Local photocrosslinking of native tissue matrix regulates lung epithelial cell mechanosensing and function.

Within most tissues, the extracellular microenvironment provides mechanical cues that guide cell fate and function. Changes in the extracellular matrix such as aberrant deposition, densification and increased crosslinking are hallmarks of late-stage fibrotic diseases that often lead to organ dysfunction. Biomaterials have been widely used to mimic the mechanical properties of the fibrotic matrix and study pathophysiologic cell function.

Constructing the optimal experimental autoimmune thyroiditis mouse model using porcine thyroglobulin.

Introduction: Autoimmune thyroiditis (AIT) is a chronic autoimmune disease characterized by lymphocytic infiltration of the thyroid gland and elevated specific antibodies. Its incidence rises annually, yet no standardized animal model fully mimics human AIT. Given unclear pathogenesis and lack of targeted immunotherapies, researchers invest significant time in developing suitable models.

InSe Dynamic Memristor-Based Reservoir Computing for Temporal and Spatial Signal Recognition.

Multimodal recognition techniques are pivotal for advancing contemporary artificial intelligence, particularly in enhancing visual perception. However, research on electronic devices capable of robust multimodal recognition remains limited. In this study, we employ an InSe/AlO/ Pb(Zr·Ti·)O (PZT) heterostructure as a dynamic memristor.

Electron beam irradiation as a physical modification approach to enhance the functional potential of dietary fiber in wheat bran.

Wheat bran (WB) is a fiber-rich byproduct with limited functionality due to its compact structure and low bioavailability of bioactive compounds. Electron beam irradiation (EBI) is a clean, non-thermal technology with potential to enhance the structural and functional properties of WB. This study investigated the effects of EBI (5-25 kGy) on the structural, physicochemical, and functional properties of WB.

2024 Update of Chinese Guidelines for Management of Hyperuricemia and Gout Part II: Recommendations for Patients With Common Comorbidities.

Objective: The aim of this updated guideline is to provide comprehensive recommendations for the management of gout in patients with common comorbidities, such as chronic kidney disease (CKD), cardiovascular disease (CVD), diabetes, osteoarthritis (OA), and gastrointestinal disorders.

Methods: This guideline was developed by a multidisciplinary expert panel consisting of specialists in endocrinology, rheumatology, nephrology, cardiology, gastroenterology, and methodology. The development process adhered to standard methodologies, including PICO (population, intervention, comparator, and outcomes) question deconstruction, systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) for evidence and recommendation evaluation, Delphi voting, and expert consensus.

Study on the trajectory and influencing factors of post-stroke cognitive development: based on a group-based trajectory model.

Background: Post-stroke cognitive impairment (PSCI) is one of the major complications of stroke and exhibits a dynamic progression. This study uses the Group-Based Trajectory Model (GBTM) to fit cognitive development trajectories in stroke patients and analyze the influencing factors and trends of PSCI across trajectory groups. It aims to facilitate early identification and intervention for high-risk PSCI patients, providing a theoretical basis for optimizing intervention strategies.

Synthetic nano-kirigami with high deformability for reconfigurable information displays.

Transformable micro/nanostructures endow optical and mechanical metamaterials with customization and tunability. However, employing existing transformation mechanisms to achieve large mechanical deformations remains challenging due to the restricted displacement in the nanometric scale. Here, we present a transformation strategy using nanoscale kirigami structures with ultrahigh deformability enabled by synthetic designs.

Identifying decision-making biases in self-care behaviours among patients with type 2 diabetes mellitus: A qualitative study from a behavioural economics perspective.

Background: Patients with type 2 diabetes mellitus often make self-care behaviour decisions according to their immediate needs and desires in the real world. Deviations from optimal choices in seeking satisfying options are known as decision-making biases, which are not obvious in the self-care behaviours of patients with type 2 diabetes mellitus. Qualitative research can provide insights into patients' descriptions of and experiences in self-care, aiding in systematically identifying decision-making biases.

Hydroalcoholic gel of Angelica sinensis polysaccharides: Antioxidant activity and promotion of wound healing.

While polysaccharides from Angelica sinensis (ASP) exhibit promising antioxidant and anti-inflammatory properties for wound healing, their efficacy in aqueous solution is transient. In this study, we extracted ASP and fractionated it via stepwise alcohol precipitation (ASP-30, ASP-50, ASP-70, ASP-80). The molecular weight, monosaccharide composition and antioxidant capacity of ASP in different graded ASP fractions were evaluated.

Accurate Non-endoscopic Detection of Early Esophageal Squamous Malignant Lesions Using Sponge-based Methylated DNA Biomarkers.

Background: Early detection of esophageal squamous cell carcinoma (ESCC) significantly improves patient quality of life and outcomes. We aimed to train and validate a predictive algorithm using methylated DNA markers (MDMs) based on encapsulated sponge cell collection device (CCD) samples.

Methods: CCD samples in the training set (n=120) were taken from two medical centers, and in the validation set (n=70) were prospectively collected from another medical center.

Animal study of adhesiolysis via transumbilical endoscopic surgery with gastric endoscopy: an exploration.

Background And Aims: Adhesive intestinal obstruction is a common clinical condition caused by obstruction of the intestinal contents. Adhesiolysis is an effective treatment, but traditional open or laparoscopic adhesiolysis is traumatic and often causes a recurrence of adhesions. In this study, we investigate the feasibility and safety of adhesiolysis via transumbilical endoscopic surgery (TUES) with a gastric endoscopy.

[Dose-effect relationship between the number of acupuncture sessions and efficacy for cervical vertigo: a Meta-regression analysis based on randomized controlled trials].

Objective: To explore the dose-effect relationship between the number of acupuncture sessions and the efficacy for cervical vertigo (CV).

Methods: Literature regarding randomized controlled trials (RCTs) of acupuncture for CV was retrieved from CNKI, Wanfang, VIP, Web of Science, and PubMed databases from inception to June 28th, 2024. Studies were included if patients were treated solely with acupuncture and the core prescription included Baihui (GV20)-Fengchi (GB20)-neck-jiaji (EX-B2).

Impact of visceral adiposity index on cognitive impairment and cognitive trajectories in Chinese middle-aged and older adults.

Introduction: The association between the visceral adiposity index (VAI) and cognitive function in middle-aged and older Chinese adults is not well understood. The "obesity paradox"-where obesity appears to be linked with better health outcomes-has also been observed. This study aims to clarify the association by using data from a nationally representative longitudinal survey.

Interventions for adult survivors discharged from the intensive care unit: a scoping review.

Objectives: To comprehensively map the available evidence on interventions implemented for adult survivors following discharge from the intensive care unit (ICU).

Design: A scoping review was conducted following the methodological framework proposed by Arksey and O'Malley.

Data Sources: A systematic search was done across Embase, Medline, Scopus, China National Knowledge Infrastructure, China Science and Technology Journal Database, Chinese Biomedical Database, Wanfang Data, ProQuest Dissertations and Theses, ClinicalTrials.

Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia.

Cerebral ischemia causes significant mortality and is accompanied by inflammatory reactions that exacerbate damage. While the gut microbiota is linked to clinical outcomes, specific treatments and mechanisms remain unclear. Our metagenomics linked low Lactobacillus abundance to cognitive decline in patients with cerebral ischemia.

Compact temperature-insensitive high-energy VCSEL side-pumped Nd:YAG laser with a VRM output coupler.

A compact temperature-insensitive high-energy Q-switch Nd:YAG laser is demonstrated based on vertical cavity surface emitted laser (VCSEL) side-pumping and a variable reflectivity mirror (VRM) output coupler (OC). With the optimization of the laser parameters, the laser delivers an output energy of 217 mJ operating at pulse repetition rate of 100 Hz with 7 ns pulse width and a peak power of 31 MW. The brightness is estimated to be 10.

Association Between Intracranial Plaque Characteristics and Stroke Recurrence Risk Stratified by Stenosis Severity.

Rationale And Objectives: This study aims to analyze the association between plaque characteristics and stroke recurrence across different degrees of stenosis, and to evaluate the predictive value of combining culprit plaque characteristics with the modified Essen score for stroke recurrence.

Materials And Methods: This retrospective analysis included 368 intracranial atherosclerotic stenosis (ICAS) patients from two centers, categorized into mild-to-moderate stenosis (<70%, n = 155) and severe stenosis (≥70%, n = 213) groups. High-resolution vessel wall images and clinical data were analyzed.

Sonoelectric Nanonet-Activated Extracellular Electron Transfer for Wireless Non-Genetic Stimulation of Pancreatic β Cells.

Engineered cell-based therapy is an emerging approach for treating intractable diseases, in which the remote control of cellular behavior necessitates robust physical input-sensing-response systems. Nanomaterials represent promising tools to enable wireless remote control of cells. To achieve this, the precise anchoring of nanomaterials to target cells is crucial for nanomaterial-engineered cells to prevent undesired effects such as endocytosis and diffusion.

RNA N4-acetylcytidine modification in gastrointestinal cancer: Novel functions, mechanisms, and therapeutic implications.

Gastrointestinal cancers represent a significant global health burden driven by complex interactions among environmental, genetic, and epigenetic factors. Among epigenetic regulators, RNA modifications have emerged as a pivotal research focus, providing novel insights into the molecular underpinnings of cancer biology. Recent advances in analytical chemistry and high-throughput sequencing have facilitated the identification of N4-acetylcytidine (ac4C) as a conserved RNA modification with critical biological functions.

High-Entropy Metallene Arrays with a Turing Structure for Electrocatalytic Upcycling of Polyethylene Terephthalate Plastics Coupled with Electrosynthesis of Ammonia.

The electrocatalytic upgrading of polyethylene terephthalate (PET) plastics and nitrate-containing wastewater into value-added chemicals provides a promising sustainable strategy for dual-waste utilization. In this work, metallene arrays with a Turing structure were constructed through the self-assembly of high-entropy alloy (HEA) nanocrystals (PdPtCuNiAg MARs) and applied for the upcycling of PET plastics coupled with the electrosynthesis of ammonia. The electrocatalytic coupled system can achieve a current density of 400 mA cm at a low voltage of 1.

ISLR as a Cuproptosis-Related Predictor and Therapeutic Target in Heart Failure: A Multi-Omics and Bioinformatics Approach.

Background: The purpose of this study was to investigate the potential correlation between Cuproptosis, a newly recognized form of programmed cell death, and heart failure (HF), using an integrative multi-omics analysis.

Methods: All the datasets were downloaded from GEO database. Cuproptosis-related genes (CRGs) were acquired from FerrDb V2 database.

Development of a Stage- and Species-Specific RNAi System for Molecular Insights in Wasps.

wasps, egg parasitoids widely used to control lepidopteran pests, have long eluded in-depth molecular mechanistic studies due to their minute size and genetic tool scarcity. While previous RNAi efforts were restricted to , we developed the first cross-species RNAi system for both and the previously intractable . Temporal expression profiling identified and as stage-specific RNAi targets, peaking during prepupal/pupal stages, which were tested across species and developmental stages using microinjection and soaking dsRNA delivery methods.

LGF-Net: A multi-scale feature fusion network for thyroid nodule ultrasound image classification.

Background: Thyroid cancer is one of the most common cancers in clinical practice, and accurate classification of thyroid nodule ultrasound images is crucial for computer-aided diagnosis. Models based on a convolutional neural network (CNN) or a transformer struggle to integrate local and global features, which impacts the recognition accuracy.

Purpose: Our method is designed to capture both the key local fine-grained features and the global spatial features essential for thyroid nodule diagnosis simultaneously.

Identification of the risk factors for predicting severe acute kidney injury in patients after liver transplantation.

Background: Acute kidney injury (AKI) is one of the most common complications after liver transplantation (LT). Few studies have focused on the risk factors for severe AKI (KDIGO criteria: stage 3) after LT. The aim of this study was to identify critical determinants associated with the progression to severe AKI in LT patients admitted to the intensive care unit (ICU).

Mediating role of depression in the relationship between allostatic load and mortality.

Allostatic load (AL), an indicator of chronic stress that reflects the cumulative cost of repeated environmental stressors on neural and neuroendocrine responses, has been considered as a potential factor in the development of depression and may increase mortality risk. This study aimed to investigate the association between AL, depression, and mortality in the general population and to evaluate the mediating role of depression in the relationship between AL and mortality. Cross-sectional data from 15,571 participants of the US National Health and Nutrition Examination Survey (NHANES) 2009-2016 were analyzed.