Research on mechanical properties of a new type of composite floor slab with split joint.

At present, the commonly used composite floor of steel bar truss in prefabricated buildings has the problem that the overhanging bent steel bars in the prefabricated floor collide with the reserved steel bars in other prefabricated components, which reduces the subsequent construction efficiency. In order to solve this problem, a new type of composite floor slab with split joints was designed. The bent steel bars are distributed centrally in the middle of the stitching edge of the prefabricated bottom plate, while the ends of the bottom plate are not reinforced, which reduces the contact with the reserved steel bars of other structures.

Safety of daratumumab in the real-world: a pharmacovigilance study based on FAERS database.

Background: Daratumumab is widely used in multiple myeloma (MM) and light chain amyloidosis (AL amyloidosis). The purpose of this study was to identify adverse event (AE) signals for daratumumab through the FDA Adverse Event Reporting System (FAERS) database to assess its safety in a large sample of people.

Methods: Based on data from the FAERS database, three disproportionality analysis methods were used to mine AE signals for daratumumab, including reporting odd ratio (ROR), proportional reporting ratio (PRR), and bayesian configuration promotion neural network (BCPNN).

Quasistatic Analysis of Precast Segmental Concrete-Filled Steel-Tube Bridge Pier with External Arched Energy Dissipation Device.

In order to further promote the application of segment-assembled bridge piers in medium- and high-intensity areas, and to reduce the post-earthquake damage and repair cost of bridge piers, in this paper, a precast segmental concrete-filled steel-tube bridge pier (PSCFSTBP) with an external arched energy dissipation device (AEDD) is proposed. Firstly, the effectiveness of the finite-element analysis software ABAQUS 6.14-4 is proved by the test results of the PSCFSTBP and the corresponding finite-element model analysis results.

Numerical Investigation of the Performance of Segmental CFST Piers with External Energy Dissipators under Lateral Cyclic Loadings.

In order to improve the construction efficiency of piers and reduce the local damage of piers, concrete-filled steel tubes (CFST) are used to precast pier segments. Aiming at the problems of the poor integrity and insufficient energy dissipation capacity of dry joint segmental assembled piers, segmental assembled concrete-filled steel tubular piers with external replaceable energy dissipators are being developed. Based on the low cyclic test of a segmental assembled CFST pier, the finite element numerical simulation model of a CFST pier is established based on ABAQUS software, and the validity of the numerical model is verified by the experimental results.

TRPV4 Complexes With the Na/Ca Exchanger and IP Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice.

Intracellular Ca is critical for regulating airway smooth muscle (ASM) tension. A rapid rise in the intracellular Ca concentration ([Ca]) of ASM cells is crucial for modulating the intensity and length of the ASM contraction. Because this rapid increase in [Ca] largely depends on the balance between Ca released from intracellular Ca stores and extracellular Ca entry, exploring the mechanisms mediating Ca transport is critical for understanding ASM contractility and the pathogenesis of bronchial contraction disorders.

Role of TRPP2 in mouse airway smooth muscle tension and respiration.

The transient receptor potential polycystin-2 (TRPP2) is encoded by the gene, and mutation of this gene can cause autosomal dominant polycystic kidney disease (ADPKD). Some patients with ADPKD experience extrarenal manifestations, including radiologic and clinical bronchiectasis. We hypothesized that TRPP2 may regulate airway smooth muscle (ASM) tension.

Aberrantly hydroxymethylated differentially expressed genes and the associated protein pathways in osteoarthritis.

Background: The elderly population is at risk of osteoarthritis (OA), a common, multifactorial, degenerative joint disease. Environmental, genetic, and epigenetic (such as DNA hydroxymethylation) factors may be involved in the etiology, development, and pathogenesis of OA. Here, comprehensive bioinformatic analyses were used to identify aberrantly hydroxymethylated differentially expressed genes and pathways in osteoarthritis to determine the underlying molecular mechanisms of osteoarthritis and susceptibility-related genes for osteoarthritis inheritance.

Association of astragaloside IV-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling.

Defective autophagy in vascular smooth muscle cells (VSMCs) is the principal cause of atherosclerosis. This study aimed to investigate the effect of astragaloside IV (AS-IV) on VSMCs autophagy. In vivo, ApoE mice were fed with high-fat diet ad libitum for eight weeks, with or without AS-IV (25 mg/kg, daily).

Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1-7) upregulation.

Atherosclerosis, the leading cause of cardiovascular diseases in the world, is a chronic inflammatory disorder characterized by the dysfunction of arteries. Oleanolic acid (OA) is a bioactive nature product which exists in various plants and herbs. Previous studies have demonstrated that OA was involved in numerous of biological processes, including atherosclerosis.

Safety of measles-containing vaccines in post-marketing surveillance in Anhui, China.

The safety of measles vaccination is of great interest and importance to public health practice and the general society. We have analyzed the adverse events following immunization (AEFIs) of currently used measles-containing vaccines (including live attenuated measles vaccine, live attenuated measles and rubella combined vaccine, live attenuated measles and mumps combined vaccine, live attenuated Measles, Mumps and Rubella Combined Vaccine) in Anhui Province, China. From 2009 to 2014, 9.

The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.

Diabetes mellitus is a chronic disease that is associated with depression. Also, depression is common in adults with type 2 diabetes mellitus (T2DM). Translocator protein (18kDa) (TSPO) and allopregnanolone play an important role in the depression treatment.

Safety, immunogenicity and cross-reactivity of a Northern hemisphere 2013-2014 seasonal trivalent inactivated split influenza virus vaccine, Anflu®.

Anflu® is a seasonal trivalent inactivated split-virion influenza vaccine manufactured by Sinovac Biotech Co., Ltd. The objectives of this study were to evaluate the safety of Anflu® (2013-14 formulation: H1N1, H3N2 and BYAM) in infants and adults and its immunogenicity and cross-reactivity against mismatched influenza B lineage and avian influenza A(H7N9) viruses (hereafter BVIC and H7N9, respectively) in adults.

Translocator protein mediates the anxiolytic and antidepressant effects of midazolam.

The translocator protein (18 kDa) (TSPO) plays an important role in stress-related disorders, such as anxiety, depression and post-traumatic stress disorder (PTSD), caused by neurosteroids (e.g. allopregnanolone).

Free and Easy Wanderer Plus (FEWP) improves behavioral deficits in an animal model of post-traumatic stress disorder by stimulating allopregnanolone biosynthesis.

Post-traumatic stress disorder (PTSD) is a severe psychiatric condition defined as a "trauma and stress-related disorder". Dampened allopregnanolone biosynthesis has been implicated as a possible contributor to PTSD aetiology. Free and Easy Wanderer Plus (FEWP) is a traditional Chinese medicine previously shown to be effective in PTSD treatment.

The role of allopregnanolone in the anxiolytic-like effect of free and easy wanderer plus (FEWP), a polyherbal preparation.

Anxiety disorders are the serious and burdensome psychiatric illnesses, which are closely correlated with allopregnanolone. The down-regulation of allopregnanolone biosynthesis has been implicated as the possible contributor to the aetiology of anxiety disorders. Free and easy wanderer plus (FEWP) is a well-known traditional Chinese medicine that had been shown to be effective in various mood disorders.

Static and Dynamic Characteristics of a Long-Span Cable-Stayed Bridge with CFRP Cables.

In this study, the scope of CFRP cables in cable-stayed bridges is studied by establishing a numerical model of a 1400-m span of the same. The mechanical properties and characteristics of CFRP stay cables and of a cable-stayed bridge with CFRP cables are here subjected to comprehensive analysis. The anomalies in the damping properties of free vibration, nonlinear parametric vibration and wind fluctuating vibration between steel cables and CFRP cables are determined.

1-(2,6-Diiso-propyl-phen-yl)-1H-benzimidazole.

In the title compound, C19H22N2, both the benzimidazole unit and the 2,6-diiso-propyl-phenyl group are essentially planar [maximum deviations from the least-squares planes of 0.005 (1) and 0.009 (1) Å, respectively].

[Application of exponent curve model to study the hepatitis B DNA recombinant yeast derived vaccine antibody levels].

Objective: To introduce exponent curve model methods in the study of the hepatitis B vaccine antibody level.

Methods: After the China made vaccine of hepatitis B DNA recombinant yeast derived vaccine (YDV) had been carried out for 5 years, data on the anti-HBsAg's titer were used to construct an exponent curve model. When the vaccination program had been carried out for 8 years, the predicating results of the model were further tested by observed number.