Recent progress in the use of periplocin, periplocymarin and periplogenin in cancer treatment.

Periplocin, periplocymarin and periplogenin are the main active components of . The most cytotoxic constituent of , periplocin is an alpha cardiac glycoside with a steroid core and an unsaturated five-membered lactone ring structure. Periplocymarin is a secondary alpha cardiac glycoside, which is produced by removing one molecule of glucose from periplocin, and periplogenin is the glycosidic portion and the basic unit of periplocin and periplocymarin.

Comparative analysis of multiple machine learning models: identifying impact factors in biochar heavy metal adsorption mechanisms.

The contribution analysis of influencing factors governing biochar-mediated heavy metal adsorption in aqueous systems holds significant implications for cost-effective water remediation. Current studies predominantly rely on single-model approaches to identify critical variables, which may introduce bias due to inherent model assumptions, thereby impeding systematic elucidation of impact mechanisms and variable interactions. To address this gap, we integrated twelve machine learning models with SHAP (Shapley Additive exPlanations) interpretation to holistically investigate determinants and key variables.

Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution.

Performing total RNA profiling on formalin-fixed, paraffin-embedded (FFPE) samples, the predominant sample conservation method in clinical practice, remains challenging for current spatial transcriptomics techniques. Here, we introduce Stereo-seq V2, which employs random primers to capture and sequence RNAs in situ on FFPE sections and provides single-cell resolution. The random-priming-based strategy offers unbiased transcript capturing and uniform gene body coverage, which increase the sensitivity to marker genes, the efficiency of non-polyadenylation (poly(A)) RNA profiling, and immune repertoire coverage.

Bibliometric Analysis of the Mental Health of International Migrants.

Background: International migration is a growing global phenomenon involving diverse groups, such as labor migrants, international marriage migrants, refugees, and international students. International migrants face unique mental health challenges influenced by adversities such as social isolation and limited access to mental health services. This study employs bibliometric methods to systematically analyze the global body of literature on international migrants' mental health.

Research on mechanical properties of a new type of composite floor slab with split joint.

At present, the commonly used composite floor of steel bar truss in prefabricated buildings has the problem that the overhanging bent steel bars in the prefabricated floor collide with the reserved steel bars in other prefabricated components, which reduces the subsequent construction efficiency. In order to solve this problem, a new type of composite floor slab with split joints was designed. The bent steel bars are distributed centrally in the middle of the stitching edge of the prefabricated bottom plate, while the ends of the bottom plate are not reinforced, which reduces the contact with the reserved steel bars of other structures.

TransGI: Real-Time Dynamic Global Illumination with Object-Centric Neural Transfer Model.

Neural rendering algorithms have revolutionized computer graphics, yet their impact on real-time rendering under arbitrary lighting conditions remains limited due to strict latency constraints in practical applications. The key challenge lies in formulating a compact yet expressive material representation. To address this, we propose TransGI, a novel neural rendering method for real-time, high-fidelity global illumination.

A Donor-Acceptor-Donor-type Organic Molecule as an Effective Electrode to Form Rapid Diffusion Pathway for High-Performance Sodium-Ion Batteries.

Carbonyl-containing organic electrodes have been widely considered as ideal substitutes for traditional inorganic compounds in sodium-ion batteries (SIBs) due to their excellent redox reversibility and structural tunability. However, constructing effective Na diffusion channels in these materials is very challenging. To address this issue, we design a new organic molecule, N,N'-bis(3,4,5-trimethoxyphenyl)-1,4,5,8-naphthalenediimide (NDI-DTMA), containing a donor-acceptor-donor (D-A-D) structure.

FTO regulates the proliferation and apoptosis of pulmonary artery smooth muscle cells through m6A demethylation modification.

Background: To investigate whether FTO-mediated N6-methyladenosine (m6A) demethylation affects the proliferative/apoptotic phenotype of mouse pulmonary artery smooth muscle cells (PASMCs).

Methods: The hypoxia model of PASMCs was established to examine changes in FTO protein expression and m6A modification levels. Cell transfection, m6A expression profiling, mRNA stability testing, and protein-RNA binding assays were used to explore the effects of FTO and its downstream target, CACNA1d, on PASMC proliferation and apoptosis.

Normobaric Hyperoxia Induces Time-Dependent Hemodynamic Fluctuations in the Middle Cerebral Artery and Cortical Damage in Neonatal Rats.

Objective: To assess the feasibility of cranial color Doppler flow imaging (CDFI) for monitoring the middle cerebral artery (MCA) hemodynamics and its correlation with histopathological changes in neonatal rats under persistent hyperoxia.

Methods: On postnatal day 1, 48 neonatal Sprague-Dawley rats were randomly divided into control and hyperoxia groups. MCA hemodynamic parameters were assessed by color Doppler ultrasound at 0 h, 24 h, 48 h, and 72 h post-exposure, followed by systematic analysis of hyperoxia-induced pathological changes in collected brain tissues in the hyperoxia group.

Depth estimation from light fields via epipolar geometry and an axial attention mechanism.

Light-field depth estimation plays a pivotal role in various applications. This technology facilitates the creation of immersive 3D environments in virtual and augmented reality, and supports real-time environmental perception for enhanced autonomous driving safety. The academic community widely recognizes that the epipolar plane image (EPI) contains essential depth cues.

Ultrasonography Combined With Sonoelastography Strain Ratio for the Differentiation of Parotid Masses.

Objectives: Accurate preoperative differentiation of benign and malignant parotid masses is crucial for determining appropriate treatment strategies. We aimed to investigate the value of combining conventional ultrasonography (US) with the measurement of sonoelastographic strain ratio (SR) for the preoperative differentiation of parotid masses.

Methods: We conducted a single-center retrospective study of 514 patients who had undergone excision of parotid gland masses from June 2019 to June 2023.

Lipophilic marine toxins effects on Neuro-2a, NG108-15 and MCF-7 cell lines.

Okadaic acid (OA), dinophysistoxin-1 (DTX1), dinophysistoxin-2 (DTX2), yessotoxin (YTX), 1-homoyessotoxin (hYTX), pectenotoxin-2 (PTX2), azaspiracid-1 (AZA1), azaspiracid-2 (AZA2), azaspiracid-3 (AZA3), pinnatoxin-G (PnTX-G), spirolide (SPX1) and gymnodimine (GYM) are lipophilic marine toxins (LMTs), which are harmful to humans and also possess potential therapeutic applications. To compare the toxicity and medical value of LMTs, Neuro-2a, NG108-15 and MCF-7 cell lines were employed to test cytotoxicity under the same conditions and toxin concentrations. These results showed OA, DTX1, DTX2, YTX, hYTX, PTX2, AZA1, AZA2 and AZA3 were cytotoxic in all tested cell types.

NAT10-mediated ac4C modification of Lipin1 mRNA contributes to the pathogenesis of PWMI.

Preterm white matter injury (PWMI) is a leading cause of cerebral palsy and chronic neurological disabilities in premature infants. It is characterized by defects in oligodendrocyte precursor cell (OPC) differentiation and dysmyelination. Currently, there are no effective therapeutic strategies available in clinical practice.

Finotonlimab (PD-1 inhibitor) plus bevacizumab (bevacizumab biosimilar) as first-tier therapy for late-stage hepatocellular carcinoma: a randomized phase 2/3 trial.

We aimed to assess the tolerability and efficacy of finotonlimab (an anti-programmed cell death protein-1 antibody) in combination with SCT510, a bevacizumab biosimilar, versus sorafenib in unresectable advanced HCC. This randomized phase 2 and 3 study (ClinicalTrials.gov, NCT04560894; Chinadrugtrials.

Identification of novel genomic regions associated with yield-related traits in cowpea ( [L.] Walp) landraces.

Unlabelled: Cowpea is an important multipurpose legume crop that used for food, feed and vegetable worldwide. Developing the high yield cultivars is the first target in cowpea breeding, however, the genetic basis of this complex trait is not yet well understood. To discover the genetic architecture of cowpea yield, a total of 215 cowpea landraces collected from Zhejiang Province were evaluated for four yield-related traits including branch number per plant (BNP), grain number per pod (GNP), pod length (PL), and pod number per plant (PNP).

Mitochondrial pyruvate dehydrogenase phosphatase metabolism disorder in malignant tumors.

This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase (PDP) in malignant tumors and its potential mechanisms. Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells, and potentially promotes tumor. Research has comprehensively explored the structural-functional characteristics of PDP, its metabolic regulatory mechanisms, and its role in various types of malignant tumors.

Intersection crash analysis considering longitudinal and lateral risky driving behavior from connected vehicle data: A spatial machine learning approach.

Existing intersection safety analysis studies have primarily focused on macro-level static infrastructure and highly aggregated traffic features. The emergence of Connected Vehicle (CV) has enabled researchers to extract micro-level driving behavior attributes from CVs. Although longitudinal driving behaviors (e.

A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer's disease.

Imaging genomics offers powerful links between genetics and neuroimaging phenotypes, but conventional methods often lack spatial correspondence. We introduce spatial imaging-transcriptomics, a paradigm that directly integrates magnetic resonance imaging (MRI) and spatially resolved transcriptomics (ST) with matched resolution from the same brain through spatially co-registered maps. We apply this framework to wild-type and Alzheimer's disease (AD) mouse models to uncover the molecular underpinnings of diffusion MRI.

Neighboring Patch Density or Patch Size? Which Determines the Importance of Forest Patches in Maintaining Overall Landscape Connectivity in Kanas, Xinjiang, China.

The precise identification of priority areas for conservation based on connectivity can significantly enhance protection efficacy and mitigate biodiversity loss in fragmented landscapes. Priority area selection efforts are typically conducted in landscapes with a limited number of patches or simplified to focus on large patches, while landscapes with numerous patches are rarely explored. In this paper, we used a forest in Kanas, Xinjiang, China, as a case study to explore priority patches for conservation according to their contribution to maintaining overall landscape connectivity, as well as to assess how structural factors influence patch importance in connectivity, based on graph theory.

Bioavailability and resupply dynamics of thallium in agricultural soils affected by lead-zinc mining: In-situ insights from DGT-DIFS modeling.

Thallium (Tl), with higher toxicity and bioaccumulation potential than mercury (Hg), cadmium (Cd), and lead (Pb), poses serious ecological and food safety threats in mining-impacted agricultural systems. Despite this, its in-situ bioavailability and desorption kinetics in soil remain poorly understood, particularly in lead-zinc mineral-rich regions of southwestern China. In this study, we combined the Diffusive Gradients in Thin-Films (DGT) technique, the DGT-Induced Fluxes in Soils (DIFS) model, and path analysis to comprehensively investigate Tl mobility, bioavailability, and its environmental controls.

Glucose-Activated Fe-Cu Dual-Ion Nanozyme Cascade Reactor with Photothermal Enhancement for Antimicrobial Therapy in Diabetic Wound Healing.

Nanozyme technology offers promising avenues for the development of new antibacterial agents to combat antibiotic resistance. However, the antibacterial efficacy of nanozymes is constrained by their dependence on hydrogen peroxide (HO). In this study, a glucose-activatable nanoreactor (FCSGP NPs) with high antimicrobial efficiency and drug loading ability is designed to enhance the anti-infection effects in diabetic wound healing.

Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness.

Importance: OTOF gene therapy (GT) has been shown to improve hearing and speech. The efficacy of GT remains to be compared against cochlear implantation (CI), the current gold standard for congenital deafness.

Objective: To evaluate treatment outcomes in auditory and speech perception between patients with congenital deafness treated with GT, CI, or both.

Balancing UV-to-blue light conversion by membrane-embedded AIE antennas for enhanced photosynthesis.

Cationic tetraphenylethylene (TPE)-based amphiphiles were developed as membrane antennas to enhance photosynthesis. The positioning of the TPE group was adjusted to balance ultraviolet to blue light conversion, significantly boosting photosynthetic activity.

The Evolving Industrial Landscape in Occupational Chronic Benzene Poisoning - 6 PLADs, China, 2020-2023.

Introduction: As a major producer and consumer of benzene, China has long confronted the challenge of occupational chronic benzene poisoning (OCBP). Between 2005 and 2019, OCBP in China primarily occurred in private enterprises, small- and medium-sized enterprises, and the general/special-purpose equipment manufacturing industry. However, with the continuous strengthening of national supervision and restrictions on the use of benzene-containing materials, the industrial distribution of OCBP may have changed from 2020 to 2023.