Laser Powder Bed Fusion (LPBF) WE43 Magnesium Scaffold with EGCG/PDA-Functionalized Silk Fibroin Membrane for Antibacterial Osteoinductive Guided Bone Regeneration.

Guided bone regeneration (GBR) is a prominent focus in biomedical materials research, yet few studies address practical clinical needs. GBR membranes must fulfill the "PASS" principles to be effective in surgery, but existing membranes often fall short in balancing antibacterial activity, controlled degradation, osteoinductive potential, and mechanical support. In this study, we employed laser powder bed fusion (LPBF) to fabricate a porous WE43 magnesium alloy scaffold suitable for large alveolar bone defects.

Entanglement between pharmacy/pharmaceutical education and cancer? A bibliometric answer.

Background: The growing role of pharmacists in cancer care highlights the need to understand research trends linking pharmaceutical education and oncology.

Objective: To quantitatively investigate the bibliometric status of the entanglement between pharmacy/pharmaceutical education and cancer-related issues, providing feasible information and suggestions for the developmental basis and research hotspots.

Methods: Bibliometric analysis was performed using the Web of Science Core Collection.

Bisphenol A and Di-n-butyl phthalate disrupt bone homeostasis bidirectionally via CD36-mediated BMSCs autophagy inhibition and exosome-promoted osteoclastogenesis.

Bisphenol A (BPA) and di-n-butyl phthalate (DBP) are ubiquitous endocrine disruptors implicated in bone metabolism disorders, but their precise mechanisms remain unclear. Here, we demonstrated that BPA and DBP bidirectionally disrupt bone homeostasis by targeting CD36 in bone marrow-derived mesenchymal stem cells (BMSCs). Mechanistically, both chemicals upregulate CD36 expression, which sequesters ATG9a at the Golgi apparatus, inhibits autophagosome maturation, and thereby impairs osteogenic differentiation of BMSCs, as evidenced by reduced ALP and RUNX-2 levels.

Design of Borole- and Silylene-Based Frustrated Lewis Pairs for Dinitrogen Activation Promoted by Aromaticity: A Combined DFT and Machine Learning Study.

In recent years, while main-group elements from the - and -block have emerged in the field of N activation, silylenes─despite their remarkable successes in the activation of diverse small molecules─remain unreported for N activation. Herein, we design "silylene-borole" frustrated Lewis pairs (FLPs) by combining silylene moieties with boron components and conduct comprehensive density functional theory (DFT) calculations to thoroughly investigate their potential for N activation. Screening silylene moieties via machine learning suggests that a smaller Δ value will benefit N activation thermodynamically.

Does Cyberchondria Influence Subjective Well-Being in Online Healthcare platforms?-An Empirical Study.

Background: Users may develop cyberchondria if they seek information about health issues excessively in online healthcare platforms. This can lead to a decline in their subjective well-being, which is essential for overall health. From the perspective of cyberchondria, we aim to investigate the factors influencing subjective well-being within the online healthcare context.

Clinical management and long-term outcomes in pulmonary inflammatory myofibroblastic tumor: a 12-Year experience with 14 surgically treated adult patients at a single center.

Background: Pulmonary inflammatory myofibroblastic tumor (PIMT) is a rare, borderline mesenchymal neoplasm with unclear etiology. It carries recurrence risks but lacks robust data on surgical outcomes in adults. This study analyzes clinicopathological features and long-term results of surgically managed adult PIMT patients at a single center.

Characterizing Spatio-Temporal Variation in Macroinvertebrate Communities and Ecological Health Assessment in the Poyang Lake Basin During the Early Stage of a Fishing Ban.

Macroinvertebrates are a crucial part of aquatic ecosystems and significantly contribute to the maintenance of their health and stability. Our aims were to explore spatio-temporal patterns in macroinvertebrate communities and evaluate the ecological health of various parts of the Poyang Lake Basin during the early stage of a fishing ban. We collected samples using a Peterson grab sampler and conducted ecological evaluations using the B-IBI index.

Wildland Fire-Related Smoke PM and Cardiovascular Disease Emergency Department Visits in the Western United States.

Background: The impact of short-term exposure to fine particulate matter with a diameter ≤2.5 μm (PM) due to wildland fire smoke on the risk of cardiovascular disease (CVD) remains unclear. We investigated the association between short-term exposure to wildfire smoke PM and emergency department visits for acute CVD in the western United States from 2007 to 2018.

Transcriptomic Meta-Analysis Unveils Shared Neurodevelopmental Toxicity Pathways and Sex-Specific Transcriptional Signatures of Established Neurotoxicants and Polystyrene Nanoplastics as an Emerging Contaminant.

Environmental contaminants exhibit heterogeneous neurotoxicity profiles, yet systematic comparisons between legacy neurotoxicants and emerging pollutants remain scarce. To address this gap, we implemented an integrative transcriptome meta-analysis framework that harmonized eight transcriptomic datasets spanning in vivo and in vitro neural models exposed to two legacy neurotoxicants (bisphenol A [BPA], 2, 2', 4, 4'-tetrabromodiphenyl ether [BDE-47]) and polystyrene nanoplastics (PSNPs) as an emerging contaminant. Our analysis revealed a substantial overlap (68% consistency) in differentially expressed genes (DEGs) between BPA and PSNPs, with shared enrichment in extracellular matrix disruption pathways (e.

Predicting Dinitrogen Activation and Coupling with Carbon Dioxide and Other Small Molecules by Methyleneborane: A Combined DFT and Machine Learning Study.

The capture of carbon dioxide is extremely important due to the increasingly severe greenhouse effect, and the conversion of dinitrogen into high-value N-C compounds is of great significance. Here, we predict through density functional theory calculations that the coupling of dinitrogen with carbon dioxide by methyleneborane becomes favorable both thermodynamically and kinetically. Machine learning analysis suggests that increasing the HOMO-LUMO gap or the charge on the boron atom or decreasing the charge of the nitrogen atom will reduce the reaction energies.

Heterozygous Kctd5 knockout mice exhibit abnormal lipid metabolism.

The KCTD gene family is conserved across species, yet the knowledge of its function is limited. Recently, increasing studies focused on KCTD5 emerged. The functions of KCTD5 and its associations with various diseases were revealed.

Integrated approach to predicting rock fracture intensity based on radon tracing and artificial neural network.

In geological and engineering practices, determining fracture intensity of rock masses is critical for the exploitation of resources such as oil, natural gas, uranium, and geothermal energy. Due to the lack of technological means to directly measure the distribution of rock fractures, it is very difficult to obtain the rock fracture intensity. This paper proposes an integrated approach to predicting rock fracture intensity based on artificial neural network (ANN) and radon tracing.

Research progress of bioactive glass in the remineralization of dental hard tissue.

Bioactive glass (BAG) is a widely researched biomaterial in medical science. Renowned for its exceptional biocompatibility and excellent biosafety profile, it has been extensively utilized in clinical practice, especially in the repair and regeneration of bone and soft tissue. In recent years, biomaterials researchers have intensified their exploration of BAG within dental medicine, spanning prosthodontics, oral and maxillofacial surgery, and periodontology.

Inhalable nanoparticle-based delivery systems for the treatment of pulmonary infections: and barrier-overcoming strategies.

Pulmonary infection is a serious public health challenge with high morbidity and mortality. The employment of antibiotics is the first-line treatment for pulmonary infections, while other novel anti-infection agents, such as antimicrobial peptides, have also been developed due to the emergence of drug resistance. Recently, inhalable nanoparticle-based delivery systems have garnered significant attention for the delivery of anti-infection agents, which possess great advantages like high lung accumulations and precise delivery performances.

Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.

Background: Spread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.

Methods: We used the NanoString GeoMx digital spatial profiling (DSP) technology to conduct a spatial transcriptomic analysis of surgically resected tissues from non-small-cell lung cancer (NSCLC) patients with or without STAS.

Results: Compared with tumor nests in non-STAS patients, and were significantly less expressed in compartments of STAS, suggesting their inhibitory roles in the occurrence of STAS.

Population Patterns and Dynamics of (Clupeiformes: Pristigasteridae) Revealed by Target Enrichment Data.

The elongate ilisha () is an important commercial species found along the Northwestern Pacific Coast. A sharp decline in the annual catch of over recent decades implies a concerning situation regarding its fishery stocks. Nonetheless, inadequate knowledge of the genetic diversity, population structure, and historical demography of this species has hindered the establishment of sustainable fishery policies and appropriate conservation measures.

Methylation detection in percutaneous lung biopsy preservation fluid: a new strategy to improve lung cancer diagnosis.

Introduction: Lung cancer is a significant global health threat, particularly in China, where it has high incidence and mortality rates. Current diagnostic methods face challenges, especially in obtaining sufficient tissue samples for accurate diagnosis. This study aimed to develop a new strategy using percutaneous lung biopsy preservation fluid for gene methylation detection to improve diagnostic accuracy.

The Synergistic Reduction of the Contact Time in the Droplet Impact on a Moving Ridge Surface.

The contact time of the droplet impacting on solid surfaces can be markedly reduced by 40% to 50% by breaking the symmetric behaviors with the help of the surface structures and motion, which is crucial to diverse applications involving anti-icing, anti-erosion, self-cleaning, etc. Herein, it is interesting to note that the contact time can be further decreased up to 60% on a moving ridge surface because of corresponding synergy, inspired by flying insects or wind-dispersal seeds. In the present work, the synergistic mechanisms of the reduction in contact time have been revealed by analyzing the 3 basic features, called Leaf-type, Ear-type, and Butterfly-type, according to their morphological and dynamical behaviors.

Lysosome-hijacking inhalable nanomimosa enhances ferroptosis for lung cancer therapy.

Ferroptosis therapy shows potential for lung tumor treatment, but precise accumulation of reactive oxygen species (ROS) remains a challenge. A lysosome-hijacking strategy was developed, aiming to induce ROS spread from lysosomes to the entire cell. The key is delivering a ROS inducer to the lysosome for rapid and targeted ROS generation.

TA@PN System-Mediated Collagen Cross-Linking and Biomimetic Mineralization for Dentinal Tubule Occlusion in Dentin Hypersensitivity Management.

The hydrodynamic theory suggests that the multidirectional flow of fluids within demineralized dentinal tubules (DTs) in response to external stimuli excites pulpal nerve fibers to produce nociception, causing dentin hypersensitivity (DH). Meanwhile, demineralized dentin's collagen fibers are susceptible to attack by endogenous enzymes and disintegration, continuously decreasing the resistance of the dentin surface and dentin's mechanical properties. Recross-linking and mineralizing damaged collagen fibers, closing DTs, and integrating antienzymatic functions remain significant challenges in dental regenerative medicine.

Antiaromaticity-Promoted Radical Stability in Boryl Heterocyclics and Its Application to Dinitrogen Activation: A Combined DFT and Machine Learning Study.

Aromaticity is one of the fundamental concepts in chemistry and generally brings additional thermodynamic stability to a compound. On the other hand, boron radicals have attracted increasing interest from both theoretical and experimental chemists due to their various applications. Here, we carry out density functional theory (DFT) calculations to explore the relationship between the (anti)aromaticity and stability of boron-centered radicals.

Glyphosate targets FYN to regulate glycolysis and promote glioblastoma proliferation: A network toxicology study.

Environmental glyphosate exposure has been linked to glioblastoma (GBM), yet its molecular basis remains unclear. Integrating network-toxicology and druggable Mendelian randomization screens, we identified the Src-family kinase FYN as the principal glyphosate target. Molecular-dynamics simulations, surface-plasmon resonance (KD = 1.

SPON2 facilitates osteosarcoma development by inducing M2 macrophage polarization through activation of the NF-κB/VEGF signaling axis.

Osteosarcoma (OS) is an aggressive bone tumor with poor prognosis, particularly in metastatic cases. Here, we identify spondin 2 (SPON2) as a key driver of OS progression. SPON2 is significantly upregulated in OS tissues and cell lines and correlates with shorter patient survival.

Association between overactive bladder and lipid accumulation product and visceral adiposity index: results from NHANES 2005-2018.

Background: Although obesity is a recognized risk factor contributing to the onset and progression of overactive bladder (OAB), the existing evidence linking lipid accumulation products (LAPs) and the visceral adiposity index (VAI) to OAB remains scarce and subject to debate. Hence, this study was conducted to evaluate the associations between VAI, LAP, and the occurrence of OAB.

Methods: The information utilized in this research was sourced from the National Health and Nutrition Examination Survey (NHANES), spanning the years 2005 to 2018.