Effects of landscape fragmentation on floodplain fishes as revealed by species-habitat networks.

How species interact with habitat patches is influenced primarily by habitat configuration (e.g., connectivity) and species' functional traits.

Dynamic Changes of Distinct Compartmental LV Remodeling Following Septal Myectomy in Hypertrophic Obstructive Cardiomyopathy.

Background: In hypertrophic obstructive cardiomyopathy, left ventricular mass index (LVMi) regresses following septal myectomy, but the specific dynamics, mechanisms (involving cellular and extracellular compartments), and related factors remain unclear.

Methods: This prospective study included hypertrophic obstructive cardiomyopathy patients who underwent septal myectomy. Cardiac magnetic resonance imaging was performed preoperatively and at 6, 12, and 24 months postoperatively.

Mechanistic insights into nutrient profiles, cellulose, and hemicellulose dynamics in red and green buds during cold storage.

() is a popular woody vegetable with distinct red and green varieties in China. Despite its significance, research on the comparative nutrient composition profiles and cellulose and hemicellulose dynamics between these two varieties remains limited. This study comprehensively investigated the refrigerated storage characteristics of buds from multiple aspects, related to cellulose and hemicellulose synthesis.

Research on Acoustic Field Correction Vector-Coherent Total Focusing Imaging Method Based on Coarse-Grained Elastic Anisotropic Material Properties.

This study aims to address the challenges posed by uneven energy amplitude and a low signal-to-noise ratio (SNR) in the total focus imaging of coarse-crystalline elastic anisotropic materials. A novel method for acoustic field correction vector-coherent total focus imaging, based on the materials' properties, is proposed. To demonstrate the effectiveness of this method, a test specimen, an austenitic stainless steel nozzle weld, was employed.

Pentavalent Uranium-Regulated U-Co-Ru Ternary Oxide: High-Efficient Electrocatalyst for Water Splitting.

RuO currently serves as a highly advantageous catalyst for water electrolysis. Nonetheless, unstable hypervalent Ru species during the oxidation process can lead to catalyst inactivation. Herein, we report the successful construction of pentavalent uranium-regulated U-Co-Ru ternary oxide with alterable valence states and stable coordination.

Cost-effective enhancement of SPR performance via spectral shaping techniques.

Surface plasmon resonance (SPR) technology has been widely applied in various fields, such as biosensing, environmental monitoring, food safety, and drug screening. However, the signal-to-noise ratio (SNR) of SPR sensors varies with wavelength and greatly affects their performance due to the fact that optics and sensors work differently for varying wavelengths of light. To address this issue, this paper proposes a simple and effective spectral shaping method based on a multi-field-of-view spectrometer combined with a mask.

WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of TMEM176A.

Mutations in the WFS1 gene, encoding wolframin (WFS1), are known to cause endoplasmic reticulum (ER) stress and lead to Wolfram Syndrome (WS). However, the role of WFS1 in immune inflammation remains unexplored. In this study, we identified that the WFS1 gene mutation (c.

36 Mitigates Alcoholic-Associated Liver Disease Through Modulation of Microbiota and AMPK Signaling.

Background: Alcohol-associated liver disease (ALD) is characterized by gut-liver axis dysfunction and metabolic dysregulation, yet the therapeutic potential of probiotics remains underexplored. This study aimed to investigate the protective effects and mechanisms of 36 (LP36) against ethanol-induced ALD in mice.

Methods: Mice were pretreated with LP36 prior to ethanol exposure.

AI-Based Quantification of Enhancing Tumor Volume on Contrast-Enhanced MRI to Predict Pathologic Response and Prognosis in HCC After HAIC Plus Targeted Therapy and Immunotherapy.

Purpose: To explore the diagnostic and prognostic value of AI-quantified MRI tumor volume for assessing pathologic response in unresectable hepatocellular carcinoma (uHCC) after hepatic arterial infusion chemotherapy plus targeted therapy and immunotherapy (HAIC-TI).

Materials And Methods: This retrospective study included 35 patients (46 lesions) who underwent HAIC-TI followed by hepatectomy. AI was used to calculate the tumor enhancement volume ratio (TEVR) from MRI.

Curcumin ameliorates benzalkonium chloride-induced dry eye disease in mice.

Dry eye disease (DED) is exacerbated by benzalkonium chloride (BAC), a preservative in ophthalmic formulations, which induces ocular damage via inflammation, apoptosis, and oxidative stress. Using network toxicology, molecular docking, dynamics simulations, and murine models, we elucidated BAC's mechanisms and evaluated curcumin (CUR) as a therapeutic agent. Network analysis identified 492 shared BAC-DED targets, functionally enriched in inflammation, leukocyte migration, and cytokine production.

CircERC1 facilitates chemoresistance through inhibiting pyroptosis and remodeling extracellular matrix in pancreatic cancer.

Background: Pancreatic ductal adenocarcinoma (PDAC) resists to neoadjuvant treatment even though overall survival (OS) is transiently prolonged while the underlying mechanism of this drug resistance remains elusive.

Methods: Gemcitabine combined with Nab-paclitaxel (GEM-NabP) treated PDAC tissues-derived EVs were isolated and underwent circRNA sequencing. CircERC1 was identified as an EVs-packaged circRNA that regulates PDAC progression and tumor microenvironment (TME) in vitro and in vivo with the help of EdU, colony formation, SRB viability assays, transwell assays and PET-CT analysis.

Metagenomic Investigation of Pathogenic RNA Viruses Causing Diarrhea in Sika Deer Fawns.

Diarrhea is a common disease in sika deer. The causes of diarrhea in sika deer are complex and involve a variety of pathogens. Additionally, new virulent pathogens are continuously emerging, which poses a serious threat to deer's health and particularly affects fawns' survival rate.

Auxiliary Electrode Tunes Wet-Electrospun Bundle Stiffness to Modulate Cell Phenotype.

The stiffness of tissue-engineered scaffolds significantly influences cell behaviour and phenotype. However, current approaches to tuning stiffness often introduce unintended variations and compromise topographical consistency. In this study, an innovative wet-electrospinning set-up, incorporating a positively charged auxiliary electrode was developed to fabricate bundles with adjustable stiffness.

Associations between follicular fluid and serum neonicotinoid insecticide exposure and sex hormones and ovarian reserve: A retrospective study among women undergoing IVF/ICSI.

Widespread utilization of neonicotinoid insecticides (NNIs) has led to their infiltration into the human body, resulting in their detrimental effects on human health. To date, studies on the impact of NNI exposure levels on the female reproductive endocrine system are limited. To address this, we aimed to explore the impact of exposure to NNIs in the environment on ovarian reserve and sex hormones to investigate potential endocrine-mediated reproductive toxicity.

Interaction between Group 3 Innate Lymphoid Cells, Microbiota, and Intestinal Diseases: Mechanisms and Therapeutic Potential.

Background: The incidence of intestinal diseases is increasing every year, placing a heavy burden on the world's health and economy. The interaction of immune, microbial, and environmental factors leading to chronic inflammation and immune dysfunction has gradually become a focus of research on the pathogenesis of intestinal diseases. Among them, type 3 innate lymphoid cells (ILC3s) have attracted much attention due to their unique features.

Mendelian randomization analysis of modifiable risk factors for breast cancer.

This review explores the role of Mendelian randomization (MR) in the analysis of modifiable risk factors for breast cancer. Breast cancer is the most common cancer in women, with risk factors including lifestyle, genetic predisposition, and hormonal influences. Mendelian randomization (MR) is a robust epidemiological tool, uses genetic variants to assess causal relationships between exposures and breast cancer risk.

Type-A and -C response regulator genes positively impact rice plant height and panicle architecture.

Thirteen type -A and two type -C RR genes exhibited distinct expression patterns and unique functions. Notably, RR2 and RR4 had the most significant positive effects impact on panicle development. Cytokinin signal transduction occurs through a "two-component system".

Enhanced Brain-Controlled Mobile Robot Based on SE-VEP Paradigm With Single Stimulus.

Brain-computer interface (BCI) systems based on steady-state visually evoked potentials (SSVEPs) have been widely adopted because of their efficiency and accuracy. However, the traditional SSVEP method has limitations, including visual fatigue and interference between different stimuli. To address these issues, a new BCI paradigm, namely, a spatial encoding-visually evoked potential (SE-VEP) model, is proposed in this work.

Acute appendicitis in children: Two microbial states associated with clinical indicators and severity.

Background: Acute appendicitis (AA) is one of the most common abdominal emergencies worldwide. It is associated with dysbiosis and is usually classified clinically as either simple appendicitis (SA) or complicated appendicitis (CA) . The etiology and pathogenesis of AA remain incompletely understood.

Automated Caries Detection Under Dental Restorations and Braces Using Deep Learning.

In the dentistry field, dental caries is a common issue affecting all age groups. The presence of dental braces and dental restoration makes the detection of caries more challenging. Traditionally, dentists rely on visual examinations to diagnose caries under restoration and dental braces, which can be prone to errors and are time-consuming.

Gut Fungi in Alzheimer's Disease: Mechanisms, Biomarkers and Therapeutic Potential.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of aging that imposes a heavy medical and socioeconomic burden. Its multifactorial pathology-including amyloid-β (Aβ) accumulation, tauopathy, and chronic neuroinflammation-lacks effective disease-modifying treatments. Recent studies highlight the gut-brain axis, specifically the intestinal mycobiome (fungal community), as a novel factor in AD.

Papillae growth and molecular responses in sea cucumber (Apostichopus japonicus) exposed to light spectra.

This study primarily investigated the light spectra that increased the number of papillae in sea cucumbers and the molecular pathways that contributed to the growth of papillae under these light conditions. At 8.0-15.

Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.

Ethnopharmacological Relevance: Buzhong Yiqi decoction (BZYQ), a compound formula comprising eight traditional Chinese medicinal herbs, has been used clinically to treat various autoimmune diseases, including autoimmune thyroiditis (AIT). Our long-term clinical practice and research have shown that BZYQ demonstrates promising anti-inflammatory efficacy in the management of AIT, and the underlying pharmacological mechanisms involved warrant further exploration.

Aim: To investigate the therapeutic effects and underlying mechanisms of the impact of BZYQ on AIT both in vitro and in vivo.

[Buzhong Yiqi Decoction alleviates immune injury of autoimmune thyroiditis in NOD.H-2~(h4)mice via c GAS-STING signaling pathway].

This study aims to explore the effects of Buzhong Yiqi Decoction(BYD) on the cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING) signaling pathway in the mouse model of autoimmune thyroiditis(AIT) and the mechanism of BYD in alleviating the immune injury. Forty-eight NOD.H-2~(h4) mice were assigned into normal, model, low-, medium-, and high-dose BYD, and selenium yeast tablets groups(n=8).