The Gma-miR4359b/GmFBX193 module is involved in the response of soybean to salt stress.

MicroRNAs (miRNAs) are key regulators of F-box-mediated signal transduction in plants and play important roles in the stress response. The ways in which miRNAs target F-box genes in soybeans under salt stress are currently unknown. In this study, the functional role of GmFBX193, the gene target of gma-miR4359b, under salt stress was investigated.

Discovery of Dual-Acting Biofilm Inhibitors against by the Coupling of 3-Hydroxypyridin-4(1)-ones with -Phenylamide QS Inhibitors.

() is prevalent in hospital infections and strongly complicates the treatment for its propensity to cause biofilm-associated resistance. Herein, a series of novel dual-acting biofilm inhibitors were designed and synthesized by coupling 3-hydroxypyridin-4(1)-ones with -phenylamides quorum sensing inhibitors. The hit compound (IC = 0.

Molecular Engineering of Plant Polyphenols Into Amorphous Room-Temperature Phosphorescent Materials.

Room-temperature phosphorescent (RTP) materials have potential applications in optoelectronics and bioimaging but encounter significant challenges. Traditional heavy-metal-based and crystalline systems are often toxic and environmentally sensitive, while strategies involving host-guest doping and encapsulation frequently suffer from phase separation and limited controllability-ultimately resulting in poor repeatability and restricted applications. Here, we developed a novel polyphenol-mediated molecular splicing and ring-locking strategy to incorporate benzo[c][1,2,5]thiadiazole (BZT) into polyphenol molecules, yielding a range of eco-friendly and processable amorphous single-component systems with a lifetime of up to 124 ms.

H3K36me3 modification by SETD2 is essential for Col11a2 and Sema3e transcription to maintain dentinogenesis in mice.

Dentin is a major mineralized component of teeth generated by odontoblasts. Several types of histone methylation have been reported to play important roles in odontoblast differentiation and dentinogenesis. However, the role of methylation on histone 3 at lysine 36 (H3K36) remains enigmatic.

Loading Pt-Ru Dual Atoms on Oxygen-Vacancy-Rich TiO for Efficient Photocatalytic H Production.

The utilization of renewable hydrogen represents a critical pathway for addressing contemporary energy challenges while aligning with global climate mitigation imperatives. Photocatalytic water splitting has emerged as a promising approach for green hydrogen generation, with single-atom catalysts (SACs) demonstrating exceptional catalytic activity and selectivity compared to conventional semiconductor materials, positioning them at the forefront of contemporary photocatalysis research. In this study, platinum (Pt) and ruthenium (Ru) species were introduced as active sites onto defective titanium dioxide (Vo-TNS) nanosheets via the deposition-precipitation method, aiming at photocatalytic hydrogen production.

Dentin sialoprotein promotes endothelial differentiation of dental pulp stem cells through DSP-endoglin-AKT1 axis.

Dentin sialoprotein (DSP), a major dentin extracellular matrix noncollagenous protein, is well recognized as an important regulator for dentinogenesis. DSP as a secreted protein can interact with membrane receptors, activate intracellular signaling, and initiate the odontoblastic differentiation of dental papilla cells. In a recent study, we have demonstrated that DSP can induce the endothelial differentiation of dental pulp stem cells (DPSCs), a type of tooth pulp-derived multipotent stem cells, dependent on membrane receptor endoglin (ENG).

Dentin sialoprotein acts as an angiogenic factor through association with the membrane receptor endoglin.

Dentin sialophosphoprotein (DSPP) is highly expressed by odontoblasts, the cell type responsible for dentin formation. DSPP therefore has been extensively studied as a regulator of dentinogenesis. Besides defective dentinogenesis in teeth, Dspp-deficient mice also display reduced blood vessels in the transition zone of femurs.

The Mdm2-p53 axis links cementocyte survival to cellular cementum volume.

Cementocytes are terminally differentiated cells embedded in cellular cementum, an important hard tissue covering the apical regions of tooth roots. However, the roles of cementocytes in cellular cementum remain enigmatic. Here, we show that Murine Double Minute 2 (Mdm2), an E3 ubiquitin ligase that plays vital roles in regulating cell proliferation, apoptosis, and differentiation to influence tissue or organ development, is highly expressed in the cementocytes of mice.

Surface immobilization of single atoms on heteroatom-doped carbon nanospheres through phenolic-mediated interfacial anchoring for highly efficient biocatalysis.

Single-atom catalysts (SACs) dispersed on support materials exhibit exceptional catalytic properties that can be fine-tuned through interactions between the single atoms and the support. However, selectively controlling the spatial location of single metal atoms while simultaneously harmonizing their coordination environment remains a significant challenge. Here, we present a phenolic-mediated interfacial anchoring (PIA) strategy to prepare SACs with Fe single atoms anchored on the surface of heteroatom-doped carbon nanospheres.

Plasma catalytic ammonia synthesis in a fluidized-bed DBD reactor over M/AlO: Enhancement of plasma-catalyst surface interaction.

Ammonia is a promising alternative energy to fossil fuels for reducing CO emissions. Plasma catalysis technology for ammonia production using clean energy is gaining attention. Introducing catalysts to the plasma increases ammonia synthesis rates, but the effect of catalyst particle movement in the plasma region, such as in a fluidized-bed reactor, is less explored.

Unveiling the roles of LEMD proteins in cellular processes.

Proteins localized in the inner nuclear membrane (INM) engage in various fundamental cellular processes via their interactions with outer nuclear membrane (ONM) proteins and nuclear lamina. LAP2-emerin-MAN1 domain (LEMD) family proteins, predominantly positioned in the INM, participate in the maintenance of INM functions, including the reconstruction of the nuclear envelope during mitosis, mechanotransduction, and gene transcriptional modulation. Malfunction of LEMD proteins leads to severe tissue-restricted diseases, which may manifest as fatal deformities and defects.

Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath.

Hertwig's epithelial root sheath (HERS) interacts with dental apical mesenchyme and guides development of the tooth root, which is integral to the function of the whole tooth. However, the key genes in HERS essential for root development are understudied. Here, we show that Axin1, a scaffold protein that negatively regulates canonical Wnt signaling, is strongly expressed in the HERS.

Tuning nitrogen adsorption and activation performances of Three-Atom transition metal clusters by modulating external electric fields.

Three-atom transition metal clusters (TATMCs) with remarkable catalytic activities, especially Nb, Zr, and Y, are proven to be suitable candidates for efficient ammonia production. The pursuit of effective strategies to further promote the ammonia synthesis performance of TATMCs is necessary. In this study, we systematically investigate the effect of external electric fields on tuning the N adsorption and NN* activation performances of Nb, Zr, and Y.

The MYB transcription factor SmMYB113 directly regulates ethylene-dependent flower abscission in eggplant.

Flower abscission is an important developmental process that can significantly reduce the yield of horticultural plants. We previously reported that SmMYB113 is a key transcription factor promoting anthocyanin biosynthesis and improve fruit quality. However, the overexpression of SmMYB113 in eggplant increased flower drop rate and reduced fruit yield.

piR-368 promotes odontoblastic differentiation of dental papilla cells via the Smad1/5 signaling pathway by targeting Smurf1.

Purpose: The important role of non-coding RNAs in odontoblastic differentiation of dental tissue-derived stem cells has been widely demonstrated; however, whether piRNA (a subclass of non-coding RNA) involved in the course of odontoblastic differentiation is not yet available. This study aimed to investigate the expression profile of piRNA during odontogenic differentiation of mDPCs and the potential molecular mechanism in vitro.

Materials And Methods: The primary mouse dental papilla cells (mDPCs) were isolated from the first molars of 1-day postnatal Kunming mice.

RNA-sequencing analysis reveals novel genes involved in the different peel color formation in eggplant.

Eggplant ( L.) is a highly nutritious vegetable. Here, the molecular mechanism of color formation in eggplants was determined using six eggplant cultivars with different peel colors and two -overexpressing transgenic eggplants with a purple peel and pulp.

Loss of Bmp2 impairs odontogenesis via dysregulating pAkt/pErk/GCN5/Dlx3/Sp7.

BMP2 signaling plays a pivotal role in odontoblast differentiation and maturation during odontogenesis. Teeth lacking Bmp2 exhibit a morphology reminiscent of dentinogenesis imperfecta (DGI), associated with mutations in dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP) genes. Mechanisms by which BMP2 signaling influences expressions of DSPP and DMP1 and contributes to DGI remain elusive.

IPO7 promotes lipopolysaccharide-induced inflammatory responses in human dental pulp cells via p38 MAPK and NF-κB signaling pathways.

Pulpitis is a chronic inflammatory process that greatly affects the physical, mental health and life quality of patients. Human dental pulp cells (hDPCs) are essential components of dental pulp tissue and play a significant role in pulpitis. Lipopolysaccharide (LPS) is an initiator of pulpitis and can induce the production of inflammatory cytokines in hDPCs by activating p38 MAPK and NF-κB signaling pathways.

CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation.

Dentin is the major hard tissue of teeth formed by differentiated odontoblasts. How odontoblast differentiation is regulated remains enigmatic. Here, we report that the E3 ubiquitin ligase CHIP is highly expressed in undifferentiated dental mesenchymal cells and downregulated after differentiation of odontoblasts.

AAV6-Mediated Gene Therapy Prevents Developmental Dentin Defects in a Dentinogenesis Imperfecta Type Ⅲ Mouse Model.

Dentin is a major type of hard tissue of teeth and plays essential roles for normal tooth function. Odontoblasts are responsible for dentin formation. Mutations or deficiency in various genes affect the differentiation of odontoblasts, leading to irreversible dentin developmental defects in animals and humans.

Reactive Oxygen Species-Induced Inhibition of Odontoblastic Differentiation of Mouse Dental Papilla Cells Is Mediated by Downregulation of Importin 7.

Tooth dentin is a crucial tooth structure. The biological process of odontoblast differentiation is essential for formation of normal dentin. Accumulation of reactive oxygen species (ROS) leads to oxidative stress, which can influence the differentiation of several cells.

IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation.

RUNX2, an important transcriptional factor for both odontoblastic and osteoblastic differentiation, is upregulated during osteoblastic differentiation, but downregulated during late odontoblastic differentiation. However, the specific mechanism of the different RUNX2 expression in bone and dentin remains largely unknown. Importin 7 (IPO7), a member of the karyopherin β-superfamily, mediates nucleocytoplasmic transport of proteins.

A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice.

WW domain-containing E3 Ubiquitin-protein ligase 2 (WWP2) has been found to positively regulate odontoblastic differentiation by monoubiquitinating the transcription factor Kruppel-like factor 5 (KLF5) in a cell culture system. However, the in vivo role of WWP2 in mouse teeth remains unknown. To explore this, here we generated Wwp2 knockout (Wwp2 KO) mice.