Pancreatic Panniculitis Complicated by Asymptomatic Acute Pancreatitis with Biliary Stricture: Analysis of a Misdiagnosed Case.

This report describes a case of pancreatic panniculitis secondary to acute pancreatitis caused by biliary stricture following multiple biliary surgeries. The aim is to highlight the importance of recognizing atypical presentations. The patient, a 46-year-old woman, presented with erythematous macules and nodules on the extremities accompanied by polyarthralgia.

Differential plasma proteome analysis reveals key proteins associated with insulin resistance in acne vulgaris patients.

Acne vulgaris (AV) is a chronic inflammatory skin disease with a complex pathogenesis, and its association with insulin resistance (IR) remains unclear. This study aimed to identify differential proteins linking AV and IR to improve diagnostic and therapeutic strategies. Plasma proteomic profiling by using LC-MS/MS was performed on 90 AV patients (with IR [n = 40], without IR [n = 50]) and 30 healthy controls (with IR [n = 11], without IR [n = 19]).

Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor.

Triple-negative breast cancer (TNBC) is a cancerous tumor that poses a global threat to women's lives and health. Currently, chemotherapy is the preferred treatment for advanced TNBC. In this work, we have identified a novel NIR fluorescent inhibitor, SWMU690, which can effectively inhibit the proliferation of TNBC at low doses.

Development and validation of a core competency scale for nursing internship supervisors.

Background: Clinical practicums are a crucial part of nursing education wherein nursing internship supervisors (NIS) play a vital role in facilitating hands-on experience. However, many NIS start their teaching roles without adequate educational training, despite the importance of this task. Therefore, the aim of this study was to develop and validate a reliable and credible core competency scale for NIS.

A novel NIR fluorescent probe inhibits melanoma progression through apoptosis and ERK/DRP1-mediated mitochondrial fission.

Melanoma, a highly metastatic malignant tumour, necessitated early detection and intervention. This study focuses on a hemicyanine fluorescent probe activated by near-infrared (NIR) light for bioimaging and targeted mitochondrial action in melanoma cells. IR-418, our newly designed hemicyanine-based NIR fluorescent probe, demonstrated effective targeting of melanoma cell mitochondria for NIR imaging.

Retraction Notice to: miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT/p70S6K and JNK Pathways through ABHD2.

[This retracts the article DOI: 10.1016/j.omto.

Downregulated BIRC5 inhibits proliferation and metastasis of melanoma through the β-catenin/HIF-1α/VEGF/MMPs pathway.

Purpose: Melanoma is a malignant skin tumor caused by melanocytes and associated with high mortality rates. This study aims to investigate the specific mechanism of ZWZ-3 in melanoma proliferation and metastasis.

Methods: RNA sequencing was performed to identify the effect of ZWZ-3 on gene expression.

Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance.

Acne vulgaris is a chronic inflammatory disease with high incidence, diverse clinical manifestations, poor clinical efficacy, and easy recurrence. Recent studies have found that the occurrence of acne is related to metabolic factors such as insulin resistance; however, the specific mechanism of action remains unclear. This study aimed to identify significantly different metabolites and related metabolic pathways in the serum of acne vulgaris patients with or without insulin resistance.

Serum Irisin: A Potential Diagnostic Marker for Insulin Resistance in Acne Vulgaris.

Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit. Many factors are involved in the occurrence of acne. It has been confirmed that some adipokines play an important role in the development of AV.

Serum Leptin and Adiponectin: Indicators of Cardiovascular Disease Secondary to Psoriasis.

Background: To explore the role and clinical significance of serum adiponectin and leptin levels in patients with psoriasis accompanied by atherosclerosis.

Methods: Eighty patients diagnosed with psoriasis in our dermatology department and 40 healthy people in our physical examination centre were included as the study group and control group, respectively. All the included patients underwent fasting blood and serum tests.

Correlation of catecholamine content and clinical influencing factors in depression among psoriasis patients: a case-control study.

Objective: Our study sought to investigate the clinical influencing factors of psoriasis patients with depression, and analyze whether the content of monoamine neurotransmitters in plasma was correlated with depression incidence among psoriasis patients.

Methods: Ninety patients with psoriasis and 40 healthy volunteers (aged from18 to 60) were recruited and interviewed with a piloted questionnaire in both groups to obtain relevant information. The catecholamine in plasma from the two groups was analyzed by radioimmunoassay.

Reliability and validity of the Chinese version of the Patient Health Questionnaire-9 (C-PHQ-9) in patients with psoriasis: a cross-sectional study.

Objective: To evaluate the clinical reliability and validity of the Chinese version of the Patient Health Questionnaire-9 (C-PHQ-9) in patients with psoriasis.

Design: Cross-sectional study.

Setting: Tertiary care centre.

miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT/p70S6K and JNK Pathways through ABHD2.

Because cutaneous melanoma (CM) is one of the most lethal human tumors, major treatment advances are vital. miR-140-3p has been suggested to act as a suppressor in a range of malignant tumors, implying its possible use as a biomarker for effective antineoplastic treatment. However, the potential role of miR-140-3p in CM and the underlying mechanism remain unclear.

Mixed lichenoid and psoriasiform drug eruption induced by rifampicin.

Rifampicin is an essential first line anti-tuberculosis drug. However, several cases of adverse reactions associated with this drug have been reported, the most common of which are cutaneous drug reactions. We report a case of mixed lichenoid and psoriasiform drug eruption induced by rifampicin.

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris.

Background: Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris.

Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis.

Objective: This study aimed to investigate the association between the use of isotretinoin and the risk of depression in patients with acne.

Design: This was a meta-analysis in which the standardised mean difference (SMD) and the relative risk (RR) were used for data synthesis employing the random-effects model.

Setting: Studies were identified via electronic searches of PubMed, Embase and the Cochrane Library from inception up to 28 December 2017.