Multiomics analysis of gibberellin involved in far-red light-regulated internode elongation in cucumber seedlings.

GA participates in FR light-induced internode elongation of cucumber by regulating the expression of genes/proteins related to aquaporins, expansins, cell wall biosynthesis, hormone metabolism, and signal transduction. This study investigated the effects of the interaction between far-red (FR) light and gibberellin (GA) on the internode elongation of cucumber (Cucumis sativus L. 'Zhongnong No.

IRE1α modulates M1 oncolytic virus sensitivity via ER stress regulation in bladder cancer.

Muscle-invasive bladder cancer (MIBC) remains lethal despite promising oncolytic virotherapy, hindered by tumor-intrinsic resistance. This study aimed to elucidate the molecular basis underlying differential sensitivity to the oncolytic M1 virus in bladder cancer. Bladder cancer cell lines with varying sensitivity to M1 were analyzed for endoplasmic reticulum (ER) stress responses and unfolded protein response (UPR) pathway activation.

Multiple Dynamic Anticounterfeiting Using Photochromic Luminescence Organic Cocrystals.

Photochromic and luminescent complexes are easy to imitate due to their single-signal output, resulting in a low encryption and anticounterfeiting level. Photochromic luminescence (PCL) complexes exhibit fluorescence and color-changing dual output, which provides additional safety and greatly improves anticounterfeiting security. However, it is challenging to overcome the competition between luminescence and the quenching effect of the photoinduced electron transfer (PET) process.

Prediction of postoperative SIRS risk factors in MetS patients undergoing PCNL.

This study aimed to identify preoperative risk factors for systemic inflammatory response syndrome (SIRS) in patients with metabolic syndrome (MetS) undergoing percutaneous nephrolithotomy (PCNL) and to develop a predictive nomogram for individualized risk stratification. A retrospective analysis was conducted on 245 MetS patients who underwent PCNL between January 2021 and December 2024, among whom 27.8% developed postoperative SIRS.

Embryonic exposure to GenX causes reproductive toxicity by disrupting the formation of the blood-testis barrier in mouse offspring.

As a replacement for perfluorooctanoic acid, hexafluoropropylene oxide dimer acid, commercially referred to as "GenX", has attracted significant attention. However, a comprehensive understanding of the reproductive systems of male offspring exposed to GenX is lacking. This study aimed to investigate how embryonic exposure to GenX affects the reproductive development of male offspring and the underlying mechanisms.

[Research progress on glycolipid metabolism of Sertoli cell in the development of spermatogenic cell].

Sertoli cells play an important role in the process of spermatogenesis, and the abnormalities in spermatogenesis are closely related to disruptions in glycolipid metabolism. The metabolic environment of Sertoli cells is hypoxic, with glycolysis and fatty acid β-oxidation being the primary metabolic pathways. In Sertoli cells, glycolysis produces lactate to provide energy for spermatogenic cells, while fatty acid β-oxidation generates ATP.

Microplastics/nanoplastics contribute to aging and age-related diseases: Mitochondrial dysfunction as a crucial role.

The pervasive utilization of plastic products has led to a significant escalation in plastic waste accumulation. Concurrently, the implications of emerging pollutants such as microplastics (MPs) and nanoplastics (NPs) on human health are increasingly being acknowledged. Recent research has demonstrated that MPs/NPs may contribute to the onset of human aging and age-related diseases.

Mechanisms for Modifying the Electronic and Spatial Distribution of the Single-Atom Ni/CeO Surface to Enhance CO-SCR Reactivity: Density Functional Theory Study.

Modulating the intrinsic activity of heterogeneous catalysts at the atomic level is an effective strategy to improve the low-temperature CO-SCR (selective catalytic reduction) reaction activity and N selectivity, but it remains challenging by the experiment. In this paper, a single-atom-loaded surface generation strategy is developed to construct single-atom catalysts by density functional theory analysis, which will effectively reduce the reaction energy barriers in CO-SCR reaction. Specifically, the reaction of NO reduction by CO before and after Ni adsorption was thoroughly investigated and the reactivity was evaluated by using the CeO (1 1 1) surface as a carrier, with the application of density functional theory, electronic structure analysis, and transition state theory.

Comparative outcomes of internal, external, and no stent in ureteroileal anastomosis for ileal orthotopic neobladder reconstruction.

Background: Ureteral stents, including internal stents and stentless techniques, are commonly employed in urological procedures such as urinary stone management and deformity correction. However, their use in radical cystectomy for bladder cancer remains relatively limited. This study aimed to compare the efficacy of internal stent, external stent, and no-stent treatments for ureteroileal anastomosis in laparoscopic radical cystectomy (LRC) combined with ileal orthotopic neobladder (IONB).

Development and validation of a nomogram model for predicting acute urinary retention after transrectal prostate biopsy.

Background: Post-biopsy acute urinary retention (AUR) is still a common complication, often leading to extended hospital stays and greater patient discomfort. This study aimed to develop and validate a nomogram for the early identification of AUR after transrectal prostate biopsy (TRPB).

Methods: We collected data on patients who underwent TRPB at The Third Affiliated Hospital of Sun Yat-sen University between January 2019 and November 2023, including all characteristics and prostate morphological parameters.

Quantification of Left Ventricular Trabecular Complexity in Patients With Hypertrophic Cardiomyopathy by Cardiovascular Magnetic Resonance Imaging Fractal Analysis: A Feasibility and Reproducibility Study.

Purpose: To investigate the left ventricular (LV) trabecular complexity and evaluate its relationship with LV cardiac function and especially myocardial strain in patients with hypertrophic cardiomyopathy (HCM).

Materials And Methods: A total of 100 patients were retrospectively recruited in the study, including 50 obstructive hypertrophic cardiomyopathy (HOCM) and 50 nonobstructive HCM (NOHCM). Fifty age-matched and sex-matched healthy participants were also enrolled.

Predictive value of left atrial strain for left ventricular reverse remodeling in dilated cardiomyopathy.

Background: Early prediction of left ventricular reverse remodeling (LVRR) can guide the subsequent treatment in dilated cardiomyopathy (DCM) patients. We aimed to investigate the value of left atrium (LA) strain for predicting LVRR in DCM patients.

Methods: Clinical and imaging data of DCM patients were gather between January 2018 and January 2023.

Auricular Acupuncture for Perioperative Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Purpose: We conducted a more comprehensive systematic review and meta-analysis to evaluate the effectiveness of auricular acupuncture (AA) in perioperative pain management.

Methods: Randomized controlled trials (RCTs) findings were retrieved from the Embase, Cochrane Central Register of Controlled Trials, PubMed, Web of Science, Chinese Biomedical Literature Database, Wanfang, VIP, and China National Knowledge Infrastructure databases from their inception to March 2024 using the search terms "pain", "auriculotherapy", and "randomized controlled trial". The experimental group was treated with AA alone or in combination with analgesic drugs, whereas the control group was treated with sham auricular acupuncture, placebo, conventional treatment, or no treatment.

Effect of electroacupuncture versus sham electroacupuncture on postoperative ileus after laparoscopic surgery for left-sided colorectal cancer: study protocol for a multicentre, randomised, sham-controlled trial.

Introduction: Postoperative ileus (POI) is an inevitable complication after abdominal surgery, often hindering recovery and prolonging hospital stay. Despite the increasing use of electroacupuncture (EA) as an alternative treatment for gastrointestinal dysfunction, its effectiveness for POI is still controversial. This study aims to verify the efficacy and safety of EA in alleviating POI.

Arming oncolytic M1 virus with gasdermin E enhances antitumor efficacy in breast cancer.

Pyroptosis, driven by the N-terminal domain of gasdermin proteins (GSDM), promotes antitumor immunity by attracting lymphocytes to the tumor microenvironment (TME). However, current pyroptosis-inducing therapies like drug injections and phototherapy are limited to localized treatments, making them unsuitable for widespread or microscopic metastatic lesions. This study engineered oncolytic M1 viruses (rM1-mGSDME_FL and rM1-mGSDME_NT) to selectively deliver GSDME to tumor cells.

A novel viologen-based hybrid crystalline material for photochromic glass films, information storage and anti-counterfeiting.

Information storage and anti-counterfeiting are two very important applications of photochromic materials. Photochromic materials with both information storage and anti-counterfeiting should meet the requirements including fast coloration, good stability and reversibility, low storage cost, and practical application value. Herein, a novel viologen-based coordination polymer, Cd[(pbpy)(HBTC)Cl]·2HO (1) (pbpy = 1,1'-[1,4-phenylenebis-(methylene)]bis(4,4'-bipyridinium); HBTC = 1,3,5-benzenetricarboxylic acid), has been constructed.

Regulatory function of glycolysis-related lncRNAs in tumor progression: Mechanism, facts, and perspectives.

Altered metabolism is a hallmark of cancer, and reprogramming of energy metabolism, known as the "Warburg effect", has long been associated with cancer. Cancer cells use the process of glycolysis to quickly manufacture energy from glucose, pyruvic acid, and lactate, which in turn accelerates the growth of cancer and glycolysis becomes a key target for anti-cancer therapies. Recent groundbreaking discoveries regarding long noncoding RNAs (lncRNAs) have opened a new chapter in the mechanism of cancer occurrence.

Risks of glaucoma among individuals with psoriasis: a population-based cohort study.

Background: Psoriasis is a chronic systemic disorder with ocular involvement.

Objectives: To evaluate the risk of glaucoma among patients with psoriasis.

Methods: Participants in this cohort study were selected based on Chang Gung Research Database from 1 January 2003 to 31 December 2012.

Is Takotsubo syndrome induced by patent ductus arteriosus occlusion?

Takotsubo syndrome (TTS), commonly referred to as "broken heart syndrome," is a distinctive form of acute and reversible heart failure that primarily affects young to middle-aged individuals, particularly women. While emotional or physical stressors often trigger TTS, rare cases have been linked to interventional procedures for congenital heart disease (CHD). Despite its recognition, the exact causes of TTS remain elusive.