Impact of Sodium-Glucose Cotransporter 2 Inhibitor on Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With or Without Metabolic Syndrome.

Aims: The impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on atrial fibrillation (AF) recurrence after catheter ablation is still inconclusive. Besides, their efficacy on AF recurrence stratified by metabolic syndrome (MetS) status remains unknown.

Methods: Patients with AF undergoing initial catheter ablation between January 2017 and December 2023 from the China-AF Registry were included.

Impact of sodium-glucose cotransporter 2 inhibitor on recurrence and cardiovascular outcomes after catheter ablation for atrial fibrillation in patients with chronic kidney disease.

Background: The effect of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on atrial fibrillation (AF) recurrence after catheter ablation in patients with chronic kidney disease (CKD) remains uncertain.

Objective: The purpose of this study was to investigate whether SGLT2i treatment is associated with a reduced risk of AF recurrence after catheter ablation in patients with CKD.

Methods: From the prospective Chinese Atrial Fibrillation Registry, we identified 628 patients with AF and CKD undergoing initial catheter ablation from January 2019 to December 2023.

Engineered PDMS microtopography: Precision regulation of tendon stem cell behavior for tendon regeneration.

Microtopography critically regulates tendon stem cell (TSC) migration for repair, yet its precise roles remain unclear. We engineered polydimethylsiloxane (PDMS) scaffolds with precisely defined micron-scale pits and columns (diameters 7-21 μm, spacings 13-47 μm) via ultraviolet lithography and etching. High-throughput screening to promote TSC viability identified six optimal topographies: three pit-based topographies (diameters/spacings: 7 μm/47 μm, 11 μm/18 μm, 21 μm/26 μm) and three column-based topographies (diameters/spacings: 8 μm/14 μm, 13 μm/13 μm, 18 μm/18 μm).

Intra-Arterial Thrombolysis Following Endovascular Recanalization for Large Vessel Occlusion Stroke: A Systematic Review and Meta-Analysis.

Background And Objectives: This systematic review and meta-analysis aims to evaluate the treatment effects of intra-arterial thrombolysis (IAT) after endovascular recanalization in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Endovascular recanalization is the standard treatment for large vessel occlusion (LVO) stroke. Despite successful reperfusion after thrombectomy, fewer than half of the patients regain functional independence at 90 days, highlighting the potential role of impaired microcirculation in poor neurologic outcomes.

High-strength chitosan-sericin cryogel with synergistically reinforced networks for hemostasis.

Developing chitosan-based hemostatic cryogels with simultaneously excellent mechanical properties and good biocompatibilities is still a challenge yet crucial for hemostasis of deep tissue bleeding. Typical approaches to enhancing the mechanical properties sacrifice biocompatibility of chitosan cryogels, thereby increasing the potential application risk. In this study, we develop a chitosan-sericin-ε-polylysine (CS-Ser-EPL) cryogel with synergistically reinforced networks achieved by physical and chemical crosslinking to address the limitations.

Clopidogrel vs. ticagrelor in ST-elevation myocardial infarction complicated by cardiogenic shock undergoing primary PCI : Findings from a National, multicenter registry.

Background: Although ticagrelor is recommended as opposed to clopidogrel in antiplatelet strategy for patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI), evidence is limited in patients with cardiogenic shock (CS).

Objective: This study aims to evaluate the comparative efficacy and safety profile of ticagrelor and clopidogrel in patients with STEMI-CS undergoing pPCI.

Methods: Using data from a nationwide, multicenter registry, eligible patients were stratified into clopidogrel or ticagrelor based on the choice of P2Y inhibitors within 24 h of first medical contact.

Impact of atrial remodeling on efficacy of catheter ablation in reducing cardiovascular risk in atrial fibrillation: Results from CABANA trial.

Background: The efficacy of catheter ablation in reducing major adverse events in atrial fibrillation (AF) is still inconclusive, warranting identification of clinical markers.

Objective: The purpose of this study was to explore whether the benefits of catheter ablation varied across different extents of atrial remodeling in the CABANA (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation) trial.

Methods: The CABANA trial randomized 2204 participants with AF to catheter ablation or drug therapy.

Patterns of Postablation Recurrence and Adverse Cardiovascular Outcomes in Patients With Atrial Fibrillation.

Background: Atrial arrhythmia recurrence after atrial fibrillation (AF) catheter ablation is conventionally assessed as a binary end point. However, the prognostic value of recurrence patterns is less studied.

Methods And Results: This study included patients undergoing catheter ablation from the multicenter China Atrial Fibrillation Registry study (2011-2022).

Safety and efficacy of post-procedure anticoagulation in ST-elevation myocardial infarction complicated by cardiogenic shock undergoing primary percutaneous coronary intervention.

Introduction: Cardiogenic shock (CS) is a lethal complication of ST-elevation myocardial infarction (STEMI). The impact of post-procedure anticoagulants (PPAC) in STEMI-CS patients undergoing primary percutaneous coronary intervention (PPCI) remains unknown.

Method: In the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome registry (2014-2019), STEMI patients with CS on admission undergoing PPCI were stratified into two groups based on the use of PPAC or not.

Outcomes and anticoagulant management for new-onset atrial fibrillation in patients with ST-elevation myocardial infarction following primary percutaneous coronary intervention: Findings from a national multicenter registry and meta-analysis.

Background: Little is known about the risk factors and prognosis of new-onset atrial fibrillation (NOAF) in patients with primary percutaneous coronary intervention (PCI).

Objective: The purpose of this study was to assess the prevalence and prognosis of NOAF after PCI and the effects of anticoagulation on clinical outcomes.

Method: Using data from the CCC-ACS (Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome) project, ST-elevation myocardial infarction (STEMI) patients undergoing PCI were stratified into 2 groups: with NOAF or without any atrial fibrillation.

Burden of Atrial Fibrillation and Atrial Flutter From 1990 to 2021 in China: Global Burden of Disease Study 2021 Update.

Background: Atrial fibrillation (AF) and atrial flutter (AFL) represent increasingly significant health burden globally. We aimed to systematically evaluate the status and trends of AF/AFL burden and attributable risk factors in China.

Methods: We assessed the burden of AF/AFL measured as prevalence, incidence, mortality, and disability-adjusted life years (DALYs), by sex and age groups in China based on the Global Burden of Diseases Study (GBD) 2021 project.

Sex difference in the relationship between childhood obesity and abnormal lipid profiles in young adults.

Background: Abnormal lipid profiles are a major risk factor for cardiovascular diseases, and childhood obesity has been linked to changes in lipid metabolism in adults. However, the relationship between childhood obesity and adult lipid profiles, as well as the potential sex differences, remain unclear. This study aimed to examine the association between childhood obesity and abnormal lipid metabolism in young adults, specifically focusing on sex differences.

Research on upper limb rehabilitation assessment model based on belief rule base.

Rehabilitation assessments hold an irreplaceable role in the field of rehabilitative therapy. However, due to the subjectivity of traditional physicians and the variability of patient conditions, this leads to a lack of detailed grading and inaccurate assessment results. To address this issue, we developed an upper limb rehabilitation evaluation model.

In vitro regulation of collective cell migration: Understanding the role of physical and chemical microenvironments.

Collective cell migration is the primary mode of cellular movement during embryonic morphogenesis, tissue repair and regeneration, and cancer invasion. Distinct from single-cell migration, collective cell migration involves complex intercellular signaling cascades and force transmission. Consequently, cell collectives exhibit intricate and diverse migration patterns under the influence of the microenvironment in vivo.

Cross-Modal self-supervised vision language pre-training with multiple objectives for medical visual question answering.

Medical Visual Question Answering (VQA) is a task that aims to provide answers to questions about medical images, which utilizes both visual and textual information in the reasoning process. The absence of large-scale annotated medical VQA datasets presents a formidable obstacle to training a medical VQA model from scratch in an end-to-end manner. Existing works have been using image captioning dataset in the pre-training stage and fine-tuning to downstream VQA tasks.

Elevated Glucose on Admission Was an Independent Risk Factor for 30-Day Major Adverse Cardiovascular Events in Patients with STEMI but Not NSTEMI.

Background: The purpose of this study was to evaluate the impact of glucose levels on admission, on the risk of 30-day major adverse cardiovascular events (MACEs) in patients with acute myocardial infarction (AMI), and to assess the difference in outcome between ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) patients.

Methods: This study was a post hoc analysis of the Acute Coronary Syndrome Quality Improvement in Kerala Study, and 13,398 participants were included in the final analysis. Logistic regression models were used to assess the association between glucose levels on admission and the risk of 30-day MACEs, adjusting for potential confounders.

Association between the preprocedural serum potassium level and atrial fibrillation recurrence after catheter ablation.

Background: The association between serum potassium and atrial fibrillation (AF) recurrence after catheter ablation remains unclear.

Objective: The purpose of this study was to investigate whether preprocedural serum potassium level influences AF recurrence in patients who underwent catheter ablation.

Methods: We used data of patients with AF who underwent de novo catheter ablation from the prospective Chinese Atrial Fibrillation Registry Study.

Small Left Ventricle in Patients With Atrial Fibrillation Is Associated With Increased Cardiovascular Risk.

Background: It is still unclear whether small left ventricle (LV) is an adverse structural prognostic feature in patients with atrial fibrillation (AF).

Objectives: The purpose of this study was to evaluate the association between small LV and risk of cardiovascular events in AF population.

Methods: From the China-AF registry, 7,764 patients with AF were enrolled and divided into groups with normal, small, and large LV size based on left ventricular end-diastolic dimension (LVEDD) measurement per the American Society of Echocardiography references.

Hierarchical porous carbon materials for lithium storage: preparation, modification, and applications.

Secondary battery as an efficient energy conversion device has been highly attractive for alleviating the energy crisis and environmental pollution. Hierarchical porous carbon (HPC) materials with multiple sizes pore channels are considered as promising materials for energy conversion and storage applications, due to their high specific surface area and excellent electrical conductivity. Although many reviews have reported on carbon materials for different fields, systematic summaries about HPC materials for lithium storage are still rare.

Evaluation of an algorithm-guided photoplethysmography for atrial fibrillation burden using a smartwatch.

Background: Wearable devices based on the PPG algorithm can detect atrial fibrillation (AF) effectively. However, further investigation of its application on long-term, continuous monitoring of AF burden is warranted.

Method: The performance of a smartwatch with continuous photoplethysmography (PPG) and PPG-based algorithms for AF burden estimation was evaluated in a prospective study enrolling AF patients admitted to Beijing Anzhen Hospital for catheter ablation from September to November 2022.

Association between the ZJU index and risk of new-onset non-alcoholic fatty liver disease in non-obese participants: a Chinese longitudinal prospective cohort study.

Background: Non-alcoholic fatty liver disease (NAFLD) is increasingly observed in non-obese individuals. The ZJU (Zhejiang University) index has been established as a new and efficient tool for detecting NAFLD, but the relationship between the ZJU index and NAFLD within non-obese individuals still remains unclear.

Methods: A evaluation was undertaken using data from a health assessment database by the Wenzhou Medical Center.

Generative adversarial network based on frequency domain data enhancement: Dual-way discriminator structure Copes with limited data.

The excellent image-generation ability of generative adversarial networks (GANs) has been widely used. However, training a GAN requires large-scale data support, which hinders in-depth development. Therefore, the research on stable training of GANs under limited data conditions is helpful to further expand the application scenarios.

Promising application of pulsed electromagnetic fields on tissue repair and regeneration.

Tissue repair and regeneration is a vital biological process in organisms, which is influenced by various internal mechanisms and microenvironments. Pulsed electromagnetic fields (PEMFs) are becoming a potential medical technology due to its advantages of effectiveness and non-invasiveness. Numerous studies have demonstrated that PEMFs can stimulate stem cell proliferation and differentiation, regulate inflammatory reactions, accelerate wound healing, which is of great significance for tissue regeneration and repair, providing a solid basis for enlarging its clinical application.