Effects of landscape fragmentation on floodplain fishes as revealed by species-habitat networks.

How species interact with habitat patches is influenced primarily by habitat configuration (e.g., connectivity) and species' functional traits.

Veillonella intestinal colonization promotes C. difficile infection in Crohn's disease.

Crohn's disease is a severe inflammatory disorder of the intestine for which there is no cure. Individuals suffering from Crohn's disease are at an increased risk of developing Clostridioides difficile infection (CDI), which considerably exacerbates symptoms. Using a prospective observational clinical study combined with animal models of intestinal inflammation, we show that intestinal colonization by Veillonella, an oral commensal, promotes CDI in Crohn's disease.

Impact Factors for Trajectories of Medication and Healthy Lifestyle Adherence in Young Adults With Hypertension: A Mixed Methods Study.

Treatment adherence is a cornerstone of effective hypertension management. However, the dynamic patterns of adherence and their influencing factors among young Chinese adults with hypertension remain insufficiently understood. This study aimed to explore the trajectories of medication adherence and healthy lifestyle behaviors, as well as the associated influencing factors, in this population.

Comprehensive metabolomic and transcriptomic analyses of the anthocyanin accumulation mechanism in the leaf veins of two Broussonetia papyrifera varieties (ZJ and CL) under cold stress.

Broussonetia papyrifera is an important native tree species in China. However, its relatively weak cold tolerance not only significantly compromises its survival and reproductive abilities in cold regions but also limits the realization of its economic potential. Notably, previous studies have demonstrated that anthocyanin accumulation enhances plant cold resistance.

The unique characteristics of extraversion: A systematic review and coordinate-based meta-analysis of resting state functional magnetic resonance imaging studies.

Extraversion, a core personality trait with significant implications for various life and work domains, has been extensively studied for its neural underpinnings, yet yielding inconsistent results. To resolve this, we employed the AES-SDM meta-analytic method and conducted a systematic review and meta-analysis of resting-state functional magnetic resonance imaging (rs-fMRI) studies to elucidate the relationship between extraversion and spontaneous brain activities at rest. Our analysis included 9 datasets from 11 studies, encompassing a total of 1242 participants, both adults and minors.

Predicting the hospitalization burdens of patients with mental disease: a multiple model comparison.

Background: Mental disorders represent a growing public health challenge, with rising hospitalization rates worldwide. Despite their significant impact, systematic investigations into the hospitalization burden (HB) of mental disorders remain notably lacking in current studies.

Objective: This study aims to employ machine learning (ML) techniques to predict the HB among patients with mental disorders.

Asynchronous and correlations of radial growth between different lateral meristems in Abies forrestii var. smithii.

Understanding radial growth phenology is crucial in the comprehension of tree physiology and its susceptibility to climate change. Numerous studies have investigated the impacts of radial growth activity in stem meristems and environmental factors on wood formation and tree growth in treeline trees. Nevertheless, studies on the radial growth dynamics of lateral meristems across different tree parts and the variations in their responses to environmental factors are scarce.

Impact of thermal ablation/cryoablation treatment on prognosis among patients with kidney cancer: a SEER database-based cohort study.

Background: Radiofrequency ablation (RFA) and cryoablation are minimally invasive treatments for renal cell carcinoma (RCC). However, their comparative efficacy remains under evaluation. This study aims to compare overall survival (OS) and cancer-specific survival (CSS) outcomes using data from the Surveillance, Epidemiology, and End Results (SEER) database.

Fe-S cluster deficiency drives small colony variant formation in persistent infections.

Introduction: Small colony variants (SCVs) of Staphylococcus aureus (S. aureus) are associated with persistent infections and poor clinical outcomes. The mechanisms driving stable SCV formation remain poorly understood, particularly concerning metabolic adaptations.

A 30-meter resolution global land productivity dynamics dataset from 2013 to 2022.

Land degradation is one of the most severe environmental challenges globally. To address its adverse impacts, the United Nations endorsed the Land Degradation Neutrality (SDG 15.3) within the Sustainable Development Goals in 2015.

Irreversible electroporation combined with PD-L1/IL-6 dual blockade promotes anti-tumor immunity via cDC2/CD4T cell axis in MHC-I deficient pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is a "cold" solid tumor with frequent Major Histocompatibility Complex I (MHC-I) deficiency, thereby making it resistant to type-1-conventional dendritic cell (cDC1)-CD8T cell mediated anti-tumor immunity. Current studies have demonstrated the emerging compensatory role of MHC-II-mediated antigen presentation and CD4T cell activation in anti-tumor immunity against MHC-I-deficient tumors. However, the underlying mechanism of the compensatory immune response by CD4T cells in cancer ablation therapy remains to be elucidate.

Patenting perspective on Keap1 inhibitors (2019-2024).

Introduction: Kelch-like ECH-associated protein 1 (Keap1), an E3 ligase negatively regulating the nuclear factor erythroid 2-related factor 2 (Nrf2), has emerged as an auspicious drug target for treating ailments associated with oxidative stress and inflammation. Discovery of Keap1 inhibitors have attracted significant interest.

Areas Covered: This review covers patents on Keap1 inhibitors from 2019 to 2024, providing a comprehensive analysis of their structural characteristics, optimization strategies, pharmacological properties and clinical progress.

Traditional Chinese exercises for the treatment of neuropsychiatric symptoms in Parkinson's disease: A systematic review and meta-analysis.

Objective: To systematically evaluate the efficacy of traditional Chinese exercises (TCEs) for neuropsychiatric symptoms (NPSs) in patients with Parkinson's disease.

Methods: A comprehensive literature search was performed across eight databases, including PubMed, Cochrane Library, Embase, Web of Science (WoS), SinoMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), and Wanfang Database, covering studies published from their inception up to April 23, 2024. The search focused on identifying randomized controlled trials (RCTs) assessing the effectiveness of TCEs for NPSs in PD patients.

Expanding the Potential of Circular RNA (CircRNA) Vaccines: A Promising Therapeutic Approach.

In recent years, circular RNAs (circRNAs) have garnered significant attention due to their unique structure and function, positioning them as promising candidates for next-generation vaccines. The circRNA vaccine, as an RNA vaccine, offers significant advantages in preventing infectious diseases by serving as a vector for protein expression through non-canonical translation. Notably, circRNA vaccines have demonstrated enduring antigenic expression and generate a larger percentage of neutralizing antibodies compared to mRNA vaccines administered at the same dosage.

Bioorthogonal strategy-triggered In situ co-activation of aggregation-induced emission photosensitizers and chemotherapeutic prodrugs for boosting synergistic chemo-photodynamic-immunotherapy.

In situ activation of prodrugs or photosensitizers is a promising strategy for specifically killing tumor cells while avoiding toxic side effects. Herein, we originally develop a bioorthogonally activatable prodrug and pro-photosensitizer system to synchronously yield an aggregation-induced emission (AIE) photosensitizer and a chemotherapeutic drug for synergistic chemo-photodynamic-immunotherapy of tumors. By employing molecular engineering strategy, we rationally design a family of tetrazine-functionalized tetraphenylene-based photosensitizers, one of which (named TzPS5) exhibits a high turn-on ratio, a NIR emission, a typical AIE character, and an excellent ROS generation efficiency upon bioorthogonal-activation.

Aqueous-Based Assembly of Plant-Derived Proteins Yields a Crosslinker-Free Biodegradable Bioplastic Consistent with Green Chemistry Principles.

Plastics are an indispensable part of modern life. Due to the harmful environmental consequences of petroleum-based plastic usage, there is an urgent need to replace them with biodegradable bioplastics that meet the sustainability standards required for a low environmental footprint. Here, we use plant-derived proteins to produce bioplastics.

The functional subclasses of AT1 receptor autoantibody in patients with coronary heart disease.

Recently, the identification of autoantibodies (AT1-AA) targeting the second extracellular loop of angiotensin II type 1 receptor (AT1R-ECII) in patients with coronary heart disease (CHD) offers a novel perspective on the interplay between immunity and cardiovascular disease. However, much remains unknown regarding the functional diversity of AT1-AA. In this study, we measured the levels of AT1-AA in the sera of 306 CHD patients and purified AT1-AA from patient's sera (n = 127).

Sleep patterns, genetic susceptibility, and venous thromboembolism: A prospective study of 384,758 UK Biobank participants.

Background: Although healthy sleep patterns have been linked to a lower risk of cardiovascular disease in earlier research, it is unclear how beneficial they are for venous thromboembolism (VTE).

Aim: This research aimed to examine the correlation between sleep patterns, genetic susceptibility, and VTE.

Methods: In the UK Biobank cohort, healthy sleep behaviors were defined as early chronotype, 7-8 hours of sleep each day, no snoring, infrequent insomnia, and infrequent daytime sleepiness.

A comprehensive study of Tianma Toutong Tablets from the dual dimensions of quality and efficacy using fingerprint techniques and network pharmacology.

Background: The quality of traditional Chinese medicine (TCM) is the prerequisite for ensuring its safe and effective clinical application. With the increasing popularity of TCM worldwide, the quality control of TCM products has become increasingly crucial. Tianma toutong tablet (TMTTT) is mainly used for migraine caused by external wind and cold, blood stasis, or deficiency of blood and nourishment.

Bridging childhood to adulthood: the impact of early life stress on acute stress responses.

Background: Childhood trauma exerts enduring impacts on the physical and psychological well-being of individuals in adulthood, influencing their daily functioning. This study aims to investigate the impact of childhood trauma on stress recovery in adults, concentrating on heart rate variations during acute stress exposure.

Methods: A cohort of 126 participants completed the Childhood Trauma Questionnaire (CTQ) and underwent the Trier Social Stress Test (TSST) to elicit acute stress, with continuous heart rate (HR) monitoring for stress recovery assessment.

Highly Stable Silicon Anode Enabled by a Water-Soluble Tannic Acid Functionalized Dual-Network Binder.

Silicon (Si), a high-capacity electrode material, is crucial for achieving high-energy-density lithium-ion batteries. However, Si suffers from poor cycling stability due to its significant volume changes during operation. In this work, a tannic acid functionalized aqueous dual-network binder with an intramolecular tannic acid functionalized network has been synthesized, which is composed of covalent-cross-linked polyamide and ionic-cross-linked alginate (Alg(Ni)-PAM-TA), and employed as an advanced binder for stabilizing Si anodes.