high-quality instruction data.

DA-PFL: Dynamic Affinity Aggregation in Personalized Federated Learning Under Class Imbalance.

Personalized federated learning (PFL) has become a hot research topic that can learn a personalized learning model for each client. Existing PFL models prefer to aggregate similar clients with similar data distribution to improve the performance of learning models. However, similarity-based PFL methods may exacerbate the class imbalance problem.

Recent progress in the use of periplocin, periplocymarin and periplogenin in cancer treatment.

Periplocin, periplocymarin and periplogenin are the main active components of . The most cytotoxic constituent of , periplocin is an alpha cardiac glycoside with a steroid core and an unsaturated five-membered lactone ring structure. Periplocymarin is a secondary alpha cardiac glycoside, which is produced by removing one molecule of glucose from periplocin, and periplogenin is the glycosidic portion and the basic unit of periplocin and periplocymarin.

A single-nanoprobe-integrated multi-modal microscope (SNIM).

Nanodiamonds hosting nitrogen-vacancy centers, as quantum sensors, have been explored for intracellular multi-physics field measurements. However, the lack of active control of the nanodiamond inside the cell hinders the intracellular targeted sensing. We develop a single nanoprobe integrated multi-modal microscope based on our recently proposed manipulable single nanodiamond (MSN) approach, capable of active manipulation of the nanoprobe, live cell culture, in situ observation, and multi-physical field measurement.

Impact of Sodium-Glucose Cotransporter 2 Inhibitor on Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With or Without Metabolic Syndrome.

Aims: The impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on atrial fibrillation (AF) recurrence after catheter ablation is still inconclusive. Besides, their efficacy on AF recurrence stratified by metabolic syndrome (MetS) status remains unknown.

Methods: Patients with AF undergoing initial catheter ablation between January 2017 and December 2023 from the China-AF Registry were included.

Effect of sorafenib on prognosis in patients with low-allelic-ratio FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation.

Background: The effect of sorafenib in acute myeloid leukemia (AML) patients with low-allelic-ratio FMS-like tyrosine kinase 3 internal tandem duplication(FLT3-ITD) is still unclear.

Objective: The purpose of this study was to evaluate whether sorafenib can improve prognosis in FLT3-ITD AML patients.

Study Design: In this study, the effect of sorafenib on the prognosis of patients with FLT3-ITD AML was retrospectively explored.

Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference.

Background: The substantial burden of cardiovascular diseases highlights the urgent need for cost-effective interventions to mitigate their impact. While existing evidence on the cardioprotective effect of the influenza vaccine comes primarily from populations with cardiovascular comorbidities, these studies remain susceptible to several sources of bias, including immortal time bias and unmeasured confounding. To attenuate these limitations, our study aimed to assess the effect of influenza vaccination on cardiovascular events in an older population in China, utilizing a target trial emulation framework in conjunction with a proximal causal inference (PCI) approach.

A Case of Measles Virus-caused Subacute Sclerosing Panencephalitis Diagnosed by Molecular and Clinical Analysis.

Subacute sclerosing panencephalitis (SSPE) is a rare and lethal neurodegenerative encephalitis caused by persistent measles virus infection. We report an SSPE case in a patient infected at 6 months old, diagnosed using clinical methods and metagenomic sequencing, highlighting the benefits of combining clinical and molecular techniques for improved diagnosis.

The activity of the EMT suppressor GRHL2 is regulated by SUMOylation.

The developmental transcription factor grainyhead-like 2 (GRHL2) has been attributed both tumor-suppressive and pro-tumorigenic functions in a large variety of human cancers. Despite its fundamental role in cancer development and progression, mechanisms modulating expression or activity of GRHL2 in cancer cells still remain elusive. We identified several components of the SUMOylation machinery as candidate GRHL2 interactors using a yeast two-hybrid screening approach and a single major GRHL2 SUMOylation site at lysine residue 159.

Proanthocyanidins inhibit CYP1B1 through mixed-type kinetics and stable binding in molecular dynamics simulations.

Cytochrome P450 1B1 (CYP1B1) is a heme-containing enzyme involved in procarcinogen activation and estrogen metabolism, contributing to tumor progression. This study investigates the inhibitory effects of proanthocyanidin (PA) on CYP1B1-catalyzed reactions and its underlying mechanisms. Enzyme kinetics revealed that PA exerts mixed-type inhibition with an IC₅₀ of 2.

Pancreatic Panniculitis Complicated by Asymptomatic Acute Pancreatitis with Biliary Stricture: Analysis of a Misdiagnosed Case.

This report describes a case of pancreatic panniculitis secondary to acute pancreatitis caused by biliary stricture following multiple biliary surgeries. The aim is to highlight the importance of recognizing atypical presentations. The patient, a 46-year-old woman, presented with erythematous macules and nodules on the extremities accompanied by polyarthralgia.

Navigating fragmented care: a qualitative study on multimorbidity management challenges in Beijing's tiered healthcare system.

Background: Multimorbidity is a growing public health concern, especially in countries with aging populations. Although a tiered healthcare system has been implemented to improve primary care, managing patients with multimorbidity has been challenging.

Methods: This study conducted focus group discussions involving 21 patients with multimorbidity in Beijing via a flexible topic guide to explore their experiences.

Adaptability of Foxtail Millet Varieties Based on Photosynthetic Performance and Agronomic Traits.

As a strategic crop of dry farming in northern China, the photosynthetic characteristics and stress resistance of foxtail millet ( L.) are crucial to yield formation. This study aimed to explore the physiological characteristics of various foxtail millet varieties and screen high-efficiency varieties adapted to semi-arid climates.

Investigation on Fuel Quality and Combustion Characteristics of Blended Fuel (Biomass and Lignite) Derived from Low-Temperature Co-Upgradation.

Co-combustion is regarded as an effective means for high-efficiency utilization of low-quality fuels. However, low-quality fuel has problems such as low energy density and high water content. The fuel quality and blending performance can be further optimized by the pretreatment of low-quality fuel, for example, calorific value, hydrophobicity, and NO conversion rate.

Local Climate Adaptation in Chinese Indigenous Pig Genomes.

Local adaptation allows animal populations to persist in diverse and changing environments, yet its genomic underpinnings remain poorly characterized in livestock. Chinese indigenous pigs, renowned for their rich phenotypic and ecological diversity, offer a powerful model for investigating environmental adaptation. Here, we integrated whole-genome resequencing data, environmental variables, genotype-environment association (GEA) analyses, and functional annotation to explore the adaptive genomic landscape of 46 native pig breeds across China.

Comprehensive validation of reference genes in Solanum nigrum under abiotic stresses: Identifying pendimethalin-responsive genes for herbicide resistance insights.

Black nightshade (Solanum nigrum L.), a globally invasive weed of the Solanaceae family, exhibits remarkable adaptability to diverse abiotic stresses. Despite its ecological and agricultural significance, validated reference genes (RGs) for reliable RT-qPCR normalization in this species remain undefined.