Factors influencing rehabilitation costs for stroke inpatients in Shenzhen: a multicenter retrospective study.

Background: Stroke is a leading cause of death and disability among Chinese residents, imposing a significant economic burden. This study aimed to analyze the current status and influencing factors of inpatient rehabilitation costs for stroke in Shenzhen, providing evidence to help reduce costs for patients with stroke in rehabilitation centers.

Methods: This multicenter retrospective study used data primarily collected from patient's medical records.

IRPruneDeXt: Efficient Infrared Small Target Detection via Musical Wavelet-Regularized Channel Pruning.

Infrared small target detection (IRSTD) refers to detecting faint targets in infrared (IR) images, which has achieved notable progress with the advent of deep learning. However, the drive for improved detection accuracy has led to larger, intricate models with redundant parameters, causing storage and computation inefficiencies. In this pioneering study, we introduce the concept of utilizing network pruning to enhance the efficiency of IRSTD.

CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability.

Background: Pancreatic cancer (PC) is highly aggressive and fatal and has dismal prognostic outcomes, primarily due to its late-stage diagnosis and limited effective treatments. The molecular mechanisms triggering PC progression are largely unclear. This study investigated how CX26 contributes to pancreatic cancer development and its potential as a therapeutic target.

Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury.

Acute kidney injury (AKI) can lead to chronic kidney disease (CKD), a transition driven by cellular senescence, a state of irreversible cell-cycle arrest. However, the molecular mechanisms promoting this pathological process remain unclear. Here we show that the channel protein Pannexin1 (Panx1) promotes this detrimental senescence and subsequent kidney fibrosis.

Atomically precise construction of uniform single-molecule junctions for molecular electronics.

Atomically precise construction of ultra-small electronic devices meets the urgent need for further device miniaturisation and enables numerous electronic applications. In particular, single-molecule junctions are attractive because they serve as platforms for studying fundamental scientific laws at the single-molecule level and can be used to build functional devices. Here, we present a robust methodology using anisotropic hydrogen plasma etching of graphene and in situ Friedel-Crafts acylation reaction to construct, with atomic precision, uniform covalently bonded graphene-molecule-graphene (GMG) single-molecule junctions with clear zigzag graphene edges.

A Donor-Acceptor-Donor-type Organic Molecule as an Effective Electrode to Form Rapid Diffusion Pathway for High-Performance Sodium-Ion Batteries.

Carbonyl-containing organic electrodes have been widely considered as ideal substitutes for traditional inorganic compounds in sodium-ion batteries (SIBs) due to their excellent redox reversibility and structural tunability. However, constructing effective Na diffusion channels in these materials is very challenging. To address this issue, we design a new organic molecule, N,N'-bis(3,4,5-trimethoxyphenyl)-1,4,5,8-naphthalenediimide (NDI-DTMA), containing a donor-acceptor-donor (D-A-D) structure.

A Potential CD8 T-Cell-Related Biomarker IFIT3 for Rheumatoid Arthritis.

Objective: The aim is to pinpoint crucial genes linked to CD8 T cells in rheumatoid arthritis (RA) for aiding in diagnosis, predicting disease progression, and ultimately discovering potential drug targets.

Methods: This study utilized datasets from the Gene Expression Omnibus (GEO) database to analyze gene expression profiles in RA patients. Weighted Gene Coexpression Network Analysis (WGCNA) was conducted to identify gene modules associated with the diseases, followed by differential gene expression analysis.

High energy nonlinear pulse compression to sub-50 fs by a hybrid bulk-air multi-pass cell.

We demonstrate a high energy nonlinear pulse compression scheme based on a hybrid bulk-air multi-pass cell (MPC), achieving a high-power ultrafast source with 45 fs pulse duration, 130 W average power at 200 kHz repetition rate, and near-diffraction-limited beam quality. The impact of air nonlinearity accumulation in the MPC on beam quality is investigated to maintain good beam quality at high pulse energy, which suggests the adoption of pre-chirped and circularly-polarized pulses can effectively improve the input pulse energy and suppress the spatial quality degradation. The nonlinear mode-matching is also adopted to minimize the impact of the self-focusing effect of solid-thin-plates on q-preserving propagation.

Early-life and adult body mass index in relation to MS disability progression.

Background And Objectives: The influence of body weight across the life course on multiple sclerosis (MS) progression remains incompletely understood. While excess body mass at diagnosis is associated with disability progression, it is unclear how early-life and adult BMI jointly affect long-term outcomes. We aimed to investigate the separate and combined effects of BMI at age 20 and at diagnosis on MS progression.

Structure-Based Drug Design Yields Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.

Human immunodeficiency virus type-1 (HIV-1) resistance severely compromises the efficacy of non-nucleoside reverse transcriptase inhibitors (NNRTIs). This study developed novel DAPY-derived NNRTIs via a structure-based drug design strategy with as the lead. All designed compounds demonstrate potent antiviral activity against the HIV-1 wild-type (WT) strain (EC = 3.

Functional characterization of OsLT9 in regulating rice leaf thickness.

Leaf thickness in rice critically influences photosynthetic efficiency and yield, yet its genetic basis remains poorly understood, with few functional genes previously characterized. In this study, we employ a pangenome-wide association study (Pan-GWAS) on 302 diverse rice accessions from southern China, identifying 49 quantitative trait loci (QTLs) associated with leaf thickness. The most significant locus, qLT9, is fine-mapped to a 79 kb region on chromosome 9.

Spatiotemporal evolution in femtosecond second-harmonic generation with back-conversion.

We systematically investigate second-harmonic generation (SHG) in a lithium triborate (LBO) crystal by a femtosecond laser system (1030 nm, 195 fs, 30 W) with particular emphasis on back-conversion phenomena. For a selected 5 mm thick crystal, an optimal conversion efficiency of 54% is achieved at 18 W input power with beam quality factor M of 1.275 (horizontal) and 1.

Enhanced Collaborative Edge Intelligence for Explainable and Transferable Image Recognition in 6G-Aided IIoT.

The Industrial Internet of Things (IIoT) has revolutionized industry through interconnected devices and intelligent applications. Leveraging the advancements in sixth-generation cellular networks (6G), the 6G-aided IIoT has demonstrated a superior performance across applications requiring low latency and high reliability, with image recognition being among the most pivotal. However, the existing algorithms often neglect the explainability of image recognition processes and fail to address the collaborative potential between edge computing servers.

A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images.

Chronic kidney disease (CKD) is a global health challenge, but invasive renal biopsies, the gold standard for diagnosis and prognosis, are often clinically constrained. To address this, we developed the kidney intelligent diagnosis system (KIDS), a noninvasive model for renal biopsy prediction using 13,144 retinal images from 6773 participants. The KIDS achieves an area under the receiver operating characteristic curve (AUC) of 0.

Genome-wide characterization of the Pyrabactin Resistance 1-like (PYL) gene family in wheat and functional identification of TaPYL2D.

The pyrabactin resistance 1-like (PYL) gene family encodes proteins that regulate drought tolerance and ABA signalling in plants. These proteins act as ABA receptors and play critical roles in abiotic stress response. The importance of studying the PYL gene family in wheat lies in its regulation of drought tolerance, a significant limiting factor in wheat production.

(R)-6-[N-(3-(4-chlorophenyl) propyl] derivative of (R)-roscovitine inhibits lung carcinoma progression via cyclin-dependent kinase suppression.

Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle checkpoints, capable of phosphorylating proteins and thereby governing essential cellular functions such as differentiation, proliferation, and apoptosis. Although various CDK inhibitors (CDKIs), including (R)-roscovitine, also known as seliciclib, have demonstrated promising outcomes in preclinical models, their clinical translation has been limited. This study aimed to design and synthesize (R)-roscovitine derivatives with improved pharmacological profiles.

Co-application of dazomet and azoxystrobin reconstructs soil microbial communities and suppresses the violet root rot of under a continuous cropping system.

Violet root rot (VRR) is a devastating soil-borne disease that severely affects () production, with limited effective control strategies available. This study aimed to develop an effective method for controlling VRR and explore its underlying mechanisms. A 2-year field experiment was conducted to investigate the impact of dazomet fumigant alone (D) and in combination with azoxystrobin (DA) on the yield, VRR incidence, medicinal component level, soil biochemical properties, and rhizosphere microbial community structure of continuously cropped .

PAX1/SOX1 gene methylation as a detection and triage method for triage of high risk HPV-Positive women in cervical cancer screening.

Objective: To evaluate the role of PAX1/SOX1 methylation testing in the triage of HPV-positive patients and compare its performance with traditional screening methods, including HPV genotyping and cytology.

Methods: A study was conducted from February 2024 to October 2024, involving women referred for colposcopy during the "two-cancer screening" in a specific region. Patients were grouped based on histopathological results [normal/cervicitis, cervical intraepithelial neoplasia 1 (CIN1), high-grade squamous intraepithelial lesion (HSIL), cervical cancer] and high-risk human papillomavirus (hrHPV) typing (HPV16/18 positive, other 12 hrHPV positive).

Experimental characterization and grain-based numerical modeling of multiscale fracture mechanisms in pre-fractured granite.

The mechanical behavior of pre-fractured granite is primarily governed by pre-existing fractures, in which macro-crack evolution emerges from micro-crack accumulation. This study employs an integrated approach combining mechanical testing, acoustic emission (AE) monitoring, and multiscale numerical simulations to systematically investigate the deformation and failure mechanisms of granite containing single and double pre-existing fractures. Key findings reveal: (1) Fracture geometry dictates strength: Uniaxial compressive strength (UCS) increases with fracture inclination angle, whereas elastic modulus remains relatively constant.

Implicit neural prior-guided diffusion for spectral CT reconstruction.

Background: Spectral computed tomography (CT) plays a crucial role in various fields. However, the cumulative radiation dose from repeated x-ray CT examinations has raised concerns about potential health risks. Reducing the projection view is an effective strategy to reduce the radiation dose, but this will lead to a notable degradation in image quality, resulting in streaking artifacts.

CircRNA Sequencing Analysis Reveals the Regulatory Role of circ_CDR1as in Penile Squamous Cell Carcinoma via the ceRNA Network.

Penile squamous cell carcinoma (PSCC) is a malignant reproductive tumor, and circRNAs are essential regulators in the progression of cancers. However, their specific roles in PSCC have not been adequately investigated, which are available to function via the competing endogenous RNA (ceRNA) network. We collected 5 normal and 6 PSCC tissue samples for bulk RNA sequencing and obtained differentially expressed circRNAs (DE-circRNAs) and differentially expressed mRNAs (DE-mRNAs).

The role of platelets in tumor immune evasion and metastasis: mechanisms and therapeutic implications.

Only circulating tumor cells (CTCs) that successfully evade immune surveillance upon entering the bloodstream can lead to clonal expansion and metastasis. Cancer progression is accompanied by pathophysiological processes such as platelet activation and thrombosis. Platelets secrete a variety of growth factors to stimulate cancer cell proliferation, regulate tumor angiogenesis, and subsequently mediate surface changes in cancer cells to promote invasion and progression.

Education, Lifestyle Risk Factors, and Treatment Choices and Multiple Sclerosis Progression.

Importance: The implications of socioeconomic factors, including educational level, for multiple sclerosis (MS) progression remain unclear. Understanding whether educational level directly affects MS outcomes or is confounded by lifestyle risk factors and treatment choices could inform personalized care strategies.

Objective: To investigate the association between educational level and outcomes related to MS, including worsening of disability, cognition, and health-related quality of life, after adjusting for potential confounding factors or mediation by lifestyle factors and treatment.