Chitosan-Based Photothermal Hydrogel with Rapid Bacterial Capture for Enhanced Disinfection.

Constructing a novel antibacterial platform is of great significance for inhibiting bacterial infections. In this work, we developed a composite hydrogel (CS/PPy/PDA hydrogel) by incorporating photothermal material polypyrrole (PPy), chitosan (CS) and polydopamine (PDA) into poly acrylamide (PAAM) hydrogel network. First, CS/PPy/PDA hydrogel could capture bacteria through strong electrostatic interactions, enhancing the contact between hydrogels and bacteria.

Impact of Sodium-Glucose Cotransporter 2 Inhibitor on Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With or Without Metabolic Syndrome.

Aims: The impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on atrial fibrillation (AF) recurrence after catheter ablation is still inconclusive. Besides, their efficacy on AF recurrence stratified by metabolic syndrome (MetS) status remains unknown.

Methods: Patients with AF undergoing initial catheter ablation between January 2017 and December 2023 from the China-AF Registry were included.

Impact of sodium-glucose cotransporter 2 inhibitor on recurrence and cardiovascular outcomes after catheter ablation for atrial fibrillation in patients with chronic kidney disease.

Background: The effect of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on atrial fibrillation (AF) recurrence after catheter ablation in patients with chronic kidney disease (CKD) remains uncertain.

Objective: The purpose of this study was to investigate whether SGLT2i treatment is associated with a reduced risk of AF recurrence after catheter ablation in patients with CKD.

Methods: From the prospective Chinese Atrial Fibrillation Registry, we identified 628 patients with AF and CKD undergoing initial catheter ablation from January 2019 to December 2023.

Comparative outcomes of transurethral resection of the prostate and prostate kinetic resection in treating benign prostatic hyperplasia with prostatic stones.

Aims: To compare the clinical outcomes of transurethral bipolar plasma enucleation (TBPE) and transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH) complicated by prostatic stones.

Methods: This retrospective study included 150 patients divided into TBPE (n = 74) and TURP (n = 76) groups. Perioperative data, urodynamic parameters, symptom scores, complications, and sexual function were evaluated up to 6 months postoperatively.

Single-cell and spatial transcriptomics profile the interaction of macrophages and fibroblasts in non-small cell lung cancer.

Background: Non-small cell lung cancer (NSCLC) remains one of the most prevalent malignancies. A series of differentially expressed genes (DEGs) have been identified in tumor samples and play critical roles in modulating the characteristics of tumor cells. However, some DEGs are specifically expressed in the tumor microenvironment (TME) cells.

Impact of disease progression avoidance by catheter ablation on clinical outcomes in atrial fibrillation: Insights from the CABANA trial.

Background: Delaying disease progression by catheter ablation has been recognized in patients with paroxysmal atrial fibrillation (AF); however, its direct association with clinical outcome improvement remains unclear.

Objective: This study aimed to evaluate the effect of catheter ablation on reducing AF progression and associations with outcomes.

Methods: The Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) trial compared the efficacy of catheter ablation with drug therapy in 2204 patients with AF.

Cross-Cultural Adaptation and Psychometric Evaluation of the Chinese Version of the Functional Disability Inventory.

Introduction: Chronic pain is a major public health issue affecting approximately one-fifth of children and adolescents worldwide, and it is also a common complaint among Chinese adolescents. Despite its impact on daily functioning in this population, culturally adapted tools for assessing pain-related disability are lacking. The Functional Disability Inventory (FDI) is a widely used measure for evaluating functional impairment, but its simplified Chinese version has yet to be validated.

Unveiling the genetic basis of floral scent formation in roses using weighted gene co-expression and protein-protein interaction network analyses.

Rosa species hold considerable economic and medicinal importance, used in traditional medicine, essential oils, and landscaping. However, the mechanisms of floral scent formation in roses are not well understood, hindering genetic improvement. To bridge this gap, we conducted a combined transcriptome and metabolome analysis, identifying nine key fragrance compounds.

Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial.

This study aims to investigate the effect of hyperbaric oxygen therapy (HBOT) on muscle damage and inflammatory responses after total knee arthroplasty (TKA). This study selected 80 patients requiring TKA for primary knee osteoarthritis from July 2023 to December 2023 and equally randomized them into two groups-the HBOT and control groups-with 40 patients in each group. The HBOT group received standard treatment supplemented with HBOT, whereas the control group received normobaric oxygen therapy.

One-step strategy for fabricating icariin-encapsulated biomimetic Scaffold: Orchestrating immune, angiogenic, and osteogenic cascade for enhanced bone regeneration.

The repair of bone defects relies on the intricate coordination of inflammation, angiogenesis, and osteogenesis. However, scaffolds capable of integrating osteo-immunomodulation and vascular-bone coupling to cascade-activate these processes remain a challenge. Here, a biomimetic scaffold (CHP@IC) with PLGA@icariin (PLGA@IC) microspheres encapsulation was successfully fabricated using a one-step emulsification and polymerization strategy.

Adipose-derived stem cell exosomes alleviate TGF-β1-induced urethral stricture fibrosis by suppressing the TGF-β/Smad pathway and downstream PDGFR-β/RAS/ERK signaling.

This study aimed to investigate the therapeutic effects and underlying mechanisms of adipose-derived stem cell exosomes (ADSCs-exo) in ameliorating fibrosis in a rat model. ADSCs were isolated and cultured from rat adipose tissue, and ADSCs-exo were extracted via ultracentrifugation. Urethral fibrosis was induced by local injection of TGF-β1 (10 μg), followed by ADSCs-exo treatment.

Circumventing Scaling Relations via Gradient Orbital Coupling Promotes Ammonia Electrosynthesis on Cobalt Catalyst.

Highly efficient electrocatalytic nitrate reduction to ammonia (NH) relies on the balanced activation of various substrates including nitrate and water, but is currently hindered by the inherent scaling relations governing the adsorption of key reaction intermediates, such as *NO and *H. Herein, we develop a strategy to circumvent these limitations by introducing f-d-p gradient orbital coupling in cobalt oxide (CoO) through Ce doping. Density functional theory calculations indicate that the lattice strain triggered by the dopant redistributes electron density at the Co and O sites, thereby modulating the adsorption strengths of *NO and *H, which favors the production of NH while suppressing hydrogen evolution reaction.

Establishment of a prognostic nomogram for evaluating non-adjuvant therapy in patients with stage I to III esophageal cancer: a population-based study.

Background: According to reports from China, esophageal cancer ranked sixth in terms of morbidity and accounted for 6.26% of all cancer cases in China. This study aimed to establish an effective prognostic nomogram for non-adjuvant therapy in patients with stage I to III esophageal cancer.

Association of Serum Total Bilirubin to Cholesterol Ratio With Progression of Chronic Kidney Disease in Patients With Type 2 Diabetes: A Retrospective Cohort Study.

Aim: To explore the influence of the serum total bilirubin to total cholesterol (TBIL/TC) ratio on the progression of chronic kidney disease (CKD) in people with type 2 diabetes.

Materials And Methods: The present retrospective discovery cohort investigated 4282 patients. The exposure was baseline TBIL/TC ratio.

Impact of atrial remodeling on efficacy of catheter ablation in reducing cardiovascular risk in atrial fibrillation: Results from CABANA trial.

Background: The efficacy of catheter ablation in reducing major adverse events in atrial fibrillation (AF) is still inconclusive, warranting identification of clinical markers.

Objective: The purpose of this study was to explore whether the benefits of catheter ablation varied across different extents of atrial remodeling in the CABANA (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation) trial.

Methods: The CABANA trial randomized 2204 participants with AF to catheter ablation or drug therapy.

Pirfenidone Ameliorates Hypertrophic Scar Through Inhibiting Proliferation and Migration of Fibroblasts by Regulating the Wnt/GSK-3β/β-Catenin Signaling Pathway.

Hypertrophic scar (HS) is a prevalent complication that arises from burn injuries. While Pirfenidone (PFD) is known to be an effective antifibrotic agent, its precise effects on HS caused by burn injuries are still unclear. This study was to assess the influence of PFD on HS fibroblasts and investigate the underlying mechanism.

Facile synthesis of water-soluble and pH-stable silicon quantum dots and their application in enzyme-free hydrogen peroxide sensing.

A sensor for non-enzymatic hydrogen peroxide (HO) detection was developed based on silicon quantum dots (SiQDs). The fluorescent SiQDs were synthesized using a one-pot hydrothermal method. The SiQDs were made water-soluble and pH-stable by covering their surfaces with amino and hydroxyl groups.

A chain mediation model of parent child relationship and academic burnout of adolescents.

This paper studied the relationship and mechanisms of parent-child relationship, interpersonal relationship on campus, academic self-efficacy and academic burnout among adolescents. A study of 913 Chinese junior high school students from Fujian province (47.20% males, mean age = 13.

Murine Model Insights: Identifying Dusp15 as a Novel Biomarker for Diabetic Cardiomyopathy Uncovered Through Integrated Omics Analysis and Experimental Validation.

Background: Diabetic Cardiomyopathy (DCM) is a heart condition that arises specifically from diabetes mellitus, characterized by cardiac dysfunction in the absence of coronary artery disease or hypertension. The prevalence of DCM is rising in tandem with the global increase in diabetes, necessitating the development of early diagnostic markers and therapeutic targets. This study integrates bioinformatics analysis with experimental validation to identify potential biomarkers for DCM.

S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis.

Protein S-nitrosylation (SNO), a redox-based posttranslational modification of cysteine thiols, plays a crucial role in various signaling pathways. Peroxiredoxin 2 (PRDX2) is one of the most potent ROS scavenging proteins, providing protection against oxidative stress damage, with its function regulated by SNO. However, the precise role of SNO-PRDX2 in hyperuricemic nephropathy remains poorly understood.

The Impact of frailty on the effectiveness of intensive blood pressure control for patients with type 2 diabetes: a secondary analysis of a randomised controlled trial.

Background: Frailty is an independent risk factor for cardiovascular events. It is uncertain whether frailty modifies the efficacy of intensive blood pressure (BP) control among participants with type 2 diabetes mellitus(T2DM).

Methods: The Action to Control Cardiovascular Risk in Diabetes Blood Pressure (ACCORD BP) trial, a two-by-two factorial trial, examined the effects of systolic BP (<120 vs <140 mm Hg) and glycaemic control on cardiovascular events in T2DM.

Comparative analysis of petal phytoconstituents reveals insights into the characteristics of an under-reported edible old rose variety native to Chongqing, China.

Chongqing Old Rose is an ancient edible rose variety native to Chongqing, China, but is under-reported. Further evidence is required to fully establish its potential benefits. The complete metabolic profiles were examined for comparative analysis between the Old Rose and three rose cultivars.

Surgical intervention for patients with fibrinopurulent pleural empyema and acute respiratory failure: a case report.

Background: Fibrinopurulent thorax is a rare condition that can lead to respiratory failure. Fibroblastic decortication surgery has been shown to be an effective treatment for chronic empyema in previous studies. However, there is limited evidence supporting surgical intervention for fibrinopurulent thorax in cases of respiratory failure.

Plasma catalytic ammonia synthesis in a fluidized-bed DBD reactor over M/AlO: Enhancement of plasma-catalyst surface interaction.

Ammonia is a promising alternative energy to fossil fuels for reducing CO emissions. Plasma catalysis technology for ammonia production using clean energy is gaining attention. Introducing catalysts to the plasma increases ammonia synthesis rates, but the effect of catalyst particle movement in the plasma region, such as in a fluidized-bed reactor, is less explored.

Non-early catheter ablation vs drug therapy in atrial fibrillation: Results from the CABANA trial.

Background: Early rhythm control reduces the risk of cardiovascular events in patients with atrial fibrillation (AF). Despite the superiority of catheter ablation in maintaining sinus rhythm, the knowledge gaps regarding the prognostic benefits of non-early (onset of AF ≥1 year) ablation remain.

Objective: The study aimed to describe outcomes of non-early AF in the CABANA trial.