Partial splenectomy and pericardial devascularization for symptomatic patients with portal hypertension: a single-center retrospective study.

Background: The dilemma of current treatments for symptomatic patients with portal hypertension is how to resolve the problems of the varices and hypersplenism simultaneously and meanwhile preserve the splenic function. Partial splenectomy and pericardial devascularization is a potential alternative to currently used approaches, but it is incompletely defined. This study aimed to evaluate the efficacy and safety of partial splenectomy and pericardial devascularization.

Linalool-triggered plant-soil feedback drives defense adaptation in dense maize plantings.

High planting density boosts crop yields but also heightens pest and pathogen risks. How plants adapt their defenses under these conditions remains unclear. In this study, we reveal that maize enhances its defense in high-density conditions through a plant-soil feedback mechanism triggered by the leaf volatile linalool.

25-hydroxyvitamin D3 exerts a protective effect on coronary artery lesions in a mouse model of Kawasaki disease by inhibiting JAK1/STAT3 and TLR4 pathways.

Background: Kawasaki disease (KD) is an acute vasculitis in children, and the resultant inflammatory process can lead to coronary artery aneurysms. The study aimed to investigate the role of 25-hydroxyvitamin D (25-OH-D), a stable circulating form of vitamin D, in KD mouse models.

Methods: The KD mouse model was established through intraperitoneal injection of 500 μg cell wall extract (LCWE).

Sandwich-structured cellulose acetate dielectric films toward high-temperature energy storage application.

Common sandwich-structured dielectric films are typically confined to comparatively low operating temperatures because of the significant conduction loss of polymer under high thermal stress that originated from the relatively weak interfacial interaction between adjacent layers. Here, all-organic sandwich-structured dielectric films were fabricated based on cellulose acetate (CA) and poly(methyl methacrylate) (PMMA) by solution casting method. Specifically, CA with high dielectric constant was designed as the intermediate polarizing layer, while PMMA with good insulation property was taken for the breakdown-resistant out layers.

Constructing polyphosphazene nanonetworks on ammonium polyphosphate to synchronously enhance the flame retardancy, mechanical and UV-shielding performances of polylactic acid.

To address the applications of polylactic acid (PLA) in various environmental conditions, this study designed a novel additive, i.e. in-situ growing polyphosphazene nano-network on ammonium polyphosphate (APP) surface to construct the core-shell like structure through the bridging effect of chitosan.

Real-world effectiveness and safety of prolonged bedaquiline course in the treatment of drug-resistant tuberculosis-a multi-center retrospective cohort study in a country with a high burden of drug-resistant tuberculosis.

Bedaquiline (BDQ) has gradually become a core drug in drug-resistant tuberculosis (DR-TB) treatment, and the additional benefits of prolonging BDQ use remain unclear. Patients with DR-TB who received a BDQ-containing regimen from three Chinese clinical centers between 1 March 2018 and 31 December 2021 were retrospectively analyzed. Treatment outcomes and adverse drug reactions were compared between 6-month and prolonged BDQ treatment group before and after adjustment by propensity score matching (PSM).

Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos.

Capturing different pluripotent state stem cells from epiblast in vitro helps understand embryonic development and provides invaluable cell sources for basic research and regenerative medicine. Sheep are not only one of the most important livestock species in agriculture but also serve as an ideal preclinical model for studying human disease. Single-cell transcriptome analysis of sheep preimplantation embryos from embryonic day (E) 1 to E14 is performed to investigate the pluripotency changes of epiblast and elucidate the pluripotent regulation signaling.

A temperature-responsive regulator that enhances virulence in the kiwifruit canker pathogen pv. a.

pv. (), the causative agent of kiwifruit canker disease, poses significant threats to global kiwifruit production, resulting in substantial economic losses. Disease incidence is notably higher under cooler temperatures (<20℃), yet the molecular mechanisms underlying 's temperature-dependent virulence remain poorly understood.

Self-Healable, Considerably Stretchable, and Wide-Temperature-Range-Damping Waterborne Polyurethane Elastomers by Constructing the Spider-Silk-Like Structures.

Waterborne polyurethane (WPU) has garnered considerable attention, owing to its environmentally friendly characteristics and diverse application potentials. However, its limited mechanical strength and toughness restrict its practical applications in demanding long-term loading scenarios. Herein, we propose a biomimetic microstructure strategy to address these limitations by preparing tannic acid-functionalized boron nitride nanosheets (TA@BNNSs) through π-π stacking interactions, thereby structurally substituting the β-sheet nanocrystals in spider silk.

Model experimental investigation on staggered segmental tunnel linings considering the surrounding soil pressure.

The surrounding soil pressure will significantly impact the existing tunnel lining. To study the deformation characteristics of the staggered segmental tunnel linings structure under this pressure, a model test device considering surrounding soil pressure effects is designed. This device simulates the impact of surrounding soil pressure on staggered lining using special prestressed springs.

Macrophage membrane coated nanoscale coordination polymers promote graft survival in allogeneic transplantation.

Organ transplantation is a crucial life-saving procedure for patients suffering from end-stage organ failure, yet it faces a global shortage. This scarcity not only impacts individual patients but also places strain on healthcare systems worldwide. However, the risk of rejection adds another layer of difficulty to this already intricate medical procedure.

Ultrasmall radical metal organic cage as cascade antioxidant nanozyme for renal injury.

As substitutes for natural enzymes, nanozymes offer tunable enzyme-like activities and remarkable structural stability, granting them the potential to treat various diseases, including renal ischemia-reperfusion (I/R) injury. However, the majority of developed nanozymes suffer from unclear structures and limited activity profiles, which hinder the study of their structure-activity relationships, catalytic diversity, mass production, and clinical application. Herein, we introduce an atomically precise and ultrasmall cascade nanozyme based on a radical-functionalized metal-organic cage (MOC-R).

Investigating the Anna Karenina principle of the breast microbiome.

The relationship between the microbiome and disease has long been a central focus of research in human microbiome. Inspired by Leo Tolstoy's dictum, the Anna Karenina Principle (AKP) offers a framework for understanding the complex dynamics of microbial communities in response to perturbations, suggesting that dysbiotic individuals exhibit greater variability/heterogeneity in their microbiome compared to healthy counterparts. While some studies have proved the alignment of microbiome responses to disease with the AKP effect, it remains uncertain whether the human breast microbiome responds similarly to breast disease.

Microstructure and performance evolution of poly (l-lactic acid) during physical aging: Determinable role of molding method on β-relaxation.

As one of the biodegradable materials, poly (L-lactic acid) (PLLA) attracts much attention and acquires fast development since it is crucial for alleviating the issue of microplastic pollution. During processing and service, polymers usually experience the physical aging process, leading to the microstructure and performance evolution. Such scenario is especially obvious for PLLA.

All-Organic Aramid Films with High Temperature Resistance and Electrical Insulation by Introducing Interfacial Hydrogen Bonds.

Although aramid nanofibers (ANFs) consist of rigid poly(terephthalic acid terephthalamide) molecular chains with good high temperature resistance for aerospace and other high-temperature applications, it has poor electrical insulation properties due to internal defects. Currently, the main method to improve the electrical insulation properties is to introduce wide band gap two-dimensional (2D) fillers, such as Boron Nitride Nanosheets (BNNS) or mica flakes, but this inevitably affects the mechanical properties and optical transparency. Cellulose acetate (CA) is originated from acetylation of natural cellulose, and the higher number of hydrogen bond donors on the molecular chain enables it to interbond with many polymers.

Hierarchically Porous Polypyrrole Foams Contained Ordered Polypyrrole Nanowire Arrays for Multifunctional Electromagnetic Interference Shielding and Dynamic Infrared Stealth.

As modern communication and detection technologies advance at a swift pace, multifunctional electromagnetic interference (EMI) shielding materials with active/positive infrared stealth, hydrophobicity, and electric-thermal conversion ability have received extensive attention. Meeting the aforesaid requirements simultaneously remains a huge challenge. In this research, the melamine foam (MF)/polypyrrole (PPy) nanowire arrays (MF@PPy) were fabricated via one-step electrochemical polymerization.

[Aggressive natural killer cell leukemia with hemophagocytic lymphohistiocytosis: a case report].

A boy, aged 14 years, was admitted due to recurrent cough and expectoration for more than 1 month, with aggravation and fever for 2 days. After admission, he presented with tachypnea and a significant reduction in transcutaneous oxygen saturation, and emergency chest CT examination showed large patchy exudation and consolidation of both lungs. The boy was given tracheal intubation and invasive mechanical ventilation immediately, and his condition was improved after active symptomatic treatment.

Fluorination Affects the Force Sensitivity and Nonequilibrium Dynamics of the Mechanochemical Unzipping of Ladderanes.

When multiple reaction steps occur before thermal equilibration, kinetic energy from one reaction step can influence overall product distributions in ways that are not well predicted by transition state theory. An understanding of how the structural features of mechanophores, such as substitutions, affect reactivity, product distribution, and the extent of dynamic effects in the mechanochemical manifolds is necessary for designing chemical reactions and responsive materials. We synthesized two tetrafluorinated [4]-ladderanes with fluorination on different rungs and found that the fluorination pattern influenced the force sensitivity and stereochemical distribution of products in the mechanochemistry of these fluorinated ladderanes.

Healable, Recyclable, and Ultra-Tough Waterborne Polyurethane Elastomer Achieved through High-Density Hydrogen Bonding Cross-Linking Strategy.

With the increasing popularity of elastomers in industry and daily life, their high performance and functionality have attracted widespread attention. However, it is a great challenge for them to possess both high mechanical properties and excellent healing and recovery capabilities due to the limitations of the preparation methods and the intrinsic microstructure of the elastomers. In this study, a strategy of ice-controlled interfacial stepwise cross-linking was proposed to prepare the waterborne polyurethane-based elastomers with ultrahigh-density hydrogen bonding interaction achieved by enhancing the utilization rate of phenol hydroxyl groups of tannic acid to the maximum extent.

Single-Step PECVD Synthesis of Graphene@Carbon Nanotubes Electrocatalyst.

Graphene (Gr) and carbon nanotubes (CNTs), the two intriguing carbon nanomaterials, have presented great potential in serving as high-performance electrocatalysts in lithium-sulfur (Li-S) chemistry. The concurrent management of both materials would achieve a promoted synergistic effect. Nevertheless, there still remains a lack of an effective material synthesis route.

Troxerutin Delays Skin Keratinocyte Senescence Induced by Ionizing Radiation Both In Vitro and In Vivo.

Backgrounds: With the increasing demand for beauty and a healthy lifespan, studies regarding anti-skin aging have drawn much more attention than ever before. Skin cellular senescence, the primary cause of skin aging, is characterized by a cell cycle arrest in proliferating cells along with a senescence-associated secretory phenotype (SASP), which can be triggered by various internal or external stimuli.

Aims: Recent studies have made significant progress in the fields of anti-senescence and anti-aging.

[Autosomal recessive polycystic kidney disease in a girl].

A 5-year-old girl was admitted due to one episode of melena and one episode of hematemesis. Upon admission, gastroscopy revealed esophageal and gastric varices. Abdominal CT scan, MRI, and color Doppler ultrasound suggested cirrhosis, intrahepatic bile duct dilation, and bilateral kidney enlargement.